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简介：
现任中山大学医学院教授，博士生导师。2005至2008年就读于香港大学生物学专业，获学士学位。2011年于香港大学获得病毒学硕士学位。硕士期间两次（2009，2011年）以访问****的身份赴美国国家疾病控制中心进修。2011年加入澳大利亚知名病毒学家Edward Holmes团队，并于2015年于获得悉尼大学的病毒学博士学位，博士就读期间与中国疾病控制中心人兽共患病室建立长期合作。之后留悉尼大学接受博士后训练，开展病原体进化和生态的研究。2017年开始在上海临床公共卫生中心任兼职教授，2018年获得悉尼大学讲师职位，2019年作为中山大学“****”引进人才加入中山大学医学院。
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学术成果：
???????? 本人主要从事病毒的遗传进化，新病原发现，以及病原体与宿主之间相互作用的研究。并且致力于将最前沿的高通量测序技术（二代，三代，单细胞测序）和生物学信息方法运用于病原学研究。其研究成果主要体现在（i）建立了独有的样品处理体系与高通量测序为基础的病毒筛查新体系，开发了针对病原发现的高效快速的生物信息分析流程、（ii）发现了超过2000种的新病毒，重新定义了非脊椎动物和脊椎动物的RNA病毒圈，改变了人们对RNA病毒的普遍性和多样性的认知、（iii）利用多组学测序产生的丰富的病毒、细菌和宿主信息，阐释了病毒、宿主、以及其它微生物之间的相互作用，开创了以组学为基础的系统病原学的先例。主要的研究工作发表在Nature （两篇长文）, NEJM, Cell, PNAS, elife, 以及Plos Pathogens等国际知名杂志。总计发表SCI论文数61篇，总引用次数达4226次。
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招生学科专业：
071000 生物学-05 微生物学，086000 生物与医药。
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联系邮箱：shim23@mail.sysu.edu.cn
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著作代表著作（共同一作#，共同通讯*）：
1. Shi M, Lin XD, Chen X, Tian JH, Chen LJ, Li K, Wang W, Eden JS, Shen JJ, Liu L, Holmes EC, Zhang YZ (2018). The evolutionary history of vertebrate RNA viruses. Nature 556:197-202.
2. Shi M, Lin XD, Tian JH, Chen LJ, Chen X, Li CX, Qin XC, Li J, Cao JP, Eden JS, Buchmann J, Wang W, Xu J, Holmes EC, Zhang YZ (2016). Redefining the invertebrate RNA virosphere. Nature 540:539-543.
3. Zhang YZ, Shi M, Holmes EC (2018). Using metagenomics to characterize an expanding virosphere. Cell 172:1168-1172.
4. Li CX#, Shi M#, Tian JH, Lin XD, Kang YJ, Chen LJ, Qin XC, Xu J, Holmes EC, Zhang YZ (2015). Unprecedented genomic diversity of RNA viruses in arthropods reveals the ancestry of negative sense RNA viruses. eLife 4:e05378.
5. Qin XC#, Shi M#, Tian JH, Lin XD, Gao DY, He JR, Wang JB, Li CX, Kang YJ, Yu B, Zhou DJ, Xu J, Plyusnin A, Holmes EC, Zhang YZ (2014). A tick-borne segmented RNA virus contains genome segments derived from unsegmented viral ancestors. Proc. Natl. Acad. Sci. USA. 111:6744-6749.
6. Shi M, White VL, Schlub T, Eden JS, Hoffmann AA, Holmes EC (2018). No detectable effect of Wolbachia wMel on the prevalence and abundance of the RNA virome of Drosophila melanogaster. Proc Biol Sci. 285.
7. Shi M, Neville P, Nicholson J, Eden J-S, Imrie A, Holmes EC (2017). High pesolution meta-transcriptomics reveals the ecological dynamics of mosquito-associated RNA viruses in Western Australia. J. Virol. 91:e00680-17.
8. Shi M, Lin XD, Vasilakis N, Tian JH, Li CX, Chen LJ, Eastwood G, Diao XN, Chen MH, Chen X, Qin XC, Widen SG, Wood TG, Tesh RB, Xu J, Holmes EC, Zhang YZ (2015). Divergent viruses discovered in arthropods and vertebrates revise the evolutionary history of the Flaviviridae and related viruses. J. Virol. 90:659-669.
9. Shi M, Jagger BW, Wise HM, Digard P, Holmes EC, Taubenberger JK (2012). Evolutionary conservation of the PA-X open reading frame in segment 3 of influenza A virus. J. Virol. 86:12411-12413.
10. Shi M, Holmes EC, Brar MS, Leung FC (2013). Recombination is associated with an outbreak of novel highly pathogenic porcine reproductive and respiratory syndrome viruses in China.? J. Virol. 87:10904-10907.
11. Shi M, Lam TT, Hon CC, Murtaugh MP, Davies PR, Hui RK, Li J, Wong LT, Yip CW, Jiang JW, Leung FC (2010). Phylogeny-based evolutionary, demographical, and geographical dissection of North American type 2 porcine reproductive and respiratory syndrome viruses. J. Virol. 84:8700-11.
12. Tao Y#, Shi M#, Chommanard C, Queen K, Zhang J, Markotter W, Kuzmin IV, Holmes EC, Tong S (2017). Surveillance of bat coronaviruses in Kenya identifies relatives of human coronaviruses NL63 and 229E and their recombination history. J. Virol. 91:e01953-16.
13. Zhao K, Ye C, Chang XB, Jiang CG, Wang SJ, Cai XH, Tong GZ, Tian ZJ, Shi M*, An TQ* (2015). Importation and recombination are responsible for the latest emergence of highly pathogenic Porcine Reproductive and Respiratory Syndrome virus in China. J. Virol. 89:10712-10716.
14. Shi M, Lemey P, Singh Brar M, Suchard MA, Murtaugh MP, Carman S, D'Allaire S, Delisle B, Lambert Mè, Gagnon CA, Ge L, Qu Y, Yoo D, Holmes EC, Leung FC (2013). The spread of type 2 Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) in North America: a phylogeographic approach. Virology. 447:146-154.
15. Shi M, Holmes EC, Zhang YZ. Meta-transcriptomics and the evolutionary biology of RNA viruses (2018). Virus Res. 243:83-90.
16. Shi M, Lam TT, Hon CC, Hui RK, Faaberg KS, Wennblom T, Murtaugh MP, Stadejek T, Leung FC (2010). Molecular epidemiology of PRRSV: a phylogenetic perspective. Virus Res. 154:7-17.
17. Kuzmin IV, Shi M, Orciari LA, Yager PA, Velasco-Villa A, Kuzmina NA, Streicker DG, Bergman DL, Rupprecht CE (2012). Molecular inferences suggest multiple host shifts of rabies viruses from bats to mesocarnivores in Arizona during 2001-2009. PLoS Pathog. 8:e**.
18. Tong S, Zhu X, Li Y, Shi M, Zhang J, Bourgeois M, Yang H, Chen X, Recuenco S, Gomez J, Chen LM, Johnson A, Tao Y, Dreyfus C, Yu W, McBride R, Carney PJ, Gilbert AT, Chang J, Guo Z, Davis CT, Paulson JC, Stevens J, Rupprecht CE, Holmes EC, Wilson IA, Donis RO (2013). New world bats harbor diverse influenza A viruses. PLoS Pathog. 9:e**.
19. Tong S, Li Y, Rivailler P, Conrardy C, Castillo DA, Chen LM, Recuenco S, Ellison JA, Davis CT, York IA, Turmelle AS, Moran D, Rogers S, Shi M, Tao Y, Weil MR, Tang K, Rowe LA, Sammons S, Xu X, Frace M, Lindblade KA, Cox NJ, Anderson LJ, Rupprecht CE, Donis RO (2012). A distinct lineage of influenza A virus from bats. Proc. Natl. Acad. Sci. USA 109:4269-4274.
20. Devault AM, Golding GB, Waglechner N, Enk JM, Kuch M, Tien JH, Shi M, Fisman DN, Dhody AN, Forrest S, Bos KI, Earn DJ, Holmes EC, Poinar HN (2014). Second-pandemic strain of Vibrio cholerae from the Philadelphia cholera outbreak of 1849.? N. Engl. J. Med. 370:334-340.
研究方向??新病原发现? ?????病毒组的宏观进化和生态 ?????传染病的精准医疗和信息医疗? ?????组学系统病原学 病原体分子流行病学
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