头像
个人简介：
现任中山大学医学院教授，博士生导师，院长助理。于2004年开始在苏州大学药学院攻读药理学硕士和博士学位，2011年博士毕业后于唐仲英血液学研究中心进行博士后研究工作。随后前往美国MD安德森肿瘤中心进行博士后研究，发现了TJP1蛋白和相关通路可以作为骨髓瘤化疗敏感性的标志物并阐明机制，对骨髓瘤病人的临床化疗提供了新的靶点以及参考。此部分结果以第一作者的身份发表于肿瘤学著名杂志Cancer Cell并受到了大量的关注和引用。2017年初受美国西北大学的聘用成为助理教授并成立实验室。同时受聘为复旦大学附属中山医院消化科的客座教授。2017年6月获聘中山大学“****”引进人才。
已在肿瘤学以及药理学方向发表高水平学术论文26篇，其中以第一作者及通讯作者在Cancer Cell, Autophagy, Cell Death Dis等杂志上发表论文13篇，总引用率大于 1000次，独立他引次数超过 500次。研究成果获得了国际同行的广泛关注和高度肯定。ISI Web of Knowledge 引用数据统计表明，其中4篇论文年度生物医学世界前 1-10%高引用率论文。并被众多高水平SCI杂志邀请作为编辑及审稿人，迄今为止支持获批并顺利完成美国骨髓瘤基金1项，主持参与完成国家自然科学基金等国内项目6项。
?
重要学术研究成果与贡献：
(1)在国际上第一次提出TJP1蛋白作为骨髓瘤化疗的标志物，并对TJP1蛋白介导化疗耐药性的机制做出了深入探讨。相关结果以第一作者研究论文发表在国际肿瘤知名杂志Cancer Cell上。
(2)完善了大鼠纹状体急性线粒体损伤的模型的建立，首次提出了p53和相关蛋白在急性线粒体损伤和兴奋性损伤中的作用。利用这些新的实验方法和实验设想，一系列自噬相关通路在线粒体和兴奋性损伤模型和脑缺血模型中被首次发现。此部分的结果于2008和2009年发表在Autophagy杂志3篇高水平研究论文。
(3)创新性的发现自噬和凋亡蛋白DRAM1，HMGB1和Bcl-2在调节大鼠纹状体急性线粒体损伤的作用。之前研究发现p53调节的DRAM1，HMGB1和Bcl-2基因在肿瘤中发挥了调节作用，但没有发现此通路对于神经性推行疾病的作用。申请人创新性的在线粒体损伤的模型中对信号通路进行研究，发现DRAM1，HMGB1和Bcl-2蛋白调节了自噬和凋亡途径来保护线粒体损伤导致的神经退行性疾病的发展，填补了相关研究的空白。此部分的结果以第一作者和通讯作者发表在Cell Death Dis, PLoS One和J Neurosci Res杂志上。
?
学术兼职：
以下SCI杂志审稿人：Autophagy，Apoptosis, Acta Pharmacologica Sinica, ?BioMed Research International, Journal of Leukemia, Bioorganic & Medicinal Chemistry, Cancer Medicine, Cancer Gene Therapy, European Journal of Cell Biology , Journal of Biological Methods, Journal of the Neurological Sciences, Neuroscience Bulletin, Neoplasma, Neuroscience Letters.
?
?
学科专业：药理学
招生学科专业：100100 基础医学-04 病理学与病理生理学，086000 生物与医药。
联系方式：zhangxd39@mail.sysu.edu.cn
?
本实验室长期招聘具有基础医学和生物学背景的专职科研人员，博士后，招收硕、博士生，诚挚欢迎有志于肿瘤生物学研究的同仁加入！
著作1. Miao Li#, Lin Qi#*, Jing-Bo Xu#, Li-Ye Zhong, Szehoi Chan, Shu-Na Chen, Xin-Rong Shao, Li-Yuan Zheng, Zhao-Xia Dong, Tian-Liang Fang, Zhi-Ying Mai, Juan Li, Yongjiang Zheng*, Xing-Ding Zhang*. Methylation of the promoter region of the Tight Junction Protein-1 by DNMT1 induces Epithelial-Mesenchymal Transition-like features in multiple myeloma. Molecular Therapy: Oncolytics. https://doi.org/10.1016/j.omto.2020.10.004.
2. Lin Qi, Zhong-Yong Wang, Xin-Rong Shao, Miao Li, Shu-Na Chen, Xue-Qi Liu, Shi Yan, Bo Zhang, Xu-Dong Zhang, Xin Li, Wenxue Zhao, Ji-An Pan, Bo Zhao, Xing-Ding Zhang*. ISL2 modulates angiogenesis through transcriptional regulation of ANGPT2 to promote cell proliferation and malignant transformation in oligodendroglioma. Oncogene. 2020. 39(37):5964-5978.
3. Hua Tan*, Weijun Su, and Xing-Ding Zhang. Stem Cells in Cancer Progression and Therapy. Stem Cells International.?2019;**. PMID: **.
4. Ping Zhang, Ping Zhang, Songbo Zhao, Chao Wu, Jialu Li, Zixuan Li, Chunmei Wen, Siyi Hu, Gangli An, Huimin Meng, Xingding Zhang,?Lin Yang*.?Effects of CSF1R-targeted chimeric antigen receptor-modified NK92MI & T cells on tumor-associated macrophages. Immunotherapy. 2018;10(11):935-949. PMID: **.
5. Xin Chen, Xue Sun, Zhe Wang, Xiaojun Zhou, Lu Xu, Feng’e Li, Xingding Zhang, Ji’an Pan, Lin Qi*, Haixin Qian*, and Zhongqi Mao*. Involvement of acid-sensing ion channel 1a in gastric carcinoma cell migration and invasion. Acta Biochim Biophys Sin (Shanghai). 2018 1;50(5):440-446. PMID: **.
6. Xing-Ding Zhang, Veerabhadran Baladandayuthapani, Heather Lin, George Mulligan, Bin Li, Dixie-Lee W. Esseltine, Lin Qi, Jianliang Xu, Walter Hunziker, Bart Barlogie, Saad Z. Usmani, Qing Zhang,John Crowley, Antje Hoering, Jatin J. Shah, Donna M. Weber, Elisabet E. Manasanch, Sheeba K. Thomas,Bing-Zong Li, Hui-Han Wang, Jiexin Zhang, Isere Kuiatse, Jin-Le Tang, Hua Wang, Jin He, Jing Yang,Enrico Milan, Simone Cenci,10 Wen-Cai Ma,1 Zhi-Qiang Wang,1 Richard Eric Davis, Lin Yang* and Robert Z. Orlowski*. Tight Junction Protein 1 Modulates Proteasome Capacity and Proteasome Inhibitor Sensitivity in Multiple Myeloma via EGFR/JAK1/STAT3 Signaling. Cancer Cell. 2016; 9;29(5):639-52. PMID: **.
7. Katarzyna Lepeta#, Mychael V#. Lourenco, Barbara C#. Schweitzer, Pamela V.Martino Adami, Priyanjalee Banerjee, Silvina Catuara-Solarz, Mario de La Fuente Revenga, Alain Marc Guillem, Mouna Haidar, Omamuyovwi M, Xing-Ding Zhang, Constanze Seidenbecher*. Synaptopathies: synaptic dysfunction in neurological disorders. Journal of Neurochemistry. 2016, 138(6):785-805. PMID: **.
8. Fenge Li*#, X. Du*#, H. Zhang#, T. Ju, C. Chen, Q. Qu, Xing-Ding Zhang, L Qi and G. Lizee*. Next Generation Sequencing of Chinese Stage IV Lung Cancer Patients Reveals an Association between EGFR Mutation Status and Survival Outcome. Clin Genet. 2016, ;91(3):488-493. PMID: **.
9. Tang J, Li J, Zhu X, Yu Y, Chen D, Yuan L, Gu Z, Zhang Xingding, Qi L, Gong Z, Jiang P, Yu J, Meng H, An G, Zheng H, Yang L*. Novel CD7-specific nanobody-based immunotoxins potently enhanced apoptosis of CD7-positive malignant cells. Oncotarget. 2016 Apr 12. doi: 10.18632/oncotarget.8710. PMID: **.
10. Yunhui Zong, Songbing He, Fuliang Chu, Yu Jing, Sally A Hunsucker, Tina Yang, Fengtao You, Sisi Ye, Yafen Li, Jinle Tang, Huimin Meng, Gangli An, Xingding Zhang, Bozhen Zhang, Lin Yang*. Identification of Co-inhibitory Receptors PD-1 and TIM-3 on T Cells from Gastric Cancer Patients. Immunother Open Acc. 2015; 1: 105. doi: 10.4172/imt.**.
11. Fenge Li, Zhi Guo , Yuewei Zhang, Haitao Wang , Xingding Zhang, Tongguo Si, Haipeng Yu, Lin Qi. Postoperative adjuvant arterial chemoembolization improves survival of hepatitis B virus-related hepatocellular carcinoma: a retrospective control study. Irish journal of medical science. 2015; 184(4): 753-9. PMID: **.
12. Bao-Song Zhu, Jia-Lei Sun, Wei Gong, Xing-Ding Zhang, Yong-You Wu, Chun-Gen Xing. Effects of 5?fluorouracil and class III phosphoinositide 3?kinase small interfering RNA combination therapy on SGC7901 human gastric cancer cells. Mol Med Rep. 2015; 11(3): 1891-8. PMID: **.
13. Jun-Jie Guan, Xing-Ding Zhang (Co-first author), Wei Sun, Lin Qi, Jun-Chao Wu, Zheng-Hong Qin*. DRAM1 regulates apoptosis through increasing protein levels and lysosomal localization of BAX. Cell Death Dis.?2015; 29; 6:e1624. PMID: **.
14. Jianxuan Zou, Dan Chen, Yunhui Zong, Sisi Ye, Jinle Tang, Huimin Meng, Gangli An, Xingding Zhang, Lin Yang*. BiTE-hIgFc-based Immunotherapy as a New Therapeutic Strategy in Multiple Myeloma. Cancer Sci. 2015; 106(5): 512-21. PMID: **.
15. Isere Kuiatse,?Veerabhadran Baladandayuthapani,?Heather Lin,?Sheeba Thomas,?Chad Bjorklund,?Donna Weber,?Michael Wang,?Jatin Shah,?Xingding Zhang, Richard Jones,?Stephen Ansell,?Guang Yang,?Steven Treon, and?Robert Orlowski*. Targeting the Spleen Tyrosine Kinase with Fostamatinib as a Strategy Against Waldenstr?m's Macroglobulinemia. Clinical Cancer Research. 2015;?1; 21(11):2538-45. PMID: **.
16. Xing-Ding Zhang. Mechanism of DRAM1’s Regulation of Autophagy and Apoptosis. J Pharmacogenomics Pharmacoproteomics. 2015; 6: e147. doi:10.4172/2153-0645.1000e147.
17. Bingzong Li, Jinxiang Fu, Ping Chen, Xueping Ge, Yali Li, Isere Kuiatse, Hua Wang, Huihan Wang, Xingding Zhang, and Robert Z. Orlowski*. The Nuclear Factor (Erythroid-derived 2)-like 2 and Proteasome Maturation Protein Axis Mediates Bortezomib Resistance in Multiple Myeloma. J Biol Chem. 2015;?11; 290(50):29854-68. PMID: **.
18. Lin Qi, Xue Sun, Feng-E Li, Bao-Song Zhu, Frank K Braun, Zhi-Qiang Liu, Jin-Le Tang, Chao Wu, Fei Xu, Hui-Han Wang, Luis A Velasquez, Kui Zhao, Feng-Rui Lei, Ji-Gang Zhang, Yun-Tian Shen, Jian-Xuan Zou, Hui-Min Meng, Gang-Li An, Lin Yang, Xing-Ding Zhang* (Corresponding Author).?HMGB1 promotes mitochondrial dysfunction–triggered striatal neurodegeneration via autophagy and apoptosis activation. PLoS One. 2015; 10(11): e**. PMID: **.
19. Lin Qi, Xing-Ding Zhang*?(Corresponding Author). Role of Chaperone-mediated Autophagy in Degrading Huntington's Disease-associated Huntingtin protein. Acta Biochimica Biophysica Sinica. 2014; 46(2): 83-91. PMID: **.
20. Huimin Meng, Yunhui Zong, Jianfei Qian, Yu Jing, Jinle Tang, Jianxuan Zou1, Gangli An, Hui Song, and Xingding Zhang,?Lin Yang*. Photothermal Targetting therapy of A20 Mouse Lymphoma model using Anti CD-138 Antibody conjugated Gold Nanospheres. Journal of Hematology & Thromboembolic Diseases. 2014; 2;3, **.
21. Xue Sun, Jun Jin, Ji-Gang Zhang, Lin Qi, Frank Karl Braun, Xing-Ding Zhang*?(Co-Corresponding Author), Feng Xu*. Expression of Acid-Sensing Ion Channels in Nucleus Pulposus Cells of the Human Intervertebral Disc Is Regulated by Non steroid Anti-Inflammatory Drugs. Acta Biochimica Biophysica Sinica. 2014; 46(9): 774-81.?PMID: **.
22. Fenge Li, Zhi Guo, Haipeng Yu, Xingding Zhang, Tongguo Si, Changfu Liu, Xueling Yang, Lin Qi. Anti-tumor immunological response induced by cryoablation and anti-CTLA-4 antibody in an in vivo RM-1 cell prostate cancer murine model. Neoplasma.?2014; 61(6): 659-71. PMID: **.
23. Xing-Ding Zhang, Lin Qi, Jun-Chao Wu, Zheng-hong Qin*. DRAM1 regulates autophagy flux through lysosomes. PLoS One. 2013; 8(5): e63245.?PMID: **.
24. Xing-Ding Zhang#, Yu Jing#, Yang Qin, Sally Hunsucker, Hui-Min Meng, Ye-Lin Jiang, Li Gao, Gang-Li An, Nan Yang, Robert Z. Orlowski, and Lin Yang*. ?The zinc finger transcription factor ZKSCAN3 promotes prostate cancer cell migration. Int J Biochem Cell Biol. 2012; 44(7): 1166-73.?PMID:?**.
25. Lin Qi, Xing-Ding Zhang (Co-first author), Jun-Chao Wu, Fang Lin, Jin Wang, Marian DiFiglia, and Zheng-Hong Qin*. The role of chaperone-mediated autophagy in huntingtin degradation. PLoS One. 2012; 7(10): e46834.?PMID: **.
26. Xing-Ding Zhang, Zheng-Hong Qin, and Jin Wang*. The role of p53 in cell metabolism. Acta Pharmacol Sin. 2010; 31(9): 1208-12.?PMID: **.
27. Xing-Ding Zhang, Ye Wang,Jun-Chao Wu,Fang Lin, Rong Han, Feng Han, Kohji Fukunaga, and Zheng-Hong Qin*. Down-regulation of Bcl-2 enhances autophagy activation and cell death induced by mitochondrial dysfunction in rat striatum. J Neurosci Res. 2009; 87: 3600–10.?PMID:?**.
28. Xing-Ding Zhang, Ye Wang, Yan Wang, Rong Han, Jun-Chao Wu, Zhong-Qin Liang, Zhen-Lun Gu, Feng Han, Kohji Fukunaga, and Zheng-Hong Qin*. p53 mediates mitochondria dysfunction-triggered autophagy activation and cell death in rat striatum. ?Autophagy 2009; 5(3): 339-50.?PMID: **.
29. Yan Wang, Rong Han, Zong-Qin Liang, Jun-Chao Wu, Xing-Ding Zhang, Zhen-Lun Gu, and Zheng-Hong Qin*. An autophagic mechanism is involved in apoptotic death of rat striatal neurons induced by the non-N-methyl-D-aspartate receptor agonist kainic acid. Autophagy 2008; 4(2): 214-26.?PMID:?**.
30. Ya-Dan Wen, Rui Sheng, Li-Sha Zhang, Rong Han, Xuan Zhang, Xing-Ding Zhang, Feng Han, Kohji Fukunaga, and Zheng-Hong Qin*. Neuronal injury in rat model of permanent focal cerebral ischemia is associated with activation of autophagic and lysosomal pathways. Autophagy 2008; 4(6): 762-9.?PMID: **.
?
研究方向多发性骨髓瘤；泌尿系统肿瘤；紧密连接蛋白；化疗耐药；血管生成；原位人源小鼠肿瘤移植模型；纳米药物递送。学科专业：肿瘤药理学。
联系我们
邮编: 510080
电话: ,
邮箱: yxyszdzb@mail.sysu.edu.cn
