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教授、博导，中山大学“卓越教师”二等奖获得者。
学科专业：细胞与分子神经生物学、人体解剖学。
招生学科专业：100100 基础医学-01 人体解剖与组织胚胎学，071000 生物学，086000 生物与医药。
研究方向：神经损伤与修复的分子机制、运动神经元凋亡的表观遗传学调控机制。
联系方式：zhoulih@mail.sysu.edu.cn
著作Tang Y, Fu R, Ling ZM, Liu LL, Yu GY, Li W, Fang XY, Zhu Z, Wu WT, Zhou LH*. MiR-137-3p rescue motoneuron death by targeting calpain-2. Nitric Oxide. 2018 Apr 1;74:74-85.
Li YQ, Song FH, Zhong K, Yu GY, Zilundu PLM, Zhou YY, Fu R, Tang Y, Ling ZM, Xu X, Zhou LH*. Pre-Injection of Small Interfering RNA (siRNA) Promotes c-Jun Gene Silencing and Decreases the Survival Rate of Axotomy-Injured Spinal Motoneurons in Adult Mice. J Mol Neurosci. 2018 Jul;65(3):400-410.
Chen X, Zhou X, Yang L, Miao X, Lu DH, Yang XY, Zhou ZB, Kang WB, Chen KY, Zhou LH*, Feng X*. Neonatal Exposure to Low-Dose (1.2%) Sevoflurane Increases Rats' Hippocampal Neurogenesis and Synaptic Plasticity in Later Life. Neurotox Res. 2018 Aug;34(2):188-197.
Tan M, Yuan MZ, Sun TY, Xie YY, Liu LL, Tang Y, Ling ZM, Li YQ, Yu GY, Zhou LH*. Identification of the Avulsion-Injured Spinal Motoneurons. J Mol Neurosci. 2015 Sep;57(1):142-51.
Zhou LN, Zhang JW, Liu XL, Zhou LH*. Co-graft of Bone Marrow Stromal Cells and Schwann Cells into Acellular Nerve Scaffold for Sciatic Nerve Regeneration in Rats, J Oral Maxillofac Surg. 2015 Aug;73(8):1651-60.
Ling ZM, Tang Y, Li YQ, Luo HX, Liu LL, Tu QQ, Zhou LH*. Evaluation of Avulsion-Induced Neuropathology in Rat Spinal Cords with 18F-FDG Micro-PET/CT. PLoS One. 2015 May 26;10(5):e**.
Fu R, Tang Y, Ling ZM, Li YQ, Cheng X, Song FH, Zhou LH*, Wu W*. Lithium enhances survival and regrowth of spinal motoneurons after ventral root avulsion. BMC Neurosci. 2014 Jul 2;15(1):84.?
Tang Y, Ling ZM, Fu R, Li YQ, Cheng X, Song FH, Luo HX, Zhou LH*. Time-specific microRNA changes during spinal motoneuron degeneration in adult rats following unilateral brachial plexus root avulsion: ipsilateral vs. contralateral changes.?BMC Neurosci. 2014 Jul 24;15(1):92.
Cheng X, Fu R, Gao M., Liu S, Li YQ, Song FH, Zhou LH*, Wu W*. Intrathecal application of short interfering RNA (siRNA) knockdowns c-jun expression and augments death of spinal motoneurons after root avulsion in adult rats. Neuroscience, 2013, Jun 25; 241:268–279.
Cheng X, Luo H, Hou Z, Huang Y, Sun J*, Zhou L*. ?Neuronal nitric oxide synthase, as a downstream signaling molecule of c?jun, regulates the survival of differentiated PC12 cells. Mol Med Rep. 2014 Jul 23. 10: 1881-1886。
Cheng X, Fu R, Gao M., Liu S, Li YQ, Song FH, Zhou LH*, Wu W*. Intrathecal application of short interfering RNA (siRNA) knockdowns c-jun expression and augments death of spinal motoneurons after root avulsion in adult rats. Neuroscience, 2013, Jun 25; 241:268–279.
Hu JM, Cheng X, Wang L, Zhu JN,?Zhou LH*. Vasoactive intestinal peptide expression in the vaginal anterior wall of patients with pelvic organ prolapse. Taiwan J Obstet Gyne. 2013 Jun;52(2):233-40. ?
Zhao XC, Wang LL, Wang YQ, Song FH, Li YQ, Fu R, Zheng WH, Wu W, Zhou LH*?. Activation of phospholipase-Cγ and protein kinase C signal pathways helps the survival of spinal motoneurons injured by root avulsion. J Neurochem. 2012 May;121(3):362-72.
Zhou LN, Zhang JW, Wang JC, Lei WL, Liu XL, Zhou LH*. Bone marrow stromal and Schwann cells from adult rats can interact synergistically to aid in peripheral nerve repair even without intercellular contact in vitro. J Tissue Eng Regen Med. 2012 Jul;6(7):579-88.
Feng X, Liu JJ, Zhou X, Song FH, Yang XY, Chen XS,?Huang WQ*, Zhou LH*, Ye JH. Single sevoflurane exposure decreases neuronal nitric oxide synthase levels in the hippocampus of developing rats. Br J Anaesth. 2012 Aug;109(2):225-33.
Liu S, Fu R, Cheng X, Chen SP, Zhou LH*. Exploring the binding of BACE-1 inhibitors using comparative binding energy analysis (COMBINE). BMC Struct Biol. 2012 Aug;12:21.
Zhou X, Song FH, He W, Yang XY, Zhou ZB,?Feng X*, Zhou LH*. ?Neonatal exposure to sevoflurane causes apoptosis and reduces nNOS protein expression in rat hippocampus. Mol Med Report. 2012 Sep;6(3):543-546.
Fu R, Wang LQ, Chu GL, Zhou LH*. Involvement of phospholipase C-γ in the pro-survival role of glial cell line-derived neurotrophic factor in developing motoneurons in rat spinal cords. Mol Med Report. 2012 Oct;6(4):805-810.
Cheng X, Liu S, Wang YQ, Li YQ, Fu R, Tang Y, Zheng WH,?Zhou LH*. Suppression of c-jun influences nNOS expression in differentiated PC12 cells. Mol Med Report. 2012 Oct;6(4):750-4.
Wang L,?Li M*, Zhou LH*. Nitric oxide promotes survival of cerebellar granule neurons cultured in vitro through the Akt pathway. Neural Regen Res. 2011, Aug 24, 6(20):1559-1563.
Wang LL, Zhao XC, Yan LF, Wang YQ, Cheng X, Fu R, Zhou LH*?. c-Jun phosphorylation contributes to down regulation of neuronal nitric oxide synthase protein and motoneurons death in injured spinal cords following root-avulsion of the brachial plexus. ?Neuroscience. 2011, Aug 25, 189:397-407.?
Wang J, Yan L, Zhao X, Wu W,?Zhou LH*.?The diversity of nNOS gene expression in avulsion-injured spinal motoneurons among laboratory rodents. Nitric Oxide, 22(1), Jan 2010, 37-42。
Li M, Wang L, Peng Y, Wang J, Zhou LH*.?Knockdown of the neuronal nitric oxide synthase gene retard the development of the cerebellar granule neurons in vitro. Dev Dyn, 2010, Feb;239(2):474-81.
Yan L, Zhao X, Wang Y, Wang L, Cheng X, Zhou LH*, Feng X*. Influence of species, age and weight on the establishment of a murine model of brachial plexus root avulsion. Neural Regen Res. 2010; May, 5(10): 764-768.?
Cheng X, Liu F, Zhang J, Wang L, Li F, Liu S, Zhou L *.?EGb761 protects motoneurons against avulsion-induced oxidative stress in rats. Journal of Brachial Plexus and Peripheral Nerve Injury (JBP&PNI), 2010, 5:12 (24 May 2010).?
Zhou LH, Han S, Xie YY, Yao ZB*. Differences in c-jun and nNOS expression levels in motoneurons following different kinds of axonal injury in adult rats. Brain Cell Biology, 2008, 36:213-227.?
Zhou LH,?Wu W*. Survival of injured spinal motoneurons in adult rat upon treatment with glial cell line-derived neurotrophic factor at 2 weeks but not at 4 weeks after root avulsion. J Neurotrauma, 2006, 23(6):920~927.
Zhou L, Wu W*. Antisense oligos to neuronal nitric oxide synthase aggravate motoneuron death induced by spinal root avulsion in adult rat. Exp Neurol, 2006,197(1):84-92.
研究方向神经损伤与修复的分子机制、运动神经元凋亡的表观遗传学调控机制。
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