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中山大学医学院副教授、硕导。分别于2003年和2007年获得赫尔辛基大学生物系微生物学硕士和博士学位。2007年博士毕业后进入赫尔辛基大学医学院哈特曼研究所进行博士后训练，2010年转入赫尔辛基大学生物技术研究所工作，2015年回国，担任武汉大学基础医学院病原生物学副研究员。主要研究领域为鼠疫病原菌耶尔森氏细菌致病机制研究，主要是在细菌全基因组水平研究宿主细胞与病原细菌相互作用的基因表达调控机制；病毒的感染复制与抗病毒免疫调控机制研究；利用电镜及3D重构技术研究内质网与生物大分子的动态分子机制。
招生学科专业：100100 基础医学-03 病原生物学，086000 生物与医药
研究方向：病原微生物的感染与免疫逃逸机制；噬菌体疗法
邮箱：lichm8@mail.sysu.edu.cn
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主持或参与的科研项目：
1. 广东省“珠江人才计划”引进创新创业团队“病毒复制与宿主免疫防御应用基础创新团队”项目，团队核心人员
2. 科技部重大专项“艾滋病和病毒性肝炎等重大传染病防治”子课题任务“CD4+T细胞的抗HIV改造”(2017/01-2020/12),?任务三负责人
3. 国家自然科学基金委重点国际合作项目(2017/01-2021/12),PTEN等宿主因子调控急性RNA病毒感染的功能与机制,?项目主要承担人
4. 芬兰科学院研究基金项目?(2010/01-2013/12), Molecular determinants of the endoplasmic reticulumstructure and dynamics,?项目主要承担人
5. 欧共体科技框架七项目?(2007/02 - 2010/01), A global RNAi approach to unravel eukaryotic host functions that modulate bacterial infections (RNAi-Net),项目主要承担人
著作1. Lang Bu#, Huan Wang, Panpan Hou, Shuting Guo, Miao He, Jingshu Xiao, Ping Li, Yongheng Zhong, Penghui Jia, Yuanyuan Cao, Guanzhan Liang, Chenwei Yang, Lang Chen, Deyin Guo*, and Chun-Mei Li*, The ubiquitin E3 ligase parkin inhibits innate antiviral immunity through K48-linked polyubiquitination of RIG-I and MDA5. Front Immunol. 2020 Sep 2;11:1926.
2. Cao, Y#, Wang, H., Yang, L., Zhang, Z., Li, C., Yuan, X., Chen, L., Chen, Y., Li, C.M*, &Guo, D*. (2017)PTEN-Long promotes type I interferon responses and antiviral immunity. Cellular & Molecular Immunology, 2017 Oct 23. doi: 10.1038/cmi.2017.102.
3. Panpan Hou#, Penghui Jia#, Kongxiang Yang#, Zibo Li, Tian Tian, Yuxin Lin, Weijie Zeng, Fan Xing, Yu Chen, Chunmei Li, Yingfang Liu & Deyin Guo*，An unconventional role of an ASB family protein in NF-κB activation and inflammatory response during microbial infection and colitis，Proc Natl Acad Sci U S A. 2021 Jan 19;118(3):e.
4. Panpan Hou#, Kongxiang Yang, Penghui Jia, Lan Liu, Yuxin Lin, Zibo Li, Jun Li, Shuliang Chen, Shuting Guo, Ji’An Pan, Junyu Wu, Hong Peng, Weijie Zeng, Chunmei Li, Yingfang Liu and Deyin Guo*，A novel selective autophagy receptor, CCDC50, delivers K63 polyubiquitination-activated RIG-I/MDA5 for degradation during viral infection，Cell Res. 2021 Jan;31(1):62-79.
5. Liu Cao#, Yanxi Ji, Lanyi Zeng, Qianyun Liu, Zhen Zhang, Shuting Guo , Xiaolong Guo , Yongjia Tong, Xiaolu Zhao , Chun-Mei Li, Yu Chen*, Deyin Guo*，?P200 family protein IFI204 negatively regulates type I interferon responses by targeting IRF7 in nucleus，PLoS Pathog.?2019 Oct 11;15(10):e**. ?doi: 10.1371/journal.ppat.**. eCollection 2019 Oct.
6. Zhou, J., Gao, G., Hou, P., Li, C.M*., & Guo, D*. (2017). Regulation of the Alternative Splicing and Function of Cyclin T1 by the Serine-Arginine-Rich Protein ASF/SF2.J. Cell Biochem.118(11), 4020-4032.
7. Li, S#, Zhu, M., Pan, R., Fang, T., Cao, YY., Chen, S., Zhao, X., Lei, CQ., Guo, L., Chen, Y., Li, C.M., Jokitalo, E., Yin, Y., Shu, HB., Guo, D.(2016). The tumor suppressor PTEN plays a critical role in antiviral innate immunity. Nat Immunol., 17, 241-249.
8. Leskinen, K#, Varjosalo, M., Li, Z., Li, C.M., & Skurnik, M. (2015). Expression of the yersinia enterocolitica O:3 LPSO-antigen and outer core gene clusters is RfaH-dependent. Microbiology, 161, 1282-1294.
9. Haapalainen, M#, Dauphin, A., Li, C.M., Bailly, G., Tran, D., Briand, J., & Taira, S. (2012). HrpZ harpins from different Pseudomonas syringae pathovars differ in molecular interactions and in induction of anion channel responses in Arabidopsis thaliana suspension cells. Plant Physiology and Biochemistry, 51, 168-174.
10. Haapalainen, M., Engelhardt, S., Kuefner, I., Li, C.M., Nuernberger, T., Lee, J., & Taira, S. (2011). Functional mapping of harpin HrpZ of Pseudomonas syringae reveals the sites responsible for protein oligomerization, lipid interactions and plant defence induction. Molecular Plant Pathology, 12, 151-166.
11. Rabsztyn, K., Kasperkiewicz, K., Duda, K. A., Li, C.M., ?ukasik, M., Radziejewska-Lebrecht, J., & Skurnik, M. (2011). Characterization of anti-ECA antibodies in rabbit antiserum against rough Yersinia enterocolitica O: 3. Biochemistry, 76, 832-839.
12. Engelhardt, S., Lee, J., G?bler, Y., Kemmerling, B., Haapalainen, M., Li, C.M., & Nuernberger, T. (2009). Separable roles of the Pseudomonas syringae pv. phaseolicola accessory protein HrpZ1 in ion–conducting pore formation and activation of plant immunity. The Plant Journal, 57, 706-717.
13. Li, C.M#, Hienonen, E., Haapalainen, M., Kontinen, V. P., Romantschuk, M., & Taira, S. (2007). Type III secretion system-associated pilus of Pseudomonas syringae as an epitope display tool. FEMS Microbiology Letters, 269, 104-109.
14. Li, C.M#, Haapalainen, M., Lee, J., Nürnberger, T., Romantschuk, M., & Taira, S. (2005). Harpin of Pseudomonas syringae pv. phaseolicola harbors a protein binding site. Molecular Plant-Microbe Interactions, 18, 60-66.
15. Li, C.M#, Brown, I., Mansfield, J., Stevens, C., Boureau, T., Romantschuk, M., & Taira, S. (2002). The Hrp pilus of Pseudomonas syringae elongates from its tip and acts as a conduit for translocation of the effector protein HrpZ. The EMBO Journal, 21, 1909-1915.
研究方向病原微生物的感染与免疫逃逸机制；噬菌体疗法
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