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教授，博导，刘迎芳是国家****基金获得者（2010年），国家百千****才入选者（2009年），享受政府特殊津贴专家（2012年），归侨贡献奖获得者，多项863、973及国家自然科学基金等重大、重点项目课题或子课题承担人。2012年获得北京市科技成果一等奖（第一完成人）。2017年加入中山大学后，入选广东省珠江领军人才，“珠江引进人才创新创业团队”带头人（2019）。
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1993-1999年毕业于北京大学植物分子生物学系研究生，获博士学位
1999-2005年先后在美国国立犹太医学研究中心免疫学系、冷泉港实验室以及杜克大学医学中心从事博士后及研究助理工作
2005-2017，中科院生物物理所，生物大分子国家重点实验室，创新课题组组长
2017.7-至今，中山大学“****”二期引进人才，学科带头人，教授，博导
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刘迎芳教授实验室主要从事与感染性疾病、天然免疫及肿瘤相关的重大疾病的研究，在Nature、Cell等国际期刊发表了数十篇研究论文。特别是其实验室作为首要贡献者，首次揭示了流感病毒复制中的关键活性蛋白：流感病毒聚合酶PA亚基的结构和其内切核酸酶的功能，揭示了流感病毒的转录机制，并为开发新型流感病毒药物提供了新靶标。该项工作在2008年级2009年先后两次在Nature杂志发表论文，申请了两项国际专利，并被CCTV新闻联播播报，并在国家“十二五重大科技成果展”中作为中国生物学科研两项重要成果之一获展。目前，国际上根据此项原创发现开发的新型强大抗流感药物Xofluza已经于2018年上市，因其有效性被称为“超级流感药”。近年来，刘迎芳带领的团队还原创发现了人体中一类新型危险信号类（DAMP类）炎症因子。这一炎症因子的发现为多种急慢性炎症疾病，如急性病原感染、关节炎、多发性硬化症等，提供了新机制并为针对各类炎症疾病开发原创的新型诊疗试剂提供了新靶标。
刘迎芳实验室初步构建了从分子生物学、生物化学、细胞生物学、蛋白质科学、实验动物体系及临床样本分析较为完整的生物医学研究体系。研究内容包含基础研究及新型医药产品应用开发等内容。本实验室长期持续欢迎有志于生物医学研究的科研人员（博士、硕士、研究员、博士后等）及研究生加入本实验室，共同探索生命的奥秘。
招生学科专业：071000 生物学-10 生物化学与分子生物学，086000 生物与医药。
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著作1.?????? Wen Li, Xiuzhen Bai1, Jun Li,Yichao Zhao, JingyanLiu,Huayu Zhao, Lan Liu, Miao Ding, Qingsong Wang, Fang-Yuan Shi, Mei Hou, JianguoJi,Ge Gao, Rong Guo, Yujie Sun, Yingfang Liu*, Dongyi Xu*. The nucleoskeleton protein IFFO1 immobilizes broken DNA and suppresses chromosome translocation during tumorigenesis. Nature Cell biology, Sep 23, 2019
2.?????? Ma X, Liu K, Li J, Li H, Li J, Liu Y, Yang C#, Liang, H.# A non-canonical GTPase interaction enables ORP1L-Rab7-RILP complex formationand late endosome positioning. Journal of Biological Chemistry 2018 Jul 16. pii: jbc.RA118.001854. doi: 10.1074/jbc.RA118.001854.
3.?????? Li H, Yang K, Wang W, Niu Y, Li J, Dong Y, Liu Y, Wang CC, Wang L#, Liang, H.#. Crystal and solution structures of human protein disulfide isomerase-like protein of the testis (PDILT) provide insight into its chaperone activity. Journal of Biological Chemistry 2018, 293(4):1192-1202.
4.?????? ZhikaiXiahou, Xiangli Wang, Juan Shen, Xiaoxiao Zhu, Feng Xu, Rong Hu, Deyin Guo, Henan Li, Yong Tian, Yingfang Liu*, and Huanhuan Liang* NMI and IFP35 serve as proinflammatory DAMPs during cellular infection and injury. Nat Commun. 2017; 8: 950. Published online 2017 Oct 16. doi:? 10.1038/s41467-017-00930-9
5.?????? Chengcheng Guan, Jun? Li, Dapeng Sun, Yingfang Liu*, and Huanhuan Liang*.The structure and polymerase-recognition mechanism of the crucial adaptor protein AND-1 in the human replisome. J Biol Chem. 2017 Jun 9;292(23):9627-9636. doi: 10.1074/jbc.M116.758524. Epub 2017 Apr 5.
6.?????? Huanhuan Liang* and Yingfang Liu*. Gasdermins pore cell membrane to pyroptosis.Sci China Life Sci.2016 Oct;59(10):1090-1092. Epub 2016 Sep 7.(Research Highlight).
7.?????? Kuo Zhang, Yuan Gao, Jingjing Li, Rebecca Burgess,Junhong Han, Huanhuan Liang, Zhiguo Zhang*, and Yingfang Liu*. A DNA binding winged helix domain in CAF-1 functions with PCNA to stabilize CAF-1 at replication forks. Nucleic Acids Res. 2016 Jun 20; 44(11): 5083–5094.
8.?????? Chang, S. *, Sun, D. *,Liang, H. *, Wang, J., Li, J., Guo, L., Wang, X., Guan, C., Boruah, B.M., Yuan, L., Feng, F., Yang, M., Wang, L., Wang, Y., Wojdyla, J., Li, L., Wang, J., Wang, M., Cheng, G., Wang, H-W*., Liu, Y*. Cryo-EM structure of influenza virus RNA polymerase complex at 4.3 ? resolution.Mol Cell. 2015, 5;57(5):925-35.
9.?????? Feng Feng, Linmin Yuan, Yao Wang , Christopher Crowley, ZongyangLv, Jingjing Li, Yingfang Liu, Genhong Cheng, Su Zeng, Huanhuan Liang*(2013).Crystal structure and nucleotide selectivity of human IFIT5/ISG58.Cell Res.Jun 18. doi: 10.1038/cr.2013.80. [Epub ahead of print]
10.? Peng Zhang, Anna Reichardt, Huanghuang Liang, Yaya Wang, David Cheng, RoghiyhAliyari, Genhong Cheng*, Yingfang Liu* (2012). Single Amino Acid Substitutions Switch TRAF5 towards TRAF3-like Specificity. Science Signaling. Nov 13;5(250):ra81. doi: 10.1126/scisignal.**.
11.? Zhenlin Yang, Huanhuan Liang, Ying Li, Qian Zhou, Wen Ye, Joy Fleming, Hongbing Shu and Yingfang Liu*(2012).ISG Structure reveals a novel RNA Binding Structure and its Molecular Mechanisms.Cell research? July 24. doi: 10.1038/cr.2012.111. [Epub ahead of print]
12.? Yanyong Kang, Dongfeng Zhao, Huanhuan Liang, Bin Liu, Qinwen Liu, Xiaochen Wang* &Yingfang Liu*(2012).Structural Study of TTR-52 Reveals the Functional Mechanisms of a Bridging Molecule in Apoptotic Cell Engulfment. Genes & Development.Jun 15;26(12):1339-50.
13.? Lin Li, Shenghai Chang,Junfeng Xiang, Qian Li, Huanhuan Liang, Yalin Tang*,Yingfang Liu*(2012). Screen Anti-influenza Lead Compounds That Target the PAC Subunit of H5N1 Viral RNA Polymerase. PLoS One7(8): e35234. doi:10.1371/journal.pone.** (Aug 24, 2012).
14.? Shoudeng Chen, Yihui Xu, Kuo Zhang,?Xinlu Wang, Jian Sun, Guangxia Gao* and Yingfang Liu*(2012).Crystal structure of the N-terminal domain of ZAP: insights into how a zinc-finger protein specifically targets complex RNA. Nature Structural and Molecular Biology.19(4):430-5.Epub 2012 Mar 11.
15.? Shixuan Liu, Maxim Balasov, Hongfei Wang, Lijie Wu, Igor Chesnokov* andYingfang Liu*(2011) . Structural analysis of human Orc6 protein reveals a homology with transcription factor TFIIB.Crystal structure of the N-terminal domain of ZAP: insights into how a zinc-finger protein specifically targets complex RNA. Proc Natl Acad Sci U S A.108(18):7373-8. Epub 2011 Apr 18.
16.? Lin Li, Sheng-Hai Chang, Jun-Feng Xiang, Qian Li, Huan-Huan Liang, Jian Li, Hong-Juan Bao, Yalin Tang* and Yingfang Liu*(2011). Screening Anti-influenza Agents that Target Avian Influenza Polymerase Protein PA(C) from Plant Extracts Based on NMR Methods. Chemistry Letters. 40(8):801-803
17.? Yanyong?Kang, Jing?Xu, Yong?Liu, Jian?Sun, Dapeng?Sun, Yingsong?Hu, Yingfang?Liu*(2011). Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans.BiochemBiophys Res Commun.410(2): 189-194? [Epub ahead of print: May 17.]
18.? Cong Zhao, Zhiyong Lou, Yu Guo, Ming Ma, Yutao Chen, Shuaiyi Liang, Liang Zhang,Shoudeng Chen, Xuemei Li,Yingfang Liu*, Mark Bartlam and Zihe Rao*(2009). Nucleoside Monophosphate Complex Structures of the Endonuclease Domain from the Influenza Polymerase PA Subunit Reveal the Substrate Binding Site inside the Catalytic Center. J. Virology ,83(18):9024-9030.
19.? Yingfang Liu, ZhiyongLou, Mark Bartlam, Zihe Rao.(2009). Structure-function studies of the influenza virus RNA polymerase PA subunit. Sci China C Life Sci，52(5):450-8.(Review)
20.? Puwei Yuan, Mark Bartlam, Zhiyong Lou, Shoudeng Chen, Jie Zhou, Xiaojing He, Zongyang Lv, Ruowen Ge, Xuemei Li, Tao Deng, Ervin Fodor, Zihe Rao*&Yingfang Liu* (2009). Crystal structure of an avian influenza polymerase PA(N) reveals an endonuclease active site. Nature,458(7240):909-13.
21.? Xiaojing He, Jie Zhou, Mark Bartlam, Rongguang Zhang, Jianyuan Ma, Zhiyong Lou, Xuemei Li, Jingjing Li, Andrzej Joachimiak, Zonghao Zeng, Ruowen Ge, Zihe Rao*, Yingfang Liu*(2008). Crystal structure of the polymerase PA_C:PB1_N complex from an avian influenza H5N1 virus. Nature, 454(7208):1123-6.
22.? Wei Tian, Cong Ma, Yingfang Liu*&Tao Xu* (2008). An efficient co-expression and purification system for the complex of Stx4 and C-terminal domain of Synip. Biochemical and Biophysical Research Communications,?371(Issue 3,?4):366-370.
23.? Xiaoyu Yang, Jie Zhou, Lei Sun, Zhiyi Wei, Jianying Gao, Weimin Gong, Rui-Ming Xu, Zihe Rao, and Yingfang Liu*(2007).Structural Basis for the Function of DCN-1 in Protein Neddylation.J. Biol. Chem. 282: 24490 – 24494.
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研究方向流感病毒、免疫及肿瘤
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