头像
教授，博士研究生导师。中国药理学学会会员、中国药理学神经精神药理学专业委员会委员、广东省药理学会理事、广东省药理学神经精神药理学专业委员会常务理事、中国神经科学学会会员和广东省“千百十”人才校级培养对象。主持国家自然科学基金与香港研究资助局联合项目、国家自然科学基金(3项)等10余研究项目。近年在Mol Neurobiol、J Biol Chem、J Neurochem及Br J Pharmacol等杂志发表论文70余篇SCI论文。论文他引次数2200余次，H指数28。申请国家发明专利15项，授权8项，PCT1项。?教育背景:??? 1989年-1993年????? 江西中医学院药学系药学学士学位（1993）；1996年-1999年????? 中山大学中山医学院药理学硕士（1999）；1999年-2002年????? 中山大学中山医学院药理学博士（20002）。?工作经历：2019.5-???????? 中山大学, 医学院, 教授?? 2013.1-2019.5, ?中山大学, 药学院, 教授2009.6-2010.6, ?耶鲁大学, 医学院, Res Assoc2005.7-2012.12, 中山大学, 药学院, 副教授2005.6-2006.6, ?奥克兰大学, 医学院, Res Assoc2003.11-2005.6, 中山大学, 药学院, 讲师2002.7-2003.7, ?香港科技大学, 生物化学系, Res Assoc1993.8-1996.8, ?江西赣南医学院, 药理学系, 助教?皮荣标教授实验室主要从事中枢神经系统重大疾病的分子机制及其创新药物的开发： 1.?中枢神经系统重大疾病（如脑缺血和阿尔茨海默氏病等）的分子机制；2.?治疗神经系统疾病的“单分子多靶点”药物的研究开发。?
招生学科专业：071000 生物学-06 神经生物学，100700 药学-06 药理学，086000 生物与医药。?
联系方式：地址：广东省广州市大学城外环东路132号?中山大学医学院?邮编：510006电话：；电子邮箱：pirb@mail.sysu.edu.cn?
著作Chen J, Yin W, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Rongbiao Pi*. L-F001, a novel multifunctional ROCK inhibitor, suppresses neuroinflammation in vitro and in vivo: Involvement of NF-κB inhibition and Nrf2 pathway activation. Eur J Pharmacol. 2017 Jul 5;806:1-9.
Chen J, Sun Z, Jin M, Tu Y, Wang S, Yang X, Chen Q, Zhang X, Han Y, Rongbiao Pi*. Inhibition of AGEs/RAGE/Rho/ROCK pathway suppresses non-specific neuroinflammation by regulating BV2 microglial M1/M2 polarization through the NF-κB pathway. J Neuroimmunol. 2017 Apr 15;305:108-114.
Chen Z, Digiacomo M, Tu Y, Gu Q, Wang S, Yang X, Chu J, Chen Q, Han Y, Chen J, Nesi G, Sestito S, Macchia M, Rapposelli S, Rongbiao Pi*. Discovery of novel rivastigmine-hydroxycinnamic acid hybrids as multi-targeted agents for Alzheimer's disease. Eur J Med Chem. 2017 Jan 5;125:784-792.
He XX, Yang XH, Ou RY, Ouyang Y, Wang SN, Chen ZW, Wen SJ, Rongbiao Pi*. Synthesis and evaluation of multifunctional ferulic and caffeic acid dimers for Alzheimer's disease. Nat Prod Res. 2017 Mar;31(6):734-737.
Chen ZW, Liu A, Liu Q, Chen J, Li WM, Chao XJ, Yang Q, Liu PQ, Mao ZX, Rongbiao Pi*. MEF2D Mediates the Neuroprotective Effect of Methylene Blue Against Glutamate-Induced Oxidative Damage in HT22 Hippocampal Cells. Mol Neurobiol. 2017 Apr;54(3):2209-2222.
Tu YL, Chen QH, Wang SN, Uri A, Yang XH, Chu JQ, Chen JK, Luo BL, Chen XH, Wen SJ*, Pi RB*. Discovery of Lipoic acid-4-Phenyl-1H-pyrazole Hybrids as Novel Bifunctional ROCK Inhibitors with Antioxidant Activity. RSC Advances, 2016, 6, 58516–58520.
Yang X, Wang S, Ouyang Y, Tu Y, Liu A, Tian Y, He M, Pi RB*. Garcinone D, a natural xanthone promotes C17.2 neural stem cell proliferation: Possible involvement of STAT3/Cyclin D1 pathway and Nrf2/HO-1 pathway. Neurosci Lett. 2016 May 10;626:6-12.
Chen M, Liu Q, Tan M, Wen S, Pi R*, Lin D*. Synthesis and biological evaluation of n-butylphthalide derivatives as anti-platelet aggregation agents. Nat Prod Res. 2016 Feb 15:1-4. [Epub ahead of print] PubMed PMID: **.
杨晓红; 王胜男; 刘庆余; 欧阳颖; 李民; 皮荣标*. Nrf2 通过上调自噬促进C17.2 神经干细胞的增殖. 中山大学学报（医学科学版）, 2016; 37(4):481-9.
Chen M, Tan M, Jing M, Liu A, Liu Q, Wen S, Chen Z, Chao X, He X, Ramassamy C, Gao Y, Pi R（皮荣标）*. Berberine protects homocysteic acid-induced HT-22 cell death: involvement of Akt pathway. Metab Brain Dis. 2015 Feb;30(1):137-42. IF 2.398
Chen Z, Mao X, Liu A, Gao X, Chen X, Ye M, Ye J, Liu P, Xu S, Liu J, He W, Lian Q, Pi R*. Osthole, a natural coumarin improves cognitive impairments and BBB dysfunction after transient global brain ischemia in C57 BL/6J mice: involvement of Nrf2 pathway. Neurochem Res. 2015 Jan;40(1):186-94.
Chen M H, Liu Q, Liu A M, Pi R（皮荣标）*. Simply combining fasudil and lipoic acid in a novel multitargeted chemical entity potentially useful in central nervous system disorders. RSC ADVANCES, 2014,4(70):37266-37269.IF 3.708
Chao XJ, Chen ZW, Liu AM, He XX, Wang SG, Wang YT, Liu PQ, Ramassamy C, Mak SH, Cui W, Kong AN, Yu ZL, Han YF, Pi RB（皮荣标）*. Effect of tacrine-3-caffeic acid, a novel multifunctional anti-Alzheimer's dimer, against oxidative-stress-inducedcell death in HT22 hippocampal neurons: involvement of Nrf2/HO-1 pathway. CNS NeurosciTher. 2014 Sep;20(9):840-50.IF 3.784
Tan M, Ouyang Y, Jin M, Chen M, Liu P, Chao X, Chen Z, Chen X, Ramassamy C, Gao Y*, Pi R*. Downregulation of Nrf2/HO-1 pathway and activation of JNK/c-Jun pathway are involved in homocysteic acid-induced cytotoxicity in HT-22 cells. Toxicol Lett. 2013 Aug 27;223(1):1-8.
Zhu D, Chen M, Li M, Luo B, Zhao Y, Huang P, Xue F, Rapposelli S, Pi R*, Wen S*. Discovery of novel N-substituted carbazoles as neuroprotective agents with potent anti-oxidative activity. Eur J Med Chem. 2013 Aug 9;68C:81-88.
Huang Y, Jin M, Pi R*, Zhang J, Chen M, Ouyang Y, Liu A, Chao X, Liu P, Liu J,Ramassamy C, Qin J*. Protective effects of caffeic acid and caffeic acid phenethyl ester against acrolein-induced neurotoxicity in HT22 mouse hippocampal cells. Neurosci Lett.2013 Feb 22;535:146-51.
Huang YJ, Jin MH, Pi RB*, Zhang JJ, Ouyang Y, Chao XJ, Chen MH, Liu PQ, Yu JC, Ramassamy C, Dou J, Chen XH, Jiang YM, Qin J*. Acrolein induces Alzheimer's disease-like pathologies in vitro and in vivo. Toxicol Lett. 2013 Mar 13;217(3):184-91.
Chen X, Chen S, Jiang Y, Zhu C, Wu A, Ma X, Peng F, Ma L, Zhu D, Wang Q, Pi R. Minocycline reduces oxygen-glucose deprivation-induced PC12 cell cytotoxicity via matrix metalloproteinase-9, integrin β1 and phosphorylated Akt modulation. Neurol Sci. 2013 Aug;34(8):1391-6.
Huang WY, Chao XJ, Ouyang Y, Liu AM, He XX, Chen MH, Wang LH, Liu J, Yu SW, Rapposelli S, RB Pi*. Tacrine-6-Ferulic Acid, a Novel Multifunctional Dimer Against Alzheimer's Disease, Prevents Oxidative Stress-Induced Neuronal Death Through Activating Nrf2/ARE/HO-1 Pathway in HT22 Cells. CNS Neurosci Ther. 2012 Nov;18(11):950-1.
Chao X, He X, Yang Y, Zhou X, Jin M, Liu S, Cheng Z, Liu P, Wang Y, Yu J, Tan Y, Huang Y, Qin J, Rapposelli S, RB Pi*. Design, synthesis and pharmacological evaluation of novel tacrine-caffeic acid hybrids as multi-targeted compounds against Alzheimer's disease. Bioorg Med Chem Lett. 2012 Oct 15;22(20):6498-502.
Xiao O, Xie ZL, Lin BW, Yin XF, RB Pi*, Zhou SY*. Minocycline inhibits alkali burn-induced corneal neovascularization in mice. PLoS One. 2012;7(7):e41858.
Chen X, Ma L, Jiang Y, Chen S, Zhu C, Liu M, Ma X, Zhu D, Liu Y, Peng F, Wang Q, Pi R. Minocycline up-regulates the expression of brain-derived neurotrophic factor and nerve growth factor in experimental autoimmune encephalomyelitis. Eur J Pharmacol. 2012 Jul 5;686(1-3):124-9.
Xuexuan Mao, Jiaotao Ye, Shiyou Zhou, Rongbiao Pi*, Juan Dou, Lingquan Zang, Xiaojuan?Chao, Xiaohong?Chen, Wenming Li, Mengfei Liu, Peiqing Liu. The effects of chronic copper exposure on the amyloid protein metabolisim associated genes' expression in chronic cerebral hypoperfused rats. Neurosci Lett. 2012. Jun 14;518(1):14-8.
Pi R*, Mao X, Chao X, Cheng Z, Liu M, Duan X, Ye M, Chen X, Mei Z, Liu P, Li W*, Han Y*. Tacrine-6-ferulic acid, a novel multifunctional dimer, inhibits amyloid-β-mediated Alzheimer's disease-associated pathogenesis in vitro and in vivo. PLoS One. 2012;7(2):e31921.
Zhang H, Mak S, Cui W, Li W, Han R, Hu S, Ye M, Pi R*, Han Y*. Tacrine(2)-ferulic acid, a novel multifunctional dimer, attenuates 6-hydroxydopamine-induced apoptosis in PC12 cells by activating Akt pathway. Neurochem Int. 2011 Dec;59(7):981-8.
Mao X, Yin W, Liu M, Ye M, Liu P, Liu J, Lian Q, Xu S, Pi R*. Osthole, a natural coumarin, improves neurobehavioral functions and reduces infarct volume and matrix metalloproteinase-9 activity after transient focal cerebral ischemia in rats. Brain Res. 2011 Apr 18;1385:275-80.
Xiao-hong Chen, Zhu-zhen Lin, An-min Liu, Jian-tao Ye, Yan Luo, Yu-yan Luo, Xue-xuan Mao, Pei-qing Liu, Rong-biao Pi*. The orally combined neuroprotective?effects of sodium ferulate and borneol against transient global ischemia in C57 BL/6J mice. J Pharm Pharmacol. 2010, 62(7): 1–9.
Ye JT, Pi RB*(co corresponding author), Mao XX, Chen XH, Qin J, Xu SW, Liu PQ. Alterations in mRNA expression of BACE1, cathepsin B, and glutaminyl cyclase in mice ischemic brain. Neuroreport. 2009; 20(16):1456-60.
Mei Z, Zhang F, Tao L, Zheng W, Cao Y, Wang Z, Tang S, Le K, Chen S, Pi R*(co corresponding author), Liu P. Cryptotanshinone, a compound from Salvia miltiorrhiza modulates amyloid precursor protein metabolism and attenuates beta-amyloid deposition through upregulating alpha-secretase in vivo and in vitro. Neurosci Lett. 2009; 452(2):90-5.
Chen X, Lan X, Mo S, Qin J, Li W, Liu P, Han Y, Pi R*. p38 and ERK, but not JNK, are involved in copper-induced apoptosis in cultured cerebellar granule neurons. Biochem Biophys Res Commun. 2009; 379(4):944-8.
RZ Lin, XH Chen, WM LI, YF Han, PQ Liu, RB Pi*. Effects of metal ions on the expression of APP and BACE1 in PC12 cells: Blocking by Curcumin. Neurosci Lett，2008；440（3）:344-347.
蓝秀健，叶敏忠，刘培庆，余剑平，皮荣标*. 铜对低钾诱导大鼠小脑颗粒神经元凋亡的保护. 中山大学学报（医学版）. 2008；29（2）：154-158.
林竹贞, 蓝明雄, 姚美村, 钟国平, 刘培庆，皮荣标*. 冰片对阿魏酸钠在小鼠血浆和脑区中分布的影响.中草药. 2008; 39（4）：551-556.
Wenming Li, Rongbiao Pi, Hugh H.N. Chan, Hongjun Fu, Nelson T.K. Lee, Hing Wai Tsang, Yongmei Pu, Donald C. Chang, Jialie Luo, Keming Xiong, Zhiwang Li, Chaoying Li, Hong Xue, Paul R. Carlier, Yuanping Pang, Karl W.K. Tsim, Mingtao Liand Yifan Han. ?Novel Dimeric AChE Inhibitor Bis(7)-tacrine, but not Donepezil, Prevents Glutamate-induced Neuronal Apoptosis by Blocking NMDA Receptors. J Biol Chem, 2005, 280(18):18179-88.
Rongbiao Pi, Wenming Li, Nelson T.K. Lee, Hugh H.N. Chan, Yongmei Pu, Ling Nga Chan, Nikolaus J Sucher, Donald C. Chang, Mingtao Li, Yifan Han. Minocycline Prevents Glutamate-induced Apoptosis of Cerebellar Granule Neurons by Differential Regulation of p38 and Akt Pathways. J. Neurochem,2004, 91(5): 1219-1230.
Rongbiao Pi, Wei Yin, Suqiu Zheng, Pengxin Qiu, Jian Zhou, Wei Guo, Tao Su, and Guangmei Yan. Adenoviral mediated transfer of TIMP-3 partially prevents glutamate-induced cell death in primary cultured cortical neurons of the rat. Brain Res Mol Brain Res, 2004, 127(1-2):?136-139.
??
研究方向神经药理学
联系我们
邮编: 510080
电话: ,
邮箱: yxyszdzb@mail.sysu.edu.cn
