孙蕾¹,
李洪祥¹,
刘敏¹,
叶婷^2,,,
王佳^1,,
1. 山东第一医科大学(山东省医学科学院), 泰安 271016;
2. 贵阳学院, 贵阳 550005

作者简介: 孙蕾(1997-),女,学士,研究方向为预防医学,E-mail:1621051379@qq.com.

通讯作者: 叶婷,1125037857@qq.com ; 王佳,65251296@qq.com

基金项目: 国家自然科学基金青年基金项目（21507099）；贵州青年科技人才成长项目（黔教合KY字[2019]096）；贵州省科学技术基金项目（黔科合基础[2018]1005）；山东省自然科学基金资助项目（ZR2015PB011）；国家级大学生创新创业训练计划项目（201810439001，201710439230，201610439234）


中图分类号: X171.5

Advances in Health Effects of DINP and Its Mechanisms

Sun Lei¹,
Li Hongxiang¹,
Liu Min¹,
Ye Ting^2,,,
Wang Jia^1,,
1. Shandong First Medical University & Shandong Academy of Medical Sciences, Tai'an 271016, China;
2. Guiyang University, Guiyang 550005, China

Corresponding authors: Ye Ting,1125037857@qq.com ; Wang Jia,65251296@qq.com

CLC number: X171.5

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摘要:增塑剂邻苯二甲酸二异壬酯（di-isononyl phthalate，DINP）广泛应用于聚氯乙烯塑料消费品和工业产品中，因其对人体多个系统均有毒性作用，DINP的健康效应成为研究热点。笔者对近年来国内外的相关研究进行综述，对DINP的内分泌毒性、生殖发育毒性、心血管毒性、免疫毒性及神经毒性等多种毒作用及机理进行了系统阐述，并针对存在的问题进行了总结和展望，有望为环境DINP相关的人体健康效应及防治提供参考。
关键词: DINP/
人体暴露与代谢/
内分泌毒性/
生殖发育毒性/
分子机理

Abstract:The plasticizer DINP is widely used in PVC consumer and industrial products. The health effect of DINP has become a research hotspot for its toxicity on multiple systems of human body. In this paper, the research progresses in related fields of study for recent years were reviewed. The endocrine toxicity, reproductive and developmental toxicity, cardiovascular toxicity, immunotoxicity, neurotoxicity and other toxic effects of DINP and its mechanisms were systematically described. The existing problems were summarized and future research directions was prospected. This study may provide references for the prevention and control of human health effects related to environmental DINP exposure.
Key words:DINP/
human exposure and metabolism/
endocrine toxicity/
reproductive and developmental toxicity/
molecular mechanism.

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