), 麻彦坤(), 曾红() 广州大学心理与脑科学研究中心, 广州 510006
收稿日期:2019-03-21出版日期:2020-03-25发布日期:2020-01-18通讯作者:孙楠,麻彦坤,曾红E-mail:nansun2019@gzhu.edu.cn;ykma@gzhu.edu.cn;soezenghyj@gzhu.edu.cn基金资助:* 国家自然科学基金项目(31771214)Differences in brain reactivity in relation to different types of drug-associated cues and disinhibition among heroin addicts: An ERP study
ZHENG Zhiling, WANG Pengfei, SU Dequan, GUO Weijie, SUN Nan(), MA Yankun(), ZENG Hong() Department of Psychology, Research Center of Psychology & Brain Science, Guangzhou University, Guangzhou 510006, China
Received:2019-03-21Online:2020-03-25Published:2020-01-18Contact:SUN Nan,MA Yankun,ZENG Hong E-mail:nansun2019@gzhu.edu.cn;ykma@gzhu.edu.cn;soezenghyj@gzhu.edu.cn摘要/Abstract
摘要： 采用ERP技术, 探究海洛因成瘾者在不同相关线索下的脑电反应及其与冲动性的关系。实验采用组间实验设计和双选择Oddball范式, 要求海洛因成瘾组和健康对照组被试对标准刺激与偏差刺激分别做不同的按键反应, 记录他们的EEG数据。结果发现：相比对照组被试, 海洛因成瘾者在观看药物相关线索时诱发的N2波幅更小, P3波幅更大; 在成瘾组内, 相比用药工具线索, 用药动作线索诱发了更小的N2波幅和更大的P3波幅。这表明海洛因成瘾者对药物相关线索存在反应抑制缺陷, 且不同的药物相关线索会激发海洛因成瘾者不同程度的反应抑制缺陷, 用药动作线索比用药工具线索更大程度地影响成瘾者的反应抑制能力, 反映出更高的动作冲动性。
图/表 5
图1实验流程图(以工具条件为例)
图1实验流程图(以工具条件为例)表1被试基本信息表(N = 36)
| 项目 | 海洛因成瘾组 (n = 19) M (SD) | 健康对照组 (n = 17) M (SD) | p |
|---|---|---|---|
| 年龄 (岁) | 39.84 (3.25) | 42.46 (12.73) | 0.391 |
| 受教育年限 (年) | 9.65 (1.41) | 11.25 (4.22) | 0.127 |
| 吸烟情况 (包/周) | 5.85 (2.08) | 2.34 (2.19) | 0.000 |
| 饮酒情况 (ml/周) | 833.82 (855.94) | 168.75 (135.53) | 0.003 |
| 焦虑水平 | 30.29 (6.35) | 26.67 (4.98) | 0.067 |
| 首次吸毒年龄 (岁) | 19.76 (3.82) | ||
| 吸毒持续时间 (月) | 205 (42.93) | ||
| 戒断时间 (月) | 37.18 (20.01) | ||
| 以前海洛因使用量 (克/天) | 0.56 (0.25) |
表1被试基本信息表(N = 36)
| 项目 | 海洛因成瘾组 (n = 19) M (SD) | 健康对照组 (n = 17) M (SD) | p |
|---|---|---|---|
| 年龄 (岁) | 39.84 (3.25) | 42.46 (12.73) | 0.391 |
| 受教育年限 (年) | 9.65 (1.41) | 11.25 (4.22) | 0.127 |
| 吸烟情况 (包/周) | 5.85 (2.08) | 2.34 (2.19) | 0.000 |
| 饮酒情况 (ml/周) | 833.82 (855.94) | 168.75 (135.53) | 0.003 |
| 焦虑水平 | 30.29 (6.35) | 26.67 (4.98) | 0.067 |
| 首次吸毒年龄 (岁) | 19.76 (3.82) | ||
| 吸毒持续时间 (月) | 205 (42.93) | ||
| 戒断时间 (月) | 37.18 (20.01) | ||
| 以前海洛因使用量 (克/天) | 0.56 (0.25) |
表2海洛因成瘾组在ERP实验前后各项生理指标及渴求感的变化状况
| 变量 | ERP前 M (SD) | ERP后 M (SD) | t | p |
|---|---|---|---|---|
| 平均体温 | 36.87 (0.34) | 36.93 (0.24) | -0.72 | 0.48 |
| 皮电 (30 s) | 5.88 (9.37) | -1.06 (20.81) | 1.584 | 0.13 |
| 皮电 (60 s) | 2.29 (11.15) | -2.35 (12.63) | 1.06 | 0.31 |
| 收缩压 (mm/Hg) | 128.12 (14.62) | 127.65 (10.40) | 0.20 | 0.85 |
| 舒张压 (mm/Hg) | 81.53 (11.73) | 82.94 (9.47) | -0.80 | 0.44 |
| 心率 (次/分) | 75.94 (9.01) | 75.65 (12.22) | 0.15 | 0.88 |
| 渴求感 | 0.94 (1.18) | 1.06 (1.27) | -1.12 | 0.28 |
表2海洛因成瘾组在ERP实验前后各项生理指标及渴求感的变化状况
| 变量 | ERP前 M (SD) | ERP后 M (SD) | t | p |
|---|---|---|---|---|
| 平均体温 | 36.87 (0.34) | 36.93 (0.24) | -0.72 | 0.48 |
| 皮电 (30 s) | 5.88 (9.37) | -1.06 (20.81) | 1.584 | 0.13 |
| 皮电 (60 s) | 2.29 (11.15) | -2.35 (12.63) | 1.06 | 0.31 |
| 收缩压 (mm/Hg) | 128.12 (14.62) | 127.65 (10.40) | 0.20 | 0.85 |
| 舒张压 (mm/Hg) | 81.53 (11.73) | 82.94 (9.47) | -0.80 | 0.44 |
| 心率 (次/分) | 75.94 (9.01) | 75.65 (12.22) | 0.15 | 0.88 |
| 渴求感 | 0.94 (1.18) | 1.06 (1.27) | -1.12 | 0.28 |
图2观看用药工具线索和用药动作线索所诱发成分的组间比较(电极点：Fz, Cz, CPz, Pz)
图2观看用药工具线索和用药动作线索所诱发成分的组间比较(电极点：Fz, Cz, CPz, Pz)
图3观看用药工具?对照工具线索和用药动作?对照动作线索的差异波的组间比较(电极点：Fz, Cz, CPz, Pz)
图3观看用药工具?对照工具线索和用药动作?对照动作线索的差异波的组间比较(电极点：Fz, Cz, CPz, Pz)参考文献 44
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