), 杨晓蕾2, 任佳文1, 张景焕1 1山东师范大学心理学院, 济南 250358
2齐鲁师范学院生命科学学院, 济南 250200
收稿日期:2021-05-19出版日期:2021-11-15发布日期:2021-09-23通讯作者:张舜E-mail:yinxingren1986@hotmail.com基金资助:国家自然科学基金(32000758)The relationship between methylation of dopamine-related genes, family environment and creativity
ZHANG Shun1(), YANG Xiaolei2, Ren Jiawen1, ZHANG Jinghuan1 1Department of Psychology, Shandong Normal University, Jinan 250358, China
2College of Life Science, Qilu Normal University, Jinan 250200, China
Received:2021-05-19Online:2021-11-15Published:2021-09-23Contact:ZHANG Shun E-mail:yinxingren1986@hotmail.com摘要/Abstract
摘要： “遗传与环境”的争论一直是创造力研究的核心问题, 但目前对于环境以及遗传与环境交互作用对创造力影响的分子生物机制还未有研究涉及。近年来, 随着表观遗传学的兴起, 揭示影响心理行为的表观遗传机制现已成为心理学研究的热点。作为环境与基因组之间的纽带, 表观遗传学研究为揭示环境以及遗传与环境交互作用对创造力影响的分子生物机制提供了机遇。本研究以多巴胺相关基因、家庭环境以及两者对于创造力的交互作用为切入点, 对影响创造力的表观遗传机制进行考察, 并在此基础之上, 对环境以及遗传与环境交互作用对创造力影响的分子生物机制进行探索。具体研究内容包括：(1)通过对多巴胺相关基因甲基化模式与创造力关系的系统考察, 筛选出甲基化模式与创造力有关的基因; (2)对筛选出的基因, 进一步考察其甲基化模式在家庭环境及其遗传多态性与家庭环境交互作用对创造力影响中的中介作用。本研究有助于揭示创造力的表观遗传机制, 深化关于遗传与环境对创造力影响的作用机制的理解。
图/表 2
表1多巴胺相关基因与创造力关系的主要研究发现
| 作者(年份) | 样本量种族 | 创造力测量工具 | 考察的多巴胺相关基因 | 主要研究发现 |
|---|---|---|---|---|
| Reuter et al. ( | 92 高加索人群 | 柏林智力结构测验(BIS)中的Inventiveness分量表 | COMT, DRD2 | DRD2基因Taq IA (rs1800497)多态性与创造力显著相关, 携带A1等位基因的个体具有更高的创造力。 |
| Lu & Shi ( | 108 中国汉族人群 | Williams创造潜能测验 Torrance创造思维测验(图形) | COMT | COMT基因 Val158Met(rs4680)多态性与想象力显著相关, 携带Val等位基因的被试更富有想象力。 |
| Runco et al. ( | 147 高加索人群 | 发散思维测验：举例任务、图形任务、真实创造性问题解决任务 | COMT, DAT, DRD2, DRD4 | COMT基因Val158Met(rs4680)多态性、DAT基因VNTR多态性、DRD4基因 VNTR多态性与创造力显著相关。 |
| Mayseless et al. ( | 185 高加索人群 | 发散思维测验：多用途任务、Torrance创造思维测验中的圆圈任务 | DRD4 | DRD4基因VNTR多态性与创造力显著相关, 携带7R等位基因的个体创造力较低。 |
| Murphy et al. ( | 147 高加索人群 | 发散思维测验：举例任务、图形任务、真实创造性问题解决任务 | COMT, DAT, DRD2, DRD4 | COMT基因Val158Met(rs4680)多态性、DAT基因VNTR多态性、DRD2基因Taq IA (rs1800497)多态性、DRD4基因VNTR多态性对创造力存在显著的二元和三元交互作用。 |
| Zhang et al. ( | 543 中国汉族人群 | 发散思维测验：多用途任务、图形任务 | DRD2 | DRD2基因Taq IA (rs1800497)、C957T(rs6277)、rs2283265、rs1076560等9个多态性位点及单体型与创造力显著相关。其中, 部分多态性位点上携带次要等位基因(如Taq IA的T等位基因, 即A1等位基因)或纯合主要等位基因的个体(如C957T的CC基因型)的个体具有更高的创造力。 |
| Zhang et al. ( | 543 中国汉族人群 | 发散思维测验：多用途任务、图形任务 | COMT, DRD2 | COMT基因Val158Met(rs4680)、rs174697、rs737865和rs5993883多态性位点与创造力显著相关。其中, 部分多态性位点的次要等位基因(如rs4680的A等位基因)与高创造力相关。DRD2基因与COMT基因对创造力存在显著的四元交互作用。 |
| Jiang et al. ( | 753 中国汉族人群 | 经典顿悟问题解决任务 | COMT | COMT基因Val158Met(rs4680)和rs4630多态性与创造力显著相关, rs4680的A等位基因、rs4633的T等位基因与高创造力相关。rs5993883多态性仅在男性中与创造力显著相关。 |
| Takeuchi et al. ( | 766 亚洲人群 | S-A创造力测验 | DRD2 | DRD2基因Taq IA (rs1800497)多态性可能通过情绪智力和情绪状态影响创造力。 |
| Zabelina et al. ( | 100 高加索人群 | Torrance创造思维测验成人简版(ATTA) 创造性成就问卷(CAQ) | COMT, DAT | COMT基因Val158Met (rs4680)多态性与DAT基因VNTR 多态性对创造力具有显著的交互作用。 |
| Zhang & Zhang ( | 425 中国汉族人群 | 经典顿悟问题解决任务 | DRD2 | DRD2基因Taq IA (rs1800497)、rs2283265、rs1076560等7个多态性位点及单体型与创造力显著相关。其中, 部分多态性位点的次要等位基因(如Taq IA的T等位基因, 即A1等位基因)与高创造力相关。 |
| Han et al. ( | 321 中国汉族人群 | 发散思维测验：多用途任务 聚合思维：远距离联想测验(RAT) | COMT, DRD2 | COMT基因rs5993883多态性与创造力显著相关。 |
表1多巴胺相关基因与创造力关系的主要研究发现
| 作者(年份) | 样本量种族 | 创造力测量工具 | 考察的多巴胺相关基因 | 主要研究发现 |
|---|---|---|---|---|
| Reuter et al. ( | 92 高加索人群 | 柏林智力结构测验(BIS)中的Inventiveness分量表 | COMT, DRD2 | DRD2基因Taq IA (rs1800497)多态性与创造力显著相关, 携带A1等位基因的个体具有更高的创造力。 |
| Lu & Shi ( | 108 中国汉族人群 | Williams创造潜能测验 Torrance创造思维测验(图形) | COMT | COMT基因 Val158Met(rs4680)多态性与想象力显著相关, 携带Val等位基因的被试更富有想象力。 |
| Runco et al. ( | 147 高加索人群 | 发散思维测验：举例任务、图形任务、真实创造性问题解决任务 | COMT, DAT, DRD2, DRD4 | COMT基因Val158Met(rs4680)多态性、DAT基因VNTR多态性、DRD4基因 VNTR多态性与创造力显著相关。 |
| Mayseless et al. ( | 185 高加索人群 | 发散思维测验：多用途任务、Torrance创造思维测验中的圆圈任务 | DRD4 | DRD4基因VNTR多态性与创造力显著相关, 携带7R等位基因的个体创造力较低。 |
| Murphy et al. ( | 147 高加索人群 | 发散思维测验：举例任务、图形任务、真实创造性问题解决任务 | COMT, DAT, DRD2, DRD4 | COMT基因Val158Met(rs4680)多态性、DAT基因VNTR多态性、DRD2基因Taq IA (rs1800497)多态性、DRD4基因VNTR多态性对创造力存在显著的二元和三元交互作用。 |
| Zhang et al. ( | 543 中国汉族人群 | 发散思维测验：多用途任务、图形任务 | DRD2 | DRD2基因Taq IA (rs1800497)、C957T(rs6277)、rs2283265、rs1076560等9个多态性位点及单体型与创造力显著相关。其中, 部分多态性位点上携带次要等位基因(如Taq IA的T等位基因, 即A1等位基因)或纯合主要等位基因的个体(如C957T的CC基因型)的个体具有更高的创造力。 |
| Zhang et al. ( | 543 中国汉族人群 | 发散思维测验：多用途任务、图形任务 | COMT, DRD2 | COMT基因Val158Met(rs4680)、rs174697、rs737865和rs5993883多态性位点与创造力显著相关。其中, 部分多态性位点的次要等位基因(如rs4680的A等位基因)与高创造力相关。DRD2基因与COMT基因对创造力存在显著的四元交互作用。 |
| Jiang et al. ( | 753 中国汉族人群 | 经典顿悟问题解决任务 | COMT | COMT基因Val158Met(rs4680)和rs4630多态性与创造力显著相关, rs4680的A等位基因、rs4633的T等位基因与高创造力相关。rs5993883多态性仅在男性中与创造力显著相关。 |
| Takeuchi et al. ( | 766 亚洲人群 | S-A创造力测验 | DRD2 | DRD2基因Taq IA (rs1800497)多态性可能通过情绪智力和情绪状态影响创造力。 |
| Zabelina et al. ( | 100 高加索人群 | Torrance创造思维测验成人简版(ATTA) 创造性成就问卷(CAQ) | COMT, DAT | COMT基因Val158Met (rs4680)多态性与DAT基因VNTR 多态性对创造力具有显著的交互作用。 |
| Zhang & Zhang ( | 425 中国汉族人群 | 经典顿悟问题解决任务 | DRD2 | DRD2基因Taq IA (rs1800497)、rs2283265、rs1076560等7个多态性位点及单体型与创造力显著相关。其中, 部分多态性位点的次要等位基因(如Taq IA的T等位基因, 即A1等位基因)与高创造力相关。 |
| Han et al. ( | 321 中国汉族人群 | 发散思维测验：多用途任务 聚合思维：远距离联想测验(RAT) | COMT, DRD2 | COMT基因rs5993883多态性与创造力显著相关。 |
图1第二阶段研究的基本假设模型
图1第二阶段研究的基本假设模型参考文献 73
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