) 西南大学心理学部, 重庆 400715
收稿日期:2017-12-29出版日期:2019-02-15发布日期:2018-12-25通讯作者:雷旭E-mail:xlei@swu.edu.cn基金资助:* 国家自然科学基金项目(31571111);重庆市基础科学与前沿技术研究专项(cstc2017jcyjAX0110);中央高校基本科研业务费专项基金项目资助(SWU1609109)Altered resting-state brain networks in insomnia: Functional connectivities within and between networks
QIN Haixia, ZHAO Wenrui, YU Jing, LEI Xu() Faculty of Psychology, Southwest University, Chongqing, 400715, China
Received:2017-12-29Online:2019-02-15Published:2018-12-25Contact:LEI Xu E-mail:xlei@swu.edu.cn摘要/Abstract
摘要： 失眠已成为现代人群中的一种高发健康问题。静息态功能磁共振以其数据采集便利性和无创性, 成为失眠研究的主要成像手段之一。基于近年来静息态功能磁共振的发现, 失眠患者存在前额叶、颞叶、前扣带回、脑岛等认知-情绪神经环路的异常。大尺度脑网络是涵盖多个脑区、功能相对单一的大脑结构。失眠患者存在默认网络、突显网络、认知控制网络和负性情绪网络内部活动与连接异常, 而且呈现出以默认网络为核心, 包含认知控制网络、突显网络、负性情绪网络的网络间连接异常模式。此外, 结合症状、治疗和大尺度脑网络的视角, 可为失眠的“精准治疗”提供神经理论依据。未来研究可结合大数据和多模态分析技术, 验证静息态功能磁共振已有发现。而失眠的纵向追踪和队列研究会有利于进一步阐释失眠的神经机制。
图/表 3
图1失眠静息态大尺度脑网络内连接与活动情况 注：DMN = 默认网络, SN：突显网络, CCN：认知控制网络, AN = 负性情绪网络, ACC = 前扣带回, aIA = 前脑岛, Amg = 杏仁核, AMPFC = 前内侧前额叶, aTH = 前丘脑, dACC = 背侧前扣带回, DLPFC = 背外侧前额叶, HP = 海马, IA = 脑岛, IPL = 顶下小叶, MPFC = 内侧前额叶, LTC = 外侧颞叶, PCC = 后扣带回, PCu = 前楔叶, PC = 顶叶皮层, PG = 中央前回。
图1失眠静息态大尺度脑网络内连接与活动情况 注：DMN = 默认网络, SN：突显网络, CCN：认知控制网络, AN = 负性情绪网络, ACC = 前扣带回, aIA = 前脑岛, Amg = 杏仁核, AMPFC = 前内侧前额叶, aTH = 前丘脑, dACC = 背侧前扣带回, DLPFC = 背外侧前额叶, HP = 海马, IA = 脑岛, IPL = 顶下小叶, MPFC = 内侧前额叶, LTC = 外侧颞叶, PCC = 后扣带回, PCu = 前楔叶, PC = 顶叶皮层, PG = 中央前回。
图2失眠静息态大尺度脑网络间连接情况 注：aDMN = 前侧默认网络, pDMN = 后侧默认网络, scDMN = 皮层下默认网络, SN = 突显网络, CCN = 认知控制网络, AN = 负性情绪网络。
图2失眠静息态大尺度脑网络间连接情况 注：aDMN = 前侧默认网络, pDMN = 后侧默认网络, scDMN = 皮层下默认网络, SN = 突显网络, CCN = 认知控制网络, AN = 负性情绪网络。
图3失眠症状、干预治疗和脑网络 注：CBT-I = 失眠认知行为疗法, rTMS = 重复经颅磁刺激, CMD = 补充替代疗法
图3失眠症状、干预治疗和脑网络 注：CBT-I = 失眠认知行为疗法, rTMS = 重复经颅磁刺激, CMD = 补充替代疗法参考文献 74
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