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心理韧性及其神经机制:来自非人类动物模型的证据

本站小编 Free考研考试/2022-01-01

刘浩然1, 张晨风1, 杨莉1,2()
1华南师范大学心理学院
2华南师范大学脑科学与康复医学研究院, 广州 510631
收稿日期:2017-11-13出版日期:2019-02-15发布日期:2018-12-25
通讯作者:杨莉E-mail:yang_li@m.scnu.edu.cn

基金资助:* 国家自然科学基金(31771219);广州市科技创新基金(201607010320);华南师范大学心理学院研究生科研创新基金资助(hsxly2017005)

The neural mechanism underlying resilience

LIU Haoran1, ZHANG Chenfeng1, YANG Li1,2()
1 School of Psychology, South China Normal University, Guangzhou 510631, China
2 Institute for Brain Research and Rehabilitation, South China Normal University, Guangzhou 510631, China
Received:2017-11-13Online:2019-02-15Published:2018-12-25
Contact:YANG Li E-mail:yang_li@m.scnu.edu.cn






摘要/Abstract


摘要: 心理韧性是指个体对不幸、逆境或挫折等压力情形的有效适应。以非人类动物为模型的心理韧性研究一般改称心理韧性为“抗逆力”, 本文也将沿用“抗逆力”来区分不同物种的韧性研究。近年来采用非人类动物模型对抗逆力神经机制的探索取得了重要进展, 内侧前额叶、海马、奖赏环路等脑区及其投射均参与调控抗逆力的表现, 操控其神经环路的影响与所面对的压力形式有关, 并且高抗动物拥有特异性适应机制。鉴于人类研究的伦理及实验手段等原因, 抗逆力的研究将为人类的韧性研究提供重要参考。



图1小鼠抗逆力的神经环路图。激活或抑制两个脑区之间的投射可以调控小鼠的抗逆力行为表型(修改自Russo & Nestler, 2013)。
图1小鼠抗逆力的神经环路图。激活或抑制两个脑区之间的投射可以调控小鼠的抗逆力行为表型(修改自Russo & Nestler, 2013)。







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