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奖赏环路与阿片成瘾:喙内侧被盖核的调节作用

本站小编 Free考研考试/2022-01-01
吴静1, 崔睿思1, 孙翠翠2, 李新旺1()
1 首都师范大学心理学院, 北京 100037
2 华中师范大学心理学院, 武汉 430079
收稿日期:2018-05-03出版日期:2019-01-15发布日期:2018-11-23


基金资助:* 国家自然科学基金项目(31470989)

Reward circuits and opioid addiction: The moderating effect of the rostromedial tegmental nucleus

WU Jing1, CUI Ruisi1, SUN Cuicui2, LI Xinwang1()
1 School of Psychology, Capital Normal University, Beijing 100037, China
2 School of Psychology, Central China Normal University, Wuhan 430079, China
Received:2018-05-03Online:2019-01-15Published:2018-11-23







摘要/Abstract


摘要： 喙内侧被盖核(RMTg)位于腹侧被盖区(VTA)的尾部, 富含抑制性的γ-氨基丁酸(GABA)能神经元.RMTg是中脑边缘多巴胺系统的一个综合调节器.它的GABA能神经元接受外侧缰核(LHb)的输入, 然后投射到VTA多巴胺能神经元, 进而抑制多巴胺的释放.这三个脑区是奖赏环路的重要组成部分, 其中RMTg在阿片类物质激活的奖赏环路中尤为重要.阿片类物质主要通过抑制RMTg GABA能神经元使VTA多巴胺能神经元去抑制, 进而激活奖赏系统.因此, RMTg有望成为治疗药物成瘾(尤其是阿片成瘾)的一个重要靶点.此外, 胆碱类物质作用于RMTg的毒蕈碱受体能够抑制阿片类物质诱导的奖赏效应.未来研究应深入探讨RMTg调控的负性奖赏环路, 这对弱化觅药动机,促进消退和戒断具有重要意义.



图1RMTg是奖赏环路和阿片成瘾的中间调节器(参考Juarez & Han, 2016)
图1RMTg是奖赏环路和阿片成瘾的中间调节器(参考Juarez & Han, 2016)







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