), 房林1, 王亭予1, 崔丽2 1辽宁师范大学心理学院, 大连 116029
2大连小海豚自闭症儿童康复中心, 大连 116000
收稿日期:2017-05-31出版日期:2018-08-15发布日期:2018-07-02通讯作者:孙岩E-mail:sun9199@163.com基金资助:教育部人文社会科学规划基金项目(17YJA190011)The influence factors and neural mechanisms of inhibitory control in autism spectrum disorders
SUN Yan1(), FANG Lin1, WANG Tingyu1, CUI Li2 1 Department of Psychology, Liaoning Normal University, Dalian 116029, China
2 Dalian Little Dolphin Autism Care Center, Dalian 116000, China
Received:2017-05-31Online:2018-08-15Published:2018-07-02Contact:SUN Yan E-mail:sun9199@163.com摘要/Abstract
摘要： 自闭症谱系障碍(ASD)是一种起源于儿童期的神经发育障碍, ASD的重复刻板行为与其抑制控制发展有密切关系。使用Go/No-go、Flanker及Stroop等范式的研究发现, ASD者抑制控制受损主要表现为反应抑制和干扰抑制能力存在缺陷; 其主要影响因素是任务状态、被试年龄及取样; 涉及的脑区和脑网络集中在前额皮层、前扣带回和基底神经节; 涉及的基因集中在谷氨酸盐、γ-氨基丁酸与5-羟色胺三种神经递质。未来应从脑机制研究入手, 综合考虑任务状态、个体特征对研究结果造成的影响, 并着力开发更有效的干预模式。
图/表 1
表1ASD与正常被试抑制控制相关脑区激活的比较
| 资料来源 | 被试及数量 | 年龄范围(岁) | 任务范式 | 测量工具 | 研究结果 |
|---|---|---|---|---|---|
| Schmitz et al., 2006 | ASD：8 正常组：10 | 18~52 | Go/No-go任务 Stroop任务 | fMRI | ASD组左下眶额叶皮层、右IFG与左脑岛激活显著增加, 右侧额下回灰质密度增加 |
| Kana et al., 2007 | ASD：12 正常组：12 | 19.1~34.5 19.3~25.7 | 包含有工作记忆成分的Go/No-go任务 | fMRI | ASD组ACC激活降低, 前脑岛激活减少; ACC与右侧额-顶抑制脑网络的同步性更低 |
| Chan et al., 2011 | ASD：20 正常组：20 | 7~14 7~14 | Go/No-go任务 | EEG | ASD组在No-go条件下的ACC激活显著低于正常组 |
| Langen et al., 2012 | ASD：21 正常组：22 | 19~44 19~44 | Go/No-go任务 | sMRI (structural MRI) DTI (diffusion tensor imaging) | ASD大脑总体白质体积显著小于正常被试, 连接壳核与前额皮层之间的白质连接强度减弱 |
| Duerden et al., 2013 | ASD：19 正常组：20 | 19.6~39.4 20.8~43.4 | 面孔表情识别的 Go/No-go任务 | fMRI | 正常组激活VLPFC、DLPFC、楔前叶、ACC、前脑岛、梭状回、顶下小叶和颞中回, ASD组的VLPFC和右侧梭状回激活更大 |
| Daly et al., 2014 | ASD：14 正常组：14 | 18~44 20~42 | Go/No-go任务 | fMRI | ASD组的额下皮质区、基底神经节、丘脑、小脑存在激活异常 |
| Solomon et al., 2014 | ASD1：13 ASD2：14 正常组1：13 正常组2：14 | 12~15 16~18 12~15 16~18 | 准备执行优势反应抑制任务(Preparing to Overcome Prepotency “POP” Task ) | fMRI | 16~18岁组的ASD在VLPFC和双侧ACC之间的功能连接增强, 16~18岁组的ASD的左顶叶激活减少 |
| Padmanabhan et al., 2015 | ASD1: 8 ASD2: 11 正常组1：14 正常组2：9 | 19~33 13~17 18~31 12~17 | 反眼跳任务与视觉 引导任务(visually guided saccade, VGS) | fMRI | ASD青少年壳核与楔前叶激活更大, 顶下小叶的激活水平下降 |
| Velasquez et al., 2017 | ASD: 19 正常组：22 | 18~35 20~46 | 面孔表情识别 Go/No-go任务 | fMRI | ASD组角回与梭状回激活更大, ASD组ACC与楔前叶激活降低 |
表1ASD与正常被试抑制控制相关脑区激活的比较
| 资料来源 | 被试及数量 | 年龄范围(岁) | 任务范式 | 测量工具 | 研究结果 |
|---|---|---|---|---|---|
| Schmitz et al., 2006 | ASD：8 正常组：10 | 18~52 | Go/No-go任务 Stroop任务 | fMRI | ASD组左下眶额叶皮层、右IFG与左脑岛激活显著增加, 右侧额下回灰质密度增加 |
| Kana et al., 2007 | ASD：12 正常组：12 | 19.1~34.5 19.3~25.7 | 包含有工作记忆成分的Go/No-go任务 | fMRI | ASD组ACC激活降低, 前脑岛激活减少; ACC与右侧额-顶抑制脑网络的同步性更低 |
| Chan et al., 2011 | ASD：20 正常组：20 | 7~14 7~14 | Go/No-go任务 | EEG | ASD组在No-go条件下的ACC激活显著低于正常组 |
| Langen et al., 2012 | ASD：21 正常组：22 | 19~44 19~44 | Go/No-go任务 | sMRI (structural MRI) DTI (diffusion tensor imaging) | ASD大脑总体白质体积显著小于正常被试, 连接壳核与前额皮层之间的白质连接强度减弱 |
| Duerden et al., 2013 | ASD：19 正常组：20 | 19.6~39.4 20.8~43.4 | 面孔表情识别的 Go/No-go任务 | fMRI | 正常组激活VLPFC、DLPFC、楔前叶、ACC、前脑岛、梭状回、顶下小叶和颞中回, ASD组的VLPFC和右侧梭状回激活更大 |
| Daly et al., 2014 | ASD：14 正常组：14 | 18~44 20~42 | Go/No-go任务 | fMRI | ASD组的额下皮质区、基底神经节、丘脑、小脑存在激活异常 |
| Solomon et al., 2014 | ASD1：13 ASD2：14 正常组1：13 正常组2：14 | 12~15 16~18 12~15 16~18 | 准备执行优势反应抑制任务(Preparing to Overcome Prepotency “POP” Task ) | fMRI | 16~18岁组的ASD在VLPFC和双侧ACC之间的功能连接增强, 16~18岁组的ASD的左顶叶激活减少 |
| Padmanabhan et al., 2015 | ASD1: 8 ASD2: 11 正常组1：14 正常组2：9 | 19~33 13~17 18~31 12~17 | 反眼跳任务与视觉 引导任务(visually guided saccade, VGS) | fMRI | ASD青少年壳核与楔前叶激活更大, 顶下小叶的激活水平下降 |
| Velasquez et al., 2017 | ASD: 19 正常组：22 | 18~35 20~46 | 面孔表情识别 Go/No-go任务 | fMRI | ASD组角回与梭状回激活更大, ASD组ACC与楔前叶激活降低 |
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