雷红星(HongxingLei)
博士生导师，“百人计划”研究员
E-Mail：leihx@big.ac.cn
研究领域：生物信息学
导师简介：学习经历：
1987年9月-1991年6月华中理工大学生物医学工程学士1998年8月-2003年7月美国堪萨斯州立大学生物化学博士学位指导教授:PaulE.Smith
工作经历：
1991年7月-1998年7月军事医学科学院研究实习员/助理研究员指导教授:吴加金
2003年8月-2004年8月美国德拉华大学博士后指导教授:段勇
2004年9月-2008年2月美国加大戴维斯分校博士后、研究组主管指导教授:段勇
2008年3月-至今中科院北京基因组研究所“百人计划”研究员
学术兼职：
AssociateEditor，JournalofAlzheimer’sDisease.AssociateEditor，Genomics,Proteomics&Bioinformatics.
获奖及荣誉：
1995年，军队科技进步三等奖
计算生物学,阿尔茨海默病
近期主要学术成果：
1.JiajiaWang,XuemeiFengX,ZhouxianBai,Lee-wayJin,YongDuanY,andHongxingLei.(2013)Chromosome19pinAlzheimer’sdisease:whengenomemeetstranscriptome.JAlzheimer’sDiseaseonline.
2.GuangchunHan,JiajiaWang,FanZeng,XuemeiFengX,JunYu,HongyiCaoH,XuYi,HuadongZhou,Lee-wayJin,YongDuanY,YanjiangWangandHongxingLei.(2013)CharacteristictransformationofbloodtranscriptomeinAlzheimer’sdisease.JAlzheimer’sDisease35:373-386.
3.DapengLiang,GuangchunHan,XuemeiFeng,JiyaSun,YongDuanandHongxingLei.ConcertedperturbationobservedinahubnetworkinAlzheimer’sdisease.PLoSOne2012，7(7):e40498(correspondingauthor)
4.JiyaSun,XuemeiFeng,DapengLiang,YongDuanandHongxingLei.Down-regulationofenergymetabolisminAlzheimer’sdiseaseisaprotectiveresponseofneuronstothemicroenvironment.JAlzheimer’sDisease2012，28,389-402(correspondingauthor)
5.HongxingLei.AmyloidandAlzheimer’sdisease.Protein&Cell2010，1（4）,312-314
6.HongxingLei,YaoSu,LianJinandYongDuan.Thefoldingnetworkofvillinheadpiecesubdomain.BiophysJ2010，99：3374-3384(correspondingauthor)
7.HongxingLei,Zhi-XiangWang,ChunWuandYongDuan.Dualfoldingpathwaysofana/bproteinfromall-atomabinitiofoldingsimulations.J.Chem.Phys.2009，131,1651058.HongxingLei,ChunWu,Zhi-XiangWang,YaoqiZhou,andYongDuan.FoldingprocessesoftheBdomainofproteinAtothenativestateobservedinall-atomabinitiofoldingsimulations.JChemPhys2008,128(23):235105
9.HongxingLei,ChunWu,HaiguangLiuandYongDuan.FoldingfreeenergylandscapeofHP35frommoleculardynamicssimulations.PNAS,2007,104(12):4925-4930
10.HongxingLeiandYongDuan.Two-stagefoldingofHP-35fromAbinitiosimulation.J.Mol.Biol.,2007,370:196-206
11.HongxingLeiandYongDuan.Abinitiofoldingofalbuminbindingdomainfromall-atommoleculardynamicssimulation.JPhysChemB,2007,111:5458-5463.
12.HongxingLeiandYongDuan.Improvedsamplingmethodsformoleculardynamics.CurrOpinStructBiol,2007,17:187-191
13.HongxingLei;ShubhraGDastidarandYongDuan.FoldingTransitionStateandDenaturedStateEnsemblesofFSD-1fromFoldingandUnfoldingSimulations.JPhysChemB,2006,110:22001-22008
14.HongxingLei;ChunWu;Zhi-XiangWangandYongDuan.Moleculardynamicssimulationsandfreeenergyanalysesonthedimerformationofanamyloidgenicheptamerpeptidefromhumanβ2-microglobulin:implicationtotheprotofibrilstructure.J.Mol.Biol.,2006,356:1049-1063
15.ChunWu,HongxingLei,andYongDuan.Elongationoforderedpeptideaggregateofanamyloidgenichexapeptide(NFGAIL)observedinmoleculardynamicssimulationswithexplicitsolvent.JAmChemSoc,2005,127:13530-13537
16.HongxingLeiandYongDuan.Incorporatingintermoleculardistanceintoprotein-proteindocking.ProteinEngDesSel,2004,17(12):837-845
17.HongxingLeiandYongDuan.Theroleofplasticβ-hairpinandweakhydrophobiccoreinthestabilityandunfoldingofafullsequencedesignprotein.JChemPhys2004,121(23):12014-12111
18.HongxingLeiandPaulE.Smith.Theroleoftheunfoldedstateinhairpinstability.BiophysJ2003,85(6):3513-3520
19.HongxingLeiandPaulE.Smith.TheEffectsofInternalWaterMoleculesontheStructureandDynamicsofChymotrypsinInhibitor2.JPhysChemB.2003,107:1395-1402
20.LiWuJu,LeiHongXing,PeiWuHongandWuJiaJin.GeneDn:forhigh-levelexpressiondesignofheterologousgenesinaprokaryoticsystem.Bioinformatics,1998,14(10):884-885
1.科技部973,2014CB964901,细胞命运维持与转化的表观遗传调控作用与机制研究,2014-2018年,在研,课题骨干。
2.自然科学基金,30870474,蛋白质-蛋白质对接的计算模型,2009-2011年,已结题,负责人。
研究组主要用生物信息学方法研究阿尔茨海默病,包括对基因组,转录组和表观遗传数据的分析,从中揭示疾病机理,发现药物靶标以及辅助临床诊断的方案。
招收生物学,统计学,计算机科学等专业背景的学生
工作经历：
1991年7月-1998年7月军事医学科学院研究实习员/助理研究员指导教授:吴加金
2003年8月-2004年8月美国德拉华大学博士后指导教授:段勇
2004年9月-2008年2月美国加大戴维斯分校博士后、研究组主管指导教授:段勇
2008年3月-至今中科院北京基因组研究所“百人计划”研究员
主要研究领域：
计算生物学,阿尔茨海默病
承担科研项目情况：
1.科技部973,2014CB964901,细胞命运维持与转化的表观遗传调控作用与机制研究,2014-2018年,在研,课题骨干。
2.自然科学基金,30870474,蛋白质-蛋白质对接的计算模型,2009-2011年,已结题,负责人。
代表论著：
1.JiajiaWang,XuemeiFengX,ZhouxianBai,Lee-wayJin,YongDuanY,andHongxingLei.(2013)Chromosome19pinAlzheimer’sdisease:whengenomemeetstranscriptome.JAlzheimer’sDiseaseonline.
2.GuangchunHan,JiajiaWang,FanZeng,XuemeiFengX,JunYu,HongyiCaoH,XuYi,HuadongZhou,Lee-wayJin,YongDuanY,YanjiangWangandHongxingLei.(2013)CharacteristictransformationofbloodtranscriptomeinAlzheimer’sdisease.JAlzheimer’sDisease35:373-386.
3.DapengLiang,GuangchunHan,XuemeiFeng,JiyaSun,YongDuanandHongxingLei.ConcertedperturbationobservedinahubnetworkinAlzheimer’sdisease.PLoSOne2012，7(7):e40498(correspondingauthor)
4.JiyaSun,XuemeiFeng,DapengLiang,YongDuanandHongxingLei.Down-regulationofenergymetabolisminAlzheimer’sdiseaseisaprotectiveresponseofneuronstothemicroenvironment.JAlzheimer’sDisease2012，28,389-402(correspondingauthor)
5.HongxingLei.AmyloidandAlzheimer’sdisease.Protein&Cell2010，1（4）,312-314
6.HongxingLei,YaoSu,LianJinandYongDuan.Thefoldingnetworkofvillinheadpiecesubdomain.BiophysJ2010，99：3374-3384(correspondingauthor)
7.HongxingLei,Zhi-XiangWang,ChunWuandYongDuan.Dualfoldingpathwaysofana/bproteinfromall-atomabinitiofoldingsimulations.J.Chem.Phys.2009，131,1651058.HongxingLei,ChunWu,Zhi-XiangWang,YaoqiZhou,andYongDuan.FoldingprocessesoftheBdomainofproteinAtothenativestateobservedinall-atomabinitiofoldingsimulations.JChemPhys2008,128(23):235105
9.HongxingLei,ChunWu,HaiguangLiuandYongDuan.FoldingfreeenergylandscapeofHP35frommoleculardynamicssimulations.PNAS,2007,104(12):4925-4930
10.HongxingLeiandYongDuan.Two-stagefoldingofHP-35fromAbinitiosimulation.J.Mol.Biol.,2007,370:196-206
11.HongxingLeiandYongDuan.Abinitiofoldingofalbuminbindingdomainfromall-atommoleculardynamicssimulation.JPhysChemB,2007,111:5458-5463.
12.HongxingLeiandYongDuan.Improvedsamplingmethodsformoleculardynamics.CurrOpinStructBiol,2007,17:187-191
13.HongxingLei;ShubhraGDastidarandYongDuan.FoldingTransitionStateandDenaturedStateEnsemblesofFSD-1fromFoldingandUnfoldingSimulations.JPhysChemB,2006,110:22001-22008
14.HongxingLei;ChunWu;Zhi-XiangWangandYongDuan.Moleculardynamicssimulationsandfreeenergyanalysesonthedimerformationofanamyloidgenicheptamerpeptidefromhumanβ2-microglobulin:implicationtotheprotofibrilstructure.J.Mol.Biol.,2006,356:1049-1063
15.ChunWu,HongxingLei,andYongDuan.Elongationoforderedpeptideaggregateofanamyloidgenichexapeptide(NFGAIL)observedinmoleculardynamicssimulationswithexplicitsolvent.JAmChemSoc,2005,127:13530-13537
16.HongxingLeiandYongDuan.Incorporatingintermoleculardistanceintoprotein-proteindocking.ProteinEngDesSel,2004,17(12):837-845
17.HongxingLeiandYongDuan.Theroleofplasticβ-hairpinandweakhydrophobiccoreinthestabilityandunfoldingofafullsequencedesignprotein.JChemPhys2004,121(23):12014-12111
18.HongxingLeiandPaulE.Smith.Theroleoftheunfoldedstateinhairpinstability.BiophysJ2003,85(6):3513-3520
19.HongxingLeiandPaulE.Smith.TheEffectsofInternalWaterMoleculesontheStructureandDynamicsofChymotrypsinInhibitor2.JPhysChemB.2003,107:1395-1402
20.LiWuJu,LeiHongXing,PeiWuHongandWuJiaJin.GeneDn:forhigh-levelexpressiondesignofheterologousgenesinaprokaryoticsystem.Bioinformatics,1998,14(10):884-885
社会任职：
AssociateEditor，JournalofAlzheimer’sDisease.AssociateEditor，Genomics,Proteomics&Bioinformatics.
获奖及荣誉：
1995年，军队科技进步三等奖
