章张(ZhangZhang)
博士生导师，“百人计划”研究员
E-Mail：zhangzhang@big.ac.cn
研究领域：生物信息学
导师简介：学习经历：
1998-2002宁夏大学计算机科学学士2002-2004南京理工大学计算机科学硕士2004-2007中国科学院计算技术研究所计算机科学博士
工作经历：
2007-2009美国耶鲁大学（YaleUniversity）博士后（PostdoctoralAssociate）
2009-2011沙特阿卜杜拉国王理工大学（KingAbdullahUniversityofScienceandTechnology）研究科学家（ResearchScientist）
2011-至今中国科学院北京基因组研究所“百人计划”研究员
学术兼职：
1、编委成员：BiologyDirect(2013—)2、学术编辑（AcademicEditor）:PlosONE(2012—),PeeJ(2013—)3、副主编（AssociateEditor-in-Chief）:Genomics,Proteomics&Bioinformatics(2012-)4、评审编辑（ReviewEditor）:FrontiersinStatisticalGeneticsandMethodology(2011-)5、评审员:Bioinformatics,BMCBioinformatics,BMCEvolutionaryBiology,BMCSystemsBiology,BriefingsinBioinformatics,ChineseBulletinofLifeSciences,CurrentBioinformatics,EvolutionaryBioinformatics,GenomicsProteomics&Bioinformatics,InSilicoBiology,JournalofMolecularEvolution,MolecularBiologyandEvolution,PLoSONE6、会员:Bioinformatics,GeneticsSocietyofChina,InternationalSocietyofComputationalBiology(ISCB),SocietyforMolecularBiologyandEvolution(SMBE)
获奖及荣誉：
分子序列进化建模与分析、海量生物数据整合与信息挖掘
近期主要学术成果：
1.Zhang,Z.*,Sang,J.Ma,L.N.,Wu,G.,Wu,H.,Huang,D.W.,Zou,D.,Liu,S.Q.,Li,A.,Hao,L.L.,Tian,M.,Xu,C.,Wang,X.M.,Wu,J.Y.,Xiao,J.F.,Dai,L.,Chen,L.-L.,Hu,S.N.,andYu,J.(2014)RiceWiki:awiki-baseddatabaseforcommunitycurationofricegenes,NucleicAcidsResearch,doi:10.1093/nar/gkt926,inpress.
2.Wu,J.Y.,Xiao,J.F.,Wang,L.P.,Zhong,J.,Yin,H.Y.,Wu,S.X.,Zhang,Z.,Yu,J.(2013)Systematicanalysisofintronsizeandabundanceparametersindiverselineages,SciChinaLifeSci,56:1–7.
3.Zhang,Z.,Wong,G.K.andYu,J.(2013)Proteincoding,In:eLS.JohnWiley&SonsLtd,Chichester.
4.Dai,L.,Tian,M.,Wu,J.Y.,Xiao,J.F.,Wang,X.M.,Townsend,J.P.andZhang,Z.*(2013)AuthorReward:increasingcommunitycurationinbiologicalknowledgewikisthroughautomatedauthorshipquantification,Bioinformatics,29(14):1837-1839.
5.Ma,L.N.,Bajic,V.B.,andZhang,Z.*(2013)Ontheclassificationoflongnon-codingRNAs,RNABiology,10(6):1-10.
6.Tong,X.,Yang,Y.,Wang,W.,Bai,Z.,Ma,L.,Zheng,X.,Sun,H.,Zhang,Z.,Zhao,M.,Yu,J.,Ge,R.L.(2013)ExpressionprofilingofabundantgenesinpulmonaryandcardiacmuscletissuesofTibetanAntelope(Pantholopshodgsonii),Gene,pii:S0378-1119(13)00245-X.doi:10.1016.
7.Dai,L.,Xu,C.,Tian,M.,Sang,J.,Zou,D.,Li,A.,Liu,G.C.,Chen,F.,Wu,J.Y.,Xiao,J.F.,Wang,X.M.,Yu,J.,andZhang,Z.*(2013)Communityintelligenceinknowledgecuration:anapplicationtomanagingscientificnomenclature,PLoSONE,8(2),e56961.
8.Zhang,Z.,andYu.J.(2013)Doesthegeneticcodehaveaeukaryoticorigin?GenomicsProteomicsBioinformatics,11(1):41-55.
9.Chen,M.,Xiao,J.F.,Zhang,Z.,Liu,J.,Wu,J.Y.,andYu,J.(2013)IdentificationofhumanHKGenesandgeneexpressionregulationstudyincancerfromtranscriptomicsdataanalysis,PLoSONE,8(1),e54082.
10.Dai,L.,Gao,X.,Guo,Y.,Xiao,J.F.andZhang,Z.*(2012)Bioinformaticscloudsforbigdatamanipulation,BiologyDirect,7,43.
11.Zhang,Z.andYu,J.(2012)Thependulummodelforgenomecompositionaldynamics:fromthefournucleotidestothetwentyaminoacids,GenomicsProteomicsBioinformatics,10(4),175-180.
12.Wu,H.,Qu,H.Z,Wan,N.,Zhang,Z.,Hu,S.N.andYu,J.(2012)Strand-biasedgenedistributioninbacteriaisrelatedtobothhorizontalgenetransferandstrand-biasednucleotidecomposition,GenomicsProteomicsBioinformatics,10(4),186-196.
13.Cui,P.,Liu,W.,Zhao,Y.,Lin,Q.,Zhang,D.,Ding,F.,Xin,C.,Zhang,Z.,Song,S.,SunFetal(2012)ComparativeanalysesofH3K4andH3K27trimethylationsbetweenthemousecerebrumandtestis.GenomicsProteomicsBioinformatics,10(2),82-93.
14.Cui,P.,Ding,F.,Lin,Q.,Zhang,L.,Li,A.,Zhang,Z.,Hu,S.andYu,J.(2012)Distinctcontributionsofreplicationandtranscriptiontomutationratevariationofhumangenomes,GenomicsProteomicsBioinformatics,10(1),4-10.
15.Zhang,Z.*,Xiao,J.,Wu,J.,Zhang,H.,Liu,G.,Wang,X.andDai,L.(2012)ParaAT:aparalleltoolforconstructingmultipleprotein-codingDNAalignments,BiochemBiophysResCommun,419(4),779-781.
16.Zhang,Z.,Li,J.,Cui,P.,Ding,F.,Li,A.,Townsend,J.P.andYu,J.(2012)CodonDeviationCoefficient:anovelmeasureforestimatingcodonusagebiasanditsstatisticalsignificance,BMCBioinformatics,13,43.
17.Wu,H.,Zhang,Z.,Hu,S.andYu,J.(2012)OnthemolecularmechanismofGCcontentvariationamongeubacterialgenomes,BiologyDirect,7,2.
18.Zhang,Z.,Bajic,V.B.,Yu,J.,Cheung,K.-H.andTownsend,J.P.(2011)Dataintegrationinbioinformatics:currenteffortsandchallenges.InMahdavi,M.A.(ed),Bioinformatics-TrendsandMethodologies.InTech-OpenAccessPublisher,Rijeka,Croatia.Availablefrom:http://www.intechopen.com/articles/show/title/data-integration-in-bioinformatics-current-efforts-and-challenges.
19.Zhang,Z.andYu,J.(2011)Ontheorganizationaldynamicsofthegeneticcode,GenomicsProteomicsBioinformatics,9(1-2),21-29.
20.Zhang,Z.andYu,J.(2010)ModelingcompositionaldynamicsbasedonGCandpurinecontentsofprotein-codingsequences,BiologyDirect,5,63.
本项目组的主要研究方向是生物信息学/计算生物学。目前的研究内容包括：
（1）基因组组分动力学和计算分子进化学研究；
（2）海量生物数据的整合和挖掘；
（3）基于Web2.0/3.0的基因组信息学数据共享系统研究；
（4）生物信息学的SemanticWebService和生物数据的标准化研究。
欢迎生物信息学、计算机科学、生物学、数学等相关背景的学生报名。
工作经历：
2007-2009美国耶鲁大学（YaleUniversity）博士后（PostdoctoralAssociate）
2009-2011沙特阿卜杜拉国王理工大学（KingAbdullahUniversityofScienceandTechnology）研究科学家（ResearchScientist）
2011-至今中国科学院北京基因组研究所“百人计划”研究员
主要研究领域：
分子序列进化建模与分析、海量生物数据整合与信息挖掘
承担科研项目情况：
代表论著：
1.Zhang,Z.*,Sang,J.Ma,L.N.,Wu,G.,Wu,H.,Huang,D.W.,Zou,D.,Liu,S.Q.,Li,A.,Hao,L.L.,Tian,M.,Xu,C.,Wang,X.M.,Wu,J.Y.,Xiao,J.F.,Dai,L.,Chen,L.-L.,Hu,S.N.,andYu,J.(2014)RiceWiki:awiki-baseddatabaseforcommunitycurationofricegenes,NucleicAcidsResearch,doi:10.1093/nar/gkt926,inpress.
2.Wu,J.Y.,Xiao,J.F.,Wang,L.P.,Zhong,J.,Yin,H.Y.,Wu,S.X.,Zhang,Z.,Yu,J.(2013)Systematicanalysisofintronsizeandabundanceparametersindiverselineages,SciChinaLifeSci,56:1–7.
3.Zhang,Z.,Wong,G.K.andYu,J.(2013)Proteincoding,In:eLS.JohnWiley&SonsLtd,Chichester.
4.Dai,L.,Tian,M.,Wu,J.Y.,Xiao,J.F.,Wang,X.M.,Townsend,J.P.andZhang,Z.*(2013)AuthorReward:increasingcommunitycurationinbiologicalknowledgewikisthroughautomatedauthorshipquantification,Bioinformatics,29(14):1837-1839.
5.Ma,L.N.,Bajic,V.B.,andZhang,Z.*(2013)Ontheclassificationoflongnon-codingRNAs,RNABiology,10(6):1-10.
6.Tong,X.,Yang,Y.,Wang,W.,Bai,Z.,Ma,L.,Zheng,X.,Sun,H.,Zhang,Z.,Zhao,M.,Yu,J.,Ge,R.L.(2013)ExpressionprofilingofabundantgenesinpulmonaryandcardiacmuscletissuesofTibetanAntelope(Pantholopshodgsonii),Gene,pii:S0378-1119(13)00245-X.doi:10.1016.
7.Dai,L.,Xu,C.,Tian,M.,Sang,J.,Zou,D.,Li,A.,Liu,G.C.,Chen,F.,Wu,J.Y.,Xiao,J.F.,Wang,X.M.,Yu,J.,andZhang,Z.*(2013)Communityintelligenceinknowledgecuration:anapplicationtomanagingscientificnomenclature,PLoSONE,8(2),e56961.
8.Zhang,Z.,andYu.J.(2013)Doesthegeneticcodehaveaeukaryoticorigin?GenomicsProteomicsBioinformatics,11(1):41-55.
9.Chen,M.,Xiao,J.F.,Zhang,Z.,Liu,J.,Wu,J.Y.,andYu,J.(2013)IdentificationofhumanHKGenesandgeneexpressionregulationstudyincancerfromtranscriptomicsdataanalysis,PLoSONE,8(1),e54082.
10.Dai,L.,Gao,X.,Guo,Y.,Xiao,J.F.andZhang,Z.*(2012)Bioinformaticscloudsforbigdatamanipulation,BiologyDirect,7,43.
11.Zhang,Z.andYu,J.(2012)Thependulummodelforgenomecompositionaldynamics:fromthefournucleotidestothetwentyaminoacids,GenomicsProteomicsBioinformatics,10(4),175-180.
12.Wu,H.,Qu,H.Z,Wan,N.,Zhang,Z.,Hu,S.N.andYu,J.(2012)Strand-biasedgenedistributioninbacteriaisrelatedtobothhorizontalgenetransferandstrand-biasednucleotidecomposition,GenomicsProteomicsBioinformatics,10(4),186-196.
13.Cui,P.,Liu,W.,Zhao,Y.,Lin,Q.,Zhang,D.,Ding,F.,Xin,C.,Zhang,Z.,Song,S.,SunFetal(2012)ComparativeanalysesofH3K4andH3K27trimethylationsbetweenthemousecerebrumandtestis.GenomicsProteomicsBioinformatics,10(2),82-93.
14.Cui,P.,Ding,F.,Lin,Q.,Zhang,L.,Li,A.,Zhang,Z.,Hu,S.andYu,J.(2012)Distinctcontributionsofreplicationandtranscriptiontomutationratevariationofhumangenomes,GenomicsProteomicsBioinformatics,10(1),4-10.
15.Zhang,Z.*,Xiao,J.,Wu,J.,Zhang,H.,Liu,G.,Wang,X.andDai,L.(2012)ParaAT:aparalleltoolforconstructingmultipleprotein-codingDNAalignments,BiochemBiophysResCommun,419(4),779-781.
16.Zhang,Z.,Li,J.,Cui,P.,Ding,F.,Li,A.,Townsend,J.P.andYu,J.(2012)CodonDeviationCoefficient:anovelmeasureforestimatingcodonusagebiasanditsstatisticalsignificance,BMCBioinformatics,13,43.
17.Wu,H.,Zhang,Z.,Hu,S.andYu,J.(2012)OnthemolecularmechanismofGCcontentvariationamongeubacterialgenomes,BiologyDirect,7,2.
18.Zhang,Z.,Bajic,V.B.,Yu,J.,Cheung,K.-H.andTownsend,J.P.(2011)Dataintegrationinbioinformatics:currenteffortsandchallenges.InMahdavi,M.A.(ed),Bioinformatics-TrendsandMethodologies.InTech-OpenAccessPublisher,Rijeka,Croatia.Availablefrom:http://www.intechopen.com/articles/show/title/data-integration-in-bioinformatics-current-efforts-and-challenges.
19.Zhang,Z.andYu,J.(2011)Ontheorganizationaldynamicsofthegeneticcode,GenomicsProteomicsBioinformatics,9(1-2),21-29.
20.Zhang,Z.andYu,J.(2010)ModelingcompositionaldynamicsbasedonGCandpurinecontentsofprotein-codingsequences,BiologyDirect,5,63.
社会任职：
1、编委成员：BiologyDirect(2013—)2、学术编辑（AcademicEditor）:PlosONE(2012—),PeeJ(2013—)3、副主编（AssociateEditor-in-Chief）:Genomics,Proteomics&Bioinformatics(2012-)4、评审编辑（ReviewEditor）:FrontiersinStatisticalGeneticsandMethodology(2011-)5、评审员:Bioinformatics,BMCBioinformatics,BMCEvolutionaryBiology,BMCSystemsBiology,BriefingsinBioinformatics,ChineseBulletinofLifeSciences,CurrentBioinformatics,EvolutionaryBioinformatics,GenomicsProteomics&Bioinformatics,InSilicoBiology,JournalofMolecularEvolution,MolecularBiologyandEvolution,PLoSONE6、会员:Bioinformatics,GeneticsSocietyofChina,InternationalSocietyofComputationalBiology(ISCB),SocietyforMolecularBiologyandEvolution(SMBE)
获奖及荣誉：
