米双利(ShuangliMi)
博士生导师，研究员
E-Mail：mishl@big.ac.cn
研究领域：基因组学生物化学与分子生物学
导师简介：学习经历：
1999年-2005年北京大学生命科学院理学博士
工作经历：
2005年7月-2008年7月PostdoctoralFellow,DepartmentofMedicine,SectionofHematology/Oncology,UniversityofChicago,USA
2008年7月-2009年8月PostdoctoralScholar/ResearchAssociate,PharmacogeneticsAnticancerAgentsResearchGroup,UniversityofChicago,USA
2009年8月-至今中国科学院北京基因组研究所研究员博士生导师
学术兼职：
获奖及荣誉：
肿瘤基因组学、药物遗传学
近期主要学术成果：
1.MiS,ZhangJ,ZhangW,HuangRS.CirculatingmicroRNAsasbiomarkersforinflammatorydiseases.MicroRNA.2013,2(1):64-72.
2.WangQF,WuG,MiS,HeF,WuJ,etal.MLLFusionProteinsPreferentiallyRegulateaSubsetofWildTypeMLLTargetGenesintheLeukemicGenome.Blood.2011,117:6895-6905
3.WenY,GamazonER,BleibelWK,WingC,MiS,etal.AneQTL-basedmethodidentifiesCTTNandZMAT3aspemetrexedsusceptibilitymarkers.HumMolGenet.2011,21:1470-1480
4.TaoY,RuanJ,YehSH,LuX,WangY,etal.Rapidgrowthofahepatocellularcarcinomaandthedrivingmutationsrevealedbycell-populationgeneticanalysisofwhole-genomedata.PNatlAcadSciUSA.2011,108:12042-12047
5.MiS,LiZ,ChenP,HeC,CaoD,etal.AberrantoverexpressionandfunctionofthemiR-17-92clusterinMLL-rearrangedacuteleukemia.PNatlAcadSciUSA.2010,107:3710-3715
6.HuangRS,JohnattySE,GamazonER,ImHK,ZiliakD,etal.Platinumsensitivity-relatedgermlinepolymorphismdiscoveredviaacell-basedapproachandanalysisofitsassociationwithoutcomeinovariancancerpatients.ClinCancerRes.2011,17:5490-500.
7.StarkAL,ZhangW,MiS,DuanS,O'DonnellPH,etal.Heritableandnon-geneticfactorsasvariablesofpharmacologicphenotypesinlymphoblastoidcelllines.PharmacogenomicsJ.2010,10:505-512
8.HuangRS,MiS.Candidategenespharmacogeneticsofanti-canceragents.Pharmacogenomics,2009,10(5):719-720
9.HartfordC,DuanS,DelaneyS,MiS,KistnerE,etal.PopulationSpecificGeneticVariantsImportantinSusceptibilitytoCytarabineArabinosideCytotoxicity.Blood.2009,113:2145-2153
10.DuanS,HuangRS,ZhangW,MiS,BleibelWK,etal.ExpressionandAlternativeSplicingofFolatePathwayGenesinHapMapLymphoblastoidCellLines.Pharmacogenomics,2009.10:549-563
11.DuanS*,MiS*,ZhangW,DolanM.E.ComprehensiveanalysisoftheimpactofSNPsandCNVsonhumanmicroRNAsandtheirregulatorygenes.RNAbiology.2009,6:412-425.(*contributeequally)
12.LiZ,LuoRT,MiS,SunM,ChenP,etal.ConsistentderegulationofgeneexpressionbetweenhumanandmurineMLL-rearrangementleukemias.CancerRes.2009,69:1109-1116
13.LiZ*,LuJ*,SunM*,MiS*,ZhangH,etal.DistinctmicroRNAexpressionprofilesinacutemyeloidleukemiawithcommontranslocations.PNatlAcadSciUSA.2008,105:15535-15540(*contributeequally)
14.MiS,LuJ,SunM,LiZ,ZhangH,etal.MicroRNAexpressionsignaturesaccuratelydiscriminateacutelymphoblasticleukemiafromacutemyeloidleukemia.PNatlAcadSciUSA.2007,104:19971-19976
15.WangM,XieH,MiS,ChenJ.RecentpatentsontheidentificationandclinicalapplicationofmicroRNAsandtargetgenes.RecentPatentsonDNA&GeneSequences.2007,1:116-124
16.ZhangXY,WuY,YanJY,GaoY,WangY,etal.Y55andD78arecrucialaminoacidresiduesofanewIgEepitopeontrichosanthin.BiochemBiophyResCo.2006,343:1251-1256
17.MiSL,AnCC,WangY,ChenJY,CheNY,etal.Trichomislin,anovelribosome-inactivatingprotein,inducesapoptosisthatinvolvesmitochondriaandcaspase-3.ArchivesofBiochemistryandBiophysics.2005,434:258-265
18.WangY,MiSL,LouM,GaoY,ChenZL,etal.EnhancedGreenFluorescenceproteintracksTrichosanthininhumanchoriocarcinomacellsasafeasibleandstablereporter.FrontiersinBioscience.2005,10:2279-2284
19.YanY,AnC,LiL,GuJ,WangL,etal.Thesenseandantisenseexpressionofgibberellin20-oxidasegene(rga5)inriceanditseffectsonGA1levelandagronomictraits.ChineseScienceBulletin.2003,48:443-448
发表专利：
1.天花粉蛋白突变体及其编码基因。200410074324.6
2.MutantsofTrichosanthinWithAnti-TumorActivityandLoweredSide-Effects.US2008261874/WO2006026906,USA
1、国家自然科学基金面上项目：白血病异常融合蛋白MLL-ENL对小鼠细胞全基因组microRNA的表达调控研究，课题负责人；
2、国家自然科学基金重大国际合作研究项目：利用开放科学数据云促进高通量肿瘤基因组研究，课题负责人；
3、科技部973项目：在肺癌微环境中表观遗传修饰对肺癌发展转移的作用机制，课题主要骨干；
4、教育部留学回国人员启动基金，课题负责人,。
本课题组利用基因芯片、高通量测序等全基因组研究手段，阐明在不同白血病类型中的microRNA的特异表达情况，以及它们与不同种类白血病的发病关系；通过分析基因调控区甲基化水平、基因拷贝数、组蛋白修饰情况等表观遗传学因素，研究microRNA差异表达的机理；同时利用造血干细胞分化培养、RNAi技术、转基因小鼠模型等，在体外和体内系统中分别研究microRNA及其靶基因对于白血病的发生发展、血细胞种系的分化所起到的作用。在药物遗传学（PharmacogeneticsandPharmacogenomics）方面，我们的工作主要利用Genome-WideAssociationStudy，研究个体基因结构与表达差异（如SNP、mRNA、miRNA、CNV等）和多种抗癌药物对个体响应或毒性差异的关联性，为临床医疗和药物试验提供依据。
欢迎生物化学与分子生物学、细胞学、遗传学、生物技术、生理学、医学、药学专业背景的同学们报考。
工作经历：
2005年7月-2008年7月PostdoctoralFellow,DepartmentofMedicine,SectionofHematology/Oncology,UniversityofChicago,USA
2008年7月-2009年8月PostdoctoralScholar/ResearchAssociate,PharmacogeneticsAnticancerAgentsResearchGroup,UniversityofChicago,USA
2009年8月-至今中国科学院北京基因组研究所研究员博士生导师
主要研究领域：
肿瘤基因组学、药物遗传学
承担科研项目情况：
1、国家自然科学基金面上项目：白血病异常融合蛋白MLL-ENL对小鼠细胞全基因组microRNA的表达调控研究，课题负责人；
2、国家自然科学基金重大国际合作研究项目：利用开放科学数据云促进高通量肿瘤基因组研究，课题负责人；
3、科技部973项目：在肺癌微环境中表观遗传修饰对肺癌发展转移的作用机制，课题主要骨干；
4、教育部留学回国人员启动基金，课题负责人,。
代表论著：
1.MiS,ZhangJ,ZhangW,HuangRS.CirculatingmicroRNAsasbiomarkersforinflammatorydiseases.MicroRNA.2013,2(1):64-72.
2.WangQF,WuG,MiS,HeF,WuJ,etal.MLLFusionProteinsPreferentiallyRegulateaSubsetofWildTypeMLLTargetGenesintheLeukemicGenome.Blood.2011,117:6895-6905
3.WenY,GamazonER,BleibelWK,WingC,MiS,etal.AneQTL-basedmethodidentifiesCTTNandZMAT3aspemetrexedsusceptibilitymarkers.HumMolGenet.2011,21:1470-1480
4.TaoY,RuanJ,YehSH,LuX,WangY,etal.Rapidgrowthofahepatocellularcarcinomaandthedrivingmutationsrevealedbycell-populationgeneticanalysisofwhole-genomedata.PNatlAcadSciUSA.2011,108:12042-12047
5.MiS,LiZ,ChenP,HeC,CaoD,etal.AberrantoverexpressionandfunctionofthemiR-17-92clusterinMLL-rearrangedacuteleukemia.PNatlAcadSciUSA.2010,107:3710-3715
6.HuangRS,JohnattySE,GamazonER,ImHK,ZiliakD,etal.Platinumsensitivity-relatedgermlinepolymorphismdiscoveredviaacell-basedapproachandanalysisofitsassociationwithoutcomeinovariancancerpatients.ClinCancerRes.2011,17:5490-500.
7.StarkAL,ZhangW,MiS,DuanS,O'DonnellPH,etal.Heritableandnon-geneticfactorsasvariablesofpharmacologicphenotypesinlymphoblastoidcelllines.PharmacogenomicsJ.2010,10:505-512
8.HuangRS,MiS.Candidategenespharmacogeneticsofanti-canceragents.Pharmacogenomics,2009,10(5):719-720
9.HartfordC,DuanS,DelaneyS,MiS,KistnerE,etal.PopulationSpecificGeneticVariantsImportantinSusceptibilitytoCytarabineArabinosideCytotoxicity.Blood.2009,113:2145-2153
10.DuanS,HuangRS,ZhangW,MiS,BleibelWK,etal.ExpressionandAlternativeSplicingofFolatePathwayGenesinHapMapLymphoblastoidCellLines.Pharmacogenomics,2009.10:549-563
11.DuanS*,MiS*,ZhangW,DolanM.E.ComprehensiveanalysisoftheimpactofSNPsandCNVsonhumanmicroRNAsandtheirregulatorygenes.RNAbiology.2009,6:412-425.(*contributeequally)
12.LiZ,LuoRT,MiS,SunM,ChenP,etal.ConsistentderegulationofgeneexpressionbetweenhumanandmurineMLL-rearrangementleukemias.CancerRes.2009,69:1109-1116
13.LiZ*,LuJ*,SunM*,MiS*,ZhangH,etal.DistinctmicroRNAexpressionprofilesinacutemyeloidleukemiawithcommontranslocations.PNatlAcadSciUSA.2008,105:15535-15540(*contributeequally)
14.MiS,LuJ,SunM,LiZ,ZhangH,etal.MicroRNAexpressionsignaturesaccuratelydiscriminateacutelymphoblasticleukemiafromacutemyeloidleukemia.PNatlAcadSciUSA.2007,104:19971-19976
15.WangM,XieH,MiS,ChenJ.RecentpatentsontheidentificationandclinicalapplicationofmicroRNAsandtargetgenes.RecentPatentsonDNA&GeneSequences.2007,1:116-124
16.ZhangXY,WuY,YanJY,GaoY,WangY,etal.Y55andD78arecrucialaminoacidresiduesofanewIgEepitopeontrichosanthin.BiochemBiophyResCo.2006,343:1251-1256
17.MiSL,AnCC,WangY,ChenJY,CheNY,etal.Trichomislin,anovelribosome-inactivatingprotein,inducesapoptosisthatinvolvesmitochondriaandcaspase-3.ArchivesofBiochemistryandBiophysics.2005,434:258-265
18.WangY,MiSL,LouM,GaoY,ChenZL,etal.EnhancedGreenFluorescenceproteintracksTrichosanthininhumanchoriocarcinomacellsasafeasibleandstablereporter.FrontiersinBioscience.2005,10:2279-2284
19.YanY,AnC,LiL,GuJ,WangL,etal.Thesenseandantisenseexpressionofgibberellin20-oxidasegene(rga5)inriceanditseffectsonGA1levelandagronomictraits.ChineseScienceBulletin.2003,48:443-448
发表专利：
1.天花粉蛋白突变体及其编码基因。200410074324.6
2.MutantsofTrichosanthinWithAnti-TumorActivityandLoweredSide-Effects.US2008261874/WO2006026906,USA
社会任职：
获奖及荣誉：
