吴佳妍(JiayanWu)
硕士生导师，副研究员
E-Mail：wujy@big.ac.cn
研究领域：生物信息学
导师简介：学习经历：
1996年-2000年沈阳化工学院精细化工学士2000年8月-2005年6月吉林大学物理化学博士指导教授:中国科学院院士孙家钟教授
工作经历：
2005年7月-2006年9月美国Emory大学博士后合作教授:美国国家艺术与科学院院士JoelM.Bowman教授2006年10月-至今中科院北京基因组研究所副研究员硕士生导师
学术兼职：
FrontiersPlantScience，编委
获奖及荣誉：
2010年入选中国科学院青年创新促进会
1）对基因组学、转录组学和表观遗传组学数据进行深度挖掘，进行以精准医疗为目的的个人基因组研究；2）延续现有原核生物泛基因组学研究成果，进行广泛的比较基因组学研究；3）发展和改进高通量测序数据深度挖掘分析方法，进行算法，并构建相应的数据库。
近期主要学术成果：
1.RuosiZhang,LiliHao,LingpingWang,MeiliChen,WenLi,MiguelEsteban,JunYu,JingfaXiao,JiayanWu,Geneexpressionanalysisofinducedpluripotentstemcellsfromaneuploidchromosomalsyndromes.BMCGenomics,accepted,(2013).2.ZaichaoZhang*,JiayanWu*,YongbingZhao,JingfaXiao,AsystematicstudyonGPCRprototypes:didtheyreallyevolvefromprokaryoticgenomes?IETSystemBiology,accepted,(2013).3.JiayanWu,JingfaXiao,LingpingWang,JunZhong,HongyanYin,ShuangxiuWang,ZhangZhang,JunYu,Systematicanalysisofintronsizeandabundanceparametersindiverselineages.ScienceinChinaLifeScience,accepted(2013).4.MeiliChen,JingfaXiao,JingxingLiu,ZhangZhang,JiayanWu*,JunYu*,IdentificationofHumanHKGenesandGeneExpressionRegulationStudyinCancerfromTranscriptomics.PLoSONE,8,e54082(2013).5.JiayanWu,JingfaXiao,JunYu.Latestnotableachievementsingenomics.ScienceinChina,55,645-648(2012).6.YanGe*,JiayanWu*,MingYang,YingjieXia,JingfaXiao,JunYu,MolecularDynamicsSimulationoftheComplexPBP-2xwithDrugCefuroximetoExploretheDrugResistanceMechanismofStreptococcussuisR61.PLoSONE,6,e35941(2012).7.DongyuZhao*,JiayanWu*,WeiGong,YuanyuanZhou,JingJin,JingfaXiao,JunYu,WikiCell:aunifiedresourceplatformforhumantranscriptomicsresearch.OMICS:AJournalofIntegrativeBiology,16(6)357-362(2012).8.YongbingZhao*,JiayanWu*,JunhuiYang,ShixiangSun,JingfaXiao,JunYu,PGAP:Pan-GenomesAnalysisPipeline.Bioinformatics,28,416-418(2012).9.YanGe*,JiayanWu,*JingfaXiao,JunYu,Explorationofthebindingmodeofα/β-typesmallacidsolubleproteins(SASPs)withDNA.JournalofMolecularModeling,Vol.17,3183-3193(2011).10.JiayanWu?,JingfaXiao?,RuosiZhang,JunYu.DNAsequencingleadstogenomicsprogressinChina.ScienceinChina,54,290-292(2011).11.JingdeBu?,JiayanWu?,MeiliChen,JingfaXiao,JunYu,XuebinChi,ZhongJin.BAsplice:Bi-directionAlignmentfordetectingsplicejunctions.2012IEEE6thInternationalConferenceonSystemsBiology(ISB),Xian,China,August18-20,pp.253-256(2012).12.ZunmingLiu,JingfaXiao,JiayanWu*,JunYu*,RNADAP-RNA-SeqDataAnnotationPipeline.IEEEISB2011,Zhuhai,China,84-86(2011).13.ZaichaoZhang?,JiayanWu?,JunYu,JingfaXiao.AbriefreviewontheevolutionofGPCR:conservationanddiversification.OpenJournalofGenetics,2,11-17(2012).14.EwanBirney,ThomasJHudson,EricDGreen,…,JiayanWu,JunYu,Prepublicationdatasharing.Nature,461(7261),168-170(2009)
课题主要研究生物信息学算法、软件和数据库的开发
工作经历：
2005年7月-2006年9月美国Emory大学博士后合作教授:美国国家艺术与科学院院士JoelM.Bowman教授2006年10月-至今中科院北京基因组研究所副研究员硕士生导师
主要研究领域：
1）对基因组学、转录组学和表观遗传组学数据进行深度挖掘，进行以精准医疗为目的的个人基因组研究；2）延续现有原核生物泛基因组学研究成果，进行广泛的比较基因组学研究；3）发展和改进高通量测序数据深度挖掘分析方法，进行算法，并构建相应的数据库。
承担科研项目情况：
代表论著：
1.RuosiZhang,LiliHao,LingpingWang,MeiliChen,WenLi,MiguelEsteban,JunYu,JingfaXiao,JiayanWu,Geneexpressionanalysisofinducedpluripotentstemcellsfromaneuploidchromosomalsyndromes.BMCGenomics,accepted,(2013).2.ZaichaoZhang*,JiayanWu*,YongbingZhao,JingfaXiao,AsystematicstudyonGPCRprototypes:didtheyreallyevolvefromprokaryoticgenomes?IETSystemBiology,accepted,(2013).3.JiayanWu,JingfaXiao,LingpingWang,JunZhong,HongyanYin,ShuangxiuWang,ZhangZhang,JunYu,Systematicanalysisofintronsizeandabundanceparametersindiverselineages.ScienceinChinaLifeScience,accepted(2013).4.MeiliChen,JingfaXiao,JingxingLiu,ZhangZhang,JiayanWu*,JunYu*,IdentificationofHumanHKGenesandGeneExpressionRegulationStudyinCancerfromTranscriptomics.PLoSONE,8,e54082(2013).5.JiayanWu,JingfaXiao,JunYu.Latestnotableachievementsingenomics.ScienceinChina,55,645-648(2012).6.YanGe*,JiayanWu*,MingYang,YingjieXia,JingfaXiao,JunYu,MolecularDynamicsSimulationoftheComplexPBP-2xwithDrugCefuroximetoExploretheDrugResistanceMechanismofStreptococcussuisR61.PLoSONE,6,e35941(2012).7.DongyuZhao*,JiayanWu*,WeiGong,YuanyuanZhou,JingJin,JingfaXiao,JunYu,WikiCell:aunifiedresourceplatformforhumantranscriptomicsresearch.OMICS:AJournalofIntegrativeBiology,16(6)357-362(2012).8.YongbingZhao*,JiayanWu*,JunhuiYang,ShixiangSun,JingfaXiao,JunYu,PGAP:Pan-GenomesAnalysisPipeline.Bioinformatics,28,416-418(2012).9.YanGe*,JiayanWu,*JingfaXiao,JunYu,Explorationofthebindingmodeofα/β-typesmallacidsolubleproteins(SASPs)withDNA.JournalofMolecularModeling,Vol.17,3183-3193(2011).10.JiayanWu?,JingfaXiao?,RuosiZhang,JunYu.DNAsequencingleadstogenomicsprogressinChina.ScienceinChina,54,290-292(2011).11.JingdeBu?,JiayanWu?,MeiliChen,JingfaXiao,JunYu,XuebinChi,ZhongJin.BAsplice:Bi-directionAlignmentfordetectingsplicejunctions.2012IEEE6thInternationalConferenceonSystemsBiology(ISB),Xian,China,August18-20,pp.253-256(2012).12.ZunmingLiu,JingfaXiao,JiayanWu*,JunYu*,RNADAP-RNA-SeqDataAnnotationPipeline.IEEEISB2011,Zhuhai,China,84-86(2011).13.ZaichaoZhang?,JiayanWu?,JunYu,JingfaXiao.AbriefreviewontheevolutionofGPCR:conservationanddiversification.OpenJournalofGenetics,2,11-17(2012).14.EwanBirney,ThomasJHudson,EricDGreen,…,JiayanWu,JunYu,Prepublicationdatasharing.Nature,461(7261),168-170(2009)
社会任职：
FrontiersPlantScience，编委
获奖及荣誉：
2010年入选中国科学院青年创新促进会
