西安交通大学生命科学与技术学院导师教师师资介绍简介-刘必武

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The Liu Lab - 刘必武Open Positions
We are hiring!
(Email: biwuliu@xjtu.edu.cn)

Graduate Students
Students with background in Chemistry, Chemical Engineering, Biology, Biomedical Engineering, Material Science, Bionanotechnology and other related majors are welcome to apply for graduate students in our lab. We are able to acceptONE PhD studentandTWO Master studentevery year.

Postdocs
We are looking for young talented researchers to join us as postdoc fellows. If you are interested in bionanotechnology, bioanalysis, functional nucleic acids, or nanozymes, do not hesitate to contact us.
More information about the salaries and future career development.
The Institute:gr.xjtu.edu.cn/web/yxzhao/11
The University:news.xjtu.edu.cn/info/1002/125845.htm

Undergraduate Students
Talented young students are always welcome to join our lab. We can always find interesting short-term projects for you to explore.

Research Assistants
If you are going to graduate as a Master student from chemistry, biology, biomedical engineering in near future and are still looking for a job for transition. Come to our lab and work as a research assistant with satisfactory payment. You can contact us and find more details here.gr.xjtu.edu.cn/web/yxzhao/11

The PI
Biwu Liu (刘必武) Ph.D.
Professor
Xi’an Jiaotong University
Biwu obtained his Ph.D. at the University of Waterloo in 2016 under the supervision of Prof. Juewen Liu. During that time, he studiedthe adsorption of DNA oligonucleotides on a range of metal oxide nanoparticles and developed fluorescent sensors for inorganic anions, heavy metals, reactive oxygen species, and nucleic acids. Biwu continued his research in the Liu lab as a postdoc for another four years. He then joined the Institute of Analytical Chemistry and Instrument for Life Science at Xi’an Jiaotong University. His current research focused on developing highly selective bio-nano conjugates to probe the biological processes. The lab is currently funded by “Young Talent Support Plan” of Xi’an Jiaotong University.

Research Interests
· Functional nucleic acids-modified nanomaterial as sensing platforms for environmental and biological applications;
· Bio-inspired nanomaterial for sensing, imaging, and coating applications;
· Bioassays based on nanozymes;
· Organic-inorganic hybrid materials as platforms for the immobilization of enzymes and enzyme-mimics for biomedical applications.

Selected Papers
1. Biwu Liu, Yu Zhao, Yu Jia and Juewen Liu*, J. Am. Chem. Soc. 2020, 142, 14702-14709.
2. Biwu Liu, Peng Wu, Zhicheng Huang, Lingzi Ma and Juewen Liu*, J. Am. Chem. Soc. 2018, 140, 4499-4502.
3. Biwu Liu and Juewen Liu*, J. Am. Chem. Soc. 2017, 139, 9471-9474.
4. Biwu Liu, Ziyi Sun, Po-Jung Jimmy Huang and Juewen Liu*, J. Am. Chem. Soc. 2015, 137, 1290-1295.
5. Biwu Liu, Tianyi Wu, Zhicheng Huang, Yibo Liu, and Juewen Liu*, Angew. Chem. Int. Ed. 2019, 58, 2109-2113.
6. Biwu Liu, Zhicheng Huang and Juewen Liu*, Angew. Chem. Int. Ed. 2018, 57, 9439-9442.
7. Biwu Liu and Juewen Liu*, Matter 2019, 1, 825-847.

Contact

Email: biwuliu@xjtu.edu.cn
地址：陕西省西安市中国西部科技创新港18号巨构4036

GROUP - 刘必武Open Positions
We are hiring!
(Email: biwuliu@xjtu.edu.cn)

Graduate Students
Students with background in Chemistry, Chemical Engineering, Biology, Biomedical Engineering, Material Science, Bionanotechnology and other related majors are welcome to apply for graduate students in our lab. We are able to acceptONE PhD studentandTWO Master studentevery year.

Postdocs
We are looking for young talented researchers to join us as postdoc fellows. If you are interested in bionanotechnology, bioanalysis, functional nucleic acids, or nanozymes, do not hesitate to contact us.
More information about the salaries and future career development.
The Institute:gr.xjtu.edu.cn/web/yxzhao/11
The University:news.xjtu.edu.cn/info/1002/125845.htm

Undergraduate Students
Talented young students are always welcome to join our lab. We can always find interesting short-term projects for you to explore.

Research Assistants
If you are going to graduate as a Master student from chemistry, biology, biomedical engineering in near future and are still looking for a job for transition. Come to our lab and work as a research assistant with satisfactory payment. You can contact us and find more details here.gr.xjtu.edu.cn/web/yxzhao/11

PUBLICATIONS - 刘必武@Waterloo
2020
68. Mehal P. Kushalkar, Biwu Liu, and Juewen Liu*, Promoting DNA Adsorption by Acids and Polyvalent Cations: Beyond Charge Screening, Langmuir, 36, 11183–11195 Invited Feature paper, in press, 2020.
67. Xiaoqi Tao*, Xin Wang, Biwu Liu and Juewen Liu*, Conjugation of antibodies and aptamers on nanozymes for developing biosensors", Biosensors & Bioelectronics, in press, 2020.
66. Biwu Liu, Yu Zhao, Yu Jia and Juewen Liu*, Heating Drives DNA to Hydrophobic Regions While Freezing to Hydrophilic Regions of Graphene Oxide for Highly Robust Biosensors", Journal of the American Chemical Society, 142, 14702–14709, 2020.

65. Junlin Duan, Biwu Liu and Juewen Liu*, Interactions between gold, thiol and As(III) for colorimetric sensing", Analyst, 145, 5166-5173, 2020.
64. Zhicheng Huang, Biwu Liu and Juewen Liu*, A high local DNA concentration for nucleating a DNA/Fe coordination shell on gold nanoparticles, Chemical Communications, 56, 4208-4211, 2020.
63. Yuqing Li, Biwu Liu, Zhicheng Huang and Juewen Liu*, Engineering base-excised aptamers for highly specific recognition of adenosine, Chemical Science, 11, 2735-2743, 2020.
62. Fang Zhang, Biwu Liu, Anand Lopez, Shaoyun Wang and Juewen Liu*, Opposite salt-dependent stability of i-motif and duplex reflected in a single DNA hairpin nanomachine, Nanotechnology, 31, 195503, 2020.
61. Tieli Zhou, Jinyi Zhang, Biwu Liu, Shihong Wu, Peng Wu and Juewen Liu*, Nucleoside-based fluorescent carbon dots for discrimination of metal ions, Journal of Materials Chemistry B, 8, 3640-3646, 2020.
60. Yanyang Chang, Biwu Liu, Zhicheng Huang, Yibo Liu, Meng Liu and Juewen Liu*, Yttrium Oxide as a Strongly Adsorbing but Non-quenching Surface for DNA Oligonucleotides, Langmuir, 36, 1034-1042, 2020.
59. Yuqing Li, Zijie Zhang, Biwu Liu and Juewen Liu*, Incorporation of Boronic Acid into Aptamer-based Molecularly Imprinted Hydrogels for Highly Specific Recognition of Adenosine, ACS Applied Bio Materials, in press, 2020.
2019

58. Biwu Liu and Juewen Liu*, Sensors and biosensors based on metal oxide nanomaterials, Trends in Analytical Chemistry, 121, 115690, 2019.

57. Yuqing Li, Zijie Zhang, Biwu Liu and Juewen Liu*, Adsorption of DNA Oligonucleotides by Boronic Acid Functionalized Hydrogel Nanoparticles, Langmuir, 35, 13727-13734 2019.
56. Anand Lopez, Biwu Liu, Zhicheng Huang, Fang Zhang and Juewen Liu*, Fluorescein-Stabilized i-motif DNA and Its Unfolding Leading to Stronger Adsorption Affinity", Langmuir, 35, 11932-11939, 2019.
55. Biwu Liu, and Juewen Liu*, Interface Driven Hybrid Materials based on DNA-Functionalized Gold Nanoparticles, Matter, 825-847, 2019.

54. Zhicheng Huang, Biwu Liu and Juewen Liu*, Mn²⁺-assisted DNA Oligonucleotide Adsorption on Ti₂C MXene Nanosheets, Langmuir, 35, 9858-9866, 2019.
53. Lingzi Ma, Sanjana Kartik, Biwu Liu and Juewen Liu*, From General Base to General Acid Catalysis in a Sodium-Specific DNAzyme by a Guanine-to-Adenine Mutation, Nucleic Acids Research, 47, 8154–8162, 2019.
52. Dai Li, Sarah L. Garisto, Po-Jung Jimmy Huang, Jeffy Yang, Biwu Liu and Juewen Liu*, Fluorescent Detection of Fluoride by CeO₂ Nanozyme Oxidation of Amplex Red, Inorganic Chemistry Communications, 106, 38-42, 2019.
51. Biwu Liu, and Juewen Liu*, Freezing Driven DNA Adsorption on Gold Nanoparticles: Tolerating Extremely Low Salt Concentration but Requiring High DNA Concentration, Langmuir, 35, 6476-6482, 2019.

50. Chenghua Zong, Zijie Zhang, Biwu Liu and Juewen Liu*, Adsorption of Arsenite on Gold Nanoparticles Studied with DNA Oligonucleotide Probes, Langmuir, 35, 7304-7311, 2019.
49. Biwu Liu, Tianyi Wu, Zhicheng Huang, Yibo Liu, and Juewen Liu*, Freezing-directed Stretching and Alignment of DNA Oligonucleotides, Angewandte Chemie International Edition, 58, 2109-2113, 2019.

48. Shengqiang Hu, Tiantian Yi, Zhicheng Huang, Biwu Liu, Jianxiu Wang*, Xinyao Yi*, and Juewen Liu*, Etching Silver Nanoparticles by DNA, Materials Horizons, 6, 155-159, 2019.
2018

47. Xiuzhong Wang, Biwu Liu and Juewen Liu*, DNA-functionalized Nanoceria for Probing Oxidation of Phosphorus Compounds, Langmuir, 34, 15871-15877, 2018.
46. Dai Li, Biwu Liu, Po-Jung Jimmy Huang, Zijie Zhang and Juewen Liu*, Highly Active Fluorogenic Oxidase-Mimicking NiO Nanozymes, Chemical Communications, 54， 12519-12522, 2018.
45. Lei Chen, Biwu Liu, Zhang-Run Xu and Juewen Liu*, NiO Nanoparticles for Exceptionally Stable DNA Adsorption and its Extraction from Biological Fluids, Langmuir, 34, 9314-9321, 2018.

44. Biwu Liu, Zhicheng Huang and Juewen Liu*, Polyvalent Spherical Nucleic Acids for Universal Display of Functional DNA with Ultrahigh Stability, Angewandte Chemie International Edition, 57, 9439-9442, 2018.

43. Li Xu*, Zijie Zhang, Xiaoqiang Fang, Yibo Liu, Biwu Liu and Juewen Liu*, Robust Hydrogels from Lanthanide Nucleotide Coordination with Evolving Nanostructures for Highly Stable Protein Encapsulation, ACS Applied Materials & Interfaces, 10, 14321-14330, 2018.
42. Biwu Liu, Peng Wu, Zhicheng Huang, Lingzi Ma and Juewen Liu*, Bromide as a Robust Backfiller on Gold for Precise Control of DNA Conformation and High Stability of Spherical Nucleic Acids, Journal of the American Chemical Society, 140, 13, 4499-4502, 2018.

41. Liu Wang, Zijie Zhang, Biwu Liu, Yibo Liu, Anand Lopez, Jian Wu* and Juewen Liu*, Interfacing DNA Oligonucleotides with calcium phosphate and other metal phosphates, Langmuir, 34, 14975-14982, 2018.
40. Biwu Liu, Lingzi Ma, Zhicheng Huang, Hao Hu, Peng Wu and Juewen Liu*, Janus DNA Orthogonal Adsorption of Graphene Oxide and Metal Oxide Nanoparticles Enabling Stable Sensing in Serum, Materials Horizons, 5, 65-69, 2018.

2017
39. Yibo Zhou#, Biwu Liu#, Ronghua Yang and Juewen Liu*, Filling in the Gaps between Nanozymes and Enzymes: Challenges and Opportunities, Bioconjugate Chemistry, 28, 2903-2909, 2017.
38. Biwu Liu and Juewen Liu*, Freezing Directed Construction of Bio/nano Interfaces: Reagentless Conjugation, Denser Spherical Nucleic Acids, and Better Nano-flares, Journal of the American Chemical Society, 139, 9471-9474, 2017.

37. Biwu Liu and Juewen Liu*, Methods for Preparing DNA-functionalized Gold Nanoparticles, a Key Reagent of Bioanalytical Chemistry, Analytical Methods, 9, 2633-2643, 2017.

36. Chang Lu, Zhicheng Huang (co-first author), Biwu Liu, Yibo Liu, Yibin Ying and Juewen Liu*, Poly-C DNA as a High Affinity Ligand for Inorganic Nanomaterials, Angewandte Chemie International Edition, 56, 6208-6212, 2017.
35. Zijie Zhang, Xiaohan Zhang, Biwu Liu and Juewen Liu*, Molecular Imprinting on Inorganic Nanozymes for Hundred-fold Enzyme Specificity, Journal of the American Chemical Society, 139, 5412-5419, 2017.
34. Samaneh Shadmehr, Michael Coleman, Biwu Liu, Juewen Liu and Xiaowu (Shirley) Tang*, Reversible Gating of Ion Transport Through DNA-functionalized Carbon Nanotube Membranes, RSC Advances, 7, 611-616, 2017.
33. Tianmeng Yu, Biwu Liu and Juewen Liu*, Adsorption of Selenite and Selenate by Metal Oxides Studied with Fluorescent DNA Probes for Analytical Application", Journal of Analysis and Testing, 1, 2, 2017.
32. Hao Liang*, Feifei Lin, Zijie Zhang, Biwu Liu, Shuhui Jiang, Qipeng Yuan and Juewen Liu*, Multicopper Laccase Mimicking Nanozymes with Nucleotides as Ligands, ACS Applied Materials & Interfaces, 9, 1352-1360, 2017.
31. Biwu Liu and Juewen Liu*, Surface Modification of Nanozymes, Nano Research, 10, 1-24., 2017.

30. Zijie Zhang, Biwu Liu and Juewen Liu*, Molecular Imprinting for Substrate Selectivity and Enhanced Activity of Enzyme Mimics, Small, 13, **, 2017.
2016

29. Zhicheng Huang, Biwu Liu and Juewen Liu*, Parallel Poly-adenine Duplex Formation at Low pH Facilitates DNA Conjugation onto Gold Nanoparticles, Langmuir, 32, 11986–11992, 2016.
28. Chang Lu, Po-Jung Jimmy Huang, Biwu Liu, Yibin Ying,* and Juewen Liu*, Comparing Graphene Oxide and Reduced Graphene Oxide for DNA Adsorption and Sensing, Langmuir, 32, 10776–10783, 2016.
27. Biwu Liu,^# Shehan Salgado,^# Vivek Maheshwari* and Juewen Liu*, DNA Adsorbed on Graphene and Graphene Oxide: Fundamental Interactions, Desorption and Applications, Current Opinion in Colloid and Interface Science, 26, 41-49, 2016. (# co-first author).

26. Feng Wang, Xiaohan Zhang, Yibo Liu, Zhi Yuan (William) Lin, Biwu Liu, and Juewen Liu*, Profiling Metal Oxides with Lipids: Magnetic Liposomal Nanoparticles Displaying DNA and Proteins, Angewandte Chemie International Edition, 55, 12063–12067, 2016.
25. Biwu Liu, Zhicheng Huang, Juewen Liu*, Boosting the Oxidase Mimicking Activity of Nanoceria by Fluoride Capping: Rivaling Protein Enzymes and Ultrasensitive F^- Detection. Nanoscale, 8, 13562-13567, 2016.

24. Biwu Liu, Xiao Han, Juewen Liu*, Iron Oxide Nanozyme Catalyzed Synthesis of Fluorescent Polydopamine for Llight-up Zn²⁺ Detection. Nanoscale, 8, 13620-13626, 2016.

23. Hao Liang*, Biwu Liu, Qipeng Yuan and Juewen Liu*, Magnetic Iron Oxide Nanoparticle Seeded Growth of Nucleotide Coordinated Polymers", ACS Applied Materials & Interfaces, 8, 15615–15622, 2016.
22. Lingzi Ma, Biwu Liu, Po-Jung Jimmy Huang, Xu Zhang and Juewen Liu*, DNA Adsorption by ZnO Nanoparticles near Its Solubility Limit: Implications for DNA Fluorescence Quenching and DNAzyme Activity Assays, Langmuir, 32, 5672–5680, 2016.
21. Biwu Liu, Po-Jung Jimmy Huang, Erin Y. Kelly and Juewen Liu*, Graphene Oxide Surface Blocking Agents Can Increase the DNA Biosensor Densitivity, Biotechnology Journal, 11, 780-787, 2016.

2015
20. Biwu Liu and Juewen Liu*, Comprehensive Screen of Metal Oxide Nanoparticles for DNA Adsorption, Fluorescence Quenching, and Anion Discrimination. ACS Applied Materials & Interfaces, 7, 24833-24838, 2015.

19. Biwu Liu and Juewen Liu*, Accelerating Peroxidase Mimicking Nanozymes Using DNA. Nanoscale, 33, 13831-13835, 2015.

18. Biwu Liu, Ziyi Sun, Po-Jung Jimmy Huang and Juewen Liu*, Hydrogen Peroxide Displacing DNA from Nanoceria: Mechanism and Detection of Glucose in Serum. Journal of the American Chemical Society, 137, 1290-1295, 2015.

17. Biwu Liu and Juewen Liu*, DNA Adsorption by Indium Tin Oxide (ITO) Nanoparticles, Langmuir, 31, 371-377, 2015.

2014

16. Zhenbao Liu, Shanshan Chen, Biwu Liu, Jianping Wu, Yanbin Zhou, Lingyun He, Jinsong Ding* and Juewen Liu*, Intracellular Detection of ATP Using an Aptamer Beacon Covalently Linked to Graphene Oxide Resisting Non-specific Probe Displacement. Analytical Chemistry, 86, 12229-12235, 2014.
15.Biwu Liu, Erin Y. Kelly, and Juewen Liu*, Cation Size Dependent DNA Adsorption Kinetics and Packing Density on Gold Nanoparticles: An Opposite Trend.Langmuir, 30, 13228-13234,2014

14.Biwu Liuand Juewen Liu*, DNA Adsorption by Magnetic Iron Oxide Nanoparticles and Its Application for Arsenate Detection.Chemical Communications, 50, 8568-8570,2014.

13. Zhenbao Liu, Biwu Liu, Jinsong Ding and Juewen Liu*, Fluorescent Sensors Using DNA-Functionalized Graphene Oxide. Analytical and Bioanalytical Chemistry, 406， 6885-6902 2014.
12. Nathan Lang, Biwu Liu and Juewen Liu*, Gold Nanoparticle Surface for Glucose Oxidation Studied Using Nanoceria. Journal of Colloid and Interface Science, 428, 78-83, 2014.
11. Xu Zhang, Feng Wang, Biwu Liu, Erin Y. Kelly, Mark R. Servos and Juewen Liu*, Adsorption of DNA Oligonucleotides by Titanium Dioxide Nanoparticles. Langmuir, 30, 839-845, 2014.
10. Feng Wang, Biwu Liu, Po-Jung Jimmy Huang and Juewen Liu*, Rationally Designed Nucleobase and Nucleotide Coordinated Nanoparticles for Selective DNA Adsorption and Detection. Analytical Chemistry, 85, 12144-12151, 2013.
Before 2013

9. Biwu Liu, Po-Jung Jimmy Huang, Xu Zhang, Feng Wang, Rachel Pautler, Alexander Ip and Juewen Liu*, Parts-per-Million of Polyethylene Glycol as a Non-Interfering Blocking Agent for Homogeneous Biosensor Development. Analytical Chemistry, 85, 10045-10050, 2013.

8. Biwu Liu,^# Ziyi Sun,^# Xu Zhang, and Juewen Liu*, Mechanisms of DNA Sensing on Graphene Oxide. Analytical Chemistry, 85, 7987-7993, 2013. (# co-first author)

7. Rachel Pautler, Erin Y. Kelly, Po-Jung Jimmy Huang, Jing Cao, Biwu Liu, and Juewen Liu*, Attaching DNA to Nanoceria: Regulating Oxidase Activity and Fluorescence Quenching. ACS Applied Materials & Interfaces, 5, 6820-6825, 2013.
6. Xu Zhang, Biwu Liu, Mark R. Servos and Juewen Liu*, Polarity Control for Non-thiolated DNA Adsorption onto Gold Nanoparticles. Langmuir, 29, 6091-6098, 2013.
5. Feng Wang, Biwu Liu, Alexander C-F. Ip, and Juewen Liu*, Orthogonal Adsorption onto Nano-Graphene Oxide Using Different Intermolecular Forces for Multiplexed Delivery. Advanced Materials, 25, 4087-4092, 2013.
4. Nathan Lang, Biwu Liu, Xu Zhang and Juewen Liu, Dissecting Colloidal Stabilization Factors in Crowded Polymer Solutions by Forming Self-Assembled Monolayers on Gold Nanoparticles. Langmuir, 29, 6018-6024, 2013.
3. Kiyoshi Morishita, James L. MacLean, Biwu Liu, Hui Jiang, and Juewen Liu*, Correlation of Photobleaching, Oxidation and Metal Induced Fluorescence Quenching of DNA-templated Silver Nanoclusters. Nanoscale, 5, 2840-2849, 2013.
2. Alexander C-F. Ip, Biwu Liu, Po-Jung Jimmy Huang and Juewen Liu*, Oxidation Level Dependent Zwitterionic Liposome Adsorption and Rupture by Graphene-based Materials and Light Induced Content Release. Small, 9, 1030-1035, 2013.
1. Xu Zhang, Biwu Liu, Neeshma Dave, Mark R. Servos, and Juewen Liu*, Instantaneous Attachment of an Ultrahigh Density of Non-thiolated DNA to Gold Nanoparticles and Its Applications. Langmuir, 28, 17053-17060, 2012.

NEWS - 刘必武NEWS
We are hiring!
2020-10-23

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中文简介 - 刘必武个人简介
刘必武，生命学院生命分析化学与仪器研究所教授，博士生导师，2020年入选西安交通大学“青年拔尖人才支持计划”A类。博士毕业于加拿大滑铁卢大学，师从Juewen Liu（刘珏文）教授，毕业后继续在课题组从事博士后研究。专注于功能核酸修饰的纳米材料在生命分析和生物医学中的基础和应用研究。迄今以第一或共同第一作者在J. Am. Chem. Soc.（4篇），Angew. Chem. Int. Ed.（2篇），Anal. Chem.（2篇），Mater. Horiz.（1篇），Matter (1篇)等国际学术期刊上发表24篇学术论文，总被引用3000余次，H-index 34, 2篇入选ESI高被引论文，获国家优秀自费留学生奖学金（2015）等奖励。本课题组（生命分析与生物界面实验室）将着力发展基于纳米生物材料与功能核酸的新型传感平台，用于复杂生物环境下靶标的快速，高灵敏，高稳定识别，为癌症的早期诊断以及重大传染性疾病的快速检测提供新方法。