西安交通大学生命科学与技术学院导师教师师资介绍简介-冯怡

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Welcome - 冯怡Basic Information

Yi Feng, Ph.D
Associate Professor
Deputy Dean
Department of Biomedical Engineering
Institute of Biomedical Imaging and Applications
School of Life Science and Technology
Xi'an Jiaotong University
冯怡 博士，副教授，博士生导师
副系主任
生物医学工程系
生物医学影像与应用研究所
西安交通大学

Contact Information
Address: No. 28 Xianning West Road, Xi'an, 710049, P. R. China
Office:Room North107s
TEL: +86--805
Email: fengyi@mail.xjtu.edu.cn
联系地址：西安市咸宁西路28号教学二楼107s/中国西部科技创新港18号楼3063
电话：+86--805
Email: fengyi@mail.xjtu.edu.cn

Visitors

News
课题组获批国家自然科学基金国际（地区）组织间合作项目资助
2020-12-15

祝贺课题组倪鹏英硕士获得硕士学位
2020-07-05

课题组合作研究成果在PNAS发表
2020-06-01

欢迎新博士生南哲洙同学
2020-05-20

课题组冯怡老师获得CSC资助赴斯坦福大学访学
2019-01-01

祝贺秦对博士顺利通过博士答辩
2018-08-30

更多新闻>>

Research Interests
Molecular Bio-effects of Biomedical Ultrasound
超声分子生物学效应
Multi-mode Cavitation and Cavitation Mechanobiology
多模空化与空化力生物学
Drug Delivery
药物运输与释放

招生信息
经师易遇，人师难遇。以身作则，忠恕任事！
冯怡老师的课题组欢迎对生物医学超声及其精准诊疗领域有兴趣的广大有志青年报考。
本团队常年面向全国高等院校招收生物医学工程、生物工程、生物化学与分子生物学、生物物理学专业的研究生及博士后，也欢迎物理、化学、材料等相关领域的博士和博士后咨询报考。

Projects - 冯怡Projects
National Natural Science Foundation of China 2020-2023
国家自然科学基金国际(地区)合作与交流项目负责人
Title: “Enhanced cancer immunotherapy by combining microbubble-mediated low frequency ultrasound and hyperthermia: mechanical and thermal mechanisms”
Role: PI
Total Award Amount: ￥2,000,000
Tasks: To develop a useful protocol of potential immunotherapy with high intensity focused ultrasound and increased cavitation with targeted microbubble; to evaluate the microbubble vibration mode under low frequency focused ultrasound and its cavitation effects; to evaluate the activation of immunotherapy with HIFU, cavitation and anti-PD-1 and their combined effects with different protocol; to prove the anti-tumor effects of combined immunotherapy in vitro and in vivo..
National Natural Science Foundation of China 2017-2020
国家自然科学基金面上项目负责人
Title: “Photoacoustic Cavitation Targeted Damage on Micro-Vessel: Mechanical Mechanism, In Situ Experiments and In Vivo Monitoring Imaging”
Role: PI
Total Award Amount: ￥630,000
Tasks: To develop a useful protocol of photoacoustic cavitation damage on micro-vessel in localized drug delivery; to evaluate the photoacoustic cavitation nucleation/ bubble dynamics via simulation, high speed microscopic imaging, passive cavitation detection; to build up the image-guided photoacoustic cavitation experimental/ pre-clinic system in an in situ micro-vessel model and the nude mice spine tumor model in vivo.
National Natural Science Foundation of Shaanxi Province 2014-2016
陕西省自然科学基金面上项目负责人
Title: “Multi-mode ultrasound contrast agents assisted ultrasound induced angiogenesis regression and its cavitation mechanobiological study”
Role: PI
Total Award Amount: ￥20,000
Tasks: To produce an effective way inducing angiogenesis regression by ultrasound and multi-mode UCA; to evaluate the influence of cavitation on the above process and its molecular mechanism.
The Fundamental Research Funds for the Central Universities 2014-2016
西安交通大学综合交叉项目负责人
Title: “In situ micro-vessel damage by photoacoustic cavitation and its mechanism”
Role: PI
Total Award Amount: ￥120,000
Tasks: To design and realize the targeted micro-vessel damage by photoacoustic cavitation in an in situ microscopic system; to evaluate the transient process and analyze the characteristics of acoustic signals from the photoacoustic cavitation.
National Natural Science Foundation of China 2013-2015
国家自然科学基金青年项目负责人
Title: “Antiangiogenic therapy based on targeted microbubble assistant low intensity focused ultrasound: transient cavitation and its molecular mechanism”
Role: PI
Total Award Amount: ￥230,000
Tasks: To develop a novel antiangiogenic therapeutic protocol with LIFU and targeted microbubbles; to design and construct A single cell-single bubble-LIFU-acoustic and light confocal/ high speed/ fluorescent microscopic system and illustrate the mechanism of above process; to test and verify the tumor growth inhibition in vivo.
Research Fund for the Doctoral Program of Higher Education of China 2012-2014
教育部博士点基金项目负责人
Title: “Inhibition of tumor growth via low intensity focused ultrasound and targeted microbubbles on angiogenesis”
Role: PI
Total Award Amount: ￥40,000
Tasks: To test the inhibition of tumor growth with low intensity focused ultrasound and microbubbles targeted to angiogenesis; to analyze the gene and protein profile contributing to the effects; to provide an effective protocol of assistant cancer therapy via above mechanism.
The Fundamental Research Funds for the Central Universities 2012-2014
西安交通大学综合交叉项目负责人
Title: “The evaluation, effects and molecular mechanism of artery hemodynamics on vascular remodeling”
Role: PI
Total Award Amount: ￥80,000
Tasks: To produce a method of echo-PIV to evaluate the artery hemodynamics; to examine its effects on vascular remodeling; to analyze its potential molecular mechanism via the gene and protein analysis.

Publications - 冯怡Publications
Book & Book Chapters
6. Wan MX, Feng Y. Computational Biomedical Ultrasound, Science Press 2019 (in Chinese)
5. Wan MX, Feng Y, and G ter Haar (Eds.). Cavitation in Biomedicine: Principles and Techniques. Springer, 2015 (ISBN: 978-94-017-7254-9)
4. Feng Y, Zhao L, G ter Haar, et al. (2015). Cavitation Mechanobiology and Applications. In: Wan MX, Feng Y, and G ter Haar (Eds.). Cavitation in Biomedicine: Principles and Techniques. Springer.
3. Feng Y, Qin D, Wan MX. (2015). Laser-Induced Cavitation and Photoacoustic Cavitation. In: Wan MX, Feng Y, and G ter Haar (Eds.). Cavitation in Biomedicine: Principles and Techniques. Springer.
2. Feng Y, Wan MX. (2010). Bioeffects of ultrasound. In Wan MX, Zong YJ and Wang SP (Eds.). Biomedical Ultrasonics. Science Press (in Chinese).
1. Feng Y, Wan MX. (2010). Examination and analysis of ultrasound induced molecular effects. In Wan MX, Zong YJ and Wang SP (Eds.). Biomedical Ultrasound Experiments. Xi’an Jiaotong University Press (in Chinese).

Peer-reviewed Journal Papers
17.Tali Ilovitsh, Yi Feng, Josquin Foiret, Azadeh Kheirolomoom, Hua Zhang, Elizabeth S. Ingham, Asaf Ilovitsh, Spencer K. Tumbale, Brett Z. Fite, Bo Wu, Marina N. Raie, Nisi Zhang, Aris J. Kare, Michael Chavez, Lei S. Qi, Gadi Pelled, Dan Gazit, Ophir Vermesh, Idan Steinberg, Sanjiv S. Gambhir, and Katherine W. Ferrara. Low frequency ultrasound-mediated cytokine transfection enhances T cell recruitment at local and distant tumor sites. PNAS. 2020, 117 (23) 12674-12685.
16. Feng Y, Qin D, Zhang J, Zhang L, Ayache Bouakaz, and Wan MX. Occlusion and rupture of ex vivo capillary bifurcation due to acoustic droplet vaporization. Applied Physics Letters, 2018, 112, 233701. (SCI)
15. Qin D, Zhang L, Chang N, Ni PY, Zong YJ, Ayache Bouakaz, Wan MX, Feng Y*. In situ obser-vation of single cell response to acoustic droplet vaporization: membrane deformation, permeabilization, and blebbing, Ultrasonics Sonochemistry 2018, 47, 141-150. (SCI)
14. Zhu HR, Qin D, Wu YS, Jing BW, Liu JJ, Hazlewood D, Zhang HM, Feng Y, Yang XM, Wan MX*, WU DC*. Laser-Activated Bioprobes with High Photothermal Conversion Efficiency for Sensitive Photoacoustic/Ultrasound Imaging and Photothermal Sensing. ACS Applied Materials & Interfaces, 2018, 10(35): 29251-29259.
13. Feng Y*, Dui Qin, Lei Zhang, Mingxi Wan. Photoacoustic cavitation of nanodroplets: high speed observation and acoustic signal analysis. Journal of Mechanics in medicine and Biology, 2017, 17(7) **. (SCI)
12.Zhao L, Feng Y*, et al. Neuroprotective effect of low-intensity pulsed ultrasound against MPP+-induced neurotoxicity in PC12 cells: involvement of K2P channels and stretch-activated ion channels. Ultrasound in Medicine & Biology, 2017, 43(9): 1986-1999. (SCI)
11. Zhao L, Feng Y*, Hu H, et al. Low-Intensity Pulsed Ultrasound Enhances Nerve Growth Factor-induced Neurite Outgrowth through Mechanotransduction-Mediated Erk1/2–Creb–Trx-1 Signaling. Ultrasound in Medicine & Biology, 2016, 42(12): 2914-2925. (SCI)
10. Zhao L, Feng Y*, Shi AW, et al. Apoptosis Induced by Microbubble-Assisted Acoustic Cavitation in K562 Cells: The Predominant Role of the Cyclosporin A-Dependent Mitochondrial Permeability Transition Pore. Ultrasound in Medicine & Biology, 2015，41(10): 2755-2764. (SCI)
9. Qin D, Feng Y*, Wan MX. Modeling photoacoustic cavitation nucleation and bubble dynamics with modified classical nucleation theory. The Journal of the Acoustical Society of America, 2015, 138: 1282-1289. (SCI)
8. Feng Y, Qin D, Zhang J, et al. Acoustic signal characteristics of laser induced cavitation in DDFP droplet: Spectrum and time-frequency analysis. Bio-Medical Materials and Engineering, 2015, 26(S1): S2083-2089. (SCI)
7. Feng Y, Wan MX. Potential Mechanism of Apoptosis Induced by Ultrasound in Human Hepatocarcinoma Cells via Comparative Proteomic Analysis. Bio-Medical Materials and Engineering, 2015, 26(S1): S423-427. (SCI)
6. Feng Y, Tian ZM, Wan MX. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974. (SCI)
5. Feng Y, Tian ZM, Wan MX, et al. Low intensity ultrasound-induced apoptosis in human gastric carcinoma cells. World J Gastroenterol, 2008, 14(31): 4873-4879. (SCI)
4. Feng Y, Tian ZM, Wan MX, et al. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614. (SCI)
3. Xu SS, Zong YJ, Feng Y, et al. Dependence of pulsed focused ultrasound induced thrombolysis on duty cycle and cavitation bubble size distribution. Ultrasonics Sonochemistry, 2015, 22:160-166. (SCI)
2. Lu MZ, Wang XD, Wan MX, Feng Y, et al. Image-Guided 256-Element Phased Array Focused Ultrasound Surgery: System and Multi-Focus Pattern Control. IEEE Engineering in Medicine and Biology Magazine, 2008, 27(5):84-9. (SCI)
1. Lei DF, Feng Y, Jiang DZ. Characterization of polyphenol oxidase from plants. Progress in Natural Science, 2004, 14(7): 553-561. (SCI)

Conferences Papers
22. Feng Y, Qin D, Zhang L, et al. (2017). Optical and acoustic study on phase transition of nanodroplets: acoustic droplet vaporization versus photoacoustic cavitation. IEEE International Ultrasonics Symposium (IUS 2017), Washington DC, USA.
21. Feng Y, Qin D, Wan MX (2015). Photoacoustic cavitation for theranostics: mechanism, current progress and application. 9th International Symposium Cavitation (CAV2015), Lausanne, Switzerland.
20. Feng Y, Qin D, Zong YJ, et al. (2015) Optical and acoustic observation of photodisruption in two liquid perfluorocarbons induced by nanosecond laser. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.
19. Zhao L, Feng Y*, Wan MX (2015). Effects of low-intensity pulsed ultrasound on nerve growth factor-induced neurite outgrowth and signaling in PC12 cells. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.
18. Feng Y, Zhao L, Wan MX (2014). The alteration of protein profile of HepG2 cells during the apoptotic process induced by low intensity pulsed ultrasound. IEEE International Ultrasonics Symposium (IUS 2014), Chicago, USA.
17. Feng Y, Qin D, Ma CX, et al. (2014). Optic and acoustic detection of laser-induced optical breakdown in DDFP. IEEE International Ultrasonics Symposium (IUS 2014), Chicago, USA.
16. Feng Y, Wan MX (2014). Apoptosis induced by low-intensity ultrasound in vitro: alteration of protein profile and potential molecular mechanism. The 14th International Symposium on Therapeutic Ultrasound (ISTU2014), Las Vegas, USA.
15. Feng Y, Wan MX (2013). Low Intensity Ultrasound Induces Apoptosis via MPT Channel on Mitochondrial membrane: Target for Regulating Cancer Therapy or Not? The 13th International Symposium on Therapeutic Ultrasound (ISTU2013), Shanghai, China.
14. Feng Y, Wan MX. Early Changes Induced by Low Intensity Ultrasound in Human Hepatocarcinoma Cells. IFMBE Proceedings, 2009, 23(1-3): 1870-1873.
13. Feng Y, Wan MX. Bio-Effects of Ultrasound: Inhibitory Effects on Ultrasound Induced Apoptosis by Cyclosporin A and Fructose Supplementation[C]. 3rd International Conference on Bioinformatics and Biomedical Engineering (ICBEB 2009), Shanghai, China.
12. Feng Y, Tian ZM, Wan MX, et al. (2007) Analysis of the Potential Mechanism Related to the Apoptosis Induced by Ultrasound in Human Hepatocarcinoma Cells via Comparative Proteomic Methods. the International Congress on Ultrasonics (ICU2007), Vienna, Austria.
11. Zong YJ, Zou XR, Wang RR, Feng Y, et al. (2015) Ultrasound-enhanced extravasation of dual-modality multifunctional nanodroplets. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.
10. Zong YJ, Wang RR, Zou XR, Zhang L, Feng Y, et al. (2015) Local cavitation induced vessel wall injury of artery and its potential application in animal model of atherosclerosis. IEEE International Ultrasonics Symposium (IUS 2015), Taipei, Taiwan.
9. Gu JH, Wan MX, Wang SP, Feng Y (2007). Chirp-excitation pulse-inversion imaging of deeper microvascular. the International Congress on Ultrasonics (ICU2007), Vienna, Austria..
8. Zhao L, Feng Y*, Shi AW, et al. (2015) Ultrasonic cavitation induced apoptosis: the key role of MPT pore. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2015) Nan Jing, China(In Chinese)
7. Qin D, Ma CX, Zhang J, Feng Y*, et al. (2015) Detection and Analysis of photoacoustic cavitation in phase-shift liquid. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2015) Nan Jing, China. (In Chinese)
6. Feng Y, Wan MX (2013). Proteomic study on low intensity focused ultrasound induced apoptosis in carcinoma cells. Annual Conference of Chinese Biomedical Ultrasound 2013. Chongqing, China. (Oral presentation) (In Chinese)
5. Wang HJ, Feng Y*, Wan MX (2011). Study on Echo-PIV of hemodynamics in carotid artery based on CFD associated ultrasonic simulation. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2011). (In Chinese)
4. Feng Y, Wan MX (2009). Low intensity focused ultrasound induced apoptosis in carcinoma cells and its molecular mechanism. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2009). (In Chinese)
3. Wan MX, Feng Y, Zhang SY, et al. (2009) Transient phenomenon of ultrasonic microbubble cavitation and its molecular effects. Annual Conference of Chinese Biophysics Society. (In Chinese)
2. Feng Y, Gao K, Tian ZM, et al. (2007) The effects of ultrasound on macromolecules and cells. Joint Annual Conference of Chinese Biomedical Engineering (CBME 2007). (In Chinese)
1. Tian ZM, Feng Y, Zheng ZB, et al. (2005) The applications of proteomics in bioeffects of ultrasound. The Ultrasonic Medical EngineeringAcademic Conference 2005. (In Chinese)

Education - 冯怡Education
EDUCATION
March 2010 Ph.D. in Biomedical Engineering, Xi’an Jiaotong University
Dissertation: “Experimental study on the physical and molecular mechanism of ultrasound induced apoptosis in carcinoma cells”
Supervisor: Prof. Mingxi Wan

July 2002 B.E. in Bioengineering, Xi’an Jiaotong University

ACADEMIC TRAINING ABROAD
March-Nov. 2008 Visiting Scholar, Clinical Proteomics Laboratories, Medical University of Vienna, Austria
Supervisor: Prof. Christopher Gerner

Group - 冯怡Research Group
Belongs to: Prof. Mingxi Wan's Lab
学科带头人：万明习教授 (生物医学工程学科领军****)

Yi Feng‘sGroup

Poster - 冯怡Research Poster