丁健， 教授。本科和硕士毕业于南京大学（生物学）。 博士毕业于美国爱荷华州立大学（生物化学、果蝇遗传学）。 之后在美国哈佛医学院/波士顿儿童医院从事心肌及骨骼肌病理生理学研究。入职西安交通大学后研究方向为发育遗传学及线粒体生物学。从事科研工作以来, 以第一作者身份在Nature Genetics（2016年影响因子 31.616）、Circulation Research （2016年影响因子 11.551）等知名期刊发表多篇文章。
联系方式：（电子邮箱）jiandingATmail.xjtu.edu.cn (请将邮箱地址中AT改成@)
研究方向（遗传学、基础生物学）：
（一）线粒体基因表达调控与器官发育
（二）细胞代谢
已发表期刊论文/书刊章节：
期刊论文(*通讯作者):
LiH-K, ZhouY,DingJ, XiongL, ShiY-X, HeY-J, YangD, DengZ-L,NieM*, Gao Y-F* (2020) LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway. Experimental Cell Research. doi:10.1016/j.yexcr.2020.112237
Gao F, Kataoka M, Liu N, Liang T, Huang Z-P, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu, WT, Wang J, Chen J*, Wang D-Z* (2019) Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nature Communications. 10(1):1082. doi:10.1038/s41467-019-09530-1
Diniz G*, Huang Z-P, Liu J, Chen J,Ding J, Fonseca R, Barreto-Chaves ML, Donato J, Hu X, Wang D-Z* (2017) Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increase energy expenditure without affecting cardiac hypertrophy.Clinical Science131:2885-2099
Ding J*,Lin Z-Q, Jiang J-M, Seidman CE, Seidman JG, Pu WT, Wang D-Z* (2016) Preparation of rAAV9 to overexpress or knockdown genes in mouse heart.Journal of Visualized Experiments118:e54787, doi:10.3791/54787(*Co-corresponding author)
Ding J,Nie M, Liu J, Hu X, Ma L, Deng Z-L, Wang D-Z* (2016) Trbp is required for differentiation and normal regeneration of skeletal muscle.PLoS ONE.11:e**.doi: 10.1371/journal.pone.**
Ding J,Wang D-Z*(2015) Mystery of Trbp, tale of a RBP in the miRNA pathway.Cell Cycle. 14:3007-3008
Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng Z-L, Pu WT, Wang D-Z* (2015) Trbp regulates heart function through miRNA-mediated Sox6 repression.Nature Genetics47: 776-783
Huang Z-P,Kataoka M, Chen J, Wu G,Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng Z-L, Seidman CE, Seidman JG, Pu WT, Wang D-Z* (2015)Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.The Journal of Clinical Investigation125: 4122-4134
Ambrosio L*, Morriss S, Riaz A, Bailey R,Ding J,MacIntosh GC* (2014) Phylogenetic analyses and characterization of RNase X25 fromDrosophila melanogastersuggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes.PLoS ONE.9:e105444. doi:10.1371/journal.pone.**
Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q,Ding J, Chen J, Wang D-Z, Li K, Wang J, Wangders RA, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK*, Pu WT* (2014) Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.Nature Medicine.20:616-623
Seok H, Chen J, Kataoka M, Huang Z-P,Ding J, Yan J, Hu X, Wang D-Z* (2014) Loss of microRNA-155 protects the heart from pathological cardiac hypertrophy.Circulation Research. 114:717-729
Chen J, Huang Z-P, Seok H,Ding J, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang D-Z* (2013)miR-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.Circulation Research. 112:1557-1568
Ding J, Wang D-Z* (2011) “RISCing” the heart: In vivo identification of cardiac miRNA targets by RISCome.Circulation Research108:3-5
Mckay J, Wang X,Ding J, Buss JE, Ambrosio L* (2011) H-RAS resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes.Biochimica et Biophysica Acta (BBA)-Molecular Cell Research1813:298-307
Ding J, Tchaicheeyan O, Ambrosio L* (2010) Drosophila Raf’s N-terminus contains a novel conserved region and can contribute to Torso RTK signaling.Genetics.184:717-729
Ding J,Shi S, Jiang B-H, Yang Y-H*, Huang J, Shen H-G, Xia K, Zhang J, Jiang X (2004) Effects of methyl jasmonate with IAA and 6-BAP on the secondary metabolism of culturedOnosma paniculatumcells.In Vitro Cellular & Developmental Biology-Plant40:581–585
Yang Y-H*, Huang J,Ding J(2003) Interaction between exogenous Brassinolide, IAA and BAP in secondary metabolism of culturedOnosma paniculatumcells.Plant Growth Regulation39: 253–261
书刊章节：
Ding J, Wang D-Z (2013) “Role of microRNAs in cardiac hypertrophy and post-infarction remodeling”Cardiac Remodeling.“Advances in Biochemistry in Health and Disease”5: 293-311. Springer,
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个人信息 - 丁 健基本信息
丁健， 教授。本科和硕士毕业于南京大学（生物学）。 博士毕业于美国爱荷华州立大学（生物化学、果蝇遗传学）。 之后在美国哈佛医学院/波士顿儿童医院从事心肌及骨骼肌病理生理学研究。入职西安交通大学后研究方向为发育遗传学及线粒体生物学。从事科研工作以来, 以第一作者身份在Nature Genetics（2016年影响因子 31.616）、Circulation Research （2016年影响因子 11.551）等知名期刊发表多篇文章。
联系方式：（电子邮箱）jiandingATmail.xjtu.edu.cn (请将邮箱地址中AT改成@)
研究方向（遗传学、基础生物学）：
（一）线粒体基因表达调控与器官发育
（二）细胞代谢
已发表期刊论文/书刊章节：
期刊论文(*通讯作者):
LiH-K, ZhouY,DingJ, XiongL, ShiY-X, HeY-J, YangD, DengZ-L,NieM*, Gao Y-F* (2020) LRTM1 promotes the differentiation of myoblast cells by negatively regulating the FGFR1 signaling pathway. Experimental Cell Research. doi:10.1016/j.yexcr.2020.112237
Gao F, Kataoka M, Liu N, Liang T, Huang Z-P, Gu F, Ding J, Liu J, Zhang F, Ma Q, Wang Y, Zhang M, Hu X, Kyselovic J, Hu X, Pu, WT, Wang J, Chen J*, Wang D-Z* (2019) Therapeutic role of miR-19a/19b in cardiac regeneration and protection from myocardial infarction. Nature Communications. 10(1):1082. doi:10.1038/s41467-019-09530-1
Diniz G*, Huang Z-P, Liu J, Chen J,Ding J, Fonseca R, Barreto-Chaves ML, Donato J, Hu X, Wang D-Z* (2017) Loss of microRNA-22 prevents high-fat diet induced dyslipidemia and increase energy expenditure without affecting cardiac hypertrophy.Clinical Science131:2885-2099
Ding J*,Lin Z-Q, Jiang J-M, Seidman CE, Seidman JG, Pu WT, Wang D-Z* (2016) Preparation of rAAV9 to overexpress or knockdown genes in mouse heart.Journal of Visualized Experiments118:e54787, doi:10.3791/54787(*Co-corresponding author)
Ding J,Nie M, Liu J, Hu X, Ma L, Deng Z-L, Wang D-Z* (2016) Trbp is required for differentiation and normal regeneration of skeletal muscle.PLoS ONE.11:e**.doi: 10.1371/journal.pone.**
Ding J,Wang D-Z*(2015) Mystery of Trbp, tale of a RBP in the miRNA pathway.Cell Cycle. 14:3007-3008
Ding J, Chen J, Wang Y, Kataoka M, Ma L, Zhou P, Hu X, Lin Z, Nie M, Deng Z-L, Pu WT, Wang D-Z* (2015) Trbp regulates heart function through miRNA-mediated Sox6 repression.Nature Genetics47: 776-783
Huang Z-P,Kataoka M, Chen J, Wu G,Ding J, Nie M, Lin Z, Liu J, Hu X, Ma L, Zhou B, Wakimoto H, Zeng C, Kyselovic J, Deng Z-L, Seidman CE, Seidman JG, Pu WT, Wang D-Z* (2015)Cardiomyocyte-enriched protein CIP protects against pathophysiological stresses and regulates cardiac homeostasis.The Journal of Clinical Investigation125: 4122-4134
Ambrosio L*, Morriss S, Riaz A, Bailey R,Ding J,MacIntosh GC* (2014) Phylogenetic analyses and characterization of RNase X25 fromDrosophila melanogastersuggest a conserved housekeeping role and additional functions for RNase T2 enzymes in protostomes.PLoS ONE.9:e105444. doi:10.1371/journal.pone.**
Wang G, McCain ML, Yang L, He A, Pasqualini FS, Agarwal A, Yuan H, Jiang D, Zhang D, Zangi L, Geva J, Roberts AE, Ma Q,Ding J, Chen J, Wang D-Z, Li K, Wang J, Wangders RA, Kulik W, Vaz FM, Laflamme MA, Murry CE, Chien KR, Kelley RI, Church GM, Parker KK*, Pu WT* (2014) Modeling the mitochondrial cardiomyopathy of Barth syndrome with induced pluripotent stem cell and heart-on-chip technologies.Nature Medicine.20:616-623
Seok H, Chen J, Kataoka M, Huang Z-P,Ding J, Yan J, Hu X, Wang D-Z* (2014) Loss of microRNA-155 protects the heart from pathological cardiac hypertrophy.Circulation Research. 114:717-729
Chen J, Huang Z-P, Seok H,Ding J, Zhang Z, Hu X, Wang G, Lin Z, Wang S, Pu WT, Liao R, Wang D-Z* (2013)miR-17-92 cluster is required for and sufficient to induce cardiomyocyte proliferation in postnatal and adult hearts.Circulation Research. 112:1557-1568
Ding J, Wang D-Z* (2011) “RISCing” the heart: In vivo identification of cardiac miRNA targets by RISCome.Circulation Research108:3-5
Mckay J, Wang X,Ding J, Buss JE, Ambrosio L* (2011) H-RAS resides on clathrin-independent ARF6 vesicles that harbor little RAF-1, but not on clathrin-dependent endosomes.Biochimica et Biophysica Acta (BBA)-Molecular Cell Research1813:298-307
Ding J, Tchaicheeyan O, Ambrosio L* (2010) Drosophila Raf’s N-terminus contains a novel conserved region and can contribute to Torso RTK signaling.Genetics.184:717-729
Ding J,Shi S, Jiang B-H, Yang Y-H*, Huang J, Shen H-G, Xia K, Zhang J, Jiang X (2004) Effects of methyl jasmonate with IAA and 6-BAP on the secondary metabolism of culturedOnosma paniculatumcells.In Vitro Cellular & Developmental Biology-Plant40:581–585
Yang Y-H*, Huang J,Ding J(2003) Interaction between exogenous Brassinolide, IAA and BAP in secondary metabolism of culturedOnosma paniculatumcells.Plant Growth Regulation39: 253–261
书刊章节：
Ding J, Wang D-Z (2013) “Role of microRNAs in cardiac hypertrophy and post-infarction remodeling”Cardiac Remodeling.“Advances in Biochemistry in Health and Disease”5: 293-311. Springer,
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