西安交通大学生命科学与技术学院导师教师师资介绍简介-靳国瑞

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个人介绍 - 靳国瑞靳国瑞

联系方式
地址：西安交通大学生命科学与技术学院（教二北）202室
电话：1 8 0 6 6 5 2 3 2 3 5
邮箱（Email）: jinguorui@xjtu.edu.cn

闹钟09

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个人介绍

靳国瑞，副教授，博士生导师。中国医药生物技术协会造影技术分会委员会委员，西安青年科技人才奖获得者，西安交通大学“十大学术新人”。
本人于2009年毕业于哈尔滨工业大学获材料科学与工程学士学位，2014年2月毕业于新加坡国立大学（National University of Singapore）获机械工程博士学位。同年受聘于新加坡科技研究局（A*Star）-材料研究与工程所，任博士后。2015年9月，全职回到西安交通大学，被聘为生命科学与技术学院，生物医学信息工程教育部重点实验室副教授，硕士生导师。
致力于功能荧光纳米探针的开发及其在肿瘤诊断与治疗及再生医学中的应用研究。针对干细胞促进组织再生机理不清楚和癌症诊疗等临床问题取得了一系列具有转化潜力的科研成果。科研成果在多个国际知名杂志如Chemical Reviews（ESI高被引论文），Chemical Society Reviews（ESI高被引论文），Advanced Functional Materials，Biomaterials，Theranostics, ACS Applied Materials & Interfaces, Acta Biomaterilia，Chemical Communications等上发表高水平专业文章42篇，H因子21，累计影响因子超过180，引用次数超过1400次，其中通讯，第一及共同第一作者文章20篇，平均影响因子超过6.5。其中利用共轭聚合物荧光纳米粒子实现了间充质干细胞的长期在体示踪的研究成果作为共同第一发明人申报新加坡专利一项并已通过PCT国际专利合作条约（PCT/SG2016/050081）。
2016年获得获得国际组织工程与再生医学学会亚太年会最佳论文奖。主持国家自然科学基金青年基金1项，中国博士后特助项目1项，中国博士后科学基金面上资助项目1项，西安交通大学综合交叉类项目1项，西安交通大学新教师支持计划1项，主持项目总经费为60余万元；2016年获邀成为Drug Discovery Today（IF=5.625）的Therapeutic Nanomaterials特刊的特邀编辑，长期担任Scientific Report等期刊的审稿人。

教育经历
教育经历
2009/09-2014/02，新加坡国立大学，机械工程，博士

2005/09-2009/07，哈尔滨工业大学，材料科学与工程，学士

工作经历
工作经历
2015/09-至今，西安交通大学，生命科学与技术学院，副教授

2013/09-2015/09，新加坡科技研究局（A*Star）-材料研究与工程所，博士后

English - 靳国瑞JIN Guorui

闹钟08

联系方式
地址：西安交通大学生命科学与技术学院（教二北）202室
电话：1 8 0 6 6 5 2 3 2 3 5
邮箱（Email）: jinguorui@xjtu.edu.cn

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Biography
Dr. Guorui Jin received his BE degree in Materials Science and Engineering from the Harbin Institute of Technology (P. R. China) in 2009. Then he moved to the National University of Singapore (NUS) to pursue his PhD degree under the supervision of Prof. Seeram Ramakrishna (former vice-president of NUS). He was a research scientist in the Institute of Materials Research and Engineering (IMRE), A*Star, Singapore. Dr. Jin’s research has been focused on regenerative medicine and development of conjugated polymer-based fluorescent nanoparticles for bioimaging applications. Dr. Jin has designed and synthesized quantum dot-sized conjugated polymer (CP) nanodots as noninvasive fluorescent trackers with high brightness and low cytotoxicity for tracking of mesenchymal stem cells (MSCs) to reveal their in vivo behaviors. The work has been published in Advanced Functional Materials (IF 11.8) and featured as the frontispiece of the journal. In addition, with the help of fluorescence imaging, Dr. Jin has developed an “all-in-one” anti-cancer platform based on AIE photosensitizer contains functionalities required for image, therapy, and RNA interference. This work has been published in Chemical Communications (IF 6.8). Dr. Jin has developed plenty forms of electrospun nanofibrous scaffolds and evaluated their cytotoxicity and capability in promoting stem cell epidermal differentiation (Biomaterials, Acta Biomaterilia). The paper titled as “Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment” has been published in Chemical Society Reviews (IF: 33.8, co-first author). Dr. Jin has published 27 journal papers, including 13 first author papers (one paper is co-first author). Some work has been published in top journals such as Advanced Functional Materials (IF:11.8)、Chemical Society Review (IF: 33.8)、Biomaterials (IF: 8.5)、Chemical Communication (IF: 6.8)、Acta Biomaterilia (IF: 6.0). The total impact factors of the papers published as the first author is around 80 with total citation around 390 and the highest citation for one single paper is 95 (google scholar). In addition, Dr. Jin has one Singapore patent and attended 5 international conferences with 2 invited talk. Moreover, Dr. jin has been appointed as the reviewer for journals such as Scientific Report, Materials Science and Engineering C, Journal of Mechanics in Medicine and Biology.

文章列表 - 靳国瑞文章列表
2020

45.Dandan Pei^a,*, Mengqi Wang^a,b,*,Wenfang Li^b,c, Meiwen Li^a,b, Qian Liu^b,c, Rui Ding^a,b, Jing Zhao^d, Ang Li^a, Feng Xu^b,c,#,Guorui Jin^b,c,#Remodeling of Aligned Fibrous Extracellular Matrix by Encapsulated Cells under Mechanical Stretching,Acta Biomaterialia,2020.

44. Guorui Jina,b*, Wenfang Lia,b*, Fan Songc*, Jing Zhaoa, Mengqi Wangd, Qian Liua,b, Ang Lid, Guoyou Huanga,b, Feng Xu, Fluorescent Conjugated Polymer Nanovector for In Vivo Tracking and Regulating the Fate of Stem Cells for Restoring Infarcted Myocardium, Acta Biomaterialia, 2020,109, 195-207.
2019
43. Huaibin Qinga,b*, Yuan Jia,b*, Wenfang Lia,b, Qingzhen Yanga,b, Xiaohui Zhanga,b, Zhengtang Luoc, Tian Jian Lud,e, Guorui Jin#, Feng Xu#, Microfluidic Printing of 3D Graphene Electroactive Microfibrous Scaffolds, ACS Applied Materials & Interfaces, 2019 (IF 8.097, 共同通讯)
42. Guorui Jin1,2*, Rongyan He1,2*, Qian Liu1,2, Min Lin1,2, Yuqing Dong2,3, Kai Li4, Ben Zhong Tang5,6, Bin Liu7, Feng Xu, Near-infrared light-regulated cancer theranostic nanoplatform based on aggregation-induced emission luminogen encapsulated upconversion nanoparticles, Theranostics 2019 (IF 8.537)

2018
41. Guorui Jin, Rongyan He, Qian Liu, Yuqing Dong, Min Lin, Wenfang Li, Feng Xu, Theranostics of Triple-Negative Breast Cancer Based on Conjugated Polymer Nanoparticles, ACS Applied Materials & Interfaces, 2018 (Front Cover, IF 8.097)
40. Guorui Jin, R.Y. He, B.Y. Sha, W.F. Li, H.B. Qing, R. Teng, F. Xu, Electrospun threedimensional aligned nanofibrous scaffolds for tissue engineering, Materials Science & Engineering C, 2018 (IF 5.01)
39.Huaibin Qing^a, Guorui Jin, Guoxu Zhao, Guoyou Huang, Yufei Ma, Xiaohui Zhang, Baoyong Sha, Tom Luo, Tian Jian Lu, Feng Xu,Silk Nanofibers-Reduced Graphene Oxide Heterostructure Composite Scaffold for Neural Stem Cell Alignment and Differentiation,ACS Applied Materials & Interfaces, 2018 (Co-first author,IF 8.097)

38. Y.Q. Dong, Guorui Jin, Y. Hong, H.Y. Zhu, T.J. Lu, F. Xu, D. Bai, M. Lin, Engineering Cell Microenvironment using Novel Photo-responsive Hydrogels, ACS Applied Materials & Interfaces, 2018 (co-first author，IF 8.097)

37. R. Zhou, Y. Han, J.Y. Cao, M. Li, Guorui Jin, Y.Z. Du, H.T. Luo, Y.C. Yang, L.Z. Zhang, B. Su, Enhanced osseointegration of hierarchically structured Ti implant with electrically bioactive SnO2-TiO2 bi-layered surface, ACS Applied Materials & Interfaces, 2018 (IF 8.097)

36. R. Zhou, Y. Han, J.Y. Cao, M. Li, Guorui Jin, H.T. Luo, L.Z. Zhang, B. Su, Electrically bioactive coating on Ti with bi-layered SnO2–TiO2 hetero-structure for improving osteointegration, Journal of Materials Chemistry B, 2018 (IF 4.776)

2017
35. Guorui Jin, Xin Zhao, Feng Xu, Therapeutic nanomaterials for cancer therapy and tissue regeneration. Drug Discovery Today, 2017 (IF 6.36)
34. Guorui Jin, Jun Li, Kai Li. Photosensitive semiconducting polymer-incorporated nanofibers for promoting the regeneration of skin wound. Mater. Sci. Eng. C, 2017, 70:1176–1181 (IF 5.01， _二区)

33. J. Zhao, Guorui Jin*, G. J. Weng, J.J. Li, J. Zhu and J.W. Zhao*, Recent advances in activatable fluorescence imaging probes for tumor imaging, Drug Discovery Today, 2017 (Co-corresponding author IF 6.36)
32. Y.Q. Dong^#, Guorui Jin^#, C.C. Ji, R.Y. He, M. Lin, X. Zhao, A. Li, F. Xu, T.J. Lu, Non-Invasive Tracking of Hydrogel Degradation Using Upconversion Nanoparticles, Acta Biomaterilia, 2017 (Co-first author, IF 6.31)
31. G.Y. Huang, F. Li, X. Zhao, Y.F. Ma, Y.H. Li, M. Lin, Guorui Jin, T.J. Lu, G. Genin, F. Xu, Functional and Biomimetic Materials for Eineering of the Three-Dimensional Cell Microenvironment, Chemical Reviews, 2017 (IF 52.613)
30. Y.Q. Dong, M. Lin, Guorui Jin, Y. Park, M.S. Qiu, Y. Zhao, H. Yang, A. Li, T.J. Lu, Fabrication of Fluorescent Composite Hydrogel Using in situ Synthesis of Upconversion Nanoparticles, Nanotechnology, 2017 （IF 3.404）
2016
29. S.J. Peng, Guorui Jin,L.L. Li, K. Li, M. Srinivasan, S. Ramakrishna, J. Chen, Multi-functional electrospun nanofibres for advances in tissue regeneration, energy conversion & storage, and water treatment, Chemical Society Reviews, 2016 (co-first author，IF 40.128, ESI Highly Cited Paper)
28. Guorui Jin, Guangxue Feng, Wei Qin, Ben Zhong Tang, Bin Liu and Kai Li. Multifunctional organic nanoparticles with aggregation-induced emission (AIE) characteristics for targeted photodynamic therapy and RNA interference therapy. Chem. Commun. DOI: 10.1039/c5cc07818k. (IF. 6.834, 一区)

27. B. Gao, Q.Z. Yang, X. Zhao, Guorui Jin, Y.F. Ma, F. Xu, 4D Bioprinting for Biomedical Applications, Trends in Biotechnology, 2016 (IF 13.578)
26. Zibiao Li, Du Yuan, Guorui Jin, Beng H. Tan, Chaobin He. Facile Layer-by-Layer Self-Assembly toward Enantiomeric Poly(lactide) Stereocomplex Coated Magnetite Nanocarrier for Highly Tunable Drug Deliveries. ACS Appl. Mater. Inter. 2016 DOI: 10.1021/acsami.5b09822 (IF 8.097，ESI highly cited paper)

25. Y.F. Ma, Y. Ji, M.L. You, S.R. Wang, Y.Q. Dong, Guorui Jin, M. Lin, Q. Wang, A, Li, X.H. Zhang, F. Xu, Labeling and long-term tracking of bone marrow mesenchymal stem cells in vitro using NaYF4:Yb³⁺,Er³⁺upconversion nanoparticles, Acta Biomaterialia, 2016 (IF 6.383)
24. M.L. You, M. Lin, S.R. Wang, X.M. Wang, G. Zhang, Y. Hong, Y.Q. Dong, Guorui Jin, F. Xu, Three-Dimensional Quick Response Code based on Inkjet Printing of Upconversion Fluorescence Nanoparticles for Drug Anti-Counterfeitin, Nanoscale, 2016 (IF 7.76)

Before 2016
23. Guorui Jin, Duo Mao, Pingqiang Cai, Jie Liu, Xiaodong Chen, Deling Kong, Dan Ding, Bin Liu, Kai Li, Conjugated Polymer Nanodots as Ultrastable Long-term Trackers to Understand Mesenchymal Stem Cell Therapy in Skin Regeneration. Adv. Funct. Mater. 2015 Cover (IF. 11.8, 一区)
22. Guorui Jin, Molamma P Prabhakaran, Dan Kai, Sathesh Kumar Annamalai, Kantha D. Arunachalam, Seeram Ramakrishna. Tissue engineered plant extracts as nanofibrous wound dressing. Biomaterials. 2012, 34:724-734. (IF 8.557，一区)
21. Guorui Jin, Molamma P Prabhakaran, Seeram Ramakrishna. Mesenchymal stem cell differentiation to epidermal lineages on electrospun nanofibrous substrates for skin tissue engineering. Acta Biomateria, 2011, 7: 3113-22 (IF 6.025，一区)

20. Guorui Jin, Molamma P Prabhakaran, Kai Dan, Seeram Ramakrishna. Controlled release of multiple epidermal induction factors through core-shell nanofibers for skin regeneration. Eur. J. Pharm. Biopharm. 2013, 85:689-98 (IF 3.85， _二区)
19. Guorui Jin, Li Kai. The electrically conductive scaffold as the skeleton of stem cell niche in regenerative medicine. Mater. Sci. Eng., 2014, 45: 671–81. (IF 5.01， _二区)
18. Guorui Jin, Yong Li, Molamma P Prabhakaran, Weiming Tian, Seeram Ramakrishna. In vitro and in vivo evaluation of the wound healing capability of electrospun gelatin/PLLCL nanofibers. J. Bioact. Compat. Pol. 2014, 29: 628-45 (IF 2.5， _二区)

17. Guorui Jin, Molamma P Prabhakaran, Seeram Ramakrishna. Photosensitive and biomimetic core-shell nanofibrous scaffolds as wound dressing. Photochem. Photobiol. 2014, 90:673-81 (IF 2.68， _二区)

16. Guorui Jin, Molamma P Prabhakaran, Kai Dan, Seeram Ramakrishna. Electrospun photosensitive nanofibers: Potential for photocurrent therapy in skin regeneration. Photochem Photobiol Sci. 2012, 12:124-34. (IF 2.9， _二区)
15. Guorui Jin, Molamma P. Prabhakaran, Susan Liao, Seeram Ramakrishna. Photosensitive materials and potential of photocurrent mediated tissue regeneration. J Photoch Photobio B, 2011, 102: 93-101 (IF 2.8， _二区)
14. Guorui Jin, Molamma P Prabhakaran, Dan Kai, Seeram Ramakrishna. Electrospun Silver nanoparticles containing PLLCL nanofibers for skin tissue engineering. J Biomater Sci Polym Ed. 2012 (IF 1.3， _二区)
13. Zibiao Li, Beng H. Tan, Guorui Jin, Kai Li and Chaobin He. Design of polyhedral oligomeric silsesquioxane (POSS) based thermo-responsive amphiphilic hybrid copolymers for thermally denatured protein protection applications. Polym. Chem., 2014 5: 6740-53 (IF 5.3，二区)
12. Kai, D, Low, ZW, Liow, SS, Ye, HY, Guorui Jin, Li, K, Loh, XJ. Elastic poly(epsilon-caprolactone)-polydimethylsiloxane copolymer fibers with shape memory effect for bone tissue engineering. Biomedical Materials. 2016 DOI:10.1088/1748-6041/11/1/015007 (IF3.697, 二区)
11. Kai Dan, Molamma P Prabhakaran, Guorui Jin, Seeram Ramakrishna. Biocompatibility evaluation of electrically conductive nanofibrous scaffolds for cardiac tissue engineering. J. Mater. Chem. B, 2013, 1, 2305-14 (IF 6.6)
10. Hongyuan Zhua,Min Lin, Guorui Jin, Tian Jian Lu, Feng Xu. A modified energy transfer model for determination of upconversion emission of β-NaYF4:Yb,Er: Role of self-quenching effect. Journal of Luminescence, 2017, 185, 292–297
9. Dan Kai, MP Prabhakaran, Guorui Jin, Lingling Tian, Seeram Ramakrishna, Potential of VEGF-encapsulated electrospun nanofibers for in vitro cardiomyogenic differentiation of human mesenchymal stem cells. J Tissue Eng Regen Med. 2015 doi: 10.1002/term.199

8. Elham Vatankhah, Molamma P Prabhakaran, Guorui Jin, Seeram Ramakrishna. Development of nanofibrous Cellulose acetate/gelatin skin substitutes for variety wound treatment applications. J. Biomater. Appl. 2014;28:909-21
7. Dan Kai,Guorui Jin, Molamma P Prabhakaran, Seeram Ramakrishna.Electrospun synthetic and natural nanofibers for regenerative medicine and stem cells.Biotechnol J, 2013, 8:59-72.
6. L. Ghasemi-Mobarakeh, M.P. Prabhakarn, Preethi,Guorui Jinet al.Advance in electrosupun nanofibers for bone and cartilage regeneration.J Nanosci Nanotechnol, 2013, 13：4656-71
5. M.P. Prabhakaran, J. Venugopal, L. Ghasemi-Mobarakeh, D. Kai,Guorui Jin, S. Ramakrishna. Stem cells and nanostructures for advanced tissue regeneration.Adv Polym Sci, 2011, 246: 21-62
4. Dan Kai, Molamma P Prabhakaran,Guorui Jin, Seeram Ramakrishna.Guided orientation of cardiomyocytes on electrospun aligned nanofibers for cardiac tissue engineering.J Biomed Mater Res B, 2011, 98:379-86
3. Su Yan, Su Qianqian, Liu Wei,Guorui Jin, Mo Xiumei, Ramakrishna Seeram.Dual-Drug Encapsulation and Release from Core–Shell Nanofiber.J Biomater Sci Polym Ed. 2011, 23: 861-7
2. M.P. Prabhakaran, L. Ghasemi-Mobarakeh,Guorui Jin, S. Ramakrishna. Electrospun conducting polymer nanofibers and electrical stimulation of nerve stem cells. J Biosci Bioeng. 2011, 112:501-7
1. Kai D, Prabhakaran MP, Guorui Jin, Ramakrishna S. Polypyrrole-contained electrospun conductive nanofibrous membranes for cardiac tissue engineering. J Biomed Mater Res A. 2011, 99:376-85

项目列表 - 靳国瑞Blank

时间
项目名称
批准单位
本人承担的研究内容
经费金额

2020-2023 温度响应型聚集诱导发光纳米探针的制备及其在肿瘤诊疗中的应用
国家自然科学基金面上项目项目负责人 57.0万元
2017-2019
基于共轭高分子荧光探针的干细胞-生物支架双示踪研究
国家自然科学基金青年项目
项目负责人
20.0万元

2019-2021
基于共轭高分子荧光探针的基因递送及干细胞示踪研究
国家博士后特助基金
项目负责人
15.0万元

2016-2018
基于包裹聚集诱导发光分子胶束的癌症近红外光动力治
西安交通大学
项目负责人
12.0万元

2016-2019
基于高稳定性的荧光纳米粒子的干细胞及支架双示踪研究
西安交通大学
项目负责人
15.0万元

2016-2018
基于共轭高分子荧光探针的生物支架示踪研究
国家博士后基金面上基金
项目负责人
5.0万元

2016-2018
共轭高分子荧光探针用于生物支架示踪研究
陕西省博士后基金面上基金
项目负责人
2.0万元

2017-2019
前沿生物传感技术创新团队
陕西省创新能力支撑计划-陕西省创新团队
参与人，生物医用纳米材料
90.0万元

2018-2021
基于石墨烯的多功能水凝胶平台用于神经组织构建和体外原位检测
国家自然科学基金国际(地区)合作与交流项目
参与人，石墨烯水凝胶的制备及神经功能检测
85.0万元

2018-2021
皮肤-肌肉组织快速原位3D生物打印的装备及工艺研究
陕西省重点研发计划
参与人，皮肤组织再生及原理研究
50.0万元

招生信息 - 靳国瑞招生信息
博士、硕士研究生招生目录

专业
研究方向
考试科目
备注

高分子化学、有机化学、生物医学工程、材料科学与工程等
方向1. 多功能癌症诊疗平台的构建及应用研究。
方向2. 基于荧光探针的在体干细胞命运调控及示踪研究。
方向3. 细胞温度探针的设计及制备。
方向4.基于荧光探针的生物材料在体示踪研究。
1. 101思想政治理论
2. 201 英语一
3. 302 数学二或714 生物综合
或723 物理化学
或721 医学基础综合
4. 833 生物化学或835 细胞生物学或821 有机化学
硕士复试
复试科目:生物技术
参考书：《现代生物技术导论》
高等教育出版社，瞿礼嘉

注：博士、硕士考试科目或考核办法以当年西安交大博士和硕士招生简章为准。

报考咨询
1、生命学院研究生办公室：
王老师联系电话：
2、联系导师 靳国瑞电子邮件：jinguorui@xjtu.edu.cn

联系电话： 180665二三235

课题组新闻 - 靳国瑞我的新闻
恭喜靳老师获批国家自然科学基金面上项目
2019-09-16

欢迎硕士生罗美青加入课题组！
2019-07-09

课题组合成近红外光调控的包裹了AIE光敏剂和上转换纳米粒子（UCNP）的肿瘤诊疗一体化平台
2019-01-09

祝贺董宇卿在国际期刊ACS Applied Materials & Interfaces 发表综述论文
2018-11-30

祝贺顷淮斌在国际期刊ACS Appl. Mater. Interfaces发表封面论文
2018-11-15

更多新闻>>

团队成员 - 靳国瑞团队成员
博士生

刘文婧博士生（Co-supervise）

研究方向：温敏荧光探针的开发及应用研究

联系方式：lwj1994@stu.xjtu.edu.cn

高欢博士生（Co-supervise）
研究方向：肿瘤转移机制研究
联系方式：@qq.com

硕士生

柳杨静
研究方向：肿瘤富集增强纳米探针的开发及应用研究

联系方式：@qq.com
毕业成员（Alumnus）
顷淮斌（博士，2019），广东省科学院材料与加工研究所
联系方式：@qq.com
王梦奇（硕士，2019），西安交通大学口腔医院医生
联系方式：@qq.com

刘倩，上海药明康德

联系方式：@qq.com

黎文芳（Co-supervise），西安生物制药公司
联系方式：wenfangli9@163.com