田中民基本情况 - 田 中民基本信息

基本情况：
田中民,教授，博士生导师。生命科学与技术学院大型仪器实验共享平台副主任。
2000年，西北大学生物系获硕士学位；
2004年，西安交通大学生物医学工程系获博士学位；
2006-2008年，美国威斯康星医学院生理系博士后；
2008年入选教育部“新世纪优秀人才”支持计划；
2009年，美国威斯康星医学院生理系访问****；
通讯地址:西安咸宁西路28号，西安交通大学生命科学与技术学院
邮编:710049
办公室：西安交通大学生命科学与技术学院，教二北楼 523
Phone: 转 92

Email: zmtian(et)mail.xjtu.edu.cn





研究领域
研究领域：生物化学与分子生物学，生理学
研究方向：
(1) 盐敏感高血压的差异蛋白质组学与代谢组学
(2)盐敏感高血压的药物靶标筛选以及诊断试剂盒开发
(3) 生物质谱分析技术及食品安全检测
(4)盐敏感高血压的生物信息学分析
科研项目
【1】国家自然科学基金面上项目：糖、脂代谢紊乱与盐敏感高血压形成分子机理的研究
【2】教育部新世纪优秀人才支持计划。（NCET-080434）；
【3】人事部、省外专局留学人员科技活动择优资助项目《盐敏感高血压临床检测试剂盒研制》
【4】 参与科技部国家重点基础研究973计划项目《心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究》2010CB732600
【5】国家自然科学基金面上项目《延胡索酸酶基因(Fh)突变在高盐饮食肾损伤及血压盐敏感性形成中的作用》**
【6】国家社会科学基金重大项目“生物技术及其产业发展的法律保障机制研究”子项目
【7】国家自然科学基金面上项目 肾脏代谢反馈调节与盐敏感高血压的形成机制研究、2016/01-2019/12
【8】国家自然科学基金面上项目 海外及港澳****合作研究基金项目，**、肾脏细胞代谢中产物对盐敏感性高血压的调控机制研究
【9】国家自然科学基金面上项目肾脏氨基酸代谢异常与盐敏感高血压形成机制的研究、2018/01-2021/12、在研。
【10】国家自然科学基金面上项目肾脏能量供给不足与盐敏感高血压发病机理的研究 2021/01-2024/12




主要任职
中国生理学会肾脏专业委员会委员
生理学报常务编委
中国生物医学工程委员会第三届超声生物效应专业委员会常务委员和副主任委员.





招生信息
欢迎对肾性高血压、复杂疾病蛋白质组学、代谢组学以及生物质谱分析、食品安全检测有兴趣的有志之士参与研究. 欢迎具有生化、生理、医学以及分析化学、有机化学背景的博士，博士后，应聘，讲师、副教授，教授等科研岗位。博士后年薪16万.
有生物学、生物技术、生物化学、细胞生物学、生理学、临床医学以及分析化学背景的考生均可报考本方向的研究生。
就业方向：毕业研究生可在农检、药检、海关、医院临床检测、公安司法检测、环境检测、食品检测等政府机构选择就业，也可在生物检测的相关企业选择就业。
实验室技术支持：
· Agilent 7890a/5975c GC-MS 气质
· Agilent 1100 capillary HPLC with ion trap mass spectrometry(LC-MSMS) 液相色谱质谱联用仪。
· Agilent capillary electrophoresis apparatus with MSD
· Applied Biosystems Voyager-DE PRO MALDI-TOF-MS 飞行时间质谱仪
· Tecan Infinite M200 Pro Reader 多功能酶标仪
· Cell culture
· Two-Dimensional Polyacrylamide Gel Electrophoresis (2-D DIGE) .
· Biochemical analysis.
2020年博士招生只考英语，没有专业科考试，详细见简章或email联系。




发表论文
Zhongmin Tian, Mingyu Liang* Renal metabolism and hypertension. Nature Communication, 2021,12,963. Doi 10.1038 IF：12.3
Di Gao#; Ting Chen#; Shuojia Chen; Xuechun Ren; Yulong Han; Yiwei Li; Ying Wang; Xiaoqing Guo; Hao Wang; Xing Chen; Ming Guo; Yu Shrike Zhang; Guosong Hong; Xingcai Zhang*; Zhongmin Tian*; Zhe Yang*; Targeting hypoxic tumors with hybrid nanobullets for oxygen-independent synergistic photothermal and thermodynamic therapy, Nano-Micro Letters, 2021, DOI: 10.1007/s40820-021-00616-4. IF：11.8
Ying Wang, Di Gao, Yan Liu, Xiaoqing Guo, Shuojia Chen, Li Zeng, Jinxuan Ma, Xingcai Zhang *, Zhongmin Tian*, Zhe Yang* Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine. Bioactive Materials，2021, 6(6):1513-1527. Q1
Zhe Yang, Di Gao, Xiaoqing Guo, Lin Jin, Juanjuan Zheng, Ying Wang, Shuojia Chen, Xuewei Zheng, Li Zeng, Ming Guo, Xingcai Zhang*, and Zhongmin Tian* ACS Nano 2020, 14(12): 17442-17457. IF：15.5
Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian ZM, Liang M.Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploin sufficiency in Dahl Salt-Sensitive Rats. Hypertension. 2019, 74(2):313-322 IF：7.017
Yuan Cheng, Haiying Song，Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R. Lanza, Pengyuan Liu, Yong Liu, Purushottam W. Laud, Kristie Usa, Yongcheng He, Mingyu Liang Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet. Theranostics. 2018; 8(6): 1468-1480 IF: 8.766
Zhe Yang*, Rui Cheng, Chenyang Zhao, Na Sun, Huiyan Luo, Ya Chen, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian* Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors. Theranostics, 2018; 8(15): 4097-4115.SCI IF：8.8
Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian，* Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Reports. 2017 19, 1631–1639 IF: 8.28
Yang Z, Sun N, Cheng R, Zhao C, Liu Z, Li X, Liu J, Tian Z*. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials. 2017，147:53-67. IF:8.402
Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian et al.MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：11.147
Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009，54: 255-260. IF：7.017
Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411 IF=11.224
Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008，51(4):899-904. IF：7.017
Xuewei Zheng Meng Chen Xiaoxue Li Pengfei Yang Xinrui Zhao Yanan Ouyang Zhe Yang Mingyu Liang Entai Hou* Zhongmin Tian*Insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in Dahl salt-sensitive rats. Hypertension Research, 2019, 42(11):1672-1682.
Xuewei Zheng, Xiaoxue Li, Meng Chen, Pengfei Yang, Xinrui Zhao, Li Zeng, Yanan OuYang, Zhe Yang and Zhongmin Tian*The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns. Food & Function. 2019, 10(2):849-858




研究队伍
招聘具有生化、生理、医学以及分析化学、有机化学背景的博士，博士后，讲师，副教授，教授参与科研工作。博士后年薪15-18万。

---

田中民基本情况 - 田 中民基本信息

基本情况：
田中民,教授，博士生导师。生命科学与技术学院大型仪器实验共享平台副主任。
2000年，西北大学生物系获硕士学位；
2004年，西安交通大学生物医学工程系获博士学位；
2006-2008年，美国威斯康星医学院生理系博士后；
2008年入选教育部“新世纪优秀人才”支持计划；
2009年，美国威斯康星医学院生理系访问****；
通讯地址:西安咸宁西路28号，西安交通大学生命科学与技术学院
邮编:710049
办公室：西安交通大学生命科学与技术学院，教二北楼 523
Phone: 转 92

Email: zmtian(et)mail.xjtu.edu.cn





研究领域
研究领域：生物化学与分子生物学，生理学
研究方向：
(1) 盐敏感高血压的差异蛋白质组学与代谢组学
(2)盐敏感高血压的药物靶标筛选以及诊断试剂盒开发
(3) 生物质谱分析技术及食品安全检测
(4)盐敏感高血压的生物信息学分析
科研项目
【1】国家自然科学基金面上项目：糖、脂代谢紊乱与盐敏感高血压形成分子机理的研究
【2】教育部新世纪优秀人才支持计划。（NCET-080434）；
【3】人事部、省外专局留学人员科技活动择优资助项目《盐敏感高血压临床检测试剂盒研制》
【4】 参与科技部国家重点基础研究973计划项目《心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究》2010CB732600
【5】国家自然科学基金面上项目《延胡索酸酶基因(Fh)突变在高盐饮食肾损伤及血压盐敏感性形成中的作用》**
【6】国家社会科学基金重大项目“生物技术及其产业发展的法律保障机制研究”子项目
【7】国家自然科学基金面上项目 肾脏代谢反馈调节与盐敏感高血压的形成机制研究、2016/01-2019/12
【8】国家自然科学基金面上项目 海外及港澳****合作研究基金项目，**、肾脏细胞代谢中产物对盐敏感性高血压的调控机制研究
【9】国家自然科学基金面上项目肾脏氨基酸代谢异常与盐敏感高血压形成机制的研究、2018/01-2021/12、在研。
【10】国家自然科学基金面上项目肾脏能量供给不足与盐敏感高血压发病机理的研究 2021/01-2024/12




主要任职
中国生理学会肾脏专业委员会委员
生理学报常务编委
中国生物医学工程委员会第三届超声生物效应专业委员会常务委员和副主任委员.





招生信息
欢迎对肾性高血压、复杂疾病蛋白质组学、代谢组学以及生物质谱分析、食品安全检测有兴趣的有志之士参与研究. 欢迎具有生化、生理、医学以及分析化学、有机化学背景的博士，博士后，应聘，讲师、副教授，教授等科研岗位。博士后年薪16万.
有生物学、生物技术、生物化学、细胞生物学、生理学、临床医学以及分析化学背景的考生均可报考本方向的研究生。
就业方向：毕业研究生可在农检、药检、海关、医院临床检测、公安司法检测、环境检测、食品检测等政府机构选择就业，也可在生物检测的相关企业选择就业。
实验室技术支持：
· Agilent 7890a/5975c GC-MS 气质
· Agilent 1100 capillary HPLC with ion trap mass spectrometry(LC-MSMS) 液相色谱质谱联用仪。
· Agilent capillary electrophoresis apparatus with MSD
· Applied Biosystems Voyager-DE PRO MALDI-TOF-MS 飞行时间质谱仪
· Tecan Infinite M200 Pro Reader 多功能酶标仪
· Cell culture
· Two-Dimensional Polyacrylamide Gel Electrophoresis (2-D DIGE) .
· Biochemical analysis.
2020年博士招生只考英语，没有专业科考试，详细见简章或email联系。




发表论文
Zhongmin Tian, Mingyu Liang* Renal metabolism and hypertension. Nature Communication, 2021,12,963. Doi 10.1038 IF：12.3
Di Gao#; Ting Chen#; Shuojia Chen; Xuechun Ren; Yulong Han; Yiwei Li; Ying Wang; Xiaoqing Guo; Hao Wang; Xing Chen; Ming Guo; Yu Shrike Zhang; Guosong Hong; Xingcai Zhang*; Zhongmin Tian*; Zhe Yang*; Targeting hypoxic tumors with hybrid nanobullets for oxygen-independent synergistic photothermal and thermodynamic therapy, Nano-Micro Letters, 2021, DOI: 10.1007/s40820-021-00616-4. IF：11.8
Ying Wang, Di Gao, Yan Liu, Xiaoqing Guo, Shuojia Chen, Li Zeng, Jinxuan Ma, Xingcai Zhang *, Zhongmin Tian*, Zhe Yang* Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine. Bioactive Materials，2021, 6(6):1513-1527. Q1
Zhe Yang, Di Gao, Xiaoqing Guo, Lin Jin, Juanjuan Zheng, Ying Wang, Shuojia Chen, Xuewei Zheng, Li Zeng, Ming Guo, Xingcai Zhang*, and Zhongmin Tian* ACS Nano 2020, 14(12): 17442-17457. IF：15.5
Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian ZM, Liang M.Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploin sufficiency in Dahl Salt-Sensitive Rats. Hypertension. 2019, 74(2):313-322 IF：7.017
Yuan Cheng, Haiying Song，Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R. Lanza, Pengyuan Liu, Yong Liu, Purushottam W. Laud, Kristie Usa, Yongcheng He, Mingyu Liang Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet. Theranostics. 2018; 8(6): 1468-1480 IF: 8.766
Zhe Yang*, Rui Cheng, Chenyang Zhao, Na Sun, Huiyan Luo, Ya Chen, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian* Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors. Theranostics, 2018; 8(15): 4097-4115.SCI IF：8.8
Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian，* Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Reports. 2017 19, 1631–1639 IF: 8.28
Yang Z, Sun N, Cheng R, Zhao C, Liu Z, Li X, Liu J, Tian Z*. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials. 2017，147:53-67. IF:8.402
Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian et al.MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：11.147
Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009，54: 255-260. IF：7.017
Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411 IF=11.224
Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008，51(4):899-904. IF：7.017
Xuewei Zheng Meng Chen Xiaoxue Li Pengfei Yang Xinrui Zhao Yanan Ouyang Zhe Yang Mingyu Liang Entai Hou* Zhongmin Tian*Insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in Dahl salt-sensitive rats. Hypertension Research, 2019, 42(11):1672-1682.
Xuewei Zheng, Xiaoxue Li, Meng Chen, Pengfei Yang, Xinrui Zhao, Li Zeng, Yanan OuYang, Zhe Yang and Zhongmin Tian*The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns. Food & Function. 2019, 10(2):849-858




研究队伍
招聘具有生化、生理、医学以及分析化学、有机化学背景的博士，博士后，讲师，副教授，教授参与科研工作。博士后年薪15-18万。

---

科学研究 - 田 中民研究领域
研究领域：生物化学与分子生物学，生理学
研究方向：
(1) 盐敏感高血压的差异蛋白质组学与代谢组学
(2)盐敏感高血压的药物靶标筛选以及诊断试剂盒开发
(3) 生物质谱分析技术及食品安全检测
(4)盐敏感高血压的生物信息学分析
科研项目
【1】国家自然科学基金面上项目：糖、脂代谢紊乱与盐敏感高血压形成分子机理的研究
【2】教育部新世纪优秀人才支持计划。（NCET-080434）；
【3】人事部、省外专局留学人员科技活动择优资助项目《盐敏感高血压临床检测试剂盒研制》
【4】 参与科技部国家重点基础研究973计划项目《心脑血管易损斑块的高分辨成像识别与风险评估预警体系重大问题的基础研究》2010CB732600
【5】国家自然科学基金面上项目《延胡索酸酶基因(Fh)突变在高盐饮食肾损伤及血压盐敏感性形成中的作用》**
【6】国家社会科学基金重大项目“生物技术及其产业发展的法律保障机制研究”子项目
【7】国家自然科学基金面上项目 肾脏代谢反馈调节与盐敏感高血压的形成机制研究、2016/01-2019/12
【8】国家自然科学基金面上项目 海外及港澳****合作研究基金项目，**、肾脏细胞代谢中产物对盐敏感性高血压的调控机制研究
【9】国家自然科学基金面上项目肾脏氨基酸代谢异常与盐敏感高血压形成机制的研究、2018/01-2021/12、在研。
【10】国家自然科学基金面上项目肾脏能量供给不足与盐敏感高血压发病机理的研究 2021/01-2024/12




研究队伍
招聘具有生化、生理、医学以及分析化学、有机化学背景的博士，博士后，讲师，副教授，教授参与科研工作。博士后年薪15-18万。




发表论文
近年发表的论文
[1] Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, and Zhongmin Tian* Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression, Biochimie, 2015, 109, 27-35 IF:3.2
[2] Le Wang , Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian* Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men, Analytica Chimica Acta , 2015,854: 95–105 IF：4.517
[3] Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian* Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats. Biochemical and Biophysical Research Communications, 2014, 18, 450 (1): 863-869. IF:2.4
[4] Zhongmin Tian*, Yu Wang, Chenyang Zhao, Tianshu Wang, Entai Hou and Na Sun Qualitative and quantitative analysis of phosphoproteomic experimental workflow based on phosphoprotein enrichment strategy and two-dimensional difference gel electrophoresis (2D-DIGE) techniques, Current Proteomics, 2014, 11(4), 252 – 263 IF: 0.5
[5]Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang*. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009, 54: 255-260. IF:7.194
[6] Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411. IF:11.224
[7] Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008,51(4):899-904. IF:7.194
[8] Zhongmin Tian, Mingxi Wan, Mingzhu Lu, Xiaodong Wang. The alteration of protein profile of walker 256 carinosarcoma cells during the apoptotic process induced by ultrasound. Ultrasound in Medicine & Biology, 2005, 31 (1): 121-128. IF: 2.221
[9] Zhongmin Tian, Mingxi Wan, Supin Wang, Juqing Kang. Effects of ultrasound and excipients on the function and structure of trypsin. Ultrasonics Sonochemistry 2004, 11(6), 399-404. IF: 2.105
[10]Zhongmin Tian, Mingxi Wan, Bo Wang, Supin Wang, Xiaoming Wu and Yusong Ruan. Effects of ultrasound on the structure and function of tumor necrosis factor-α. Ultrasound in Medicine & Biology, 2003, 29 (9): 1331-1339. IF: 2.221
[11]Zhongmin Tian, Mingxi Wan, Zenglu Wang, Bo Wang. The preparation of genistein and LC-MS/MS on line analysis. Drug Development Research, 2004, 66 (1): 6-12. IF: 0.891
[12]Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian（等同第一作者），Domagoj Mladinov，Isaac R. Matus, Xiaoqiang Ding, Andrew S. Greene and Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：7.479
[13]Xiaofeng He , Yong Liu , Kristie Usa , Zhongmin Tian, Allen W. Cowley Jr., Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014, 15; 306(10):1190-1197. IF：3.3
[14]Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, Zhongmin Tian. MicroRNA: A New Frontier in Kidney and Blood Pressure Research. Am J Physiol Renal Physiol, 2009，297:553-558. IF：4.416
[15]Yi Feng, Zhongmin Tian, Ming-Xi Wan. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974 SCI：607CB
[16]Yi Feng, Zhongmin Tian, Ming-Xi Wan, Zhao-Bin Zheng. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614 SCI :175PE

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发表论文 - 田 中民发表论文
近年发表的论文
[1] Liqing He, Xiaochang Xue, Zhengjun Wang, Entai Hou, Yong Liu, Mingyu Liang, Yingqi Zhang, and Zhongmin Tian* Transcriptional regulation of heterogeneous nuclear ribonucleoprotein K gene expression, Biochimie, 2015, 109, 27-35 IF:3.2
[2] Le Wang , Entai Hou, Lijun Wang, Yanjun Wang, Lingjian Yang, Xiaohui Zheng, Guangqi Xie, Qiong Sun, Mingyu Liang, Zhongmin Tian* Reconstruction and analysis of correlation networks based on GC–MS metabolomics data for young hypertensive men, Analytica Chimica Acta , 2015,854: 95–105 IF：4.517
[3] Le Wang, Entai Hou, Liqing He, Zhengjun Wang, Na Sun, Lan Chen, Pu Jia, Xiaohui Zheng, Mingyu Liang, Zhongmin Tian* Analysis of metabolites in plasma reveals distinct metabolic features between Dahl salt-sensitive rats and consomic SS.13BN rats. Biochemical and Biophysical Research Communications, 2014, 18, 450 (1): 863-869. IF:2.4
[4] Zhongmin Tian*, Yu Wang, Chenyang Zhao, Tianshu Wang, Entai Hou and Na Sun Qualitative and quantitative analysis of phosphoproteomic experimental workflow based on phosphoprotein enrichment strategy and two-dimensional difference gel electrophoresis (2D-DIGE) techniques, Current Proteomics, 2014, 11(4), 252 – 263 IF: 0.5
[5]Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang*. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009, 54: 255-260. IF:7.194
[6] Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411. IF:11.224
[7] Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008,51(4):899-904. IF:7.194
[8] Zhongmin Tian, Mingxi Wan, Mingzhu Lu, Xiaodong Wang. The alteration of protein profile of walker 256 carinosarcoma cells during the apoptotic process induced by ultrasound. Ultrasound in Medicine & Biology, 2005, 31 (1): 121-128. IF: 2.221
[9] Zhongmin Tian, Mingxi Wan, Supin Wang, Juqing Kang. Effects of ultrasound and excipients on the function and structure of trypsin. Ultrasonics Sonochemistry 2004, 11(6), 399-404. IF: 2.105
[10]Zhongmin Tian, Mingxi Wan, Bo Wang, Supin Wang, Xiaoming Wu and Yusong Ruan. Effects of ultrasound on the structure and function of tumor necrosis factor-α. Ultrasound in Medicine & Biology, 2003, 29 (9): 1331-1339. IF: 2.221
[11]Zhongmin Tian, Mingxi Wan, Zenglu Wang, Bo Wang. The preparation of genistein and LC-MS/MS on line analysis. Drug Development Research, 2004, 66 (1): 6-12. IF: 0.891
[12]Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian（等同第一作者），Domagoj Mladinov，Isaac R. Matus, Xiaoqiang Ding, Andrew S. Greene and Mingyu Liang. MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：7.479
[13]Xiaofeng He , Yong Liu , Kristie Usa , Zhongmin Tian, Allen W. Cowley Jr., Mingyu Liang. Ultrastructure of mitochondria and the endoplasmic reticulum in renal tubules of Dahl salt-sensitive rats. Am J Physiol Renal Physiol. 2014, 15; 306(10):1190-1197. IF：3.3
[14]Mingyu Liang, Yong Liu, Domagoj Mladinov, Allen W. Cowley, Jr., Hariprasad Trivedi, Yi Fang, Xialian Xu, Xiaoqiang Ding, Zhongmin Tian. MicroRNA: A New Frontier in Kidney and Blood Pressure Research. Am J Physiol Renal Physiol, 2009，297:553-558. IF：4.416
[15]Yi Feng, Zhongmin Tian, Ming-Xi Wan. Bio-effects of low intensity ultrasound in vitro: apoptosis, alteration of protein profile and potential molecular mechanism. Journal of Ultrasound in Medicine. 2010, 29: 963-974 SCI：607CB
[16]Yi Feng, Zhongmin Tian, Ming-Xi Wan, Zhao-Bin Zheng. Protein profile of human hepatocarcinoma cell line SMMC-7721: Identification and functional analysis. World J Gastroenterol, 2007, 13(18): 2608-2614 SCI :175PE

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招生方向 - 田 中民招生信息
欢迎对肾性高血压、复杂疾病蛋白质组学、代谢组学以及生物质谱分析、食品安全检测有兴趣的有志之士参与研究. 欢迎具有生化、生理、医学以及分析化学、有机化学背景的博士，博士后，应聘，讲师、副教授，教授等科研岗位。博士后年薪16万.
有生物学、生物技术、生物化学、细胞生物学、生理学、临床医学以及分析化学背景的考生均可报考本方向的研究生。
就业方向：毕业研究生可在农检、药检、海关、医院临床检测、公安司法检测、环境检测、食品检测等政府机构选择就业，也可在生物检测的相关企业选择就业。
实验室技术支持：
· Agilent 7890a/5975c GC-MS 气质
· Agilent 1100 capillary HPLC with ion trap mass spectrometry(LC-MSMS) 液相色谱质谱联用仪。
· Agilent capillary electrophoresis apparatus with MSD
· Applied Biosystems Voyager-DE PRO MALDI-TOF-MS 飞行时间质谱仪
· Tecan Infinite M200 Pro Reader 多功能酶标仪
· Cell culture
· Two-Dimensional Polyacrylamide Gel Electrophoresis (2-D DIGE) .
· Biochemical analysis.
2020年博士招生只考英语，没有专业科考试，详细见简章或email联系。

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English - 田 中民(1.)Basic Information

Zhongmin,Tian., Ph.D.
Professor
Department of Biomedical and Bioengineering
School of Life Science and Technology
Xi’an Jiao-tong University
28# Xian-ning road, Xi’an, Shaanxi, P.R.China, 710049
Email: zmtian@mail.xjtu.edu.cn
Room: 202 School of Life Science and Technology
Xi’an Jiao-tong University

M.B. biology, North-west University, xian, China, 1997
Ph.D. Biomedical and bioengineering, Xian Jiao-tong university 2001
Postdoctoral Fellow, Nephrology, Medical college of Wisconsin, USA, 2006
Visiting scholar, Physiology, Medical College of Wisconsin, USA ,2009
Professor，Associate Professor ， Assistant Professor Faculty Positions and postdoctoral position are available NOW. 2020-2025
Postdoctoral position is open now. Interested candidates sent the CV to my email box.mzhtmzht@163.com
Post Doctoral and Tenure-Track Faculty Positions are available in school of life science and technology, Xian Jiaotong University, China. The job is involved in unbiased profiling of metabolome by LC-MS/MS GC-MS analysis in blood, tissue samples from the disease modeling rat. The current project focusses on salt-sensitive hypertension.
The candidate should have a Ph.D degree, with a solid graduate training and a strong background in biochemistry or bioinformatics or physiology or analytical chemistry or related fields are encouraged to apply. Qualified applicants should have the hand-on experience on GC-MS, LC-MSMS operation, method development, maintenance, sample preparation, metabolite quantification and identification using MS/MS. The successful candidates should be highly motivated and have excellent scientific skills. S/he should have excellent communication skills in English and an open, proactive personality to work in a team. Experience with data analysis or metabolic modeling is desirable.
The position is open and applications are accepted immediately. The initial appointment is for 4 years. Renewal is subject to annual evaluations. The salary for this position is around 160, 000(RMB)/per year.
Interested candidates should submit a curriculum vitae, to Prof. Tian by email mzhtmzht@163.com.

Research areas:
u Renal Physiology
u Proteomics and metabonomics
My laboratory's research interest is in understanding and interpreting the development of salt sensitive hypertension. With kidney injury and metabolic disorders as the hypertension context, our current work is focused on:
1. Proteomic analysis on salt-sensitive Hypertension
Arterial blood pressure of many essential hypertensive patients, exhibits an increased sensitivity to dietary salt intake. However, Sodium such an environmental factor has received the greatest attention. Approximately one third of the essential hypertensive population is responsive to high salt diet. SS-rat is considered as a useful rat model to understand human salt-sensitive hypertension. A number of physiological processes have been shown to be potentially involved in the increased blood pressure. Particularly, abnormalities?in the kidneys appear to play a critical role.Quantitative trait loci analyses have indicated that regions of several Chromosomes are associated with the increased blood pressure salt-sensitivity in the SS rat. Howerer, the cut way to understand the development of salt-sensitive hypertension is to generate various Congenic or Consomic rat strains by substituting a small part of the genome from salt-resistant rat into the SS-rat to understand the genetic background.
SS-13BN from SS-rat except Chromosome 13 replaced by the Brown Norway, has become a valuable control strain for the study of the SS-rat. This made SS-13BN genetically 98.05% identical to SS. However, the blood pressure salt-sensitivity is significantly reduced in SS-13BN.Several interesting physiological differences have been identified between SS-13BN and SS rats, including a reduced level of hypertension renal injuryand cardiac hypertrophy.
There are only 1.95% difference in genetic background, and the arterial blood pressure had reduced significantly, but we still didn’t know what gene located on chromosome 13 and involved in the salt hypertension. So the purpose of my research team was to investigate differential expressed protein using current 2D DIGE technology so that we can understand the differential gene located on Chromosome 13.
The most interested results of our current work are fumarase and Hnrnp K, which we fund by 2D-DIGE analysis. (1) Fumarase locates on chromosome 13. (2) different modification lead to PI shift. (3) The activity of fumarase was detected and there were 2.88 fold difference between SS-rat and SS-13BN. (4) The activity of fumarase is also influenced by the ions concentration in the reaction medium in vitro, and reduced with increasing the concentration of sodium chloride in buffer. (5) Fumarase cDNA sequence analysis indicated that there was only one base difference between SS-rat and SS-13BN. This lead to glutimic acid was replaced by lysine at site 481 in SS-rat. Of course, we still found other interested proteins such as Hnrnp K. These results had been published on Hypertension 2009,2008 and Genome Research 2008
2.The role of renal cellular metabolism in hypertension
In the area of cellular intermediary metabolism, my laboratory has made a completely novel discovery about a possible role of renal medullary insufficiency of fumarase activity in hypertension (Hypertension 2008, 2009).This discovery helped us to open a new direction of hypertension research focusing on the heretofore largely unrecognized importance of cellular intermediary metabolism in hypertension. The initial discovery has generated significant excitement in the field as evidenced by recommendation by Faculty 1000 Biology and invitations from colleagues to present this specific work at national conferences or research institutions.
The cellular intermediary metabolism in renal medulla and cortex had been separated and identified by LC-MSMS and GC-MS. The ongoing work is collecting all these metabolism intermediate compounds. Recent discoveries that we are exploring in depth include novel roles of abnormalities in cellular metabolism in the development of salt sensitive hypertension and kidney injury.
3. Phosphoproteomic
Protein phosphorylation is a key reversible modification that is involved in many cellular processes such as metabolism and transcription. Unfortunately, the dynamic nature of phosphorylation and the availability of multiple phosphorylation sites on the same protein add significant complexity to the analysis of cell signaling pathways through the monitoring of phosphoproteins. The purpose of our research work was to investigate whether such a strategy, the phosphoprotein enriched by the Pro-Q? Diamond Enrichment Kit, quantification by a 2D DIGE system and identification by Pro-Q and MALDI-TOF-MS, could be used to produce reliable quantitative data of phosphoproteins that accurately reflects biological differences in a cell system.

Technical Resources of our team
· Agilent 7890a/5975c GC-MS
· Agilent 1100 capillary HPLC with ion trap mass spectrometry(LC-MSMS)
· Agilent capillary electrophoresis apparatus with MSD
· Applied Biosystems Voyager-DE PRO MALDI-TOF-MS
· Tecan Infinite M200 Pro Reader
· Cell culture
· Two-Dimensional Polyacrylamide Gel Electrophoresis (2-D DIGE) .
· Biochemical analysis.
Grants:
v Chinese National Natural Science Foundation Grants No.** 2016-2021
v Chinese National Natural Science Foundation Grants No. **（700，000 RMB）2013.2-2017.2
v Chinese National Natural Science Foundation Grants No. **（360，000 RMB）2011.2-2014.2
v New Century Excellent Talents in University. Grants No. NCET-08-0434, 500,000 Yuan/RMB 2008.9-2011.9
v Natural Science Foundation of Shaanxi Province. Grants No. 2005C259, 20,000 Yuan/RMB 2005.9-2008.9
v Natural Science Foundation of Xi’an Jiao-tong University Grants No.xjj**, 12.000 Yuan/RMB
Professional memberships:
? Member, Chinese Physiological Society, committee of Renal Physiology
? Vice–Chief, Ultrasound Medical Engineering Bio-effect Committee in China.
Selected publication
Zhongmin Tian, Mingyu Liang* Renal metabolism and hypertension. Nature Communication, 2021,12,963. Doi 10.1038 IF：12.3
Di Gao#; Ting Chen#; Shuojia Chen; Xuechun Ren; Yulong Han; Yiwei Li; Ying Wang; Xiaoqing Guo; Hao Wang; Xing Chen; Ming Guo; Yu Shrike Zhang; Guosong Hong; Xingcai Zhang*; Zhongmin Tian*; Zhe Yang*; Targeting hypoxic tumors with hybrid nanobullets for oxygen-independent synergistic photothermal and thermodynamic therapy, Nano-Micro Letters, 2021, DOI: 10.1007/s40820-021-00616-4. IF：11.8
Ying Wang, Di Gao, Yan Liu, Xiaoqing Guo, Shuojia Chen, Li Zeng, Jinxuan Ma, Xingcai Zhang *, Zhongmin Tian*, Zhe Yang* Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine. Bioactive Materials，2021, 6(6):1513-1527. Q1
Zhe Yang, Di Gao, Xiaoqing Guo, Lin Jin, Juanjuan Zheng, Ying Wang, Shuojia Chen, Xuewei Zheng, Li Zeng, Ming Guo, Xingcai Zhang*, and Zhongmin Tian* ACS Nano 2020, 14(12): 17442-17457. IF：15.5
Xue H, Geurts AM, Usa K, Wang F, Lin Y, Phillips J, Henderson L, Baker MA, Tian ZM, Liang M.Fumarase Overexpression Abolishes Hypertension Attributable to endothelial NO synthase Haploin sufficiency in Dahl Salt-Sensitive Rats. Hypertension. 2019, 74(2):313-322 IF：7.017
Yuan Cheng, Haiying Song，Xiaoqing Pan, Hong Xue, Yifei Wan, Tao Wang, Zhongmin Tian, Entai Hou, Ian R. Lanza, Pengyuan Liu, Yong Liu, Purushottam W. Laud, Kristie Usa, Yongcheng He, Mingyu Liang Urinary Metabolites Associated with Blood Pressure on a Low- or High-Sodium Diet. Theranostics. 2018; 8(6): 1468-1480 IF: 8.766
Zhe Yang*, Rui Cheng, Chenyang Zhao, Na Sun, Huiyan Luo, Ya Chen, Zerong Liu, Xian Li, Jie Liu, Zhongmin Tian* Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors. Theranostics, 2018; 8(15): 4097-4115.SCI IF：8.8
Entai Hou, Na Sun, Fuchang Zhang, Chenyang Zhao, Kristie Usa, Mingyu Liang*, Zhongmin Tian，* Malate and Aspartate Increase L-arginine and Nitric Oxide and Attenuate Salt-Sensitive Hypertension. Cell Reports. 2017 19, 1631–1639 IF: 8.28
Yang Z, Sun N, Cheng R, Zhao C, Liu Z, Li X, Liu J, Tian Z*. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells. Biomaterials. 2017，147:53-67. IF:8.402
Alison J. Kriegel, Yi Fang, Yong Liu, Zhongmin Tian et al.MicroRNA-Target Pairs in Human Renal Epithelial Cells treated with Transforming Growth Factor β1: A Novel Role of miR-382 Nucleic Acids Research. 2010, 38(22): 8338-8347. IF：11.147
Zhongmin Tian, Yong Liu, Kristie Usa, Domagoj Mladinov, Yi Fang, Xiaoqiang Ding, Andrew S. Greene, Allen W. Cowley, Jr. Mingyu Liang. Novel Role of Fumarate Metabolism in Dahl-Salt Sensitive Hypertension. Hypertension. 2009，54: 255-260. IF：7.017
Zhongmin Tian, Andrew S. Greene, Jennifer Pietrusz, Isaac R. Matus, and Mingyu Liang MicroRNA–target pairs in the rat kidney identified by microRNA microarray, proteomic, and bioinformatic analysis Genome Research. 2008.18:404-411 IF=11.224
Zhongmin Tian, Andrew S. Greene, Kristie Usa, Isaac R. Matus, Jesse Bauwens, Jennifer L. Pietrusz, Allen W. Cowley, Jr. and Mingyu Liang. Renal Regional Proteomes in Young Dahl Salt-Sensitive Rats. Hypertension. 2008，51(4):899-904. IF：7.017
Xuewei Zheng Meng Chen Xiaoxue Li Pengfei Yang Xinrui Zhao Yanan Ouyang Zhe Yang Mingyu Liang Entai Hou* Zhongmin Tian*Insufficient fumarase contributes to hypertension by an imbalance of redox metabolism in Dahl salt-sensitive rats. Hypertension Research, 2019, 42(11):1672-1682.
Xuewei Zheng, Xiaoxue Li, Meng Chen, Pengfei Yang, Xinrui Zhao, Li Zeng, Yanan OuYang, Zhe Yang and Zhongmin Tian*The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns. Food & Function. 2019, 10(2):849-858