西安交通大学生命科学与技术学院导师教师师资介绍简介-孙晓龙

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Home Page - 孙晓龙基本信息

孙晓龙
教授、博导
海外高层次人才引进青年项目
校青年拔尖人才项目A类
Xiaolong Sun, Professor
ORCID:0000-0003-4003-6924

研究方向
1. 荧光染料、荧光探针、荧光材料、荧光成像
2. 软物质水凝胶、便携设备、细胞支架、组织工程

联系方式
地址：陕西省西安市中国西部科技创新港18号-泓生楼2045室，西安交通大学
邮编：710049
Email: xs2759@xjtu.edu.cn

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Education
03.2015–09.2018, Postdoc fellow/project leader, Depart.Chemistry, University of Texas at Austin, USA.Collaborators: Prof. Eric V. Anslyn, Prof. Andrew Ellington;
09.2012–02. 2015, PhD,Depart. of Chemistry, University of bath,UK.Supervisors: Prof. Tony D. James, Prof. Steven Bull；
03.2012–09. 2012, R&D researcher, Shanghai, 日本东京化成上海化学品公司（TCI）；
09.2009–03.2012, MSc, Applied Chemistry, School of Phamacy, 上海华东理工大学,Supervisor：钱旭红 (Member of Chinese Academy of Engineering);
09.2005–06.2009, BSc, Department of Resources and Environment; Shaanxi Univ. Sci. Tech.

Research Summary
近年来，主持国家自然科学基金、校青年拔尖人才项目、青年教师跟踪项目、JG项目。重要成果体现在以第一/通讯作者发表科研论文16篇，包括Chem. Rev.（2015, IF: 54.301）、Chem Soc. Rev. (2020, IF：42.846)、Nat. Chem. （2019, IF: 23.193）、JACS（2017, 2018, 2020, IF: 14.695）、Angew. Chem. Int. Ed.（2017, IF: 12.257）、ACS Cent. Sci.（2018, IF：12.837）、Chem. Sci.（2014, 2015, 2019, IF：9.556）等。发表在Nat. Chem.上的科研成果，被Nature Research Chem. Commun.、X-Mol、西安交通大学官网等新闻媒体亮点报道；发表于ACS Cent. Sci.???????的研究成果，被《泰晤士报》The Times、福克斯新闻 Fox News、美国科学促进会EurekAlert、人民网、参考消息等100多家国内外新闻媒体以通讯稿/视频采访的形式予以报道; 一作揭示葡萄糖荧光识别机理的研究成果（JACS,2018, 140,2348），被美国化学会志选为热点以DEMYSTIFYING THE FLUORESCENCE OF BORONIC ACID-BASED SUGAR SENSORS 为题在Spotlights on Recent JACS Publications上报道。国内外****、杂志主编、副主编等对其在荧光传感识别领域的诸多成绩给予引用报道。另外，团队申请国际发明专利一项（PCT：WO ）；中国发明专利一项（CN ）。
在2016年分子传感与逻辑门（MSMLG）国际会议做邀请报告、2019年环境催化与传感国际会议（CASE）上做邀请报告；参加国际会议6次，获得2016 MSMLG 会议最佳墙报奖、2013年英日双边J400 Chemonostics会议最佳墙报奖。此外，还曾担任JACS、RSC Adv.、Dyes Pigm.、Textile Research Journal、ChemistrySelect、???????《精细化工》等期刊审稿人。

Research Directions - 孙晓龙具体研究方向
通过化学键的剪裁和重组，以及超越分子层次的非共价作用和组装，化学创造和构建了一个全新的世界，为其他学科的创新研究和快速发展提供了知识基础和物质保障。纵观近年来化学学科的发展，化学正在不断的走向精准化。为此，本课题组以分子的精准合成为原则，通过原理和技术创新，开发新型化学反应，构建特定功能光学分子，探索动态调控的功能材料体系，应用于荧光探针的开发、生物材料的合成、生物成像检测、以及靶向治疗等方面的研究，为开发新材料以及临床诊断和治疗提供有效手段。
方向1：荧光染料，荧光探针，光学标记，荧光成像，生物传感
技术：新型荧光染料开发；信号扩增体系构建；超分辨荧光探针开发
应用：细胞氧化还原平衡标志物检测；低浓度分析物信号扩增检测；糖分子检测和标记；生物应力可视化检测。
方向2：化学合成软物质功能材料（如水凝胶）开发及应用；
技术：动态共价键构筑可调控材料体系；拓扑结构转化材料；生物正交点击化学材料制备
应用：模拟细胞外基质，研究生物力学问题；细胞支架材料；

项目支撑
国家自然科学基金青年项目（2020-2022）
陕西省自然科学基金面上项目（2020-2021）
西安交通大学校青年拔尖人才项目A类（2018-2024）
西安交通大学团队和人才支持青年教师跟踪项目B类（2019-2021）
JG火花课题项目（2020-2021）
陕西省创新团队项目（2020-2022，参与）

分子识别和荧光传感
分子识别与荧光传感在化学工程与材料、生物医学等交叉学科领域有着广阔的应用前景，尤其在医学精准医疗、疾病早期诊断、生物环境检测等方向受到越来越多的关注。
Organic synthesis to prepare small molecules fluorescence probes that can be utilized to understand and exploit biological/environmental systems, mainly in the fluorescent detection of reactive oxygen and nitrogen species, carbohydrates, self-propagating cascades for the detection of nerve agents and combination of small molecular fluorescent probe with supporting materials, such as graphene oxide, porous silicon material, hydrogels. We proposed the strategy of selective detection of peroxynitrile over other reactive oxygen species by using boron-nitrogen interaction. Based on the traditional indicator displacement assay (IDA), we reported a new protocol for the selective detection of targets, referring to reaction-based indicator displacement assay (RIA). We also developed new approaches to auto-Inductive cascades for the optical sensing of fluoride/thiol: application in the ultratrace detection of phosphoryl nerve agents. And we explored and summarized the true mechanism by using nitrogen-boron interaction based fluorescent probe in the detection of saccharides.

软物质功能材料
生物材料新技术：通过化学精准合成，研究开发软物质功能材料，利用动态共价键调控材料性能；水凝胶材料应用于细胞培养、药物释放、组织修复。
Based on dynamic covalent bonding, we are exploring new functional materials, such as hydrogels, plastics.
Chemically TriggeredSynthesis, Remodeling, and Degradation of Soft Materials;
Chemically Triggered Hydrogel Rearrangement through Covalent Adaptable Networks and Applications in 2D/3D Cell Culture;
Synthesis and Degradation of Plasticsvia New Click and Declick Reactions;
Recycling of Soft Materials through Amine-Thiol Coupling and Amine-Amine Decoupling;

Journal of the American Chemical Society 2020, 142 (8), 3913-3922.

Publication - 孙晓龙代表论文
Publications in XJTU:
35. Sun X.,* Wu T.,# Feng X.,#Chemically Triggered Surface-Accessible Soft Material Macroscopic Degradation via Thiol-Initiated Self-Propagating Cascades and Fluorescence Enhancement in Aqueous Media. 2021. In preparation.
34. Wu T.,# Liang T.,# Hu W.,# Du M., Zhang S., Zhang Y., Anslyn E. V.,* Sun X.*Chemically Triggered Click and Declick Reactions: Application in Synthesis and Degradation of Thermosetting Plastics.2021. ACS Macro. Lett.Under review.
33. Feng X., Fu T., Zhang J.,*Sun X.*Synthesis and Recycling of Soft Materials through Amine-Thiol Coupling and Amine-Amine Decoupling via Conjugate Acceptors. 2021,Green Chemistry.In peer review.
32. Liang T.,# Zhang D.,# Hu W.,* Tian C., Zeng L., Wu T., Lei D., Qiang T., Yang X.,* Sun X.*A Dual Lock-and-Key Activatable Fluorescence Probe for Hydrogen Peroxide and Viscosity: High Fidelity Imaging and Therapy in Inflammation. 2021,Talanta. In revision.
31. Chang L., Wang C., Han S., Anslyn E. V.,Sun. X.,* Xu F.* Chemically Triggered Hydrogel Transformations through Covalent Adaptable Networks and Applications inCell Culture.2021,ACS Macro. Lett. Accepted.
30. Wang Y., Sun X.,* Han Q., James, T. D., Wang, X.* Highly Sensitive and Selective Water-Soluble Fluorescent Probe for the Detection of Formaldehyde Extracted from Leather Products. Dyes Pigm. 2021, Accepted.DOI:doi.org/10.1016/j.dyepig.2021.109175(IF: 4.613)
29. Sedgwick A., Brewser J. T., Wu T., Feng X., Bull D. B., Qian X. Sessler J. L.,* James T. D.,* Anslyn E. V.,* and Sun X.* Indicator Displacement Assays (IDAs): The Past, Present and Future. Chem. Soc. Rev., 2021, 50, 9-38 (IF: 42.846, Front cover)

28. Liang T., Yang P., Wu T., Shi M., Xu X., Qiang T., andSun X.*A general strategy to quantify analytes through fluorescence chromaticity and luminosity. Chin. Chem. Lett.2020, 31 (11),2975-2979 (IF: 4.632)

27.Sun X.,ChwatkoM., Lee D. H., Batchman J. L., Reuther J. F., Lynd N. A.,*Anslyn E. V.*Chemically-Triggered Synthesis, Remodeling, and Degradation of Soft Materials.J. Am. Chem. Soc. 2020, 142 (8), 3913-3922 (IF: 14.695)
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纳米人https://mp.weixin.qq.com/s/QuuWj4STC7naRDPMrUaN_w

26. Xiong N., Zhang G., Sun X.*, Zeng R.* Metal-Metal Cooperation in Dinucleating Complexes Involving Late Transition Metals Directed Towards Organic Catalysis. Chin. J. Chem. 2019, 38, 185-201 (IF: 2.376)
25. Wu, L.; Sedgwick, A. C.; Sun, X.; Bull, S. D.; He, X.; James, T. D.*Reaction-based fluorescent probes for the detection and imaging of reactive oxygen, nitrogen and sulfur species. Acc. Chem. Res. 2019,52 (9), 2582-2597(IF: 21.661, ESI 高被引)
Highlighted by X-Mol:mp.weixin.qq.com/s/TRzHc9s9P9zgcxtJq62Qrw
Most Read Articles:https://pubs.acs.org/action/showMostReadArticles?journalCode=achre4
ESI高被引：https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=7&SID=5EeKYdIxpzcRxKro1aT&page=1&doc=1

24.MeadowsM. K.,?Sun X.?KolesnichenkoI. V., Hinson C., JohnsonK. A.,* AnslynE. V.*Mechanistic Studies of a “Declick” Reaction. Chem. Sci. 2019, 10(38), 8817-8824(IF: 9.556)
Highlighted by CBG资讯mp.weixin.qq.com/s/6UDEU5QF5CT3isf85RS08g

23.Sun X., Chapin B. M., Metola P., Collins B., Wang B.,* James T. D.,* Anslyn E. V.*The mechanisms of boronate esterformation and fluorescent turn-on inortho-aminomethylphenylboronic acids.Nat. Chem. 2019, 11, 768-778(IF: 23.193)
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Publications prior XJTU:
22. Sun X.,? Boulgakov A. A.,? Smith L. N., Metola P., Marcotte E. M.,* Anslyn E. V.* Photography Coupled with Self-Propagating Chemical Cascades: Differentiation and Quantitation of G and V Nerve Agent Mimics via Chromaticity. ACS. Cent. Sci. 2018, 4, 854-861 (IF: 12.837)
Highlighted in more than 100 international medias, including The Fox News, The Times, Atlas, etc. Link: blog.sciencenet.cn/home.php

21.Sun X., James T. D.,* Anslyn E. V.* Arresting “Loose Bolt” Internal Conversion from ?B(OH)2 Groups is the Mechanism for Emission Turn-On in ortho-Aminomethylphenylboronic Acid-Based Saccharide Sensors. J. Am. Chem. Soc. 2018, 140, 2348–2354 (IF: 14.695)
Highlighted in Spotlights on Recent JACS Publications
.
20. Sun X., Anslyn E. V.* An Auto-Inductive Cascade for the Optical Sensing of Thiols in Aqueous Condition: Application in the Detection of a VX Nerve Agent Mimic. Angew. Chem. Int. Ed. 2017, 129, 9650-9654 (IF: 12.257);

19. Sun X., Dahlhauser S. D. Anslyn E. V.* New Auto-Inductive Cascade for the Optical Sensing of Fluoride: Application in the Detection of Phosphoryl Fluoride Nerve Agents. J. Am. Chem. Soc. 2017, 139, 4635-4638 (IF: 14.695);
18. Sun, X., James, T. D.* Glucose Sensing in Supramolecular Chemistry. Chem. Rev. 2015, 115, 8001-8037 (IF: 54.301);
ESI高被引文章：https://apps.webofknowledge.com/full_record.do?product=UA&search_mode=GeneralSearch&qid=13&SID=5EeKYdIxpzcRxKro1aT&page=2&doc=18

17.Guo, S.; Chen, J.; Cai, B.-Y.; Chen, W.-W.; Li, Y.-F.; Sun, X.; Chen, G.-R.; He, X.-P.; James, T. D., Low-dimensional materials facilitate the conjugation between fluorogenic boronic acids and saccharides. Materials Chemistry Frontiers 2017, 1 (1), 61-64.
16. Sun X.,Lacina K., Ramsamy E., Flower S. E., Fossey J. S., Qian X. H., Anslyn E. V.,* Bull S.,* and James T. D.* Reaction-based Indicator displacement Assay (RIA) for the selective colorimetric and fluorometric detection of peroxynitrite. Chem. Sci. 2015,6, 2963-2967 (IF: 9.556);
15.Sun, X., Xu, Q.; Kim, G., Flower, S. E., Lowe, J. P., Yoon, J., Fossey, J. S., Qian, X. H., Bull, S.,* and James, T. D.* A water-soluble boronate-based fluorescence probe for the selective detection of peroxynitrite and imaging in living cells. Chem. Sci. 2014. 5, 3368-3373 (Front cover, IF: 9.556);
14.Lampard, E. V.; Sedgwick, A. C.; Sun, X.; Filer, K. L.; Hewins, S. C.; Kim, G.; Yoon, J.; Bull, S. D.; James, T. D., Boronate‐Based Fluorescence Probes for the Detection of Hydrogen Peroxide. ChemistryOpen 2018, 7 (3), 262-265.
13. Yevglevskis, M.; Lee, G. L.; Sun, J.; Zhou, S.; Sun, X.; Kociok-K?hn, G.; James, T. D.; Woodman, T. J.; Lloyd, M. D., A study on the AMACR catalysed elimination reaction and its application to inhibitor testing. Org. Bio. Chem. 2016, 14 (2), 612-622.
12.Sun, X.,? Zhu, B.,? Ji, D.-K., Chen, Q., He, X.-P.,* Chen, G. R.,* James, T. D.,* Selective Fluorescence Detection of Monosaccharides Using a Material Composite Formed Between Graphene Oxide and Boronate-based Receptors. ACS Appl. Mater. Interfaces. 2014, 6, 10078–10082 (IF: 8.456);
11.Sun, X., S.-Y. Xu, S. E. Flower, J. S. Fossey, X. Qian and T. D. James.* "Integrated" and "insulated" boronate-based fluorescent probes for the detection of hydrogen peroxide. Chem. Commun. 2013, 49, 8311-8313 (Front cover, reported in various scientific media, IF: 6.164);
10.Sedgwick, A. C.; Sun, X.; Kim, G.; Yoon, J.; Bull, S. D.; James, T. D., Boronate based fluorescence (ESIPT) probe for peroxynitrite. Chem. Commun. 2016, 52 (83), 12350-12352.
9.Sun X., Zhai W., Fossey J. S. and James T. D.* Boronic acid for fluorescence imaging of carbohydrate. Chem. Commun. feature article. 2016, 52, 3456-3469 (Front cover, IF: 6.164);
8.Sun X., Reuther J. F., Phillips S. T.,* Anslyn E. V.* Coupling Activity-based Detection, Target Amplification, Colorimetric and Fluorometric Signal Amplification, for Quantitative Chemosensing of Fluoride Generated from Nerve Agents. Chem. Eur. J. 2017, 23, 3903-3909 (IF: 5.160);
7.Zhai, W.; Sun, X.; James, T. D.; Fossey, J. S., Boronic Acid‐Based Carbohydrate Sensing. Chem. Asian J. 2015, 10 (9), 1836-1848.
6. Sun, X.; Shabat, D.; Phillips, S. T.; Anslyn, E. V., Self-propagating amplification reactions for molecular detection and signal amplification: Advantages, pitfalls, and challenges. J. Phy. Org. Chem.2018, DOI: 10.1002/poc.3827.
5. Sun, X.; Odyniec, M. L.; Sedgwick, A. C.; Lacina, K.; Xu, S.; Qiang, T.; Bull, S. D.; Marken, F.; James, T. D., Reaction-based indicator displacement assay (RIA) for the colorimetric and fluorometric detection of hydrogen peroxide. Org. Chem. Front.2017, 4 (6), 1058-1062 (IF: 5.076)；
4. Sun, X.; Kim, G.; Xu, Y.; Yoon, J.; James, T. D., A Water-Soluble Copper(II) Complex for the Selective Fluorescence Detection of Nitric Oxide/Nitroxyl and Imaging in Living Cells. ChemPlusChem 2016, 81 (1), 30-34 (IF: 3.441)；
3.Xu, S.-Y.; Sun, X.; Ge, H.; Arrowsmith, R. L.; Fossey, J. S.; Pascu, S. I.; Jiang, Y.-B.; James, T. D., Synthesis and evaluation of a boronate-tagged 1,8-naphthalimide probe for fluoride recognition. Org. Bio. Chem. 2015, 13 (14), 4143-4148.
2.Xu, L.; Xu, Y.; Zhu, W.; Sun, X.; Xu, Z.; Qian, X., Modulating the selectivity by switching sensing media: a bifunctional chemosensor selectivity for Cd 2+ and Pb 2+ in different aqueous solutions. RSC Adv. 2012, 2 (15), 6323-6328
1. Sun, X.; Xu, Y.; Zhu, W.; He, C.; Xu, L.; Yang, Y.; Qian, X., Copper-promoted probe for nitric oxide based on o-phenylenediamine: Large blue-shift in absorption and fluorescence enhancement. Anal. Methods 2012, 4 (4), 919-922 (IF: 2.378).

Team Members - 孙晓龙团队成员
Staff
付涛副教授
Graduates

王丽君博士吴田宏博士宁攀博士

魏泓贝博士边文海博士冯星硕士

王应杰硕士杜美清硕士张鹏科研助理

阮潇潇科研助理韦芳婷科研助理石梦寒本科

Alumini：
康思雨，保送东南大学研究生
王聪，西安交通大学生命学院研究生
常乐，西安交通大学博士生
王岩松，陕西科技大学博士生
胡伟：陕西科技大学师资博士后
王宝帅：陕西科技大学硕士
梁天宇：陕西科技大学博士

Team Activity - 孙晓龙活动内容

Recruitment - 孙晓龙招生信息
1. 团队招聘青年拔尖人才、青秀计划助理教授、科研助理
a) 符合西安交通大学青年拔尖人才计划A类教授和B类特聘研究员的青年才俊。薪酬待遇分别为45万/年、35万/年。
b) 符合“青年优秀人才”计划A、B类，聘为助理教授。A类30万/年，B类16万/年（学校）。薪酬待遇：学校+团队。
c) 有意向申请团队博士、助理教授的人员，在通过学校学院面试考核之前，可先聘为科研助理。
2. 团队招收不同背景的硕士、博士加入SunLab课题组
硕士：招收具有保送资格的应届本科毕业生及2021年报考西安交大的考生。硕士期间表现优异的学生，可在硕士第二年或第三年结束后转博。
博士：招收已有硕士学位或2021年硕士毕业的考生。报考实行考核制，先与导师联系，然后需经过学院组织的面试。硕士和博士的待遇按交大统一标准执行，导师另提供一定数额的助研津贴，优秀者推荐国家奖学金。

博士后：获得国内外高校博士学位，对团队研究方向感兴趣的优秀人才；本实验室提供有竞争力的薪资待遇（待遇大于18万/年，最高可达36万，子女可享受交大优质中小幼教育资源，表现优秀者博士后出站后可申请交大副教授职位)。（不限/年）
1.推荐硕博研究生到英国、美国、欧洲知名高校联合培养或攻读博士学位；
2. 加入课题组的博士后或科研助理，除享受学校和省政府薪资待遇外，课题组会有额外3-5万/年的奖金；
3. 宽松的氛围、严格的训练、亲身的指导、国际国内会议的机会。Let's play with science and enjoy the research!

English Version - 孙晓龙INTRODUCTION
Principle Investigator: Xiaolong Sun
Professor, Xi'an Jiaotong University
E-mail: xs2759@xjtu.edu.cn
WORK EXPERIENCE
10. 2018– Now, Professor (Young Talent A level) in School of Life Sci. Tech., Xi’an Jiaotong Univ., Xi’an, China;
03. 2015– 09. 2018, Postdoc Research Fellow in Chemistry, Univ. of Texas at Austin, U.S. Collaborator: Eric V. Anslyn and Andrew Ellington;
03. 2012 – 09. 2012, R&D Chemist, Tokyo Chemical Industry, Shanghai, China;

EDUCATION
09. 2012 – 03. 2015, PhD, Organic Chemistry, Department of Chemistry, Univ. of Bath, UK; Supervisor: Prof. Tony D. James;
09. 2009 – 02. 2012, MSc, Applied Chemistry, School of Pharmacy, East China Univ. Sci. Tech., Shanghai, China; Supervisor: Prof. Xuhong Qian;
Fluorescence probes; Fluorescence dyes; Fluorescence materials; Fluorescence imaging
One of my research interests include organic synthesis to prepare small molecules fluorescence probes that can be utilized to understand and exploit biological/environmental systems, mainly in the fluorescent detection of reactive oxygen and nitrogen species (Chem. Sci. 2014. 5, 3368-3373; Chem. Sci., 2015, 6, 2963-2967), carbohydrates (Chem. Rev. 2015, 115, 8001-8037), self-propagating cascades for the detection of nerve agents (ACS. Cent. Sci. 2018, 4, 854-861; J. Am. Chem. Soc., 2017, 139, 4635-4638;Angew. Chem. Int. Ed., 2017, 129, 9650-9654) and combination of small molecular fluorescent probe with supporting materials, such as graphene oxide. We proposed the strategy of selective detection of peroxynitrile over other reactive oxygen species by using boron-nitrogen interaction. Based on the traditional indicator displacement assay (IDA), we reported a new protocol for the selective detection of targets, referring to reaction-based indicator displacement assay (RIA) (Chem. Soc. Rev., 2020, DOI: 10.1039/c9cs00538b). We also developed new approaches to auto-inductive cascades for the optical sensing of fluoride/thiol: application in the ultratrace detection of phosphoryl nerve agents. And we explored and summarized the true mechanism by using nitrogen-boron interaction based fluorescent probe in the detection of saccharides (Nat. Chem. 2019, 11, 768-778;J. Am. Chem. Soc., 2018, 140, 2348–2354)

Functional materials: Soft materials; hydrogels; plastics
Based on dynamic covalent bonding, we focuse on designing covalent adaptable networks and constructingconstitutional dynamic networks in soft materials. Werealized chemically-triggered synthesis, remodeling and degradation of soft materials via conjugate acceptor (J. Am. Chem. Soc. 2020, 142, 3913-3922). Other work is under exploration and investigation.