西安交通大学生命科学与技术学院导师教师师资介绍简介-杨哲

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首页 - 杨哲基本信息

杨哲/副教授
硕士生导师
西安交通大学生命科学与技术学院
西安交通大学“十大学术新人”

联系方式

邮箱:yangzhe@xjtu.edu.cn

地址：陕西省西安市西咸新区中国西部创新港18号楼2062

站点计数器

教育经历

2006.9~2010.7 西北大学化学与材料科学学院理学学士
2010.9~2015.6 中山大学生物医学工程学院工学博士
2015.7~2019.1 西安交通大学生命科学与技术学院讲师
2017.10~2018.10 美国加州大学圣地亚哥分校（UCSD) Institute of Genomic Medicine 访问****
2019.2~至今西安交通大学生命科学与技术学院副教授

研究领域
本人及所在研究团队一直从事生物材料、药物控释以及相关生物评价的研究工作，并担任Molecules期刊Broad Editors。在高分子材料合成、纳米载体的制备、分子生物学评价、细胞与动物实验等方面都有丰富的研究经验。目前以第一作者及通讯作者发表SCI论文20余篇，包括纳米技术及高分子材料领域著名期刊ACS Nano, Nano-Micro Letters, Biomaterials, Bioactive Materials及Theranostics等，其中ESI高被引论文一篇；获4项国家发明专利、1件实用新型专利。
主要研究方向：
新型生物可降解材料的设计与合成
纳米医学与肿瘤免疫治疗
靶向纳米技术针对盐敏感高血压等慢性代谢疾病的诊疗研究
组织修复与再生

研究成果 - 杨哲发表文章
Gao Di, Chen Ting, Chen Shuojia, Ren Xuechun, Han Yulong, Li Yiwei, Wang Ying, Guo Xiaoqing, Wang Hao, Chen Xing, Guo Ming, Zhang Yu Shrike, Hong Guosong, Zhang Xingcai*, Tian Zhongmin*, Yang Zhe* (Correspondence author). Targeting Hypoxic Tumors with Hybrid Nanobullets for Oxygen-Independent Synergistic Photothermal and Thermodynamic Therapy (2021). Nano-Micro Letters, 12, 99. （Cover）
Wang Y., Gao D., Liu Y., Guo X., Chen S., Zeng L., Ma J., Zhang X., Tian Z.*, Yang Z.* (Correspondence author). Immunogenic-cell-killing and immunosuppression-inhibiting nanomedicine (2021). Bioactive Materials, 6, 1513-1527.
Jin Lin*, Guo Xiaoqing, Gao Di, Wu Cui, Hu Bin, Tan Guangxuan, Du Nannan, Cai Xiaolu, Yang Zhe* (Co-correspondence author), Zhang Xingcai*. NIR-responsive MXene nanobelts for wound healing (2021). NPG Asia Materials, 13, 24.
Yang Z., Gao D., Guo X., Jin L., Zheng J., Wang Y., Chen S., Zheng X., Zeng L., Guo M., Zhang X.*, Tian Z.* Fighting immune cold and reprogramming immunosuppressive tumor microenvironment with red blood cell membrane-camouflaged nanobullets (2020). ACS Nano, 14, 17442–17457.
Gao D., Guo X.Q., Zhang X., Chen S., Wang Y., Chen T., Huang G., Gao Y.Z.*, Tian Z.*, Yang Z.* (Correspondence author). Multifunctional phototheranostic nanomedicine for cancer imaging and treatment (2020). Materials Today Bio, 5:100035. （ESI高被引）
Gao D., Wong R., Wang Y., Guo X., Yang Z.* (co-correspondence author), Lo P.C.* Shifting the absorption to the near-infrared region and inducing a strong photothermal effect by encapsulating zinc (II) phthalocyanine in poly(lactic-co-glycolic acid)-hyaluronic acid nanoparticles (2020). Acta Biomaterialia, 116, 329-343.
Huang R., Chen X., Dong Y., Zhang X., Wei Y., Yang Z.F., Li W., Guo Y., Liu J., Yang Z. (co-correspondence author)*, Wang H.*, Jin L.* MXene composite nanofibers for cell culture and tissue engineering (2020). ACS Applied Bio Materials, 3, 2125-2121.
Zheng X.W., Li X.X., Chen M., Yang P.F., Zhao X.R., Zeng L., OuYang Y.N., Yang Z.* (co-correspondence author) and Tian Z.M.* The protective role of hawthorn fruit extract against high salt-induced hypertension in Dahl salt-sensitive rats: impact on oxidative stress and metabolic patterns (2019). Food & Function, 2019: 10, 849-858.
Yang Z., Cheng R., Zhao C., Sun N., Luo H., Chen Y., Liu Z., Li X., Liu J., Tian Z. M. Thermo- and pH-dual responsive polymeric micelles with upper critical solution temperature behavior for photoacoustic imaging-guided synergistic chemo-photothermal therapy against subcutaneous and metastatic breast tumors (2018). Theranostics, 8: 4097-4115.
Sun N., Zhao C., Cheng R., Liu Z., Li X., Lu A., Tian Z. M.*, Yang Z.*(Correspondence author) Cargo-free nano-medicine with pH-sensitivity for co-delivery of DOX conjugated prodrug with SN38 to synergistically eradicate breast cancer stem cells (2018). Molecular Pharmaceutics, 15: 3343-3355
Zhao C., Cheng R., Yang Z.* (co-correspondence author), Tian Z. M.* Nanotechnology for Cancer Therapy Based on Chemotherapy (2018). Molecules, 23:826
Wang Y., Yang P.F., Zhao X. R., Gao D., Tian Z.M., Ma T. Y. and Yang Z.* (Correspondence author) Multifunctional Cargo-Free Nanomedicine for Cancer Therapy (2018). International Journal of Molecular Sciences, 19: E2963.
Yang Z., Sun N., Cheng R., Zhao C. Y., Liu Z., Li X., Liu J. and Tian Z. M. pH multistage responsive micellar system with charge-switch and PEG layer detachment for co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells (2017). Biomaterials, 147: 53-67.
Yang Z.，Li Y.Q.，Gao J.B.，Cao Z.，Jiang Q. and Liu J.，pH and redox dual-responsive multifunctional gene delivery with enhanced capability of transporting DNA into the nucleus (2017). Colloids and Surfaces B: Biointerfaces，153:111-122.
Yang Z., Sun N., Cheng R., Zhao C. Y., Liu J. and Tian Z. M. Hybrid nanoparticles coated with hyaluronic acid lipoid for targeted co-delivery of paclitaxel and curcumin to synergistically eliminate breast cancer stem cells (2017). Journal of Materials Chemistry B, 5: 6762-6775.
Yang Z., Tang W.X., Luo X.G., Zhang X.F., Zhang C., Li H., Gao D., Luo H.Y., Jiang Q. and Liu J. Dual-Ligand Modified Polymer-Lipid Hybrid Nanoparticles for Docetaxel Targeting Delivery to Her2/neu Overexpressed Human Breast Cancer Cells (2015). Journal of Biomedical Nanotechnology, 11:1401-1417.
Yang Z., Gao D., Cao Z., Zhang C., Cheng D., Liu J. and Shuai X.T. Drug and gene co-delivery systems for cancer treatment (2015). Biomaterials Science, 3:1035-1049.
Yang Z., Jiang Z.Z., Cao Z., Zhang C., Gao D., Luo X.G., Zhang X.F., Luo H.Y., Jiang Q. and Liu J. Multifunctional non-viral gene vectors with enhanced stability, improved cellular and nuclear uptake capability, and increased transfection efficiency (2014). Nanoscale, 6:10193-10206.
Yang Z., Zhang X.F., Luo X.G., Jiang Q., Liu J., and Jiang Z.Z. Enzymatic Synthesis of Poly(butylene-co-sebacate-co-glycolate) Copolyesters and Evaluation of the Copolymer Nanoparticles as Biodegradable Carriers for Doxorubicin Delivery (2013). Macromolecules, 46:1743-1753.
Yang Z., Luo X.G., Zhang X.F., Liu J. and Jiang Q. Targeted delivery of 10-hydroxycamptothecin to human breast cancers by cyclic RGD-modi?ed lipid–polymer hybrid nanoparticles (2013). Biomedical Materials, doi:10.1088/1748-6041/8/2/025012.

申请国家发明专利
1. 杨哲，田中民，赵晨阳，孙娜，程瑞。《pH响应型无载体纳米药物制剂及制备方法、应用》 2017，国家发明专利，专利申请号：3.3
2.杨哲，田中民，程瑞，赵晨阳，孙娜。《高临界相转变温度及pH双响应型“化疗-光热协同治疗”纳米粒子的制备方法及应用》2018，国家发明专利，专利申请号：1.1

3.刘杰，蒋庆，杨哲。《一种靶向复合型纳米粒子的制备方法》 2013，国家发明专利，授权专利号：4.1

4.刘杰，杨哲，骆卉妍，蒋庆，徐瑞华，李颖琴。《一种负载7-乙基-10-羟基喜树碱的双靶向复合纳米粒子及其制备方法和应用》2015，国家发明专利，授权专利号：5.2

5.刘杰，蒋庆，杨哲，路振平，甘盛龙。《一种聚乳酸-羟基乙酸共聚物纳米药物载体及其制备方法和应用》2014，国家发明专利，授权专利号：4.2

6.刘杰，蒋庆，罗新根，舒雅俊，杨哲。《一种集成式多功能微纳样品制备装置》2013，国家发明专利，授权专利号：8.0