西安交通大学生命科学与技术学院导师教师师资介绍简介-谢文俊

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基本信息 - 谢文俊基本信息
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谢文俊 PhD
特聘研究员,博导
西安交通大学青年拔尖人才
本科和硕士毕业于北京大学力学系，博士毕业于北京大学分子医学研究所。2010-2015在美国哥伦比亚大学医学中心从事博士后研究。2015年加入西安交通大学。中国老年学会老年病学分会衰老基础医学专家委员会委员。迄今发表论文30余篇，总影响因子超过300，被引用2000余次。主持多项国家及省部级自然科学基金项目。

联系方式
单位：西安交通大学生命科学与技术学院
地址：陕西省西安市西咸新区沣西新城交大创新港科创基地18号楼1059
email：xiewenjun (a) xjtu.edu.cn

工作经历
2015-至今西安交通大学生命科学与技术学院健康与康复科学研究所，特聘研究员
2010-2015美国哥伦比亚大学医学中心生理学与细胞生物物理学系，博士后
2005-2006北京大学分子医学研究所钙信号实验室，研究助理

教育经历
2010理学博士北京大学分子医学研究所生物物理学专业
2002理学硕士北京大学力学与工程科学系流体力学专业
1999理学学士北京大学力学与工程科学系理论与应用力学专业

研究领域
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心血管疾病是当前威胁人类健康的最重大问题，特别是老年人口，很大部分都受到心血管疾病的影响。过去几十年世界各国都投入很大精力对心血管疾病进行研究和治疗，然而至今许多问题仍然亟待解决，心血管病患病人数仍在持续增长。随着人口老龄化进程的加速，预计未来这一问题必将更加突出。因此开辟新的研究视野和角度对探索心血管疾病的机理，寻求有效的防治策略很有必要。
当前本实验室研究课题聚焦在各类心血管疾病中细胞内钙离子和其它重要离子信号的重构以及由此引起的细胞和器官的功能紊乱。研究方法包括细胞和完整组织上的共聚焦成像，电生理记录，以及分子生物学技术等，此外还通过计算机数值模拟从理论上预测和解释复杂的病生理现象。具体的研究方向如下：
心脏病生理钙信号转导。钙离子是最广泛、最重要的胞内第二信使。在心脏中，钙离子是心肌细胞兴奋收缩耦联的关键因子，对调控心脏的收缩功能起着至关重要的作用。许多常见的心脏疾病，包括心肌肥大、心力衰竭、心律失常等，都与心肌细胞内钙信号的失调相关联。胞外溶液、细胞质、细胞器（肌质网和线粒体等）构成了心肌细胞钙离子活动的亚空间，这些亚空间之间钙离子转运平衡被打破将引起心肌细胞和心脏功能紊乱。我们拟通过探索各个亚空间钙信号的生理和病理调控作用，进一步理解心血管疾病的发病机制，并寻找新的分子靶点和药物。
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???????Qi Y, Li JJ, Di XH, Zhang Y et al., Biochim Biophys Acta Mol Cell Res???????. 2021
心血管病的力学-生物学探讨。心血管是一个具有显著的力学特性的系统，一方面，心脏通过兴奋收缩偶联产生节律的收缩舒张实现泵血功能，另一方面，血流通过剪切力和压力等作用于心脏和血管，调控其各种细胞的功能，很多心血管病理情况（如高血压等）往往伴随着力和机械作用的变化。我们拟通过结合力学和生理学的相关知识，研究病生理情况下心血管系统中力学和机械作用的变化以及其对细胞和组织功能的影响和调控，从力学-生物医学这一新的角度来研究心血管疾病发生发展的分子机制，为进一步阐明这些问题、探寻解决方案提供新的思路。
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Zhang Y, Qi Y, Li JJ et al., Cardiovasc Res. 2021
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心血管病的数字细胞模型研究。钠钾钙等离子是心脏兴奋收缩偶联的关键因子，这些离子信号的失调是导致心血管疾病的一个非常重要因素。尽管当前很多生物医学实验室对这方面进行了研究，但大部分研究都是定性的，在定量研究上还比较缺乏。我们将采取生物实验与计算机数值模型结合，研究细胞内不同离子在病生理条件下的定量变化，建立一个较全面的数字细胞以及虚拟心脏模型来分析不同条件下心肌细胞内这些离子信号的变化，及其对组织宏观信号和行为的影响，以期掌握心血管病生理变化规律，为心血管疾病提供预报系统。
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研究成果 - 谢文俊已发表论文
(^# co-first authors, * corresponding author)
???????1. Yi Zhang^#, Ying Qi^#, Jing-Jing Li^#, Wen-Jin He, Xiao-Hang Gao, Yu Zhang, Xia Sun, Jie Tong, Jianbao Zhang, Xiu-Ling Deng, Xiao-Jun Du, andWenjun Xie*. Stretch-induced sarcoplasmic reticulum calcium leak is causatively associated with atrial fibrillation in pressure-overloaded hearts.Cardiovasc Res.2021 Apr. 117(4):1091-1102. (IF:8.168)
2. Ying Qi^#, Jing-Jing Li^#, Xiao-Hui Di^#, Yu Zhang^#, Jie-Long Chen, Zi-Xuan Wu, Zi-Yue Man, Ru-Yue Bai, Fujian Lu, Jie Tong, Xue-Liang Liu, Xiu-Ling Deng, Jianbao Zhang, Xing Zhang, Yi Zhang*, and Wenjun Xie*. Excess sarcoplasmic reticulum-mitochondria calcium transport induced by Sphingosine-1-phosphate contributes to cardiomyocyte hypertrophy.Biochim Biophys Acta Mol Cell Res.2021 Apr. 1868(5):118970.??????(IF:4.105)
3. Yongfa Huang^#, Chuxiang Lei^#, Wenjun Xie^#, Li Yan^#, Yanru Wang^#, Su Yuan^#, Jing Wang^#, Yan Zhao, Zhaojian Wang, Xiaoying Yang, Xiaohan Qin, Quan Fang, Ligang Fang, and Xiaoxiao Guo*. Oxidation of ryanodine receptors promotes Ca²⁺ leakage and contributes to right ventricular dysfunction in pulmonary hypertension.Hypertension.2021Jan. 77(1):59-71. (IF:7.713)
4. Fujian Lu*^#, Yan Zhao^#, Wenjun Xie, Qianjin Guo, Shi-Qiang Wang, Xianhua Wang, and Heping Cheng*. Imaging Sarcoplasmic Reticulum Ca²⁺ Signaling in Intact Cardiac Myocytes. Circulation.2020 October 13. 142(15):1503-1505. (IF:23.603)
5. Yi Zhang^#, Meng-Chen Hou^#, Jing-Jing Li, Ying Qi, Yu Zhang, Gang She, Yu-Jie Ren, Wei Wu, Zheng-Da Pang, Wenjun Xie, Xiu-Ling Deng*, and Xiao-Jun Du*. Cardiac β-adrenergic receptor activation mediates distinct and cell type-dependent changes in the expression and distribution of connexin 43. J Cell Mol Med.2020 Aug. 24(15):8505-8517.(IF:4.486)
6. Xiao-Hui Wang^#, Min Su^#, Feng Gao^#, Wenjun Xie^#, Yang Zeng^#, De-Lin Li^#, Xue-Lei Liu, Hong Zhao, Li Qin, Fei Li, Qun Liu, Oliver B Clarke, Sin Man Lam, Guang-Hou Shui, Wayne A Hendrickson*, and Yu-Hang Chen*. Structural basis for activity of TRIC counter-ion channels in calcium release. Proc Natl Acad Sci U S A. 2019 Mar 5; 116(10):4238-4243. (IF:9.580)
7. Jun Li, Jie Xu, Xinghua Qin, Hongyan Yang, Juntao Han, Yanhui Jia, Huayu Zhu, Liang Zhu, Jia Li, Wenjun Xie, Dahai Hu, Xing Zhang*, and Feng Gao*. Acute pancreatic beta cell apoptosis by IL-1β is responsible for postburn hyperglycemia: Evidence from humans and mice. Biochim Biophys Acta Mol Basis Dis. 2019 Feb 1;1865(2):275-284. (IF:4.328)
8. Jie Tong, Ying Qi, Xiangmiao Wang, Liyin Yu, Chang Su, Wenjun Xie, and Jianbao Zhang*. Cell micropatterning reveals the modulatory effect of cell shape on proliferation through intracellular calcium transients. Biochim Biophys Acta Mol Cell Res. 2017 Dec; 1864(12):2389-2401. (IF:4.521)
9. Junqing Sun, Wenjun Xie, Liang Shi, Liyin Yu, and Jianbao Zhang*. Simulation of intracellular Ca²⁺ transients in osteoblasts induced by fluid shear stress and its application. BioMech Model Mechanobiol. 2017 Apr; 16(2):509-520. (IF:3.323)
10.Jinghui Li, Wenjun Xie, Xi Chen, Yunlong Huo, Heping Cheng, and Wenchang Tan*. A novel stochastic reaction-diffusion model of Ca²⁺ blink in cardiac myocytes. Sci Bull. 2017 Jan; 62(1):5-8. (IF:6.277)
11.David L. Waning^#, Khalid S. Mohammad^#, Steven Reiken, Wenjun Xie, Daniel C. Andersson, Sutha John, Antonella Chiechi, Laura E. Wright, Alisa Umanskaya, Maria Niewolna, Trupti Trivedi, Sahba Charkhzarrin, Pooja Khatiwada, Anetta Wronska, Ashley Haynes, Maria Serena Benassi, Frank A. Witzmann, Gehua Zhen, Xiao Wang, Xu Cao, G. David Roodman, Andrew R. Marks, and Theresa A. Guise*. Excess TGF-β mediates muscle weakness associated with bone metastases in mice. Nat Med. 2015 Nov; 21(11):1262-1271. (IF:30.357)
12.Gaetano Santulli^#, Wenjun Xie^#, Steven R. Reiken, and Andrew R. Marks*. Mitochondrial calcium overload is a key determinant in heart failure. Proc Natl Acad Sci U S A. 2015 Sep 8; 112(36):11389-94. (IF:9.674)
13.Wenjun Xie^#, Gaetano Santulli^#, Steven R. Reiken, Qi Yuan, Brent W. Osborne, Bi-Xing Chen, and Andrew R. Marks*. Mitochondrial oxidative stress promotes atrial fibrillation. Sci Rep. 2015 Jul 14; 5:11427. (IF:5.578)
14.Gaetano Santulli, Gennaro Pagano, Celestino Sardu, Wenjun Xie, Steven Reiken, Salvatore Luca D’Ascia, Michele Cannone, Nicola Marziliano, Bruno Trimarco, Theresa A. Guise, Alain Lacampagne, and Andrew R. Marks*. Calcium release channel RyR2 regulates insulin release and glucose homeostasis. J Clin Invest. 2015 May; 125(5):1968-78. (IF:13.215)
15.Jim W. Cheung*^#, Albano C. Meli^#, Wenjun Xie, Suneet Mittal, Steven Reiken, Anetta Wronska, Linna Xu, Jonathan S. Steinberg, Steven M. Markowitz, Sei Iwai, Alain Lacampagne, Bruce B. Lerman, and Andrew R. Marks*. Short-coupled polymorphic ventricular tachycardia at rest linked to a novel ryanodine receptor (RyR2) mutation: leaky RyR2 channels under non-stress conditions. Int J Cardiol. 2015 Feb 1; 180:228-36. (IF:6.175)
16.Alisa Umanskaya^#, Gaetano Santulli^#, Wenjun Xie^#, Daniel C. Andersson, Steven R. Reiken, Andrew R. Marks*. Genetically enhancing mitochondrial antioxidant activity improves muscle function in aging. Proc Natl Acad Sci U S A. 2014 Oct 21; 111(42):15250-5. (IF:9.809)
17.Wenjun Xie, Gaetano Santulli, Xiaoxiao Guo, Melanie Gao, Bi-Xing Chen, and Andrew R. Marks*. Imaging atrial arrhythmic intracellular calcium in intact heart. J Mol Cell Cardiol. 2013 Nov; 64:120-3. (IF:5.148)
18.Prakash Subramanyam, Donald D. Chang, Kun Fang, Wenjun Xie, Andrew R. Marks, and Henry M. Colecraft*. Manipulating L-type calcium channels in cardiomyocytes using split-intein protein transsplicing. Proc Natl Acad Sci U S A. 2013 Sep 17; 110(38):15461-6. (IF:9.737)
19.Xiaoping Liu, Matthew J. Betzenhauser, Steve Reiken, Albano C. Meli, Wenjun Xie, Bi-Xing Chen, Ottavio Arancio, and Andrew R. Marks*. Role of leaky neuronal ryanodine receptors in stress-induced cognitive dysfunction. Cell. 2012 Aug 31; 150(5):1055-67. (IF:32.403)
20.Jian Shan, Wenjun Xie, Matthew Betzenhauser, Steven Reiken, Bi-Xing Chen, Anetta Wronska, and Andrew R. Marks*. Calcium leak through ryanodine receptors leads to atrial fibrillation in 3 mouse models of catecholaminergic polymorphic ventricular tachycardia. Circ Res. 2012 Aug 31; 111(6):708-17. (IF: 11.551)
21.Kaitao Li, Wanrui Zhang, Huaqiang Fang, Wenjun Xie, Jie Liu, Ming Zheng, Xianhua Wang, Wang Wang, Wenchang Tan*, and Heping Cheng*. Superoxide flashes reveal novel properties of mitochondrial reactive oxygen species excitability in cardiomyocytes. Biophys J. 2012 Mar 7; 102(5):1011-21. (IF:4.218)
22.Daniel C. Andersson, Mathew J. Betzenhauser, Steven Reiken, Albano C. Meli, Alisa Umanskaya, Wenjun Xie, Takayuki Shiomi, Ran Zalk, Alain Lacampagne, and Andrew R. Marks*. Ryanodine receptor oxidation causes intracellular calcium leak and muscle weakness in aging. Cell Metab. 2011 Aug 3; 14(2):196-207. (IF:18.207)
23.Didier X.P. Brochet*, Wenjun Xie, Dongmei Yang, Heping Cheng*, and W. Jonathan Lederer. Quarky calcium release in the heart. Circ Res. 2011 Jan 21; 108(2):210-8. (IF: 11.551)
24.Wenjun Xie, Didier X.P. Brochet, Sheng Wei, Xianhua Wang, and Heping Cheng*. Deciphering ryanodine receptor array operation in cardiac myocytes. J Gen Physiol. 2010 Aug; 136(2):129-33. (IF:4.511)
25.Xianhua Wang*^#, Wenjun Xie^#, Yi Zhang^#, Peihui Lin, Liang Han, Peidong Han, Yanru Wang, Zheng Chen, Guangju Ji, Ming Zheng, Noah Weisleder, Rui-Ping Xiao, Hiroshi Takeshima, Jianjie Ma*, and Heping Cheng. Cardioprotection of ischemia/reperfusion injury by cholesterol-dependent MG53-mediated membrane repair. Circ Res. 2010 Jul 9; 107(1):76-83. (IF: 11.551)
26.Gang Wang^#, Xiaojun Zhu^#, Wenjun Xie, Peidong Han, Kaitao Li, Zhongcui Sun, Yanru Wang, Chunlei Chen, Ruisheng Song, Chunmei Cao, Jifeng Zhang, Caihong Wu, Jie Liu*, and Heping Cheng. Rad as a novel regulator of excitation–contraction coupling and β-adrenergic signaling in heart.Circ Res. 2010 Feb 5; 106(2):317-27. (IF: 11.551)
27.Wangyi Wu*, Wenjun Xie. Basic function method: A new numerical method on unstructured grids. Sci China Ser G. 2009, 52(12):2016-26. (IF:1.575)
28.Yuan Yan, Jie Liu, Chaoliang Wei, Kaitao Li, Wenjun Xie, Yanru Wang, and Heping Cheng*. Bidirectional regulation of Ca²⁺ sparks by mitochondria-derived reactive oxygen species in cardiac myocytes. Cardiovasc Res. 2008 Jan 15; 77(2):432-41. (IF:6.127)
29.Bailong Xiao, Xixi Tian, Wenjun Xie, Peter P. Jones, Shitian Cai, Xianhua Wang, Dawei Jiang, Huihui Kong, Lin Zhang, Keyun Chen, Michael P. Walsh, Heping Cheng, and S. R. Wayne Chen*. Functional consequence of protein kinase A-dependent phosphorylation of the cardiac ryanodine receptor: sensitization of store overload-induced Ca²⁺ release. J Biol Chem. 2007 Oct 12; 282(41):30256-64. (IF:5.581)
30.Wenchang Tan*, Chaoqi Fu, Ceji Fu, Wenjun Xie, and Heping Cheng*. An anomalous subdiffusion model for calcium spark in cardiac myocytes. Appl Phys Lett. 2007, 91(18):183901-3. (IF:3.596)

专利与软件著作权
1. 谢文俊，贺雯瑾，张伊，李晶晶，戚瑛。一种评价肌浆网钙泄漏的方法，国家发明专利，授权日期：2020.07.10，专利号：ZL6.2
2. 谢文俊，贺雯瑾，张伊，戚瑛，李晶晶。钙火花全自动分析系统v1.0，计算机软件著作权，授权日期：2019.07.16，登记号：2019SR**