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西安交通大学生命科学与技术学院导师教师师资介绍简介-郭 燕

本站小编 Free考研考试/2021-06-26

个人主页 - 郭 燕联系方式

郭燕,教授
博士,博士生导师
Email: guoyan253mail.xjtu.edu.cn
单位:生命科学与技术学院生物信息中心,教二楼北211
地址:西安交通大学咸宁西路28号,710049




友情链接
研究生院
交大生命学院
杨铁林老师




站点计数器




教育经历


2007.03-2009.12 西安交通大学生命科学与技术学院 生物学 理学博士

2004.09-2007.01 西安交通大学生命科学与技术学院 生物物理学 理学硕士

2000.09-2004.07 西安交通大学生命科学与技术学院 生物工程 工学学士


2008.08-2009.11 研究助理,美国密苏里大学堪萨斯城分校医学院 国家公派留学
2005.01-2006.01 研究助理,美国Creighton大学骨质疏松研究中心





学术交流

2014.10 参加第七届国际骨质疏松及骨矿盐疾病学术会议 厦门 中国 口头发言 “Genetic association study identifies DDR2 as a new gene for bone mineral density and osteoporotic fractures in Chinese population”
2009.09 Oral Presentation: The 31st Annual Meeting of American Society for Bone and Mineral Research (ASBMR), 2009.09, USA. “PTH and IL21R May Underlie Variation of Femoral Neck Bone Mineral Density as Suggested by a Genome-wide Association Study”
2006.10 参加国际骨质疏松-骨与关节大会 中国 成都 会议收录论文“女性初潮年龄与骨密度的遗传及环境相关性研究”
2005.10 参加第27届美国骨矿盐研究学会 纳什维尔 美国




获奖情况
2013.03 陕西高等学校科学技术奖 一等奖(13Y10) 骨质疏松症易感基因/位点检验及遗传通路研究 第2完成人
2010.09 博士毕业论文“骨质疏松症及其相关性状易感基因定位的系统遗传学研究”被评为西安交通大学优秀博士论文
2009.09 获得第31届美国骨矿盐研究学会(ASBMR)颁发的Shun-Ichi Harada Young Investigator Award(青年学奖),大会仅三人获此殊荣,奖金1000美金。投递的论文被大会选中,并应邀作大会报告
2009.06 获得美国华盛顿大学(西雅图)资助的旅行奖1300美金,参加华盛顿大学主办的夏季统计遗传学研讨班
2007.07-2007.08 获得教育部资助的旅行奖,参加由清华大学主办的“2007年全国生物信息学研究生暑期学校”,获得结业证书。
2006-2007 西安交通大学“优秀毕业生”称号
2005-2006 唐文治特别优秀研究生奖学金 8000RMB,“优秀研究生”称号








个人主页 - 郭 燕联系方式

郭燕,教授
博士,博士生导师
Email: guoyan253mail.xjtu.edu.cn
单位:生命科学与技术学院生物信息中心,教二楼北211
地址:西安交通大学咸宁西路28号,710049




友情链接
研究生院
交大生命学院
杨铁林老师




站点计数器




教育经历


2007.03-2009.12 西安交通大学生命科学与技术学院 生物学 理学博士

2004.09-2007.01 西安交通大学生命科学与技术学院 生物物理学 理学硕士

2000.09-2004.07 西安交通大学生命科学与技术学院 生物工程 工学学士


2008.08-2009.11 研究助理,美国密苏里大学堪萨斯城分校医学院 国家公派留学
2005.01-2006.01 研究助理,美国Creighton大学骨质疏松研究中心





学术交流

2014.10 参加第七届国际骨质疏松及骨矿盐疾病学术会议 厦门 中国 口头发言 “Genetic association study identifies DDR2 as a new gene for bone mineral density and osteoporotic fractures in Chinese population”
2009.09 Oral Presentation: The 31st Annual Meeting of American Society for Bone and Mineral Research (ASBMR), 2009.09, USA. “PTH and IL21R May Underlie Variation of Femoral Neck Bone Mineral Density as Suggested by a Genome-wide Association Study”
2006.10 参加国际骨质疏松-骨与关节大会 中国 成都 会议收录论文“女性初潮年龄与骨密度的遗传及环境相关性研究”
2005.10 参加第27届美国骨矿盐研究学会 纳什维尔 美国




获奖情况
2013.03 陕西高等学校科学技术奖 一等奖(13Y10) 骨质疏松症易感基因/位点检验及遗传通路研究 第2完成人
2010.09 博士毕业论文“骨质疏松症及其相关性状易感基因定位的系统遗传学研究”被评为西安交通大学优秀博士论文
2009.09 获得第31届美国骨矿盐研究学会(ASBMR)颁发的Shun-Ichi Harada Young Investigator Award(青年学奖),大会仅三人获此殊荣,奖金1000美金。投递的论文被大会选中,并应邀作大会报告
2009.06 获得美国华盛顿大学(西雅图)资助的旅行奖1300美金,参加华盛顿大学主办的夏季统计遗传学研讨班
2007.07-2007.08 获得教育部资助的旅行奖,参加由清华大学主办的“2007年全国生物信息学研究生暑期学校”,获得结业证书。
2006-2007 西安交通大学“优秀毕业生”称号
2005-2006 唐文治特别优秀研究生奖学金 8000RMB,“优秀研究生”称号








科学研究 - 郭 燕研究领域
研究领域主要包括:生物信息学,复杂疾病遗传学,细胞生物学,生物化学与分子生物学。具体研究方向:1. 肥胖/骨质疏松症等复杂疾病易感基因鉴定及遗传流行病学分析2.拷贝数变异、ROH等变异对复杂疾病的影响研究3.高通量数据挖掘4.测序数据分析及方法探索5.疾病新易感基因功能研究




学术任职

SICOT(国际矫形与创伤外科学会)中国骨科分会基础学组委员,2015至今
Journal of Orthopaedics, 编委




科研项目

国家自然科学基金面上项目(**),基于GWAS遗传信息构建生物分子互作网络鉴定中国人群骨质疏松症易感基因,2015.01-2018.12,负责人,85万

国家自然科学基金青年项目(**),PTH和IL21R基因多态性与骨质疏松症的遗传关联研究,2011.01-2013.12,负责人,20万

国家自然科学基金国际(地区)合作与交流项目(), 骨质疏松症的全基因组关联分析结果在不同人群中的验证, 2011.07-2013.06, 负责人,4.5万
中国博士后科学基金,一等(2015M570820),探寻骨质疏松新易感基因
SOX6功能致病位点及分子机制,2015.01-2016.12, 负责人,8万

陕西省自然科学基础研究计划(2015JQ3089),GWAS鉴定的骨质疏松新易感基因SOX6分子遗传机制深层探究,2015.01-2017.12, 负责人,2万
国家自然科学基金(**),MTHFR和TRHR基因多态性与少肌症的遗传关联研究,2010.01-2012.12,参与,22万
教育部聘请外国文教专家计划,高维数据模拟在复杂疾病研究中的应用,2011,负责人,1万
西安交通大学“新兴前沿、学科综合交叉类科研项目”(xjj**),建立基于通路的全基因组关联分析方法并用其研究骨质疏松症的发病机制,2011.01-2013.12,负责人,8万
西安交通大学“国际科技合作项目”( 2012jdhz44),基于基因组富集分析的骨质疏松症的全基因组关联研究,2012-2014,负责人,8万
西安交通大学“新教师科研支持计划”, 骨质疏松症重要易感基因定位的遗传学关联研究,2010.03-2013.02,负责人,15万
国家级大学生创新基金,线粒体DNA变异对中国人群骨质疏松症的影响,2011.01-2012.12,指导教师,1万元








研究团队 - 郭 燕研究团队

一、教师
郭燕,博士,博士生导师 闫菡:博士
研究方向:基因组学,高通量数据挖掘, 研究方向:疾病新易感基因鉴定
疾病新易感基因功能研究 email: iamyanhan@126.com
email:guoyan253@mail.xjtu.edu.cn
二、教研室全体成员
三、博士研究生
董珊珊:13级博士,山东人 荣正 勤:14级博士,江苏人
研究方向:高通量数据挖掘 研究方向:高通量数据挖掘及算法开发
email:ssdong1985@gmail.com email:h**f@stu.xjtu.edu.cn

朱 东 丽:2014级博士生,山东人 Tyhnn:15级博士,缅甸人
研究方向:骨质疏松新易感基因功能 研究方向:肥胖新易感基因功能
email:zhudongli@stu.xjtu.edu.cn email:hlaingnwethynn@gmail.com

四、硕士研究生
荆颖艾莎:13级硕士,陕西人 郝 若 涵:14级硕士,陕西人
研究方向:骨质疏松易感基因鉴定及功能分析 研究方向:肥胖易感基因鉴定及功能分析
email:jingyingaisha@stu.xjtu.edu.cn email:haoruohan@stu.xjtu.edu.cn

陈 晓 峰:14级硕士,湖南人 陈佳斌:14级硕士,陕西人
研究方向:基因功能网络分析 研究方向:生物信息学
email:a123456@stu.xjtu.edu.cn email:johnlcd@stu.xjtu.edu.cn

杨 熳:15级硕士,湖北人 姚 石:15级硕士,河北人
研究方向:生物信息人类学 研究方向:高通量数据挖掘
email:ymx6800@stu.xjtu.edu.cn email:studentyaoshi@stu.xjtu.edu.cn

卢 冰 婕:15级硕士,广西人 陈一霄:15级硕士,海南人
研究方向:生物信息人类学 研究方向:肥胖易感基因鉴定及功能分析
email:bing1314@stu.xjtu.edu.cn email:chenyixiao@stu.xjtu.edu.cn







论文专著 - 郭 燕发表文章
发表文章列表
1. Guo Y, Tan LJ, Lei SF, Yang TL, Chen XD, Zhang F, Chen Y, Pan F, Yan H, Liu XG, Tian Q, Zhang ZX, Zhou Q, Qiu C, Dong SS, Xu XH, Guo YF, Zhu XZ, Liu SL, Wang XL, Li X, Luo Y, Zhang LS, Li M, Wang JT, Wen T, Drees B, Hamilton J, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis. PLoS Genetics. 2010 Jan,6(1): e** [Impact Factor: 9.54] 1区
2. Guo Y, Zhang LS, Yang TL, Tian Q, Xiong DH, Pei YF, Deng HW. IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study. The Journal of Bone and Mineral Research, 2010 May,25(5):1042-8 [Impact Factor: 7.06] 1区
3. Guo Y, Xiong DH, Yang TL, Guo YF, Recker RR, Deng HW. Polymorphisms of estrogen-biosynthesis genes CYP17 and CYP19 may influence age at menarche: a genetic association study in Caucasian females. Human Molecular Genetics, 2006 Aug,15(16): 2401-8 [Impact Factor: 8.06] 2区
4. Guo Y, Shen H, Xiao P, Xiong DH, Yang TL, Guo YF, Long JR, Recker RR, Deng HW. Genomewide linkage scan for quantitative trait loci underlying variation in age at menarche. Journal of Clinical Endocrinology & Metabolism, 2006 Mar, 91(3):1009-14 [Impact Factor: 6.50] 2区
5. Guo Y, Zhao LJ, Shen H, Guo YF, Deng HW. Genetic and environmental correlations between age at menarche and bone mineral density at different skeletal sites. Calcified Tissue International, 2005 Dec, 77(6):356-60. [Impact Factor: 2.76] 3区
6. Guo Y, Yang TL, Liu YZ, Shen H, Lei SF, Yu N, Chen J, Xu T, Cheng Y, Tian Q, Yu P, Deng HW. Mitochondria-wide Association Study of Common Variants in Osteoporosis. Ann Hum Genet. 2011 Sep;75(5):569-74. [Impact Factor: 2.60] 3区
7. Guo Y, Liu H, Yang TL, Li SM, Li SK, Tian Q, Liu YJ, Deng HW. The Fat Mass and Obesity Associated Gene, FTO, is Also Associated with Osteoporosis Phenotypes. PLoS One. 2011, 6(11):e27312. Epub 2011 Nov 18. [Impact Factor: 4.41]2区
8. Guo Y, Wang JT, Liu H, Li M, Yang TL, Zhang XW, Liu YZ, Tian Q, Deng HW. Are Bone Mineral Density Loci Associated with Hip Osteoporotic Fractures? A Validation Study on the Previously Reported Genome-wide Association Loci in a Chinese Population. Genetics and Molecular Research. 2012, Jan 31; 11(1):202-210 [Impact Factor: 1.01] 4区
9. Guo Y,Yang TL, Dong SS, Yan H, Hao RH, Chen XF, Chen JB, Tian Q, Li J, Shen H, Deng HW. Genetic Analysis Identifies DDR2 as a Novel Gene Affecting Bone Mineral Density and Osteoporotic Fractures in Chinese Population. PLoS One. 2015 Feb 6;10(2):e**.2区
10. Yang TL, Guo Y(通讯作者), Shen H, Lei SF, Liu YJ, Li J, Liu YZ, Yu N, Chen J, Xu T, Cheng Y, Tian Q, Yu P, Papasian CJ, Deng HW. Genetic association study of common mitochondrial variants on body fat mass. PLoS One. 2011;6(6):e21595. Epub 2011 Jun 29. [Impact Factor: 4.41] 2区
11. Yang TL, Guo Y(通讯作者), Liu YJ, Shen H, Liu YZ, Lei SF, Li J, Tian Q, Deng HW. Genetic variants in the SOX6 gene are associated with bone mineral density in both Caucasian and Chinese populations. Osteoporos Int. 2012 Feb;23(2):781-7. [Impact Factor: 4.86] 2区
12. Yan H, Guo Y(通讯作者), Yang TL, Zhao LJ, Deng HW. A family-based association study identified CYP17 as a candidate gene for obesity susceptibility in Caucasians. Genetics and Molecular Research. 2012 Aug 6;11(3):1967-74. 4区
13. Zhang Y, Yang TL, Li X,Guo Y(通讯作者). Functional analyses reveal the essential role of SOX6 and RUNX2 in the communication of chondrocyte and osteoblast. Osteoporos Int. 2015 Feb;26(2):553-61.2区
14. Dong SS, Yang TL, Yan H, Rong ZQ, Chen JB, Hao RH, Chen XF,Guo Y(通讯作者). Association analyses of FGFR2 gene polymorphisms with femoral neck bone mineral density in Chinese Han population. Mol Genet Genomics.2015 Apr;290(2):485-91. [Impact Factor: 2.78] 3区
15. Wang JT, Guo Y(并列第一作者), Yang TL, Xu XH, Dong SS, Li M, Li TQ, Chen Y, Deng HW. Polymorphisms in the estrogen receptor genes are associated with hip fractures in Chinese. Bone, 2008 Nov, 43(5): 910-4 [Impact Factor: 4.60] 2区
16. Zhao J, Xiong DH, Guo Y(并列第一作者), Yang TL, Recker RR, Deng HW. Polymorphism in the insulin-like growth factor 1 gene is associated with age at menarche in Caucasian females. Human Reproduction, 2007 Jun, 22(6): 1789-94 [Impact Factor: 4.36] 1区
17. Yang TL, Guo Y, Li J, Zhang L, Shen H, Li SM, Li SK, Tian Q, Liu YJ, Papasian CJ, Deng HW. Gene-gene interaction between RBMS3 and ZNF516 influences bone mineral density. The Journal of Bone and Mineral Research, 2013 Apr;28(4):828-37. 1区
18. Yang TL, Guo Y, Shen H, Li J, Glessner JT, Qiu C, Deng FY, Tian Q, Yu P, Liu YZ, Liu YJ, Hakonarson H, Grant SFA, Deng HW. Copy number variation on chromosome 10q26.3 for obesity identified by a genome-wide study. Journal of Clinical Endocrinology & Metabolism.2013 Jan, 98(1): E191-5. 2区
19. Yang TL, Guo Y, Zhang LS, Tian Q, Yan H, Papasian CJ, Recker RR, Deng HW. Runs of Homozygosity Identify a Recessive Locus 12q21.31 for Human Adult Height. Journal of Clinical Endocrinology & Metabolism. 2010 Aug, 95(8):3777-8. [Impact Factor: 6.50] 2区
20. Yang TL, Guo Y, Zhang LS, Tian Q, Yan H, Guo YF, Deng HW. HMGA2 is confirmed to be associated with human adult height. Annals of Human Genetics, 2010 Jan, 74(1):11-6. [Impact Factor: 2.60] 3区
21. Yang TL, Guo Y, Li SM, Li SK, Tian Q, Liu YJ, Deng HW. Ethnic Differentiation of Copy Number Variation on Chromosome 16p12.3 for Association with Obesity Phenotypes in European and Chinese Populations. International Journal of Obesity. 2013 Feb; 37(2):188-90. [Impact Factor: 5.125] 2区
22. Yang TL, Guo Y, Zhang JG, Xu C, Tian Q,Deng HW. Genome-wide Survey of Runs of Homozygosity Identifies Recessive Loci for Bone Mineral Density in Caucasian and Chinese Populations. The Journal of Bone and Mineral Research, 2015 May 18. doi: 10.1002/jbmr.2558. [Impact Factor: 6.5] 1区
23. Xu XH, Dong SS, Guo Y, Yang TL, Lei SF, Papasian CJ, Zhao M, Deng HW. Molecular Genetic Studies of Gene Identification for Osteoporosis: The 2009 Update. Endocrine Review. 2010 Aug, 31(4):447-505. [Impact Factor: 22.47] 1区
24. Yang TL, Chen XD, Guo Y, Lei SF, Wang JT, Zhou Q, Pan F, Chen Y, Zhang ZX, Dong SS, Xu XH, Yan H, Liu X, Qiu C, Zhu XZ, Chen T, Li M, Zhang H, Zhang L, Drees BM, Hamilton JJ, Papasian CJ, Recker RR, Song XP, Cheng J, Deng HW. Genome-wide copy-number-variation study identified a susceptibility gene, UGT2B17, for osteoporosis. The American Journal of Human Genetics, 2008 Dec, 83(6): 663-74. [Impact Factor: 11.68] 1区
25. Peng YM, Lei SF, Guo Y, Xiong DH, Yan H, Wang L, Guo YF, Deng HW. Gender-specific association of the glucocorticoid receptor gene with extreme bone mineral density. The Journal of Bone and Mineral Research, 2008 Feb, 23(2): 247-52. [Impact Factor: 7.06] 1区
26. Yang TL, Xiong DH, Guo Y, Recker RR, Deng HW. Comprehensive association analyses of IGF1, ESR2, and CYP17 genes with adult height in Caucasians. European Journal of Human Genetics, 2008 Nov, 16(11): 1380-7. [Impact Factor: 4.38] 2区
27. Pan F, Xiao P, Guo Y, Liu YJ, Shen H, Deng HY, Recker RR, Deng HW. Chromosomal regions 22q13 and 3p25 may harbor QTLs influencing both age at menarche and bone mineral density. Human Genetics, 2008 May, 123(4): 419-27. [Impact Factor: 5.05] 2区
28. Yang TL, Xiong DH, Guo Y, Recker RR, Deng HW. Association analyses of CYP19 gene polymorphisms with height variation in a large sample of Caucasian nuclear families. Human Genetics, 2006 Aug, 120(1): 119-125. [Impact Factor: 5.05] 2区
29. Zhao J, Xiao P, Guo Y, Liu YJ, Pei YF, Yang TL, Pan F, Chen Y, Shen H, Zhao LJ, Papasian CJ, Drees BM, Hamilton JJ, Deng HY, Recker RR, Deng HW. Bivariate genome linkage analysis suggests pleiotropic effects on chromosomes 20p and 3p for body fat mass and lean mass. Genetics Research, 2008 Jun, 90(3): 259-68. [Impact Factor: 1.75] 4区
30. Yang F, Xiong DH, Guo Y, Shen H, Xiao P, Zhang F, Jiang H, Recker RR, Deng HW. The chemokine (C-C-motif) receptor 3 (CCR3) gene is linked and associated with age at menarche in Caucasian females. Human Genetics, 2007 Mar, 121(1): 35-42. [Impact Factor: 5.05] 2区
31. Zhang YP, Liu YZ, Guo Y, Liu XG, Xu XH, Guo YF, Chen Y, Zhang F, Pan F, Zhu XZ, Deng HW. Pathway-Based Association Analyses Identified TRAIL Pathway for Osteoporotic Fractures. PLoS One. 2011;6(7):e21835. [Impact Factor: 4.41] 2区
32. Xu XH, Xiong DH, Liu XG, Guo Y, Chen Y, Zhao J, Recker RR, Deng HW. Association analyses of vitamin D-binding protein gene with compression strength index variation in Caucasian nuclear families. Osteoporosis International, 2010 Jan, 21(1):99-107. [Impact Factor: 4.86] 2区
33. Dong SS, Liu XG, Chen Y, Guo Y, Wang L, Zhao J, Xiong DH, Xu XH, Recker RR, Deng HW. Association analyses of RANKL/RANK/OPG gene polymorphisms with femoral neck compression strength index variation in Caucasians. Calcified Tissue International, 2009 Aug, 85(2):104-12. [Impact Factor: 2.76] 3区
34. Lei SF, Shen H, Yang TL,Guo Y, Dong SS, Xu XH, Deng FY, Tian Q, Liu YJ, Liu YZ, Li J,Deng HW. Genome-wide association study identifies HMGN3 locus for spine bone size variation in Chinese. Human Genetics, 2012 Mar;131(3):463-9. [Impact Factor: 5.05] 2区
35. Yang TL, Shen H, Xiong DH, Xiao P, Guo Y, Guo YF, Liu YZ, Recker RR, Deng HW. Epistatic interactions between genomic regions containing the COL1A1 gene and genes regulating osteoclast differentiation may influence femoral neck bone mineral density. Annals of Human Genetics, 2007 Mar, 71(Pt2):152-9. [Impact Factor: 2.60] 3区
36. He LN, Liu YJ, Xiao P, Zhang L, Guo Y, Yang TL, Zhao LJ, Drees BM, Hamilton JJ, Deng HY, Recker RR, Deng HW. Genomewide linkage scan for combined obesity phenotypes using principal component analysis. Annals of Human Genetics, 2008 May, 72(Pt3):319-26. [Impact Factor: 2.60] 3区
37. Lei SF, Yang TL, Tan LJ, Chen XD, Guo Y, Guo YF, Zhang L, Liu XG, Yan H, Pan F, Zhang ZX, Peng YM, Zhou Q, He LN, Zhu XZ, Cheng J, Liu YZ, Papasian CJ, Deng HW. Genome-wide association scan for stature in Chinese: evidence for ethnic specific loci. Human Genetics, 2009 Feb, 125(1): 1-9. [Impact Factor: 5.05] 2区
38. Sha BY, Yang TL, Zhao LJ, Chen XD, Guo Y, Chen Y, Pan F, Zhang ZX, Dong SS, Xu XH, Deng HW. Genome-wide association study suggested copy number variation may be associated with body mass index in the Chinese population. Journal of Human Genetics, 2009 Apr, 54(4):199-202. [Impact Factor: 2.50] 3区
39. Liu YZ, Pei YF, Liu JF, Yang F, Guo Y, Zhang L, Liu XG, Yan H, Wang L, Zhang YP, Levy S, Recker RR, Deng HW. Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males. Plos One, 2009 Aug, 4(8):e6827 [Impact Factor: 4.41] 2区
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招生信息 - 郭 燕Blank3
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生物学 生物化学与分子生物学 疾病易感基因功能分析
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生物医学工程 生物信息技术 遗传算法开发






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