西安交通大学生命科学与技术学院导师教师师资介绍简介-陈锋

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个人简介 - 陈锋基本信息

陈锋副教授/博士
博士研究生导师
陕西省普通高校青年杰出人才
主要研究方向为核酸化学生物学、单细胞测序与DNA纳米生物技术。主持国家自然科学基金重大研究计划培育项目、青年项目等；近五年，以第一作者或通讯作者在Nat. Commun. (IF: 12.121)、JACS (IF: 14.69)、Angew. Chem. Int. Edit. (IF: 12.27)、Nucleic Acids Res.(IF:11.15)、ACS Nano (IF: 13.90)、Adv. Funct. Mater. (IF: 15.62)、Chem. Sci. (IF: 9.56)等发表学术论文20余篇。

站点计数器

获奖荣誉
2021陕西省教育厅陕西高等学校科学技术奖一等奖(排名第三)
2020陕西省教育厅陕西高校青年创新团队(排名第二)
2018中国分析测试协会中国分析测试协会科学技术奖一等奖(排名第三)
2017陕西省委高教工委陕西省普通高校青年杰出人才

工作经历与教育背景
2019.02-至今西安交通大学生命科学与技术学院副教授
2016.10-2019.01西安交通大学生命科学与技术学院讲师

联系方式
办公地址：创新港18号楼4030，兴庆校区教二楼北楼223
邮箱地址：fengchencf@mail.xjtu.edu.cn

科学研究 - 陈锋研究方向
核酸化学与生物学、单细胞测序、空间组学检测技术、DNA纳米生物技术、微流控芯片、核酸检测与临床诊断

主持科研项目
项目名称与编号
项目类别
器官再生修复中染色质修饰纳米环境的DNA邻近编码成像及功能研究（**）
国家自然科学基金重大研究计划
培育项目

支链DNA编码的高通量RNA原位扩增成像（2020JQ-021）陕西省自然科学基础研究计划一般项目
活细胞内源酶驱动DNA步移机器实现高灵敏自校准成像（2018T111032）中国博士后科学基金特别资助项目
基于仿真双向链置换组合回路的活细胞多水平高灵敏成像分析（**）
国家自然科学基金青年项目
等位富集不对称及仿真置换用于循环突变精准分析（2017M613102）中国博士后科学基金面上项目
基于核酸定向扩增的转录变异体高准确单分子成像分析中央高校基本业务费

学术成果 - 陈锋代表性学术论文（*表示通讯作者，#表示共同第一作者）

2021年
[44]Feng Chen^#,Min Bai^#, Xiaowen Cao,Jing Xue,Yue Zhao, Na Wu, Lei Zhang,Dexin Zhang, andYongxi Zhao*.Cellular macromolecules-tethered DNA walking indexing to explore nanoenvironments of chromatin modifications.Nature Communications,2021, 12, 1965.(IF 12.121)https://www.nature.com/articles/s41467-021-22284-z
Selected as Research Highlightby Nature Methods.
Walking through chromatin modifications. Nature Methods, 2021, 18: 446.
https://www.nature.com/articles/s41592-021-01159-7
2020年
[43]Yongxi Zhao, Xiaolei Zuo, Qian Li, Feng Chen,,,,,,,,,,Chaoyong Yang, Xiaobing Zhang, Huanghao Yang, Weihong Tan, Chunhai Fan.Nucleic Acids Analysis.SCIENCE CHINA Chemistry,2020,10.1007/s11426-020-9864-7(IF 6.356)
[42]Jing Xue, Feng Chen,Min Bai, Xiaowen Cao,Wenhao Fu, Jin Zhang, andYongxi Zhao*.Aptamer-Functionalized Microdevices for Bioanalysis.ACS Applied Materials & Interfaces,2020,10.1021/acsami.0c16138(IF 8.758)
[41]Jing Xue^#,Feng Chen^#,Li Su^#,Xiaowen Cao, Min Bai, Yue Zhao, Chunhai Fan, and Yongxi Zhao*.Pairwise Proximity-differentiated Visualization of Single-cell DNA Epigenetic Marks.Angewandte Chemie International Edition,2020,10.1002/anie.(IF 12.959)
[40]Xiaowen Cao,Huahang Yu, Jing Xue, Min Bai, Yue Zhao, Youjun Li, Yongxi ZhaoandFeng Chen*.RNA-primed Amplification for Noise-suppressed Visualization of Single-cell Splice Variants. Analytical Chemistry,2020,92,13,9356-9361.(IF 6.350)
[39]Min Bai,Xiaowen Cao, Wei Huang, Feng Chen,Yue Zhao, Jing Xue, Youjun Li, Yilong Cheng, Lei Zhang, andYongxi Zhao*.Visualizing Newly Synthesized RNA by Bioorthogonal Labeling-primed DNA Amplification.Analytical Chemistry,2020, 92, 12, 8444–8449.(IF 6.350)
[38]Min Bai^#,Feng Chen^#,Xiaowen Cao, Yue Zhao, Jing Xue, Xu Yu, Chunhai Fan, and Yongxi Zhao*.Intracellular Entropy-driven Multi-bit DNA Computing for Tumor Progression Discrimination.Angewandte Chemie International Edition,DOI: 10.1002/anie.(IF 12.257)
Highlighted by
国家自然科学基金委员会,http://www.nsfc.gov.cn/csc/20340/20343/53227/index.html
[37]Feng Chen#, Jing Xue#, Jin Zhang, Min Bai, Xu Yu, Chunhai Fan and Yongxi Zhao*. Differentiated Visualization of Single-Cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding. Journal of the American Chemical Society, 2020, 142, 6, 2889-2896. (IF 14.695)
Highlighted by
科技日报http://digitalpaper.stdaily.com/http_www.kjrb.com/kjrb/html/2020-03/16/content_441516.htm?div=-1
2019年
[36]Feng Chen^#, Min Bai^#, Xiaowen Cao, Yue Zhao,Jing Xue,andYongxiZhao*.Click-encoded rolling FISH for visualizing single-cell RNA polyadenylation and structures.Nucleic Acids Research, 2019,47, 22, e145.(IF 11.157)
[35]Yue Zhao, Xiaoxing Fang, Feng Chen, Min Bai, Chunhai Fan,Yongxi Zhao*.Locus-patterned sequence oriented enrichment for multidimensional gene analysis.Chemical Science, 2019, 10,8421-8427.(IF 9.556)
[34]Yu Xu,Na Wu, Feng Chen,Jing Wei,Yongxi Zhao*.Engineering Microfluidic chip for Circulating Tumor Cells: From Enrichment, Release to Single Cell Analysis.Trends in Analytical Chemistry,DOI: 10.1016/j.trac.2019.03.027(IF 8.428)
[33]Jing Xue^#,Feng Chen^#, Min Bai, Xiaowen Cao, Ping Huang,andYongxiZhao*.All-in-one Synchronized DNA Nanodevices Facilitating Multiplexed Cell Imaging.Analytical Chemistry, 2019, 91, 7,4696-4701.(IF 6.042)
[32]Feng Chen^#, Jing Xue^#, Min Bai, Jing Qin,andYongxiZhao*.Programming in situ accelerated DNA walkers in diffusion-limited microenvironments.Chemical Science, 2019, 10，3103-3109(IF 9.063)
2018年
[31]Na Wu, Feng Chen,Yue Zhao, Yu Xu, Jing Wei andYongxiZhao*.Functional and Biomimetic DNA Nanostructures on Lipid Membranes.Langmuir,2018, 34(49), 14721-14730(IF 3.789)
[30]Dongzhen Chen, Xiaodong Zhu, Jian Huang, Gen Wang, Yue Zhao, Feng Chen, Jing Wei, Zhongxiao Song, andYongxiZhao*.Polydopamine @ Gold Nanowaxberry Enabling Improved SERS Sensing of Pesticides, Pollutants and Explosives in Complex Samples.Analytical Chemistry,2018, 90, 9048?9054(IF 6.042)
[29]Jing Wei^#, Gen Wang^#, Feng Chen^#, Min Bai, Yan Liang, Huanting Wang, Dongyuan Zhao,YongxiZhao*.Sol-gel Synthesis of Metal-Phenolic Coordination Spheres and Their Derived Carbon Composites.Angewandte Chemie International Edition,2018, 57, 9838 –9843(IF 12.102)
[28]Feng Chen^#, Min Bai^#, Yue Zhao, Ke Cao, Xiaowen Cao andYongxiZhao*.MnO₂-Nanosheet-Powered Protective Janus DNA Nanomachines Supporting Robust RNA Imaging.Analytical Chemistry,2018,DOI:10.1021/acs.analchem.7b04634.
2017年
[27]YueZhao,Feng Chen,Jing Qin,JingWei,Wenhua WuandYongxiZhao*.Engineered Janus probes modulating nucleic acid amplification to expand dynamic range for viral genome direct detection in one microliter crude serum samples.Chemical Science,2018,9: 392-397.(IF 8.668)PDF

[26]Feng Chen^#,Min Bai^#,Ke Cao, Yue Zhao, Xiaowen Cao, Jing Wei, Na Wu, Jiang Li, Lihua Wang, Chunhai Fan,andYongxiZhao* .ProgrammingEnzyme-Initiated Autonomous DNAzyme Nanodevices in Living Cells.ACS Nano,2017,11: 11908-11914.(IF 13.942)PDF
[25]Min Bai, Xiaowen Cao, Feng Chen, YueZhao,Yongxi Zhao*.A FRET Ratiometric Probe Based on Quantum Dot-Cresyl Violet for Imaging Hydrogen Sulfide in Living Cells.Chinese Journal of Analytical Chemistry.(IF 0.795)Accepted.

[1] Lin Qi,Yongxi Zhao*, Hui Yuan, Kai Bai,Yue Zhao,Feng Chen,Yanhua Dong,Yayan Wu. Amplified fluorescence detection of mercury(II) ions(Hg²⁺) using target-induced DNAzyme cascade with catalytic and molecular beacons.Analyst, 2012, 137:2799-2805.(IF 3.885)PDF

[24]Feng Chen, Min Bai,KeCao,YueZhao,JingWei,Yongxi Zhao*. Fabricating MnO₂Nanozymes as Intracellular Catalytic DNA Circuit Generators for Versatile Imaging of Base-Excision Repair in Living Cell.Advanced Functional Materials, 2017, 27, **(IF 12.124)PDF

[23]Feng Chen^#, Xuyao Wang^#, Xiaowen Cao,Yongxi Zhao*. Accurate Electrochemistry Analysis of Circulation Methylated DNA from Clinical Plasma Based on Paired-End Tagging and Amplifications.Analytical Chemistry,2017, 89: 10468-10473.(IF 6.320)PDF

[22] Jing Xue, Feng Chen, Min Bai, Xu Yu, Jing Wei, Ping Huang,Yongxi Zhao*. DNA-Mediated Assembly of Gold Nanoparticles and Its Applications inBioanalysis.ChemNanoMat,2017, 3: 725-735.(IF 2.937)PDF

[21] Xuyao Wang^#, Feng Chen^#, Dexin Zhang, Yue Zhao, Jing Wei, Lihua Wang, Shiping Song, Chunhai Fan,Yongxi Zhao*. Single copy-sensitive electrochemical assay for circulating methylated DNA in clinical samples with ultrahigh specificity based on a sequential discrimination-amplification strategy.Chemical Science,2017, 8: 4764-4770.(IF 8.668)PDF（Outside Back Cover）

[20]Jian Huang^#,Dayan Ma^#,Feng Chen,Dongzhen Chen, Min Bai, Kewei Xu,Yongxi Zhao*.Green in Situ Synthesis of Clean 3D Chestnut-Like Ag/WO_3-xNanostructures for Highly Efficient, Recyclable and Sensitive SERS Sensing.ACS Applied Materials & Interfaces,2017, 9: 7436-7446.(IF 7.504).PDF

2016 年
[19] Yue Zhao,Huaqing Liu,Feng Chen,Min Bai,Yongxi Zhao*.Fidelity quantification of mercury(II) ion via circumventing biothiols-induced sequestration in enzymatic amplification system.RSC Advances,2016, 6: 80296-80301.(IF 3.108)PDF

[18] Yue Zhao,Huaqing Liu,Feng Chen,Min Bai, Junwu Zhao*,Yongxi Zhao*.Trifunctional Molecular Beacon-Mediated Quadratic Amplification for Highly Sensitive and Rapid Detection of Mercury(II) Ion with Tunable Dynamic Range.Biosensors and Bioelectronics,2016, 86: 892-898.(IF 7.78)PDF
[17] Dongzhen Chen,Zhongxiao Song,Feng Chen,Jian Huang,Jing Wei,Yongxi Zhao*.Simply Controllable Growth of Single Crystal Plasmonic Au-Ag Nano-spines with Anisotropic Multiple Site for Highly Sensitive and Uniform Surface-Enhanced Raman Scattering Sensing.RSC Advances,2016, 6: 66056-66065.(IF 3.108)PDF

[16]Feng Chen^#, Manli Lin^#, Yue Zhao,Yongxi Zhao*.Catalase-functionalized SiO₂nanoparticles mediate growth of gold nanoparticles for plasmonic biosensing of attomolar microRNA with the naked eye.RSC Advances,2016, 6: 15709-15715.(IF 3.108)PDF
[15]Feng Chen, Dexin Zhang, Qing Zhang, Xiaolei Zuo, Chunhai Fan,Yongxi Zhao*.Zero-background helicase-dependent amplification and its application to reliable assay of telomerase activity in cancer cell byeliminating primer-dimer artifacts.ChemBioChem,2016, 17: 1171-1176.(IF 2.847)PDF
2015年

[14]Yongxi Zhao*,Feng Chen, Qian Li, Lihua Wang, Chunhai Fan*.Isothermal amplification of nucleic acids.Chemical Reviews,2015, 115: 12491-12545.(IF 47.928)PDF

[13] Jian Huang^#, Dayan Ma^#,Feng Chen, Min Bai, Kewei Xu,Yongxi Zhao*. Ag nanoparticles decorated cactus-like Ag dendrites/Si nanoneedles as highly efficient 3D SERS substrates toward sensitive sensing.Analytical Chemistry,2015, 87: 10527-10534.(IF 6.32)PDF
[12]Feng Chen, Chunhai Fan,Yongxi Zhaoo*. Inhibitory impact of 3′-terminal 2′-O-methylated small silencing RNA on target-primed polymerization and unbiased amplified quantification of the RNA inarabidopsis thaliana.Analytical Chemistry, 2015,87: 8758-8764.(IF 6.32)PDF

[11]Feng Chen,Yue Zhao,Chunhai Fan,Yongxi Zhao*. Mismatch extension of DNA polymerases and high-accuracy single nucleotide polymorphism diagnostics by gold nanoparticle-improved isothermal amplification.Analytical Chemistry, 2015,87: 8718-8723.(IF 6.32)PDF

[10] Jian Huang,Feng Chen, Qing Zhang, Yonghua Zhan, Dayan Ma*, Kewei Xu*,Yongxi Zhaoo*. 3D silver nanoparticles decorated zinc oxide/silicon heterostructured nanomace arrays as high-performance surface-enhanced raman scattering substrates.ACS Applied Materials & Interfaces, 2015,7: 5725-5735.(IF 7.105)PDF

2014年
[9]Yongxi Zhao*,Feng Chen, QingZhang, YueZhao, XiaoleiZuo, ChunhaiFan*. Polymerase/nicking enzyme synergetic isothermal quadratic DNA machine and its application for one-step amplified biosensing of lead (II) ions at femtomole level and DNA methyltransferase.NPG Asia Materials,2014,6:e131.(IF 9.157)PDF
[8] Qing Zhang^#,Feng Chen^#, Feng Xu,Yongxi Zhao*, Chunhai Fan. Target-triggered three-way junction structure and polymerase/nicking enzyme synergetic isothermal quadratic DNA machine for highly speci?c, one-step, and rapid microRNA detection at attomolar level.Analytical Chemistry,2014,86(16):8098-8105.(IF 6.32)PDF

[7]Yongxi Zhao*,Feng Chen, Manli Lin, Chunhai Fan. A methylation-blocked cascade amplification strategy for label-free colorimetric detection of DNA methyltransferase activity.Biosensors and Bioelectronics,2014,54:565-570.(IF 7.78)PDF

[6]Yongxi Zhao*,Feng Chen, Yayan Wu, Yanhua Dong, Chunhai Fan.Highly sensitive fluorescence assay of DNA methyltransferase activity via methylation-sensitive cleavage coupled with nicking enzyme-assisted signal amplification.Biosensors and Bioelectronics, 2013,42:56-61.(IF 7.78)PDF

2013年
[5]Yongxi Zhao*, Lin Qi,Feng Chen, Yue Zhao, Chunhai Fan. Highly sensitive detection of telomerase activity in tumor cells by cascade isothermal signal amplification based on three-way junction and base-stacking hybridization.Biosensors and Bioelectronics, 2013,41:764-770.(IF 7.78)PDF

[4]Feng Chen,Yongxi Zhao*, Lin Qi, Chunhai Fan. One-step highly sensitive florescence detection of T4 polynucleotide kinase activity and biological small molecules by ligation-nicking coupled reaction-mediated signal amplification.Biosensors and Bioelectronics, 2013,47:218-224.(IF 7.78)PDF

[3]Feng Chen,Yongxi Zhao*. Methylation-blocked enzymatic recycling amplification for highly sensitive fluorescence sensing of DNA methyltransferase activity.Analyst,2013,138:284-289.(IF 3.885)PDF

2012年

[2]Yongxi Zhao*, Lin Qi,Feng Chen,Yanhua Dong, Yu Kong,Yayan Wu, Chunhai Fan*. Ultrasensitive and selective detection of nicotinamide adenine dinucleotide by target-triggered ligation-rolling circle amplification.Chemical Communications,2012, 48:3354-3356.(IF 6.319)PDF

招生/招聘 - 陈锋Blank9

欢迎化学、生物、生物医学工程、材料、信息、物理等相关专业的有志之士报考博士、硕士研究生，或从事博士后研究！
研究所招聘详见赵永席教授主页http://gr.xjtu.edu.cn/web/yxzhao/11。