西安交通大学生命科学与技术学院导师教师师资介绍简介-王昌河

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王昌河 - 王昌河基本信息

王昌河教授
Ph.D. 博士生导师国家级人才
线粒体生物医学研究所神经科学研究中心主任
陕西省科技创新团队带头人
陕西省****基金获得者
西安交通大学青年拔尖人才
贝时璋青年生物物理学家奖
陕西青年科技奖
教育部自然科学一等奖（第3完成人）

王昌河，教授，博士生导师，国家级人才，陕西省科技创新团队带头人、陕西省****基金获得者，西安交通大学青年拔尖人才，荣获第六届贝时璋青年生物物理学家奖、第十三届陕西省青年科技奖、教育部自然科学一等奖（第三）、北京大学优秀博士后、北大-清华生命科学联合中心优秀博士后等；目前担任生物系主任、线粒体生物医学研究所神经科学研究中心主任、中国生物物理学会神经生物物理分会副主任兼秘书长、中国神经科学学会突触可塑性分会委员、中国神经科学学会离子通道与受体分会委员、中国生理学会衰老与健康专业委员会委员、中国生物物理学会科普委员会委员、中国老年学学会衰老与抗衰老科学委员会委员、CAMPUS Asia Project学术委员会委员、中国神经修复学会精准治疗分会委员、科普中国特聘专家、Neuroscience Bulletin青年编委。

联系方式
西安交通大学
生命科学与技术学院
联系电话：-409
E-mail: changhewang@xjtu.edu.cn
changhecool@163.com
通讯地址：陕西省西安市碑林区咸宁西路28号西安交通大学生命科学与技术学院, 西安，710049

站点计数器

科研背景
2003年于四川大学吴玉章学院（原创新班学院）四川大学-华盛顿大学联合创新班获理学学士学位；2006年于四川大学生命学院获动物学硕士学位；2012年于北京大学分子医学研究所获生理学博士学位；2012-2015年于北京大学分子医学研究所、北大-清华生命科学联合中心（周专实验室）从事博士后研究，2016年获北京大学优秀博士后。2015年入选西安交通大学‘青年拔尖人才’计划，2018年获教育部自然科学一等奖（第三完成人），2019年获陕西省****基金，2019年获贝时璋青年生物物理学家奖，同年入选国家级人才，2020年获陕西省青年科技奖，2021年获批陕西省科技创新团队，目前担任生物系主任、线粒体生物医学研究所神经科学研究中心主任、中国生物物理学会神经生物物理分会副主任、秘书长，中国生物物理学会科普委员会委员，中国老年学学会衰老与抗衰老科学委员会委员、CAMPUS Asia Project（亚洲校园计划）学术委员会委员，中国神经修复学会精准治疗分会委员，Neuroscience Bulletin青年编委，科普中国特聘专家，陕西省细胞生物学会理事。
主要研究方向包括：1）神经分泌与囊泡循环的调控机制，2）突触传递与突触可塑性的调控机制，3）分泌相关神经疾病（帕金森病、精神分裂症、成瘾、痛）的病理机制。实验室拥有电生理（膜片钳记录、sniffer patch、UV-flash、钙成像）、电化学（微碳纤电极细胞/脑片/in vivo水平的实时记录、微透析-HPLC分析）、生物成像（confocal、TIRF、two photon、电镜等）、光遗传、行为学及分子生化等特色技术手段，在囊泡分泌、内吞及循环的分子调控机制和帕金森病等相关神经疾病的发病机理等方面取得一系列突破性研究进展。在国际权威学术期刊发表研究论文（SCI）32篇，累计影响因子~233；其中，第一/通讯作者论文共计16篇（中科院1区TOP期刊10篇），分别发表在Neuron（2017, Nature Reviews Neuroscience亮点评述；F1000Prime特别推荐），Nature Communications（2018, Movement Disorders亮点评述），PNAS（2019），Nature Communications（2014），EMBO Reports（2016,封面文章），Journal of Cell Biology （2016,同刊发表评述文章对本文进行高度评价），Science Signaling （2017,封面文章，Science亮点评述），Diabetologia（2015,Up front特别推荐论文），Neuroscientists（2020）等期刊上，累计影响因子~119（平均影响因子~7.43）。受邀在《中国大百科全书》第三版中负责《胞吐》、《胞吞》和《胞饮》三个条目的撰写工作。

教育经历
2008-2012 北京大学分子医学研究所，生理学博士（指导老师: 周专教授、张曦教授）
2003-2006 四川大学生命科学学院，动物学硕士（指导老师: 郭聪教授）
2000-2003 四川大学吴玉章学院（四川大学－华盛顿大学联合创新班），生物科学学士

工作经历

2018- 西安交通大学生命科学与技术学院，教授，博士生导师
2016-2017西安交通大学生命科学与技术学院，研究员，博士生导师
2012-2015 北京大学分子医学研究所/北大-清华生命科学联合中心，博士后（合作导师: 周专教授）
2006-2014 齐齐哈尔大学生命科学与农林学院，助教/讲师/副教授

荣誉与获奖
2021 陕西省科技创新团队
2020 陕西省青年科技奖
2020 第四届全国大学生生命科学竞赛一等奖指导老师
2020 第二届陕西省大学生生命科学竞赛特等奖指导老师
2019 贝时璋青年生物物理学家奖
2019 陕西省****基金获得者
2018 量子化神经递质囊泡的分泌机理，教育部自然科学一等奖(第三完成人)
2016 西安交通大学青年拔尖人才
2017 第一届全国大学生生命科学竞赛三等奖指导老师
2016 北京大学优秀博士后
2014 北大-清华生命科学联合中心优秀博士后
2014 生物膜与膜生物工程国家重点实验室学术报告二等奖
2010 北京大学李彦宏奖学金
2008 北京大学学业奖学金二等奖
2005 四川大学优秀硕士光华一等奖
2004 四川大学优秀硕士二等奖
2003 四川大学优秀本科毕业论文三等奖
2002 四川大学本科跳级资格
2002'四川大学-华盛顿大学****'荣誉称号
2001 四川大学台禅祖寺奖助学金

学术任职
分会主任
2019 - 陕西省脑疾病分子医学专业委员会副主任委员
2018 - 中国生物物理学会神经生物物理分会副主任委员、秘书长
学会委员
2020 - 中国神经科学学会突触可塑性分会委员
2020 - 中国神经科学学会离子通道与受体分会委员
2020 - 中国生理学会衰老与健康专业委员会委员
2019 - 中国神经修复学会精准治疗分会委员
2017 - 中国老年学与老年医学学会抗衰老分会委员
2017 - CAMPUS Asia Project学术委员会委员
2017- 中国生物物理学会科普委员会委员
2018 - 科普中国特聘专家
学会理事
2018- 陕西省细胞生物学会理事
2012-2017 黑龙江省蛋白质组学会理事
2011-2015 黑龙江省微生物学会理事
期刊编辑
Neuroscience Bulletin青年编辑委会委员

近期代表论文
1. Bing Liu^#, Yiman Li^#, Shujiang Shang, Changhe Wang*, Michael X. Zhu* and Zhuan Zhou*. Reply to: TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium. J Cell Biol. 2020, DOI:10.1083/JCB.. (IF: 8.89, *Corresponding authors) .
2. Xuanang Wu, Shaoqin Hu, Xinjiang Kang^#, andChanghe Wang^#. (2020) Synaptotagmins: beyond presynaptic neurotransmitter release.Neuroscientist. 26(1):9-15.(IF: 7.46,# Corresponding authors) .
3. Rong Huang, Yuan Wang, Jie Li, Xiaohan Jiang, Yinglin Li, Bing, Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang^#, Zuying Chai^#, Zhuan Zhou^#. (2019) Ca²⁺-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian synpathetic nervous system. Proc Natl Acad Sci U S A. 116(40):20201-20209. (IF: 9.58, #Corresponding authors).
4. Mingzhu Huang, Bianbian Wang, Xiaopeng Li, Chongluo Fu^#, Changhe Wang^#, and Xinjiang Kang^#. (2019) ɑ-Synuclein: a multifunctional player in exocytosis, endocytosis, and vesicle recycling. Frontiers in Neuroscience. 13:28. doi: 10.3389/fnins.2019.00028. (IF: 3.88, # Corresponding authors) (Invited review)
5. Qian Song, Mingzhu Huang, Bianbian Wang, Xinjiang Kang, Wang Changhe^#. (2018) Bidirectional regulation of Ca²⁺ in exo-endocytosis coupling. Science China Life Sciences. 61(12):1583-1585. (IF: 3.09, # Corresponding author) (Invited review)
6. Changhe Wang *, Xinjiang Kang *, Li Zhou *, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, and Zhuan Zhou. (2018) Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s Disease like pathology. Nature Communications. 9:81. doi:10.1038/s41467-017-02593-y. (IF: 12.35, *Co-first authors).
Highlighted in Movement Disorders (Moghaddam HS and Arabi MH, Synaptotagmin-11 is a novel hotspot in the pathogenesis of parkin-linked Parkinson’s disease: new implications for clinical targeting, 2018, 33(4):582).
7. Zuying Chai *, Changhe Wang *, Rong Huang*, Yuan Wang*, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, and Zhuan Zhou. (2017) CaV2.2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons. Neuron. 96(6):1317-26. (IF: 14.32, *Co-first authors).
Highlighted in Nature Reviews Neuroscience (Natasha Bray, A discrete form of secretion, 2017, 19(1):6. doi: 10.1038/nrn.2017.162).
Recommended by the Faculty of 1000 (F1000Prime recommendations by Ronald W Holz, F1000Prime recommendations by Yang Yang, and F1000Prime recommendations by William Colmers).
8. Yeshi Wang, Qihui Wu, Meiqin Hu, Bin Liu, Zuying Chai, Rong Huang, Yuan Wang, Zhou Li, Xu Huadong, Changhe Wang^#, and Zhuan Zhou^#. (2017) Ligand- and voltage-gated Ca²⁺ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Science Signaling. 10(484), eaal1683. (IF: 7.36, # Corresponding authors) (Front Cover).
Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p).
9. Zhenli Xie, Jiangang Long, Jiankang Liu, Zuying Chai^#, Xinjiang Kang^#, Changhe Wang^#. (2017) Molecular mechanisms for the coupling of endocytosis to exocytosis in neurons. Frontiers in Molecular Neuroscience. 10:47. doi:10.3389/fnmol.2017.00047. (IF: 5.2, # Corresponding authors) (Invited review)
10. Zuying Chai, Yang Chen, Changhe Wang^# (2017) β-arrestin-1: bridging GPCRs to active TRP channels. Channels. 11(5):357-9. (IF: 2.54, # Corresponding author) (Invited commentary)
11. Changhe Wang*, Yeshi Wang*, Meiqin Hu*, Zuying Chai, Qihui Wu, Rong Huang, Weiping Han, Claire Xi Zhang, Zhuan Zhou. (2016) Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports. 17(1):47-63. (IF: 9.06, *Co-first authors) (Front Cover)
12. Shujiang Shang, Feipeng Zhu, Bin Liu, Zuying Chai, Qihui Wu, Meiqin Hu, Yuan Wang, Rong Huang, Xiaoyu Zhang, Xi Wu, Lei Sun, Yeshi Wang, Li Wang, Huadong Xu, Sasa Teng, Bing Liu, Lianghong Zheng, Chen Zhang, Fukang Zhang, Xinghua Feng, Desheng Zhu, Changhe Wang^#, Tao Liu^#, Michael Xi Zhu^#, Zhuan Zhou^#. (2016) Intracellular TRPA1 Mediates Ca²⁺ Release from lysosomes in dorsal root ganglion neurons. The Journal of Cell Biology. 215(3):369-381. (IF: 8.72, # Corresponding authors)
Highlighted in Journal of Cell Biology (Mingxue Gu and Haoxing Xu, A painful TR(i)P to lysosomes, 2016, 215(3):309-312).
13. Haiqiang Dou*, Changhe Wang*, Xi Wu, Lijun Yao, Xiaoyu Zhang, Sasa Teng, Huadong Xu, Bin Liu, Qihui Wu, Quanfeng Zhang, Meiqin Hu, Yeshi Wang, Li Wang, Yi Wu, Shujiang Shang, Xinjiang Kang, Lianghong Zheng, Jin Zhang, Matthieu Raoux, Jochen Lang, Qing Li, Jing Su, Xiao Yu, Liangyi Chen, Zhuan Zhou. (2015) Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 58(2):324-33. (IF: 6.67, *Co-first authors) (被该刊编辑部选为‘Up front’特别推荐论文).
14. Huadong Xu, Panli Zuo, Shirong Wang, Li Zhou, Xiaoxuan Sun, Meiqin Hu, Bin Liu, Qihui Wu, Haiqiang Dou, Bing Liu, Feipeng Zhu, Sasa Teng, Xiaoyu Zhang, Li Wang, Qing Li, Mu Jin, Xinjiang Kang^#, Wei Xiong, Changhe Wang^#, Zhuan Zhou^#. (2015) Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst. 140:3840-3845. (IF: 4.11, # Corresponding authors)
15. Li Wang, Shujiang Shang, Xinjiang Kang, Sasa Teng, Feipeng Zhu, Bin Liu, Qihui Wu, Mingli Li, Wei Liu, Huadong Xu, Li Zhou, Ruiying Jiao, Haiqiang Dou, Panli Zuo, Xiaoyu Zhang, Lianghong Zheng, Shirong Wang, Changhe Wang^# and Zhuan Zhou^#. (2014) Modulation of dopamine release in the striatum by physiologically relevant level of nicotine. Nature Communications. 5:3925. DOI: 10.1038/ncomms4925. (IF: 11. 47, # Corresponding authors)
16. Shujiang Shang*, Changhe Wang*, Bin Liu, Qihui Wu, Quanfeng Zhang, Wei Liu, Lianghong Zheng, Huadong Xu, Xinjiang Kang, Xiaoyu Zhang, Yeshi Wang, Hui Zheng, Shirong Wang, Wei Xiong, Tao Liu, Zhuan Zhou. (2014) Extracellular Ca²⁺ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells. Cell Calcium. 56(3):202-7. (IF: 4.3, *Co-first authors)
17. Mingli Li, Huadong Xu, Guoqing Chen, Suhua Sun, Qinglong Wang, Bing Liu, Xi Wu, Li Zhou, Zuying Chai, Xiaoxuan Sun, Yang Lu, Muhammad Younus, Lianghong Zheng, Feipeng Zhu, Hongbo Jia, Xiaowei Chen, Changhe Wang and Zhuan Zhou. (2019) Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson’s disease. Brain. doi: 10.1093/brain/awz243. (Epub ahead of print, IF: 11.81).
18. Quanfeng Zhang, Bin Liu, Qihui Wu, Bing Liu, Yinglin Li, Suhua Sun, Yuan Wang, Xi Wu, Zuying Chai, Xiaohan Jiang, Xiaoyao Liu, Meiqin Hu, Yeshi Wang, Yunting Yang, Li Wang, Xinjiang Kang,1 Yingfei Xiong, Yang Zhou, Xiaoke Chen, Lianghong Zheng, Bo Zhang, Changhe Wang, Feipeng Zhu, and Zhuan Zhou. (2019) Differential co-release of two neurotransmitters from a vesicle fusion pore in mammalian adrenal chromaffin cells. Neuron. 102(1):173-83. (IF: 14.32).
19. Qihui Wu, Quanfeng Zhang, Bin Liu, Yinglin Li, Xi Wu, Shuting Kuo, Lianghong Zheng, Changhe Wang, Feipeng Zhu and Zhuan Zhou. (2019) Dynamin-1 restrains vesicular release to a sub-quantal mode in mammalian adrenal chromaffin cells. J Neurosci. 39(2):199-211. (IF: 5.97).
20. Zhuan Zhou, Zuying Chai, Changhe Wang. (2018) From structure to function: unveiling the structure of the Nav channel–toxin complex. Natl Sci Rev. doi: 10.1093/nsr/nwy090 (Epub ahead of print, IF: 13.22).
21. Yingfei Xiong, Sasa Teng, Lianghong Zheng, Suhua Sun, Jie Li, Ning Guo, Mingli Li, Li Wang, Feipeng Zhu, Changhe Wang, Zhiren Rao, Zhuan Zhou. (2018) Stretch-induced Ca²⁺ independent ATP release in hippocampal astrocytes. J Physiol. 596: 1931-47. (IF: 4.74)
22. Chen Hou, Yongyao Wang, Jiankang Liu, Changhe Wang, Jiangang Long. (2017) Neurodegenerative disease related proteins have negative effects on SNARE-mediated membrane fusion in pathological confirmation. Front Mol Neurosci. 10:66. DOI: 10.3389/fnmol.2017.00066. (IF: 5.2)
23. Linling He, Quanfeng Zhang, Liecheng Wang, Jingxia Dai, Changhe Wang, Lianghong Zheng, Zhuan Zhou. (2015) Muscarinic inhibition of nicotinic transmission in neurons and adrenal chromaffin cells. Philos Trans R Soc Lond B Biol Sci. 370:**. DOI: 10.1098/rstb.2014.0188. (IF: 7.06)
24. Xinjinag Kang, Huadong Xu, Sasa Teng, Xiaoyu Zhang, Zijun Deng, Li Zhou, Panli Zuo, Bing Liu, Bin Liu, Qihui Wu, Li Wang, Meiqin Hu, Haiqiang Dou, Wei Liu, Feipeng Zhu, Qing Li, Shu Guo, Qian Lei, Jing Lv, Yu Mu, Mu Jin, Shirong Wang, Wei Jiang, Kun Liu, Changhe Wang, Weilin Li, Kang Zhang, Zhuan Zhou. (2014) Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci USA. 111(44):15804-9. (IF: 9.81) (Weekly press tipsheet特别推荐论文)
25. Li Wang, Xiaoyu Zhang, Huadong Xu, Li Zhou, Ruiying Jiao, Wei Liu, Feipeng Zhu, Xinjiang Kang, Bin Liu, Sasa Teng, Qihui Wu, Mingli Li, Haiqiang Dou, Panli Zuo, Changhe Wang, Shirong Wang and Zhuan Zhou. (2014) Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice. J Physiol. 592:3559-76. (IF: 5.04)
26. Lina Liu, Feipeng Zhu, Meiying Song, Xinjiang Kang, Shujiang Shang, Xiaoyu Zhang, Huadong Xu, Sasa Teng, Bin Liu, Shuting Kuo, Wei Liu, Mingli Li, Li Zhou, Ruiying Jiao, Changhe Wang, Shirong Wang, Hui Yang, Bo Zhang, Zhuan Zhou, Zhiqing Xu. (2014) Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons. J Mol Neurosci. 53(3):345-51. (IF: 2.76)
27. Shuting Kuo, Qihui Wu, Bin Liu, Zhenli Xie, Xi Wu, Shujiang Shang, Xiaoyu Zhang, Xinjiang Kang, Lina Liu, Feipeng Zhu, Yeshi Wang, Meiqin Hu, Huadong Xu, Li Zhou, Bin Liu, Zuying Chai, Quanfeng Zhang, Wei Liu, Sasa Teng, Changhe Wang, Ning Guo, Haiqiang Dou, Panli Zuo, Lianghong Zheng, Claire Xi Zhang, Desheng Zhu, Li Wang, Shirong Wang, Zhuan Zhou. (2014) Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese university. J Mol Neurosci. 53(3):487-92. (IF: 2.76)
28. Tao Liu, Shujiang Shang, Bin Liu, Changhe Wang, Yeshi Wang, Wei Xiong, Lianghong Zheng, Claire Xi Zhang, Zhuan Zhou. (2011) Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons. J Physiol. 589 (14): 3507-15. (IF: 4.72)
29. Tao Liu, Lei Sun, Yingfei Xiong, Shujiang Shang, Ning Guo, Sasa Teng, Yeshi Wang, Bin Liu, Changhe Wang, Li Wang, Lianghong Zheng, Claire Xi Zhang, Weiping Han, Zhuan Zhou. (2011) Calcium triggers exocytosis from two types of organelles in a single astrocyte. J Neurosci. 31(29): 10593-601. (IF: 7.12)

Changhe Wang - 王昌河Blank1
Changhe Wang
Professor, Ph.D.
Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology and Frontier Institute of Science and Technology
Xi’an Jiaotong University,
No. 28, Xianning West Road, Xi’an, 710049, China
Tel: +86-**;
Email: changhewang@xjtu.edu.cn; changhecool@163.com
RESEARCH INTEREST
With our expertise on neurobiology, especially electrophysiological recordings (patch clamp, UV-flash, sniffer patch, Ca²⁺ imaging), electrochemical recordings (amperometric current at quantal, cellular and in vivo level), bio-imaging (confocal, STED, TIRF, two photon, EM), opto-genetic/chemical-genetic stimulation, in vivo virus infection and molecular/biochemical assays, our ongoing research is aimed to address some of the most important questions in the molecular mechanism underlying exocytosis, endocytosis and vesicle recycling during synaptic transmission and in the diseased brain:
1)Mechanisms of vesicle docking, priming and fusion processes, especially the fusion machinery, fusion modes & fusion-pore dilation.
2)Mechanisms of exo-endocytosis coupling, vesicle recycling and the sustained neurotransmission.
3)Synaptic transmission and synaptic plasticity in health and diseased brain, e.g. Parkinson’s diseases (PD), Alzheimer’s disease (AD) and other neural disorders.
EDUCATION
2008-2012 Ph.D. in Physiology (Thesis advisors: Drs. Zhuan Zhou & Claire Xi Zhang), Peking University (PKU), China.
2003-2006 M.S. in Zoology (Thesis advisor: Dr. Cong Guo), Sichuan University (SCU), China.
2000-2003 B.S. in Bioscience (SCU-University of Washington Joint program), SCU, China.
POSITIONS
2016-present Professor, School of Life Science and Technology, Xi’an Jiaotong University, China
2012-2015 Postdoctoral Fellow (with Dr. Zhuan Zhou), Peking University, China
2006-2008 Teaching assistant & Lecturer, Qiqihar University, China
FELLOWSHIPS AND AWARDS
2019 Winner of Shitsan Pai Award for Young Biophysicists
2018 Winner of Natural Science Fund for Outstanding Scholars of Shaanxi Province, China.
2017 The first prize of Science Research Famous Achievement Award in Higher Institution (Natural Science Award, the 3^rd contributor), Ministry of Education, China.
2017 Hundred Talents Program of Shaanxi Province, Shaanxi Province Government, China.
2016 Excellent Postdoctoral Fellowship of Peking University, Peking University, China.
2015 Young Talent Support Plan of Xi’an Jiaotong University, Xi’an Jiaotong University, China.
2014 Excellent Postdoctoral Fellowship of Peking-Tsinghua Center for Life Sciences, Peking University, China.
2014 The second prize for academic reports of State key laboratory of biomembrane and membrane biotechnology, Peking University, China.
2008-2012 Academic scholarship, in Dr. Zhuan Zhou lab, Institute of Molecular Medicine, Peking University, China.
2009 Robin Li scholarship, Dr. Zhuan Zhou lab, Institute of Molecular Medicine, Peking University, China.
2004 The first prize for Guanghua scholarship, Dr. Cong Guo lab, College of Life Sciences, Sichuan University, China.
2003 The second prize graduate scholarship, Dr. Cong Guo lab, College of Life Sciences, Sichuan University, China.
2002 The third prize of excellent undergraduate thesis, Dr. Cong Guo lab, Wu Yuzhang Honors College, Sichuan University, China.
2001 Undergraduate grade-skipping, Wu Yuzhang Honors College, Sichuan University, China.
2001 ‘Outstanding youth of SCU-UW (University of Washington) program’ honor, Wu Yuzhang Honors College, Sichuan University, China.
2000 Taichanzu temple scholarship, , Wu Yuzhang Honors College, Sichuan University, China.
ORGANISATION OF SCIENTIFIC MEETINGS
2018 Organizing Committee number of the 12th international Symposium on Calcium Signaling in China, Shenyang, China
2018 Symposium chair for ‘Neurobiophysics – Cell & Molecule’ in the 16^th Chinese Biophysics Congress, Chengdu, China
2018 Symposium chair for ‘Joint Session – Israeli Society of Physiology and Parmacology and Austrian Biophysical Society’ in the 16^th Chinese Biophysics Congress, Chengdu, China
2016 Organizing Committee number of the 11th international Symposium on Calcium Signaling in China, Zunyi, China
2014 Symposium chair for ‘sympathetic nerve activity and cardiogenic sudden death’ in the 24th Congress of Chinese Association for Physiological Sciences, Shanghai, China
MEMBERSHIPS OF SCIENTIFIC SOCIETIES
2016-2020 Member and secretory of the Neural BioPhysical Committee, Biophysical Society of China
2017-2020 Member of the Scientific Committee of Aging and Antiaging, Gerontological Society of China
2017-2021 Academic committee member of CAMPUS Asia Project
2018-2021 Popular science expertise for China Science and Technology Press
2018-2022 Council member of the Cell Biology Society of Shaan Xi Province
2012-2016 Council member of the Proteome Society of Heilongjiang Province
2011-2015 Council member of the Microbiology Society of Heilongjiang Province
Selected Peer-Reviewed Publications
1. Bing Liu^#, Yiman Li^#, Shujiang Shang, Changhe Wang*, Michael X. Zhu* and Zhuan Zhou*. Reply to: TRPA1-dependent calcium transients and CGRP release in DRG neurons require extracellular calcium. J Cell Biol. 2020, DOI:10.1083/JCB.. (IF: 8.89, *Corresponding authors) .
2. Xuanang Wu^#, Shaoqin Hu^#, Xinjiang Kang*, and Changhe Wang*. Synaptotagmins: beyond presynaptic neurotransmitter release. Neuroscientist. 2020, 26(1):9-15. (IF: 7.46, *Corresponding authors) .
3. Rong Huang^#, Yuan Wang^#, Jie Li^#, Xiaohan Jiang^#, Yinglin Li, Bing Liu, Xi Wu, Xingyu Du, Yuqi Hang, Mu Jin, Feipeng Zhu, Changhe Wang*, Zuying Chai*, Zhuan Zhou*. Ca²⁺-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian synpathetic nervous system. Proc Natl Acad Sci U S A, 2019, 116(40):20201-20209. (IF: 9.58, *Corresponding authors).
4. Mingzhu Huang^#, Bianbian Wang^#, Xiaopeng Li^#, Chongluo Fu*, Changhe Wang*, and Xinjiang Kang*. ɑ-Synuclein: a multifunctional player in exocytosis, endocytosis, and vesicle recycling. Frontiers in Neuroscience. 2019, 13:28. doi: 10.3389/fnins.2019.00028. (IF: 3.88, *Corresponding authors)
5. Qian Song^#, Mingzhu Huang^#, Bianbian Wang^#, Xinjiang Kang, Wang Changhe*. Bidirectional regulation of Ca²⁺ in exo-endocytosis coupling. Science China Life Sciences. 2018, 61(12):1583-1585. (IF: 3.09, *Corresponding author)
6. Changhe Wang^#, Xinjiang Kang^#, Li Zhou^#, Zuying Chai, Qihui Wu, Rong Huang, Huadong Xu, Meiqin Hu, Xiaoxuan Sun, Suhua Sun, Jie Li, Ruiying Jiao, Panli Zuo, Lianghong Zheng, Zhenyu Yue, and Zhuan Zhou*. Synaptotagmin-11 is a critical mediator of parkin-linked neurotoxicity and Parkinson’s Disease like pathology. Nature Communications. 2018, 9:81. doi:10.1038/s41467-017-02593-y. (IF: 12.35, ^#Co-first authors).
Highlighted in Movement Disorders (Moghaddam HS and Arabi MH, Synaptotagmin-11 is a novel hotspot in the pathogenesis of parkin-linked Parkinson’s disease: new implications for clinical targeting, 2018, 33(4):582).
7. Zuying Chai^#, Changhe Wang^#, Rong Huang^#, Yuan Wang^#, Xiaoyu Zhang, Qihui Wu, Yeshi Wang, Xi Wu, Lianghong Zheng, Chen Zhang, Wei Guo, Wei Xiong, Jiuping Ding, Feipeng Zhu, and Zhuan Zhou*. CaV2.2 gates calcium-independent but voltage-dependent secretion in mammalian sensory neurons. Neuron. 2017, 96(6):1317-26. (IF: 14.32, ^#Co-first authors).
Highlighted in Nature Reviews Neuroscience (Natasha Bray, A discrete form of secretion, 2017, 19(1):6. doi: 10.1038/nrn.2017.162).
Recommended by the Faculty of 1000 (F1000Prime recommendations by Ronald W Holz, F1000Prime recommendations by Yang Yang, and F1000Prime recommendations by William Colmers).
8. Yeshi Wang^#, Qihui Wu^#, Meiqin Hu, Bin Liu, Zuying Chai, Rong Huang, Yuan Wang, Zhou Li, Xu Huadong, Changhe Wang*, and Zhuan Zhou*. Ligand- and voltage-gated Ca²⁺ channels differentially regulate the mode of vesicular neuropeptide release in mammalian sensory neurons. Science Signaling. 2017, 10(484), eaal1683. (IF: 7.36, *Corresponding authors) (Front Cover).
Highlighted in Science (Ferrarelli LK, 2017, Kiss-and-run or a full commitment? 356(6344):1243-1245. doi: 10.1126/science.356.6344.1243-p).
9. Zhenli Xie, Jiangang Long, Jiankang Liu, Zuying Chai*, Xinjiang Kang*, Changhe Wang*. Molecular mechanisms for the coupling of endocytosis to exocytosis in neurons. Frontiers in Molecular Neuroscience. 2017, 10:47. doi:10.3389/fnmol.2017.00047. (IF: 5.2, *Corresponding authors)
10. Zuying Chai, Yang Chen, Changhe Wang*. β-arrestin-1: bridging GPCRs to active TRP channels. Channels. 2017, 11(5):357-9. (IF: 2.54, *Corresponding author)
11. Changhe Wang^#, Yeshi Wang^#, Meiqin Hu^#, Zuying Chai, Qihui Wu, Rong Huang, Weiping Han, Claire Xi Zhang*, Zhuan Zhou. Synaptotagmin 11 inhibits clathrin-mediated and bulk endocytosis. EMBO Reports. 2016, 17(1):47-63. (IF: 9.06, ^#Co-first authors) (Front Cover)
12. Shujiang Shang^#, Feipeng Zhu^#, Bin Liu^#, Zuying Chai, Qihui Wu, Meiqin Hu, Yuan Wang, Rong Huang, Xiaoyu Zhang, Xi Wu, Lei Sun, Yeshi Wang, Li Wang, Huadong Xu, Sasa Teng, Bing Liu, Lianghong Zheng, Chen Zhang, Fukang Zhang, Xinghua Feng, Desheng Zhu, Changhe Wang*, Tao Liu*, Michael Xi Zhu*, Zhuan Zhou*. Intracellular TRPA1 Mediates Ca²⁺ Release from lysosomes in dorsal root ganglion neurons. The Journal of Cell Biology. 2016, 215(3):369-381. (IF: 8.72, * Corresponding authors)
Highlighted in Journal of Cell Biology (Mingxue Gu and Haoxing Xu, A painful TR(i)P to lysosomes, 2016, 215(3):309-312).
13. Haiqiang Dou^#, Changhe Wang^#, Xi Wu, Lijun Yao, Xiaoyu Zhang, Sasa Teng, Huadong Xu, Bin Liu, Qihui Wu, Quanfeng Zhang, Meiqin Hu, Yeshi Wang, Li Wang, Yi Wu, Shujiang Shang, Xinjiang Kang, Lianghong Zheng, Jin Zhang, Matthieu Raoux, Jochen Lang, Qing Li, Jing Su, Xiao Yu*, Liangyi Chen*, Zhuan Zhou*. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 2015, 58(2):324-33. (IF: 6.67, ^#Co-first authors) (被该刊编辑部选为‘Up front’特别推荐论文).
14. Huadong Xu, Panli Zuo, Shirong Wang, Li Zhou, Xiaoxuan Sun, Meiqin Hu, Bin Liu, Qihui Wu, Haiqiang Dou, Bing Liu, Feipeng Zhu, Sasa Teng, Xiaoyu Zhang, Li Wang, Qing Li, Mu Jin, Xinjiang Kang*, Wei Xiong, Changhe Wang*, Zhuan Zhou*. Striatal dopamine release in a schizophrenia mouse model measured by electrochemical amperometry in vivo. Analyst. 2015, 140:3840-3845. (IF: 4.11, *Corresponding authors)
15. Li Wang^#, Shujiang Shang^#, Xinjiang Kang^#, Sasa Teng, Feipeng Zhu, Bin Liu, Qihui Wu, Mingli Li, Wei Liu, Huadong Xu, Li Zhou, Ruiying Jiao, Haiqiang Dou, Panli Zuo, Xiaoyu Zhang, Lianghong Zheng, Shirong Wang, Changhe Wang* and Zhuan Zhou*. Modulation of dopamine release in the striatum by physiologically relevant level of nicotine. Nature Communications. 2014, 5:3925. DOI: 10.1038/ncomms4925. (IF: 11. 47, *Corresponding authors)
16. Shujiang Shang^#, Changhe Wang^#, Bin Liu, Qihui Wu, Quanfeng Zhang, Wei Liu, Lianghong Zheng, Huadong Xu, Xinjiang Kang, Xiaoyu Zhang, Yeshi Wang, Hui Zheng, Shirong Wang, Wei Xiong*, Tao Liu*, Zhuan Zhou*. Extracellular Ca²⁺ per se inhibits quantal size of catecholamine release in adrenal slice chromaffin cells. Cell Calcium. 2014, 56(3):202-7. (IF: 4.3, ^#Co-first authors)
17. Mingli Li^#, Huadong Xu^#, Guoqing Chen, Suhua Sun, Qinglong Wang, Bing Liu, Xi Wu, Li Zhou, Zuying Chai, Xiaoxuan Sun, Yang Lu, Muhammad Younus, Lianghong Zheng, Feipeng Zhu, Hongbo Jia, Xiaowei Chen, Changhe Wang and Zhuan Zhou*. Impaired D2 receptor-dependent dopaminergic transmission in prefrontal cortex of awake mouse model of Parkinson’s disease. Brain. 2019, 142(10):3099-3115. (IF: 11.81).
18. Quanfeng Zhang^#, Bin Liu^#, Qihui Wu^#, Bing Liu, Yinglin Li, Suhua Sun, Yuan Wang, Xi Wu, Zuying Chai, Xiaohan Jiang, Xiaoyao Liu, Meiqin Hu, Yeshi Wang, Yunting Yang, Li Wang, Xinjiang Kang,1 Yingfei Xiong, Yang Zhou, Xiaoke Chen, Lianghong Zheng, Bo Zhang, Changhe Wang, Feipeng Zhu, and Zhuan Zhou*. Differential co-release of two neurotransmitters from a vesicle fusion pore in mammalian adrenal chromaffin cells. Neuron. 2019, 102(1):173-83. (IF: 14.32).
19. Qihui Wu^#, Quanfeng Zhang^#, Bin Liu, Yinglin Li, Xi Wu, Shuting Kuo, Lianghong Zheng, Changhe Wang, Feipeng Zhu and Zhuan Zhou*. Dynamin-1 restrains vesicular release to a sub-quantal mode in mammalian adrenal chromaffin cells. J Neurosci. 2019, 39(2):199-211. (IF: 6.07).
20. Zhuan Zhou*, Zuying Chai, Changhe Wang. From structure to function: unveiling the structure of the Nav channel–toxin complex. Natl Sci Rev. 2019, 6(5): 859-860 (IF: 13.22).
21. Yingfei Xiong^#, Sasa Teng^#, Lianghong Zheng, Suhua Sun, Jie Li, Ning Guo, Mingli Li, Li Wang, Feipeng Zhu, Changhe Wang, Zhiren Rao*, Zhuan Zhou*. Stretch-induced Ca²⁺ independent ATP release in hippocampal astrocytes. J Physiol. 2018, 596: 1931-47. (IF: 4.74)
22. Chen Hou^#, Yongyao Wang, Jiankang Liu, Changhe Wang, Jiangang Long*. Neurodegenerative disease related proteins have negative effects on SNARE-mediated membrane fusion in pathological confirmation. Front Mol Neurosci. 2017, 10:66. DOI: 10.3389/fnmol.2017.00066. (IF: 5.2)
23. Linling He^#, Quanfeng Zhang^#, Liecheng Wang, Jingxia Dai, Changhe Wang, Lianghong Zheng*, Zhuan Zhou*. Muscarinic inhibition of nicotinic transmission in neurons and adrenal chromaffin cells. Philos Trans R Soc Lond B Biol Sci. 2015, 370:**. DOI: 10.1098/rstb.2014.0188. (IF: 7.06)
24. Xinjinag Kang^#, Huadong Xu^#, Sasa Teng^#, Xiaoyu Zhang, Zijun Deng, Li Zhou, Panli Zuo, Bing Liu, Bin Liu, Qihui Wu, Li Wang, Meiqin Hu, Haiqiang Dou, Wei Liu, Feipeng Zhu, Qing Li, Shu Guo, Qian Lei, Jing Lv, Yu Mu, Mu Jin, Shirong Wang, Wei Jiang, Kun Liu, Changhe Wang, Weilin Li*, Kang Zhang*, Zhuan Zhou*. Dopamine release from transplanted neural stem cells in Parkinsonian rat striatum in vivo. Proc Natl Acad Sci USA. 2014, 111(44):15804-9. (IF: 9.81) (Weekly press tipsheet特别推荐论文)
25. Li Wang^#, Xiaoyu Zhang^#, Huadong Xu, Li Zhou, Ruiying Jiao, Wei Liu, Feipeng Zhu, Xinjiang Kang, Bin Liu, Sasa Teng, Qihui Wu, Mingli Li, Haiqiang Dou, Panli Zuo, Changhe Wang, Shirong Wang and Zhuan Zhou*. (2014) Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice. J Physiol. 592:3559-76. (IF: 5.04)
26. Lina Liu, Feipeng Zhu, Meiying Song, Xinjiang Kang, Shujiang Shang, Xiaoyu Zhang, Huadong Xu, Sasa Teng, Bin Liu, Shuting Kuo, Wei Liu, Mingli Li, Li Zhou, Ruiying Jiao, Changhe Wang, Shirong Wang, Hui Yang, Bo Zhang, Zhuan Zhou*, Zhiqing Xu*. Effect of Cocaine on Ion Channels and Glutamatergic EPSCs in Noradrenergic Locus Coeruleus Neurons. J Mol Neurosci. 2014, 53(3):345-51. (IF: 2.76)
27. Shuting Kuo^#, Qihui Wu^#, Bin Liu^#, Zhenli Xie, Xi Wu, Shujiang Shang, Xiaoyu Zhang, Xinjiang Kang, Lina Liu, Feipeng Zhu, Yeshi Wang, Meiqin Hu, Huadong Xu, Li Zhou, Bin Liu, Zuying Chai, Quanfeng Zhang, Wei Liu, Sasa Teng, Changhe Wang, Ning Guo, Haiqiang Dou, Panli Zuo, Lianghong Zheng, Claire Xi Zhang, Desheng Zhu, Li Wang, Shirong Wang*, Zhuan Zhou*. Importing, caring, breeding, genotyping, and phenotyping a genetic mouse in a Chinese university. J Mol Neurosci. 2014, 53(3):487-92. (IF: 2.76)
28. Lianghong Zheng, Changhe Wang, Shujiang Shang, Xiaoyu Zhang, Yeshi Wang, Qihui Wu, Meiqin Hu, Zuying Chai, Xi Wu, Hui Zheng, Chen Zhang, Liecheng Wang, Wei Xiong, Zhuan Zhou*. Real-time endocytosis imaging as a rapid assay of ligand-GPCR binding in single cells. Am J Physiol Cell Physiol. 2013, 305(7):C751-60. (IF: 3.67)
29. Tao Liu, Shujiang Shang, Bin Liu, Changhe Wang, Yeshi Wang, Wei Xiong, Lianghong Zheng, Claire Xi Zhang*, Zhuan Zhou*. Two distinct vesicle pools for depolarization-induced exocytosis in somata of dorsal root ganglion neurons. J Physiol. 2011, 589 (14): 3507-15. (IF: 4.72)
30. Tao Liu^#, Lei Sun^#, Yingfei Xiong, Shujiang Shang, Ning Guo, Sasa Teng, Yeshi Wang, Bin Liu, Changhe Wang, Li Wang, Lianghong Zheng, Claire Xi Zhang*, Weiping Han*, Zhuan Zhou*. Calcium triggers exocytosis from two types of organelles in a single astrocyte. J Neurosci. 2011, 31(29): 10593-601. (IF: 7.12)