龙建纲的个人主页空间 - 龙 建纲基本信息

教育及工作背景
1992-1996 第二军医大学药学系 本科
1999-2002 第二军医大学军队卫生教研室 营养学硕士
2002-2006 第二军医大学生化与分子生物学/中科院上海营养科学研究所 博士
2006-2009 美国UC IRVINE大学、Sunhealth(Banner Health) Research Institute 博士后
2009-2011 西安交通大学生命科学与技术学院 副教授
2011- 西安交通大学生命科学与技术学院 教授(青年骨干教师)，博士生导师
2015-2016 西安交通大学生命科学与技术学院 副院长
2016- 西安交通大学研究生院 副院长




联系方式

龙建纲 博士
Tel: (School of Life Science)
(Graduate School)
E-mail: jglong@mail.xjtu.edu.cn
西安交通大学生命科学与技术学院# 421





站点收藏
类别/站点
刘健康教授
第二军医大学
中科院营养科学研究所
王福俤研究员
Banner Health Research Institute
University of California, Irvine


闹钟




站点计数器

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龙建纲的个人主页空间 - 龙 建纲基本信息

教育及工作背景
1992-1996 第二军医大学药学系 本科
1999-2002 第二军医大学军队卫生教研室 营养学硕士
2002-2006 第二军医大学生化与分子生物学/中科院上海营养科学研究所 博士
2006-2009 美国UC IRVINE大学、Sunhealth(Banner Health) Research Institute 博士后
2009-2011 西安交通大学生命科学与技术学院 副教授
2011- 西安交通大学生命科学与技术学院 教授(青年骨干教师)，博士生导师
2015-2016 西安交通大学生命科学与技术学院 副院长
2016- 西安交通大学研究生院 副院长




联系方式

龙建纲 博士
Tel: (School of Life Science)
(Graduate School)
E-mail: jglong@mail.xjtu.edu.cn
西安交通大学生命科学与技术学院# 421





站点收藏
类别/站点
刘健康教授
第二军医大学
中科院营养科学研究所
王福俤研究员
Banner Health Research Institute
University of California, Irvine


闹钟




站点计数器

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科研与教学 - 龙 建纲研究领域


衰老及相关疾病的发生机制及其早期干预策略



随着我国经济社会的发展和人口结构逐步进入老龄化社会，衰老和衰老相关疾病（如老年痴呆症）以及代谢性疾病（如2型糖尿病）发病率迅速上升，已经对我国的公共卫生和医疗保健系统提出严峻挑战。该类疾病现有治疗手段仅能部分缓解疾病症状，尚未发现有效的治疗办法。揭示该类疾病的发生机制并发展有效的防治办法具有重要的科学意义和应用价值。
针对上述重大慢性疾病，研究团队围绕细胞能量代谢的核心细胞器-线粒体的代谢和退变机制等中的科学问题，着力探索衰老、老年痴呆症、2型糖尿病发生的线粒体机制，主要包括以下研究方向：
1.揭示线粒体在发育，代谢，动态变化等方面的基本科学问题。
2.针对衰老及衰老相关疾病以及代谢性疾病中的线粒体退变，研究营养素靶向于线粒体及修复线粒体损伤的机制。
这些研究的展开与深入不仅有助于揭示线粒体生物学与医学中的基本规律，而且有助于发展安全、有效的线粒体营养产品，将为线粒体相关疾病的危险人群的早期预防和治疗提供重要的科学依据。




科研项目

项目名称
项目来源
起止时间

胰岛素抵抗中的线粒体自噬研究
国家自然科学基金面上项目
2011-2013

HT-ac维持高强度脑力作业能力及其线粒体机制研究
国家自然科学基金应急管理项目
2018

mtKAS调节细胞硫辛酸水平及参与胰岛素抵抗的作用机制
国家自然科学基金面上项目
2019-2022

线粒体生物学与医学
教育部新世纪优秀人才项目
2011

线粒体代谢动态平衡的分子调控和干预
国家重点基础研究973课题
2015-2019

药效学研究
后勤开放项目
2020-2024

骨代谢研究
中国航天员科研训练中心
2019-2022

磁性水凝胶的肌细胞负载模型中线粒体动态变化研究
航天员中心国家重点实验室开放基金
2015-2016

线粒体DNA甲基化调节线粒体稳态的分子机制
陕西省自然科学基础研究计划重点项目
2018-2020

西安交大创新团队
西安交通大学
2013-2015

Warburg效应与细胞代谢周期
西安交大自然基金重点项目
2017-2019

肉苁蓉提取物等在细胞水平的抗疲劳效应及其线粒体机制研究
杏辉天力(杭州)药业有限公司
2014-2015

天然提取物在细胞水平的抗疲劳效应及其线
粒体机制研究
杏辉天力(杭州)药业有限公司
2016

人参提取物在细胞水平的抗疲劳效应研究
安利（中国）研发中心有限公司
2017

老年人早衰和阿尔茨海默病（AD）代谢标志物筛选及体外检测试剂盒开发
苏州颐生生物医药有限公司
2015-2017





讲授课程

讲授课程：开设并主讲线粒体生物医学（研究生学位课）
主讲生物化学（生命科学人才培养基地班专业课主干课）
生命科学仪器操作及实验安全
生命科学研究进展
其他教学工作:
指导多项国家大学生创新项目

优秀本科生毕业设计指导教师





更新日期
2019年1月

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科研团队 - 龙 建纲科研团队

一、博士后

王大权博士后 杨志伟博士后
研究方向：纳米生物材料基于蛋白质互作的分子设计 研究方向：生物大分子相互作用；

联系方式：yelide@163.com 联系方式：yzws-123@xjtu.edu.cn
二、 研究生

王永耀 博士研究生 赵黛娜 博士研究生
研究方向：膜融合分子机制研究 研究方向：AD的炎症发生机制研究
联系方式：newman315@163.com 联系方式：@qq.com

孙琼 博士研究生 秦川博士研究生 研究方向：线粒体生物医学 研究方向：针对AD的线粒体营养素预防方案
联系方式：jimoshuwo@126.com 联系方式：riverqc@stu.xjtu.edu.com

胡亚冲 博士研究生 张田田 博士研究生
研究方向：线粒体生物医学 研究方向：线粒体生物医学
联系方式：huyachong@126.com 联系方式：sanjie1993@126.com

张爽曦 博士研究生 高佩佩 博士研究生 研究方向：线粒体生物医学 研究方向：线粒体生物医学
联系方式：zhangshuang1994@163.com 联系方式：@qq.com
王珍 博士研究生 杜冬玥博士研究生 研究方向：线粒体生物医学 研究方向：线粒体生物医学
联系方式：**@qq.com 联系方式：dongydu@163.com


刘皓淼 专业学位硕士 周彦章专业学位硕士
研究方向：线粒体生物医学 研究方向：线粒体生物医学
联系方式：@qq.com 联系方式：yanzhang95@qq.com

车佳行专业学位硕士 杨韬 学士学位硕士 研究方向：线粒体生物医学 研究方向：线粒体生物医学
联系方式：@qq.com 联系方式：@qq.com 范强 学士学位硕士 王路遥 专业学位硕士
研究方向：线粒体生物医学 研究方向：线粒体生物医学
联系方式：@qq.com 联系方式：@qq.com


赵壮专业学位硕士
研究方向：线粒体生物医学
联系方式：@qq.com
三、同等学力博士研究生

马庆庆同等学历博士研究生 谢振丽同等学历博士研究生
研究方向：分子诊断及细胞治疗的临床应用 研究方向:神经退行性疾病的线粒体机制
联系方式：xiezhenlili@163.com 联系方式：@qq.com

邱英锋同等学历博士研究生 梁冰同等学历博士研究生 兰州大学第二附属医院 锦州医学院附属医院
研究方向：病毒性肝炎的诊治 研究方向：线粒体生物医学
联系方式：@qq.com 联系方式：**@163.com
四、已毕业学生

陈磊 博士研究生 刘甲 博士研究生
毕业去向：青岛大学食品学院 毕业去向：西安交通大学医学部
联系方式：chenlei2019@qdu.edu.cn 联系方式：chenlei2019@qdu.edu.cn

李华 硕士研究生 侯晨 博士研究生 毕业去向：西安交通大学生命学院实验员 毕业去向：陕西师范大学博士后
联系方式：lhinsistence@stu.xjtu.edu.cn 联系方式：houchen_**@126.com


杨子琪 硕士研究生 李彩霞 硕士研究生 研究方向：自由基生物学与线粒体代谢 毕业去向：新奥集团股份有限公司
联系方式：luoqinmimi@qq.com 联系方式：@qq.com

时乐博士研究生 樊璠 硕士研究生

毕业去向：西安交通大学生命学院 研究方向：线粒体与代谢综合症
联系方式：shile@outlook.com 联系方式：@qq.com
五、大学生本科创新项目成员研究课题1：不同运动强度下大鼠血液中线粒体相关代谢分析 黄恩洪 何旺骁 联系方式：reden@foxmail.com 联系方式： hewangxiao5366@sina.com
闫思琪 联系方式：@qq.com
研究课题2：淀粉样beta肽对人神经母细胞瘤细胞线粒体弹性的影响 廖崇兵 朱益灵 联系方式：basilliao@yeah.net 联系方式：@qq.com 研究课题3：模拟微重力生物学效应的大鼠模型建立及线粒体功能分析

崔智炜 吴志民 联系方式：@qq.com 联系方式：shuiyunyue199@163.com

研究课题4：瑞香素对早衰小鼠SAMP8认知功能改善效应研究
樊思越 张天培 联系方式：@qq.com 联系方式：yyzz0613@163.com

罗宁烽 王文昊 联系方式：@qq.com 联系方式：wangwenhao@stu.xjtu.edu.cn 研究课题5：线粒体生命活动中的热力场研究
李斯珩 朱璇 联系方式：li_seng@163.com 联系方式：@qq.com

杨韬 李晨玉 联系方式：@qq.com 联系方式：kristenmintlee@stu.xjtu.edu.cn

雷洲权 联系方式：@qq.com

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学术成果 - 龙 建纲学术成果

研究团队围绕细胞能量代谢的核心细胞器-线粒体的代谢和退变机制等重要科学问题，在探索衰老、老年痴呆症、2型糖尿病发生的线粒体机制，以及研究靶向干预线粒体退变损伤等方面取得一些重要的原创性发现，为衰老、老年痴呆症、2型糖尿病等的防治提出了新的治疗靶点和防治策略。
一、率先提出并论证细胞脂质代谢中产生的醛类所引起的线粒体退变机制，为Harman博士提出的经典的自由基衰老理论增添了新的理论内容和实验依据。
二、首次实验证实：老年痴呆症发生过程中，脑内性激素参与调节神经元线粒体活性，与老年痴呆症的发生密切相关。该研究解决了本领域研究中一个困扰研究者多年的问题，即性激素水平与老年痴呆症发生之间的关系。
三、在2型糖尿病研究中获得重要发现：胰岛素抵抗的发生伴随细胞自噬异常，后者参与调控线粒体自身代谢。该研究首次揭示了能量代谢的核心细胞器-线粒体自身代谢在糖尿病中的基本调节规律，对于解答糖尿病发生的基本科学问题及其预防有重要意义。
上述研究工作的开展，得到国家基金委、相关国际基金以及教育部“985工程”建设的大力支持。目前，研究团队针对衰老、老年痴呆症、2型糖尿病等重要的线粒体相关疾病，专注于探索其线粒体代谢规律及疾病防治策略，已经形成特色鲜明、有一定国际影响力的学科方向。


荣誉与奖励 1. 入选2011年度教育部新世纪优秀人才计划

2. 获得2011年度陕西省高等院校科学技术一等奖(第二完成人)

3. 入选西安交通大学青年骨干教师
4. 获得2015年度陕西省科技二等奖(第一完成人)
5. 2016年度王宽诚育才奖
6. 陕西省生物化学与分子生物学会理事
7. 陕西省细胞生物学会常务理事



论文发表

英文论文：Publication (* corresponding author) Peng Y, Gao P, Shi L, Chen L, Liu J,Long J*. Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention. [J]. Antioxidants and Redox Signaling, 2020, 32(16). IF=6.323
Liu J, Peng Y, Zhang J,Long J*, Liu J, Wei W. Targeting SCF E3 Ligases for Cancer Therapies.[J]. Advances in experimental medicine and biology, 2020, 1217. IF=2.450
Liu R, Chen L, Wang Z, Zheng X, Wang Y, Li H, Noda Mami, Liu J,Long J*. Downregulation of the DNA 5-hydroxymethylcytosine is involved in mitochondrial dysfunction and neuronal impairment in high fat diet-induced diabetic mice.[J]. Free Radical Biology and Medicine,2020,148. IF=6.170
Zhao D, Zhang S, Wang X, Gao D, Liu J, Cao K, Chen L, Liu R, Liu J, Long J*. ATG7 regulates hepatic Akt phosphorylation through the c-JUN/PTEN pathway in high fat diet-induced metabolic disorder[J]. FASEB journal : official publication of the Federation of American Societies for Experimental Biology,2019,33(12). IF=4.966
Wang D, Meng L, Fei Z, Hou C,Long J*, Zeng L, Dyson Paul J, Huang P. Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity. [J]. Nanoscale,2018,10(18). IF=6.895
Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K,Long J.Li Z,Shen W,Liu J.SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress [J].Cell Death and Differentiation,2018, 25(2): 229. (IF=8.339，中科院1区)
Ouyang C, Chen L, Rees TW, Chen Y, Liu J, Ji L, Long J*, Chao H*. A mitochondria-targeting hetero-binuclear Ir (III)-Pt (II) complex induces necrosis in cisplatin-resistant tumor cells[J]. Chemical Communications, 2018.(IF=6.319，中科院1区)
Hou C, Peng Y, Qin C, Fan F, Liu J, Long J*. Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance[J]. Free Radical Research, 2018: 1-12.(IF=3.18，中科院3区)
Wang K, Xu Y, Sun Q, Long J, Liu J, Ding J. Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms[J]. Free Radical Research, 2018: 1-10.(IF=3.18，中科院3区)
Hou C, Wang Y, Liu J, Wang C, Long J*.（2017）Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.Front Mol Neurosci. [Epub ahead of print] IF 5.154
Xie Z, Long J, Liu J, Chai Z, Kang X, Wang C. （2017）Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons. Front Mol Neurosci. [Epub ahead of print] IF 5.154
Qing Y, Tian Z, Bi Y, Wang Y, Long J, Song CX, Diao J. （2017）Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine.Bioessays. [Epub ahead of print] IF 4.725
Chen L, Liu L, Li C, Hu C, Su F, Liu R, Zeng M, Zhao D, Liu J, Guo Y*, Long J*.（2017）A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice. Mol Nutr Food Res [Epub ahead of print]IF 4.551
Shi L, Zhao D, Hou C, Peng Y, Liu J, Zhang S, Liu J, Long J (2017).Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65.Neurobiol Aging.[Epub ahead of print]IF 5.117
Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K, Long J, Li Z, Shen W, Liu J. (2017)SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.Cell Death Differ.[Epub ahead of print] IF 8.339
Lu Z, Li H, Hou C, Peng Y, Long J*, Liu J* (2017). Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells.Eur Biophys J. [Epub ahead of print] IF 1.444
Chen, L., L. Liu, C. Li, C. Hu, F. Su, R. Liu, M. Zeng, D. Zhao, J. Liu, Y. Guo and J. Long* (2016). Apple pomace polysaccharides improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice." Mol Nutr Food Res. [Epub ahead of print] IF 4.551
Wang, Y., L. Li, C. Hou, Y. Lai, J. Long, J. Liu, Q. Zhong and J. Diao (2016). SNARE-mediated membrane fusion in autophagy. Semin Cell Dev Biol. 60:97-104. IF 5.181
Peng, Y., C. Hou, Z. Yang, C. Li, L. Jia, J. Liu, Y. Tang, L. Shi, Y. Li, J. Long* and J. Liu* (2016). Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. Mol Nutr Food Res. 60(11):2331-2342.IF 4.551
Yan, C., W. Sun, X. Wang, J. Long, X. Liu, Z. Feng and J. Liu* (2016). Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res 60(5): 1139-1149. IF 4.551
Peng, Y., J. Liu, L. Shi, Y. Tang, D. Gao, J. Long* and J. Liu* (2016). Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons. J Neurochem 137(5): 701-713. IF 3.842
Hu, R., J. Diao, J. Li, Z. Tang, X. Li, J. Leitz, J. Long, J. Liu, D. Yu and Q. Zhao (2016). Intrinsic and membrane-facilitated alpha-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep 6: 20776. IF 5.228
Wang, P., L. Jia, B. Chen, L. Zhang, J. Liu, J. Long* and Y. Li* (2016). Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock 46(3): 312-318. IF 3.048
Huang, H., L. Yang, P. Zhang, K. Qiu, J. Huang, Y. Chen, J. Diao, J. Liu, L. Ji, J. Long* and H. Chao* (2016). Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. Biomaterials 83: 321-331. IF 8.387
Hou, C., Y. Wang, E. Zhu, C. Yan, L. Zhao, X. Wang, Y. Qiu, H. Shen, X. Sun, Z. Feng, J. Liu* and J. Long* (2016). Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol 103: 85-97. IF 5.091
Liu, J., Y. Peng, X. Wang, Y. Fan, C. Qin, L. Shi, Y. Tang, K. Cao, H. Li, J. Long* and J. Liu* (2016). Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. Mol Pharm 13(1): 73-84. IF 4.384
Tang Y, Peng Y, Liu J, Shi L, Wang Y, Long J*, Liu J*. (2015) Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer's disease. J Neurochem. 2015 Nov 18. doi: 10.1111/jnc.13437. [Epub ahead of print] IF 4.281
Tang Y, Liu J, Long J*. (2015) Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig 3, 250-5. IF 1.8
Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y, Long J, Liu J, Feng Z.(2015) Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr, 111667-76. IF 3.453
Sun L, Liu T, Li H, Yang L, Meng L, Lu Q, Long J.(2015) Fluorescent and cross-linked organic-inorganic hybrid nanoshells for monitoring drug delivery. ACS Appl Mater Interfaces 8, 4990-7.IF 6.723
Luo C, Li Y, Yang L, Zheng Y, Long J, Jia J, Xiao S, Liu J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.Int J Nanomedicine 9,4763-72. IF 4.383
Zou, X., Yan, C., Shi, Y., Cao, K., Xu, J., Wang, X., Chen, C., Luo, C., Li, Y., Gao, J., Pang, W., Zhao, J., Zhao, F., Li, H., Zheng, A., Sun, W., Long, J., Szeto, I. M., Zhao, Y., Dong, Z., Zhang, P., Wang, J., Lu, W., Zhang, Y., Liu, J., and Feng, Z. (2014) Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal 21, 1557-1570. IF 7.67
Zhao, L., Zou, X., Feng, Z., Luo, C., Liu, J., Li, H., Chang, L., Wang, H., Li, Y., Long, J*., and Gao, F. (2014) Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol 56, 3-12.IF 3.53
Tang, Y., Mi, C., Liu, J., Gao, F., and Long, J*. (2014) Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Cardiovasc Pathol 23, 101-106. IF 2.4
Peng, Y., Liu, J., Tang, Y., Han, T., Han, S., Li, H., Hou, C., and Long, J*. (2014) High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AbetaPP Processing and Cognition in Female APP/PS1 Mice. Front Cell Neurosci 8, 225. IF 4.18
Luo, C., Li, Y., Zhou, B., Yang, L., Li, H., Feng, Z., Long, J., and Liu, J. (2014) A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. Apoptosis 19, 542-553. IF 3.61
Luo, C., Li, Y., Yang, L., Zheng, Y., Long, J., Jia, J., Xiao, S., and Liu, J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. Int J Nanomedicine 9, 4763-4772. IF 4.20
Luo, C., Li, Y., Yang, L., Wang, X., Long, J., and Liu, J. (2014) Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses. Arch Toxicol . IF 5.1
Liu, Y., Long, J., and Liu, J. (2014) Mitochondrial free radical theory of aging: who moved my premise? Geriatr Gerontol Int 14, 740-749. IF 1.58
Liu, J., Tang, Y., Feng, Z., and Long, J*. (2014) (-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto-Kakizaki (GK) rats. Free Radic Res 48, 898-906. IF 3.00
Liu, J., Tang, Y., Feng, Z., Hou, C., Wang, H., Yan, J., Shen, W., Zang, W., and Long, J*. (2014) Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism 63, 1314-1323. IF 3.61
Liu, J., Peng, Y., Feng, Z., Shi, W., Qu, L., Li, Y., and Long, J*. (2014) Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic Biol Med 69, 116-128. IF 5.71
Chen, C., Han, X., Zou, X., Li, Y., Yang, L., Cao, K., Xu, J., Long, J., Liu, J., and Feng, Z. (2014) 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem 289, 17184-17194. IF 4.6
Chang, L., Liu, X., Liu, J., Li, H., Yang, Y., Guo, Z., Xiao, K., Zhang, C., Zhao-Wilson, X., and Long, J*. (2014) D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment. J Med Food 17, 357-364. IF 2.5
Cao, K., Zheng, A., Xu, J., Li, H., Liu, J., Peng, Y., Long, J., Zou, X., Li, Y., Chen, C., and Feng, Z. (2014) AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med 75, 156-166. IF 5.71
Cao, K., Xu, J., Zou, X., Li, Y., Chen, C., Zheng, A., Li, H., Szeto, I. M., Shi, Y., Long, J., Liu, J., and Feng, Z. (2014) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67, 396-407. IF 5.71
Luo C, Wang H, Chen X, Cui Y, Li H, Long J, Mo X, Liu J (2013) Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae. Phytomedicine 21, 20-24.IF 3.3
Luo C, Li Y, Yang L, Feng Z, Long J, Liu J (2013) A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology 14, 503-511. IF 3.2
Luo C, Li Y, Wang H, Feng Z, Long J*, Liu J (2013) Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biochem 114, 212-219. IF 3.4
Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Wang Y, Wurtz K, Weber P, Long J*, Liu J (2013) Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells. Curr Cancer Drug Targets 13, 625-639. IF 4.3
Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Szeto IM, Shi Y, Long J, Liu J, Feng Z (2013) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67C, 396-407. IF 5.3
Aksenov V, Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD (2013) A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice. Age (Dordr) 35, 23-33. IF 6.2
Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P, Long J*, Liu J (2012) Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem 23, 716-724. IF 4.2
Long J, He P, Shen Y, Li R (2012) New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-beta. J Alzheimers Dis 30, 545-558. IF 4.2
Long J, Gao M, Kong Y, Shen X, Du X, Son YO, Shi X, Liu J, Mo X (2012) Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine 19, 672-676. IF 3.3
Long J, Aksenov V, Rollo CD, Liu J (2012) A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging. Mech Ageing Dev. IF 4.2
Liu J, Peng Y, Long J* (2012) The Role of Brain Mitochondrial Estrogen Receptor beta in The Pathogensis of Female Alzheimer's Disease. Progress In Biochemistry And Biophysics, 785-790. IF 0.5
Liu J, Peng Y, Cui Z, Wu Z, Qian A, Shang P, Qu L, Li Y, Long J* (2012) Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading. IUBMB Life. IF 3.8
Hao J, Shen W, Sun L, Long J, Sharman E, Shi X, Liu J (2011) Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients. Br J Nutr 106, 648-655. IF 3.2
Gao M, Li Y, Sun Y, Shah W, Yang S, Wang Y, Long J* (2011) Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix. Basic Clin Pharmacol Toxicol 109, 398-406. IF 2.3
Gao M, Li Y, Sun Y, Long J, Kong Y, Yang S, Wang Y (2011) A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Mutat Res 724, 69-75. IF 3.2
Gao M, Li Y, Long J, Shah W, Fu L, Lai B, Wang Y (2011) Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene. Mutat Res 719, 52-59. IF 3.2
McAllister C, Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R (2010) Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J Neurosci 30, 7326-7334.（co-first）IF 7.2
Gao M, Long J, Li Y, Shah W, Fu L, Liu J, Wang Y (2010) Mitochondrial decay is involved in BaP-induced cervical damage. Free Radic Biol Med 49, 1735-1745. IF 5.7
Aldarmaa J, Liu Z, Long J, Mo X, Ma J, Liu J (2010) Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem Res 35, 33-41.IF 2.7
Aksenov V, Long J, Lokuge S, Foster JA, Liu J, Rollo CD (2010) Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med (Maywood) 235, 66-76.IF 2.7
Long J, Ma J, Luo C, Mo X, Sun L, Zang W, Liu J (2009) Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart. Life Sci 85, 276-280.IF 2.5
Long J, Liu C, Sun L, Gao H, Liu J (2009) Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res 34, 786-794.IF 2.7
Long J, Gao H, Sun L, Liu J, Zhao-Wilson X (2009) Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Res 12, 321-331.IF 4.1
Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J (2009) Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res 34, 755-763.IF 2.7
Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C, Long J, Sharman E, Liu J (2009) Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med 13, 701-711. IF 4.6
Luo C, Long J, Liu J (2008) An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity. Clin Chim Acta 395, 38-41. IF 2.85
Long J, Liu C, Sun L, Gao H, Liu J (2008) Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria. Neurochem Res.IF 2.1
Shen H, Zhang Y, Xu J, Long J, Qin H, Liu F, Guo J (2007) Zinc distribution and expression pattern of ZnT3 in mouse brain. Biol Trace Elem Res 119, 166-174. IF 1.5
Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Cui X, Packer L, Liu J (2007) D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 8, 373-381. IF 3.0
Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P, Long J, Liu J (2007) Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem 103, 2690-2700.IF 4.1
Sun L, Luo C, Long J, Wei D, Liu J (2006) Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion 6, 136-142. IF 3.7
Luo C, Wang X, Long J, Liu J (2006) An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods 68, 101-111. IF 2.2
Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Liu J (2006) Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci 79, 1466-1472. IF 2.5
Cui X, Zuo P, Zhang Q, Li X, Hu Y, Long J, Packer L, Liu J (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res 83, 1584-1590. IF 2.9
中文论文：(*通讯作者)
冯晗珂,崔玉婷,毕金淼,米捷,高月华,陈杰巃,龙建纲,李华,孔宇.UPLC-UV法分离分析橄榄叶及生物样本中的羟基酪醇[J].分析试验室,2020,39(07):800-805.
张婷华,胡亚冲,龙建纲,许小红.羟基酪醇丁酸酯的处方前研究[J].国际药学研究杂志,2020,47(04):300-303.
李斯珩,雷洲权,李晨玉,朱璇,杨韬,胡亚冲,谢振丽,刘健康,龙建纲.线粒体的温度及其检测技术[J].航天医学与医学工程,2019,32(04):364-369.
高佩佩,王珍,刘静,龙建纲.氧化苦参碱的药代动力学、毒理学及药理作用[J].中国药理学通报,2019,35(07):898-902.
王珍,高佩佩,彭韵桦,刘健康,龙建纲.阿尔茨海默病病理发生中的性别差异[J].生物化学与生物物理进展,2019,46(05):449-455.
郭谦楠,王莉,李涛,肖海,冯战启,刘红彦,候巧芳,康冰,廖世秀,龙建纲.MTRR 66A>G基因多态性与410例原发性男性不育患者的相关性研究[J].重庆医学,2019,48(01):44-47+51.
张爽曦, 龙建纲, 刘健康. 胰岛素降解酶与阿尔兹海默病的发生[J]. 中国生物化学与分子生物学报, 2018.
樊璠, 龙建纲*, 刘健康. AD早期诊断的体液生物标志物[J].生命科学研究,2017,212(4):370-376.
田芷淇, 胡亚冲, 龙建纲, 刘健康, 刁佳杰*. 单分子生物物理技术在神经递质释放研究中的应用[J]. 生物化学与生物物理学进展,2016,43(10):946-951.
杨子琪, 龙建纲*, 刘健康. 羟基酪醇的生物学活性及其代谢特征[J]. 中国药理学报,2016,32(9):1189-1193.
李彩霞, 胡亚冲, 龙建纲*, 刘健康. 线粒体DNA甲基化研究进展[J]. 中国科学：生命科学,2016,46(7):880-885.
龙建纲, 刘健康. 线粒体营养素[J]. 肿瘤代谢与营养电子杂志：专家论坛,2016,3(2):71-76.
罗成, 李艳, 龙建纲*. 纳米材料模拟酶的研究进展[J]. 中国科学：化学,2015,45(10):1026-1041.
罗成, 李艳, 龙建纲*. 四氧化三铁纳米颗粒过氧化物酶样活性的应用[J]. 科学通报,2015,60(35):3478-3488.
贾丽妍, 龙建纲, 刘健康. 氢分子对心肌损伤的防护效应及机制[J]. 生物化学与生物物理进展,2015,42(8):713-720.
时乐, 龙建纲*, 刘健康. 酮体代谢与阿尔兹海默病[J]. 生物化学与生物物理进展,2015,42(4):323-328.
刘静, 龙建纲*, 刘健康. 运动与氧化还原信号调控[J]. 生理科学进展,2014,04:263-266.
刘烨, 孙文艳, 龙建纲. 刘健康. S100A7的生物学特征及其与疾病的关系[J]. 医学研究生学报,2014,307:767-771.
高静, 龙建纲, 刘健康. 骨质疏松症发生与防治的线粒体机制[J].航天医学与医学工程,2013,26(006),491-494.

纪元, 龙建纲, 刘健康. 自噬发生中的ROS调节机制[J].中国生物化学与分子生物学报,2014,30,321-327.

刘静, 龙建纲, 刘健康. 后肢失负荷诱导的骨骼肌萎缩中线粒体功能紊乱[J]. 航天医学与医学工程,2013,26(002),140-144.

王逊, 龙建纲, 刘健康. 运动和营养素的细胞内作用靶点—线粒体:阿尔茨海默病防治的新思路[J]. 体育科研,2013,34(6).

鲁卓阳, 龙建纲*, 李涤尘, 刘健康. 基于原子力显微镜的细胞弹性测量及分析方法[J]. 电子显微学报,2012,31(4),54-60.

侯晨, 龙建纲*, 刘健康. 氢医学研究及可能的线粒体机制[J].医学综述,2012.

李华, 龙建纲*, 刘健康. 阿尔茨海默病(Alzheimer's disease)与动力相关蛋白1(dynamin-related protein1, Drp1)[J]. 生物学杂志.2012.

刘健康, 彭韵桦, 龙建纲. 脑内线粒体雌激素受体茁在女性阿尔茨海默病发生过程中的作用[J]. 生物化学与生物物理学进展,2012,39(8):785-790.

龙建纲,王学敏,高宏翔,刘志,缪明永,刘健康. 黄素单核苷酸对羟自由基损伤的大鼠肝线粒体复合物I的保护作用[J]. 第二军医大学学报,2005,
26:1136-1139.

龙建纲,王洁,缪明永,王学敏. 改良PCR-RFLP法测定异质性线粒体基因的相对含量[J]. 第二军医大学学报,2004,25:1036-1037.

龙建纲,张燕琴,沈慧,秦海宏,王福俤. 锌对断乳小鼠金属离子转运体mRNA表达的影响[J]. 中国公共卫生,2004,20:772-774.

龙建纲,张燕琴,沈慧,秦海宏,王福俤,王海明.基因芯片技术筛选孕期缺锌仔鼠脑中差异表达基因[J]. 营养学报,2004,26:89-93.

龙建纲,汪振诚,王学敏. 线粒体:新的细胞内药物作用靶点[J]. 中国药理学通报,2003,19:859-863.

龙建纲, 陈坚,王福俤. 小鼠ZnT3cDNA片断的克隆及其mRNA表达[J]. 卫生研究,2003,31:103-105.

龙建纲, 王福俤.二价金属子子转运体DMT1的研究进展[J]. 国外医学:卫生学分册,2002,29:97-100.

龙建纲,王福俤, 王海明. 锌转运体研究进展[J]. 国外医学(卫生学分册),2001,28:33-37.

刘芳,许家军,龙建纲,向正华,沈慧,张传森,王福俤. 地高辛原位杂交显示锌转运体3mRNA在脑、脊髓和脊神经节中的分布[J]. 解剖学杂志,2001,31:747-750.

韩秋成,朱有华,朱雄伟,龙建纲,刘健康. SMO保存液对犬肾低温保存期间线粒体功能的保护作用[J]. 中华器官移植杂志,2007,28:239-241.

张元勋,龙建纲,王荫淞,李德禄,王福俤,沈慧,李爱国,张桂林,黄宇营,何玮. 小鼠脑中Zn元素和ZnT3mRNA表达的研究[J]. 中国病理生理杂志,2006,22:1784-1787.

王洁,王学敏,龙建纲,于军,汪振诚,焦炳华.人肝癌SMMC-7721细胞株部分线粒体基因表达的研究[J]. 第二军医大学学报,2006,27:46-50.

孙青菊,龙建纲,汪振诚,缪明永,王学敏.人胚肺二倍体成纤维细胞WI-38年轻和衰老细胞中线粒体量和mtDNA相对含量以及功能变化的比较[J]. 第二军医大学学报,2006,27:1290-1294.

沈慧,秦海宏,龙建纲,王福俤,郭俊生.锌对Caco2细胞ZIP4mRNA表达的影响[J]. 卫生研究,2006,35:426-427.

沈慧,秦海宏,龙建纲,王福俤,郭俊生.锌对Caco2细胞锌转运体mRNA表达的影响[J]. 中国临床康复,2006,10:87-189

王洁,王学敏,龙建纲,汪振诚,高建国.60C0照射后SMMC-7721细胞线粒体DNA部分非编码区断裂敏感位点初探[J]. 第二军医大学报,2005,26:615-617.

沈慧,秦海宏,王福悌,龙建纲,郭俊生. 锌铁调控蛋白4cDNA片断的获得及mRNA表达[J]. 中国公共卫生,2005,21:155-156.

沈慧,龙建纲,王福俤,秦海宏,郭俊生. 不同锌营养状态小鼠肾MT-1mRNA表达的观察[J]. 解放军预防医学杂志,2005,23:98-298.

张燕琴, 龙建纲, 沈慧, 秦海宏,王福俤. 不同饲料锌水平对哺乳期后幼鼠大脑及睾丸组织ZnT3mRNA表达的影响[J]. 第二军医大学学报,2004,25:838-841.

王洁,龙建纲,缪明永, 王学敏. 人线粒体DNA复制控制区与疾病和衰老的关系[J]. 生命的化学,2004,24:36-38.

沈慧, 龙建纲. 金属硫蛋白-3研究进展[J]. 国外医学：卫生学分册,2003,30:37-39.

专著： 《线粒体医学与健康》副主编,科学出版社,2012.8出版
专利：

名称
专利类型
发明人
申请号
申请日
实审生效日

3-羟基-3’,4’-二羟基-丁酸苯乙酯在制备改善主动脉内皮细胞功能药物中的应用
发明
刘健康;柳絮云;朱才悦;楼静;赵琳;龙建纲;
CN7.2
**
**

瑞香素在制备改善主动脉内皮细胞功能的药物中的应用
发明
龙建纲;柳絮云;刘健康;
CN3.6
**
**

瑞香素改善衰老相关认知能力衰退的药物应用
发明
龙建纲;高佩佩;王珍;祁红斌;熊跃;马庆庆;梁冰;刘健康;
CN3.7
**
**

一种增强免疫力的组合物及其制备方法和用途
发明
刘健康;曹可;彭韵桦;郑阿迪;王潇捷;龙建纲;
CN4.6
**
**

一种辅助降血糖组合物及其制备方法和用途
发明
刘健康;曹可;彭韵桦;郑阿迪;王潇捷;龙建纲;
CN5.1
**
**

基于线粒体营养素理论的缓解体力疲劳的组合物及用途
发明
刘健康;樊璠;刘静;李华;胡亚冲;祁红斌;龙建纲;
CN1.6
**
**

一种缓解眼疲劳的复方组合物
发明
刘健康;龙建纲;冯智辉;刘中博;
CN4.0
**
**

一种用于TNF?α检测的半定量核酸适配体试纸条及其制备方法
发明
孔宇;孔令洪;杨桂芳;樊璠;祁红斌;刘健康;龙建纲;
CN5.5
**
**

NF-κB p65/HMGCS2调控途径在制备调控酮体合成的药物中的应用
发明
龙建纲;时乐;刘健康;赵黛娜;秦川;王永耀;
CN3.2
**
**

氢分子固态载体在制备防治肥胖相关代谢炎症的药物中的应用
发明
刘健康;龙建纲;侯晨;
CN4.X
**
**
**（发明专利申请公布后的视为撤回）

Composition for enhancing immunity as well as preparation method and application of composition
发明
刘健康;曹可;彭韵桦;郑阿迪;王潇捷;龙建纲;
CN:4:A
**
**

羟基酪醇在制备防治阿尔茨海默病的药物中的应用
发明
龙建纲;彭韵桦;侯晨;刘静;时乐;刘健康;
CN4.3
**
**
**（发明专利申请公布后的视为撤回）

氢分子固态载体在制备抑制肥胖的保健品和药物中的应用
发明
刘健康;龙建纲;侯晨;唐颖;赵琳;
CN3.6
**
**
**（专利申请权、专利权的转移）

EGCG在制备防治心肌能量代谢障碍的食品和药物的应用
发明
刘健康;龙建纲;刘甲;唐颖;冯智辉;严炯;
CN5.X
**
**
**（发明专利申请公布后的视为撤回）

α-硫辛酸,乙酰左旋肉碱,辅酶Q10及羟基酪醇配伍在防治肌萎缩发生中的应用
发明
刘健康;龙建纲;刘静;彭韵桦;
CN1.7
**
**
**（授权）

一种解淀粉产乳酸固氮的酵母菌及其应用
发明
杨水云;王玲;吴耀彬;林杰;黄敬亮;龙建纲;刘健康;
CN3.3
**
**
**（授权）
**（专利权的终止）

---

招生信息 - 龙 建纲招生信息

硕士/博士研究生招生目录

专 业

研究方向

考试科目

备 注


生物学

1.生物化学与分子生物学






2.神经生物学

---

生物医学工程


1.生物化学与分子生物学：
线粒体生物医学，研究老年痴呆症，糖尿病
中代谢紊乱的线粒体机制及靶向预防方案。
2.神经生物学：
研究衰老、老年痴呆症中认知衰退机制及
早期代谢标志物鉴定，营养素与功能分子的作用机制。

---

延缓认知功能衰退和调节糖脂代谢的功能
食品研发，早期诊断试剂盒的研发。

学术型硕士：
1.101思想政治理论
2.201 英语一
3.302 数学二
或714 生物综合
或723 物理化学
或721 医学基础综合
4.833 生物化学
或835 细胞生物学
或821 有机化学
专业学位硕士（营养与健康产品研发方向）
参考当年招生简章
博士：
采取申请考核制，请关注当年博士招生简章。
学术型硕士复试
复试科目:生物技术
参考书：《现代生物技术导论》高等教育出版社，瞿礼嘉
招生类别
硕士：
学术型硕士；
专业学位硕士
博士：
全日制博士；
同等学历博士



注：硕士及博士考试科目或考核办法以当年西安交大硕生和博士招生简章为准。


报考咨询

1、致电或致信实验室研究生

胡亚冲
电子邮件：huyachong@126.com;
联系电话：**

李华
电子邮件：lhinsistence@stu.xjtu.edu.cn;
联系电话：**


2、生命学院研究生办公室
王老师
联系电话：

3、联系导师

龙建纲
电子邮件：jglong@mail.xjtu.edu.cn
联系电话：

---

English Version - 龙 建纲Basic Information


Jiangang Long，PH. D.

Professor
Institute of Mitochondrial Biology and Medicine of Xi’an Jiaotong University School of Life Science and Technology




Research Interests
Mitochondrial Degeneration & Therapeutic Intervention in Aging, Neurodegenerative Diseases and Metabolic Syndromes



Contact Information
Tel:+86-29-8266 4232

Fax:+86-29-8266 5849

Email:jglong@mail.xjtu.edu.cn

Address:Xi’an Jiaotong University School of Life Science and Technology (Room North 417)28 W.Xianning Road, Xi’an 710049, China





闹钟




站点计数器




Education
2006 Ph.D. Biochemistry and Molecular Biology
Dept. of Chemistry and Molecular Biochemistry, Second Military Medical University and Institute for
Nutritional Sciences, Chinese Academy of Sciences
2002 M.S. Public Health
Dept. of Public Health, Second Military Medical University
1996 B.S. Pharmacy
Pharmacy school, Second Military Medical University




Working Experience
2016- Graduate School, Xi'an Jiaotong University, Vice Dean
2015-2016 School of Life Science,Xi'an Jiaotong University, Vice Dean
2011- School of Life Science,Xi'an Jiaotong University, Professor
2009-2011 School of Life Science, Xi'an Jiaotong University, Associate Professor
2008-2009 Sunhealth Research Institute, USA. Postdoc
2006-2008 UC Irvine, USA. Postdoc




Publications
Publication (* corresponding author)
Peng Y,Gao P,Shi L,Chen L,Liu J,Long J*. Central and Peripheral Metabolic Defects Contribute to the Pathogenesis of Alzheimer's Disease: Targeting Mitochondria for Diagnosis and Prevention.[J]. Antioxidants and Redox Signaling,2020,32(16). IF=6.323
Liu J,Peng Y,Zhang J,Long J*,Liu J,Wei W. Targeting SCF E3 Ligases for Cancer Therapies.[J]. Advances in experimental medicine and biology,2020,1217. IF=2.450
Liu R,Chen L,Wang Z,Zheng X,Wang Y,Li H,Noda Mami,Liu J,Long J*. Downregulation of the DNA 5-hydroxymethylcytosine is involved in mitochondrial dysfunction and neuronal impairment in high fat diet-induced diabetic mice.[J]. Free Radical Biology and Medicine,2020,148. IF=6.170
Zhao D,Zhang S,Wang X,Gao D,Liu J,Cao K,Chen L,Liu R,Liu J,Long J*. ATG7 regulates hepatic Akt phosphorylation through the c-JUN/PTEN pathway in high fat diet-induced metabolic disorder[J]. FASEB journal : official publication of the Federation of American Societies for Experimental Biology,2019,33(12). IF=4.966
Wang D,Meng L,Fei Z,Hou C,Long J*,Zeng L,Dyson Paul J,Huang P. Multi-layered tumor-targeting photothermal-doxorubicin releasing nanotubes eradicate tumors in vivo with negligible systemic toxicity.[J]. Nanoscale,2018,10(18). IF=6.895
Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K,Long J.Li Z,Shen W,Liu J.SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress [J].Cell Death and Differentiation,2018, 25(2): 229. (IF=8.339，中科院1区)
Ouyang C, Chen L, Rees TW, Chen Y, Liu J, Ji L,Long J*, Chao H*. A mitochondria-targeting hetero-binuclear Ir (III)-Pt (II) complex induces necrosis in cisplatin-resistant tumor cells[J].Chemical Communications, 2018.(IF=6.319，中科院1区)
Hou C, Peng Y, Qin C, Fan F, Liu J,Long J*. Hydrogen-rich water improves cognitive impairment gender-dependently in APP/PS1 mice without affecting Aβ clearance[J].FreeRadicalResearch, 2018: 1-12.(IF=3.18，中科院3区)
Wang K, Xu Y, Sun Q,Long J, Liu J, Ding J. Mitochondria regulate cardiac contraction through ATP-dependent and independent mechanisms[J].FreeRadicalResearch, 2018: 1-10.(IF=3.18，中科院3区)
Hou C, Wang Y, Liu J, Wang C,Long J*.（2017）Neurodegenerative Disease Related Proteins Have Negative Effects on SNARE-Mediated Membrane Fusion in Pathological Confirmation.Front Mol Neurosci. [Epub ahead of print] IF 5.154
Xie Z,Long J, Liu J, Chai Z, Kang X, Wang C. （2017）Molecular Mechanisms for the Coupling of Endocytosis to Exocytosis in Neurons. Front Mol Neurosci. [Epub ahead of print] IF 5.154
Qing Y, Tian Z, Bi Y, Wang Y,Long J, Song CX, Diao J. （2017）Quantitation and mapping of the epigenetic marker 5-hydroxymethylcytosine.Bioessays. [Epub ahead of print] IF 4.725
Chen L, Liu L, Li C, Hu C, Su F, Liu R, Zeng M, Zhao D, Liu J, Guo Y*,Long J*.（2017）A mix of apple pomace polysaccharide improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice. Mol Nutr Food Res [Epub ahead of print]IF 4.551
Shi L, Zhao D, Hou C, Peng Y, Liu J, Zhang S, Liu J,Long J(2017).Early interleukin-6 enhances hepatic ketogenesis in APPSWE/PSEN1dE9 mice via 3-hydroxy-3-methylglutary-CoA synthase 2 signaling activation by p38/nuclear factor κB p65.Neurobiol Aging.[Epub ahead of print]IF 5.117
Gao J, Feng Z, Wang X, Zeng M, Liu J, Han S, Xu J, Chen L, Cao K,Long J, Li Z, Shen W, Liu J. (2017)SIRT3/SOD2 maintains osteoblast differentiation and bone formation by regulating mitochondrial stress.Cell Death Differ.[Epub ahead of print] IF 8.339
Lu Z, Li H, Hou C, Peng Y,Long J*, Liu J* (2017). Endogenously generated amyloid-β increases stiffness in human neuroblastoma cells.Eur Biophys J. [Epub ahead of print] IF 1.444
Chen, L., L. Liu, C. Li, C. Hu, F. Su, R. Liu, M. Zeng, D. Zhao, J. Liu, Y. Guo andJ. Long*(2016). Apple pomace polysaccharides improves mitochondrial function and reduces oxidative stress in the liver of high-fat diet-induced obese mice." Mol Nutr Food Res. [Epub ahead of print] IF 4.551
Wang, Y., L. Li, C. Hou, Y. Lai,J. Long, J. Liu, Q. Zhong and J. Diao (2016). SNARE-mediated membrane fusion in autophagy. Semin Cell Dev Biol. 60:97-104. IF 5.181
Peng, Y., C. Hou, Z. Yang, C. Li, L. Jia, J. Liu, Y. Tang, L. Shi, Y. Li,J. Long*and J. Liu* (2016). Hydroxytyrosol mildly improve cognitive function independent of APP processing in APP/PS1 mice. Mol Nutr Food Res. 60(11):2331-2342.IF 4.551
Yan, C., W. Sun, X. Wang,J. Long, X. Liu, Z. Feng and J. Liu* (2016). Punicalagin attenuates palmitate-induced lipotoxicity in HepG2 cells by activating the Keap1-Nrf2 antioxidant defense system. Mol Nutr Food Res 60(5): 1139-1149. IF 4.551
Peng, Y., J. Liu, L. Shi, Y. Tang, D. Gao,J. Long*and J. Liu* (2016). Mitochondrial dysfunction precedes depression of AMPK/AKT signaling in insulin resistance induced by high glucose in primary cortical neurons. J Neurochem 137(5): 701-713. IF 3.842
Hu, R., J. Diao, J. Li, Z. Tang, X. Li, J. Leitz,J. Long, J. Liu, D. Yu and Q. Zhao (2016). Intrinsic and membrane-facilitated alpha-synuclein oligomerization revealed by label-free detection through solid-state nanopores. Sci Rep 6: 20776. IF 5.228
Wang, P., L. Jia, B. Chen, L. Zhang, J. Liu,J. Long*and Y. Li* (2016). Hydrogen Inhalation is Superior to Mild Hypothermia in Improving Cardiac Function and Neurological Outcome in an Asphyxial Cardiac Arrest Model of Rats. Shock 46(3): 312-318. IF 3.048
Huang, H., L. Yang, P. Zhang, K. Qiu, J. Huang, Y. Chen, J. Diao, J. Liu, L. Ji,J. Long*and H. Chao* (2016). Real-time tracking mitochondrial dynamic remodeling with two-photon phosphorescent iridium (III) complexes. Biomaterials 83: 321-331. IF 8.387
Hou, C., Y. Wang, E. Zhu, C. Yan, L. Zhao, X. Wang, Y. Qiu, H. Shen, X. Sun, Z. Feng, J. Liu* andJ. Long*(2016). Coral calcium hydride prevents hepatic steatosis in high fat diet-induced obese rats: A potent mitochondrial nutrient and phase II enzyme inducer. Biochem Pharmacol 103: 85-97. IF 5.091
Liu, J., Y. Peng, X. Wang, Y. Fan, C. Qin, L. Shi, Y. Tang, K. Cao, H. Li,J. Long*and J. Liu* (2016). Mitochondrial Dysfunction Launches Dexamethasone-Induced Skeletal Muscle Atrophy via AMPK/FOXO3 Signaling. Mol Pharm 13(1): 73-84. IF 4.384
Tang Y, Peng Y, Liu J, Shi L, Wang Y,Long J*, Liu J*. (2015) Early inflammation-associated factors blunt sterol regulatory element-binding proteins-1-mediated lipogenesis in high-fat diet-fed APPSWE /PSEN1dE9 mouse model of Alzheimer's disease. J Neurochem. 2015 Nov 18. doi: 10.1111/jnc.13437. [Epub ahead of print] IF 4.281
Tang Y, Liu J,Long J*. (2015) Phosphatase and tensin homolog-induced putative kinase 1 and Parkin in diabetic heart: Role of mitophagy. J Diabetes Investig 3, 250-5. IF 1.8
Zheng A, Li H, Xu J, Cao K, Li H, Pu W, Yang Z, Peng Y,Long J, Liu J, Feng Z.(2015) Hydroxytyrosol improves mitochondrial function and reduces oxidative stress in the brain of db/db mice: role of AMP-activated protein kinase activation. Br J Nutr, 111667-76. IF 3.453
Sun L, Liu T, Li H, Yang L, Meng L, Lu Q,Long J.(2015) Fluorescent and cross-linked organic-inorganic hybrid nanoshells for monitoring drug delivery. ACS Appl Mater Interfaces 8, 4990-7.IF 6.723
Luo C, Li Y, Yang L, Zheng Y,Long J, Jia J, Xiao S, Liu J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts.Int J Nanomedicine 9,4763-72. IF 4.383
Zou, X., Yan, C., Shi, Y., Cao, K., Xu, J., Wang, X., Chen, C., Luo, C., Li, Y., Gao, J., Pang, W., Zhao, J., Zhao, F., Li, H., Zheng, A., Sun, W.,Long, J., Szeto, I. M., Zhao, Y., Dong, Z., Zhang, P., Wang, J., Lu, W., Zhang, Y., Liu, J., and Feng, Z. (2014) Mitochondrial dysfunction in obesity-associated nonalcoholic fatty liver disease: the protective effects of pomegranate with its active component punicalagin. Antioxid Redox Signal 21, 1557-1570. IF 7.67
Zhao, L., Zou, X., Feng, Z., Luo, C., Liu, J., Li, H., Chang, L., Wang, H., Li, Y.,Long, J*., and Gao, F. (2014) Evidence for association of mitochondrial metabolism alteration with lipid accumulation in aging rats. Exp Gerontol 56, 3-12.IF 3.53
Tang, Y., Mi, C., Liu, J., Gao, F., andLong, J*. (2014) Compromised mitochondrial remodeling in compensatory hypertrophied myocardium of spontaneously hypertensive rat. Cardiovasc Pathol 23, 101-106. IF 2.4
Peng, Y., Liu, J., Tang, Y., Han, T., Han, S., Li, H., Hou, C., andLong, J*. (2014) High-Fat-Diet-Induced Weight Gain Ameliorates Bone Loss without Exacerbating AbetaPP Processing and Cognition in Female APP/PS1 Mice. Front Cell Neurosci 8, 225. IF 4.18
Luo, C., Li, Y., Zhou, B., Yang, L., Li, H., Feng, Z.,Long, J., and Liu, J. (2014) A monocarbonyl analogue of curcumin, 1,5-bis(3-hydroxyphenyl)-1,4-pentadiene-3-one (Ca 37), exhibits potent growth suppressive activity and enhances the inhibitory effect of curcumin on human prostate cancer cells. Apoptosis 19, 542-553. IF 3.61
Luo, C., Li, Y., Yang, L., Zheng, Y.,Long, J., Jia, J., Xiao, S., and Liu, J. (2014) Activation of Erk and p53 regulates copper oxide nanoparticle-induced cytotoxicity in keratinocytes and fibroblasts. Int J Nanomedicine 9, 4763-4772. IF 4.20
Luo, C., Li, Y., Yang, L., Wang, X.,Long, J., and Liu, J. (2014) Superparamagnetic iron oxide nanoparticles exacerbate the risks of reactive oxygen species-mediated external stresses. Arch Toxicol . IF 5.1
Liu, Y.,Long, J., and Liu, J. (2014) Mitochondrial free radical theory of aging: who moved my premise? Geriatr Gerontol Int 14, 740-749. IF 1.58
Liu, J., Tang, Y., Feng, Z., andLong, J*. (2014) (-)-Epigallocatechin-3-gallate attenuated myocardial mitochondrial dysfunction and autophagy in diabetic Goto-Kakizaki (GK) rats. Free Radic Res 48, 898-906. IF 3.00
Liu, J., Tang, Y., Feng, Z., Hou, C., Wang, H., Yan, J., Shen, W., Zang, W., andLong, J*.(2014) Acetylated FoxO1 mediates high-glucose induced autophagy in H9c2 cardiomyoblasts: regulation by a polyphenol -(-)-epigallocatechin-3-gallate. Metabolism 63, 1314-1323. IF 3.61
Liu, J., Peng, Y., Feng, Z., Shi, W., Qu, L., Li, Y., andLong, J*. (2014) Reloading functionally ameliorates disuse-induced muscle atrophy by reversing mitochondrial dysfunction, and similar benefits are gained by administering a combination of mitochondrial nutrients. Free Radic Biol Med 69, 116-128. IF 5.71
Chen, C., Han, X., Zou, X., Li, Y., Yang, L., Cao, K., Xu, J.,Long, J., Liu, J., and Feng, Z. (2014) 4-methylene-2-octyl-5-oxotetrahydrofuran-3-carboxylic acid (C75), an inhibitor of fatty-acid synthase, suppresses the mitochondrial fatty acid synthesis pathway and impairs mitochondrial function. J Biol Chem 289, 17184-17194. IF 4.6
Chang, L., Liu, X., Liu, J., Li, H., Yang, Y., Guo, Z., Xiao, K., Zhang, C., Zhao-Wilson, X., andLong, J*. (2014) D-galactose induces a mitochondrial complex I deficiency in mouse skeletal muscle: potential benefits of nutrient combination in ameliorating muscle impairment. J Med Food 17, 357-364. IF 2.5
Cao, K., Zheng, A., Xu, J., Li, H., Liu, J., Peng, Y.,Long, J., Zou, X., Li, Y., Chen, C., and Feng, Z. (2014) AMPK activation prevents prenatal stress-induced cognitive impairment: modulation of mitochondrial content and oxidative stress. Free Radic Biol Med 75, 156-166. IF 5.71
Cao, K., Xu, J., Zou, X., Li, Y., Chen, C., Zheng, A., Li, H., Szeto, I. M., Shi, Y.,Long, J., Liu, J., and Feng, Z. (2014) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67, 396-407. IF 5.71
Luo C, Wang H, Chen X, Cui Y, Li H,Long J, Mo X, Liu J (2013) Protection of H9c2 rat cardiomyoblasts against oxidative insults by total paeony glucosides from Radix Paeoniae Rubrae. Phytomedicine 21, 20-24.IF 3.3
Luo C, Li Y, Yang L, Feng Z,Long J, Liu J (2013) A cigarette component acrolein induces accelerated senescence in human diploid fibroblast IMR-90 cells. Biogerontology 14, 503-511. IF 3.2
Luo C, Li Y, Wang H, Feng Z,Long J*, Liu J (2013) Mitochondrial accumulation under oxidative stress is due to defects in autophagy. J Cell Biochem 114, 212-219. IF 3.4
Luo C, Li Y, Wang H, Cui Y, Feng Z, Li H, Wang Y, Wurtz K, Weber P,Long J*, Liu J (2013) Hydroxytyrosol promotes superoxide production and defects in autophagy leading to anti-proliferation and apoptosis on human prostate cancer cells. Curr Cancer Drug Targets 13, 625-639. IF 4.3
Cao K, Xu J, Zou X, Li Y, Chen C, Zheng A, Li H, Szeto IM, Shi Y,Long J, Liu J, Feng Z (2013) Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice. Free Radic Biol Med 67C, 396-407. IF 5.3
Aksenov V,Long J, Liu J, Szechtman H, Khanna P, Matravadia S, Rollo CD (2013) A complex dietary supplement augments spatial learning, brain mass, and mitochondrial electron transport chain activity in aging mice. Age (Dordr) 35, 23-33. IF 6.2
Yan J, Feng Z, Liu J, Shen W, Wang Y, Wertz K, Weber P,Long J*, Liu J (2012) Enhanced autophagy plays a cardinal role in mitochondrial dysfunction in type 2 diabetic Goto-Kakizaki (GK) rats: ameliorating effects of (-)-epigallocatechin-3-gallate. J Nutr Biochem 23, 716-724. IF 4.2
Long J, He P, Shen Y, Li R (2012) New evidence of mitochondria dysfunction in the female Alzheimer's disease brain: deficiency of estrogen receptor-beta. J Alzheimers Dis 30, 545-558. IF 4.2
Long J, Gao M, Kong Y, Shen X, Du X, Son YO, Shi X, Liu J, Mo X (2012) Cardioprotective effect of total paeony glycosides against isoprenaline-induced myocardial ischemia in rats. Phytomedicine 19, 672-676. IF 3.3
Long J, Aksenov V, Rollo CD, Liu J (2012) A complex dietary supplement modulates nitrative stress in normal mice and in a new mouse model of nitrative stress and cognitive aging. Mech Ageing Dev. IF 4.2
Liu J, Peng Y,Long J*(2012) The Role of Brain Mitochondrial Estrogen Receptor beta in The Pathogensis of Female Alzheimer's Disease. Progress In Biochemistry And Biophysics, 785-790. IF 0.5
Liu J, Peng Y, Cui Z, Wu Z, Qian A, Shang P, Qu L, Li Y,Long J*(2012) Depressed mitochondrial biogenesis and dynamic remodeling in mouse tibialis anterior and gastrocnemius induced by 4-week hindlimb unloading. IUBMB Life. IF 3.8
Hao J, Shen W, Sun L,Long J, Sharman E, Shi X, Liu J (2011) Mitochondrial dysfunction in the liver of type 2 diabetic Goto-Kakizaki rats: improvement by a combination of nutrients. Br J Nutr 106, 648-655. IF 3.2
Gao M, Li Y, Sun Y, Shah W, Yang S, Wang Y,Long J*(2011) Benzo[a]pyrene exposure increases toxic biomarkers and morphological disorders in mouse cervix. Basic Clin Pharmacol Toxicol 109, 398-406. IF 2.3
Gao M, Li Y, Sun Y,Long J, Kong Y, Yang S, Wang Y (2011) A common carcinogen benzo[a]pyrene causes p53 overexpression in mouse cervix via DNA damage. Mutat Res 724, 69-75. IF 3.2
Gao M, Li Y,Long J, Shah W, Fu L, Lai B, Wang Y (2011) Induction of oxidative stress and DNA damage in cervix in acute treatment with benzo[a]pyrene. Mutat Res 719, 52-59. IF 3.2
McAllister C,Long J, Bowers A, Walker A, Cao P, Honda S, Harada N, Staufenbiel M, Shen Y, Li R (2010) Genetic targeting aromatase in male amyloid precursor protein transgenic mice down-regulates beta-secretase (BACE1) and prevents Alzheimer-like pathology and cognitive impairment. J Neurosci 30, 7326-7334.（co-first）IF 7.2
Gao M,Long J, Li Y, Shah W, Fu L, Liu J, Wang Y (2010) Mitochondrial decay is involved in BaP-induced cervical damage. Free Radic Biol Med 49, 1735-1745. IF 5.7
Aldarmaa J, Liu Z,Long J, Mo X, Ma J, Liu J (2010) Anti-convulsant effect and mechanism of Astragalus mongholicus extract in vitro and in vivo: protection against oxidative damage and mitochondrial dysfunction. Neurochem Res 35, 33-41.IF 2.7
Aksenov V,Long J, Lokuge S, Foster JA, Liu J, Rollo CD (2010) Dietary amelioration of locomotor, neurotransmitter and mitochondrial aging. Exp Biol Med (Maywood) 235, 66-76.IF 2.7
Long J, Ma J, Luo C, Mo X, Sun L, Zang W, Liu J (2009) Comparison of two methods for assaying complex I activity in mitochondria isolated from rat liver, brain and heart. Life Sci 85, 276-280.IF 2.5
Long J, Liu C, Sun L, Gao H, Liu J (2009) Neuronal mitochondrial toxicity of malondialdehyde: inhibitory effects on respiratory function and enzyme activities in rat brain mitochondria. Neurochem Res 34, 786-794.IF 2.7
Long J, Gao H, Sun L, Liu J, Zhao-Wilson X (2009) Grape extract protects mitochondria from oxidative damage and improves locomotor dysfunction and extends lifespan in a Drosophila Parkinson's disease model. Rejuvenation Res 12, 321-331.IF 4.1
Long J, Gao F, Tong L, Cotman CW, Ames BN, Liu J (2009) Mitochondrial decay in the brains of old rats: ameliorating effect of alpha-lipoic acid and acetyl-L-carnitine. Neurochem Res 34, 755-763.IF 2.7
Hao J, Shen W, Tian C, Liu Z, Ren J, Luo C,Long J, Sharman E, Liu J (2009) Mitochondrial nutrients improve immune dysfunction in the type 2 diabetic Goto-Kakizaki rats. J Cell Mol Med 13, 701-711. IF 4.6
Luo C,Long J, Liu J (2008) An improved spectrophotometric method for a more specific and accurate assay of mitochondrial complex III activity. Clin Chim Acta 395, 38-41. IF 2.85
Long J, Liu C, Sun L, Gao H, Liu J (2008) Neuronal Mitochondrial Toxicity of Malondialdehyde: Inhibitory Effects on Respiratory Function and Enzyme Activities in Rat Brain Mitochondria. Neurochem Res.IF 2.1
Shen H, Zhang Y, Xu J,Long J, Qin H, Liu F, Guo J (2007) Zinc distribution and expression pattern of ZnT3 in mouse brain. Biol Trace Elem Res 119, 166-174. IF 1.5
Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Cui X, Packer L, Liu J (2007) D-galactose toxicity in mice is associated with mitochondrial dysfunction: protecting effects of mitochondrial nutrient R-alpha-lipoic acid. Biogerontology 8, 373-381. IF 3.0
Liu Z, Sun L, Zhu L, Jia X, Li X, Jia H, Wang Y, Weber P,Long J, Liu J (2007) Hydroxytyrosol protects retinal pigment epithelial cells from acrolein-induced oxidative stress and mitochondrial dysfunction. J Neurochem 103, 2690-2700.IF 4.1
Sun L, Luo C,Long J, Wei D, Liu J (2006) Acrolein is a mitochondrial toxin: effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Mitochondrion 6, 136-142. IF 3.7
Luo C, Wang X,Long J, Liu J (2006) An NADH-tetrazolium-coupled sensitive assay for malate dehydrogenase in mitochondria and crude tissue homogenates. J Biochem Biophys Methods 68, 101-111. IF 2.2
Long J, Wang X, Gao H, Liu Z, Liu C, Miao M, Liu J (2006) Malonaldehyde acts as a mitochondrial toxin: Inhibitory effects on respiratory function and enzyme activities in isolated rat liver mitochondria. Life Sci 79, 1466-1472. IF 2.5
Cui X, Zuo P, Zhang Q, Li X, Hu Y,Long J, Packer L, Liu J (2006) Chronic systemic D-galactose exposure induces memory loss, neurodegeneration, and oxidative damage in mice: protective effects of R-alpha-lipoic acid. J Neurosci Res 83, 1584-1590. IF 2.9

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Recruitment - 龙 建纲

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Postdoc position - 龙 建纲招聘信息

人才招聘启事
一、招聘方向
生物化学与分子生物学、细胞生物学，遗传学、微生物学、生物物理学、基因工程、神经生物学、线粒体生物学与医学、转化医学等。
二、招聘岗位
（一）领军****
1. 招聘条件：国家级高层次人才、在国际著名大学担任教授或在研究机构担任相当职务者。
2. 工作条件：提供科研配套经费，办公条件和科研平台。
3. 待遇：提供安家费、入住人才公寓或购买人才住房，子女享受本校中小幼优质教育资源，薪酬面议。
（二）青年拔尖人才
1. 招聘条件：具有博士学位，一般不超过40岁；已取得突出学术业绩，获得同行的高度认可；具有广阔的学术视野和创新思维，具备成为该领域领军人才的潜质。
2. 科工作条件：提供100-200万元科研配套经费、基本办公条件和研平台，硕导博导资格和招生指标。
3. 待遇：年薪35-45万，提供安家费、入住人才公寓或购买人才住房，子女可享受本校中小幼优质教育资源。
（三）教授
1. 招聘条件：博士学位，具有较高的学术造诣，在科学研究方面取得国内外同行公认的成果:年龄一般不超过40周岁。
2. 工作条件：提供50万科研配套经费、基本办公条件和研平台。
3. 待遇：采用长期聘用形式，享受国家工资福利、校内津贴等；可租住学校过渡房或按月享受租房补贴，子女可享受本校中小幼优质教育资源。
（四）副教授
1. 招聘条件：博士学位，两年及以上的工作经历,具有国(境)外连续12个月及以上的学习、工作经历；在相关学术领域已有突出业绩，具有成为学术带头人的潜质；年龄一般不超过35周岁。
2. 工作条件：提供30万科研配套经费、基本办公条件和研平台。
3. 待遇：年薪制，年薪不低于22万；三年期满考核优秀转长期聘用；可租住学校过渡房或按月享受租房补贴；子女可享受本校中小幼优质教育资源。
（五）新讲师
1. 招聘条件：博士学位，年龄一般不超过32岁，具有海外连续12个月学习或工作经历者优先；以第一作者发表高水平论文2-3篇。
2. 工作条件：提供10万科研配套经费、基本办公条件和研平台。
3. 待遇：实行准聘-长聘制度。讲师准聘期为4年,准聘期满被聘为副教授者，进入副教授准聘期（3年）；年薪16万，可租住学校过渡房或按月享受租房补贴；子女可享受本校中小幼优质教育资源。
（六）专职科研博士后
1. 招聘条件：具有博士学位；年龄不超过32周岁；学术领域已取得显著业绩。
2. 待遇：年薪不低于15万元，并提供有竞争力的绩效津贴；入住人才公寓；子女可享受本校中小幼优质教育资源。
3. 应聘方式：应聘者申请时需提供一下材料：
（1）电子版简历（中英文）：格式不限，但应包含本人研究领域和应聘的岗位（学科方向）名称、个人成长经历与家庭信息、研究成果列表。
（2）主要研究成果：3项主要成果的电子版，含成果水平的简要介绍（中英文）。
（3）推荐信：2份业内专家的推荐信（中英文）。
（4）对交叉学科的理解及本人定位（中英文）。
三、联系方式
联系人：龙建纲
电 话：（86）
Email：jglong@xjtu.edu.cn
通讯地址：陕西省西安市咸宁西路28号西安交通大学兴庆校区生命科学与技术学院
邮政编码：710049
欢迎有志于从事线粒体生物医学的优秀人才加入！





Recruitment of Postdoctoral Positions
Postdoctoral Positions at the Institute of Mitochondria Biology and Medicine (IMBM), Xi’an Jiaotong University in Xi’an, China for Studying Mitochondrial Molecular and Cell Biology
Postdoctoral positions are immediately available at the Institute of Mitochondria Biology and Medicine (IMBM), Xi’an Jiaotong University in Xi’an, China. The IMBM conducts research and education in cell biology, molecular biology, developmental biology, structural biology and nutritional biology. Our main research focuses on deciphering the molecular mechanisms involved in the pathogenesis of metabolic syndrome, aging related disorders of the nervous system and cancer using mass spectrometry, super resolution microscopy, cryoEM, electrophysiology, cellular and experiment animal approaches.
Duties
We are seeking highly motivated and enthusiastic postdoctoral fellows interested in studying the molecular and cell biology of mitochondrial mechanism on aging, aging related neurodegenerative diseases, metabolic diseases.
Entry requirements
The successful applicant will have a Ph.D. degree graduated recently three years and have a strong track record in biochemistry, molecular biology, and/or neuron biology. Experiences with mass spectrometry, super resolution microscopy, cryoEM, protein expression and purification, patch clamp are a plus. A documented ability to independently carry out experimental research projects is required, as are good communication skills in spoken and written English.
Type of scholarship
A scholarship for carrying out postdoctoral research can be granted for a maximum of four years with a mid-term review. The amount is ¥160,000 basic payment before tax per year and paid out on a monthly basis. An extra tax free living support of ¥60,000 will be paid by the Shaanxi Province government during the first two years on a one payment basis. In exceptional cases, shorter periods may be acceptable.
Application process
Please send a brief statement of research interests, a curriculum vitae and contact information of three references to this email address.
Contact: Mrs Cui Li
E-mail:cuilitjpu@163.com

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其他 - 龙 建纲