吴道澄，男，江苏镇江市人，1962年7月生，博士学位，西安交通大学生命科学与技术学院教授，博士生导师。研究方向为生物材料与组织工程，生物大分子与药物载体。
教育经历
1980.9-1984.7 扬州大学化学系本科生
1986.9-1989.5 国防科学技术大学材料科学与应用化学系硕士研究生
2000.3-2003.6 西安交通大学生物医学工程专业 博士研究生
社会工作
中国医药生物技术协会生物医学信息技术专业委员会委员
科技部中小企业创新基金评审专家
西安交通大学教学委员会委员 (2009-2012)
陕西省生物医学工程学会生物信息专业委员会主任委员
陕西省生物产业发展专家咨询委员会委员(2008-2010)
陕西省生物化工专业委员会委员
西安市高新区管理委员会首批产业顾问
世界华人消化杂志编委
工作经历
1989.5-1992.9 第四军医大学药学系药物化学教研室 助教
1992.9-2004.9 第四军医大学药学系药物化学教研室讲师,副教授，
2000.9-2004.9 教研室副主任
2004.9- 西安交通大学生物医学工程系 教授，博士生导师
其中2004.9-2005.2 在新疆大学生命科学与技术学院挂职副院长、教授。
2006.6- 2011. 6西安交通大学生命科学与技术学院副院长
2011.6- 西安交通大学生命学院，教授，博士生导师,生物信息中心主任
2016.12- 西安交通大学生命学院生物医学工程系主任
联系方式
联系方法:电话 86-（办）（传真）
E-mail: wudaocheng@mail.xjtu.edu.cn
站点计数器
个人简介 - 吴 道澄基本信息
吴道澄，男，江苏镇江市人，1962年7月生，博士学位，西安交通大学生命科学与技术学院教授，博士生导师。研究方向为生物材料与组织工程，生物大分子与药物载体。
教育经历
1980.9-1984.7 扬州大学化学系本科生
1986.9-1989.5 国防科学技术大学材料科学与应用化学系硕士研究生
2000.3-2003.6 西安交通大学生物医学工程专业 博士研究生
社会工作
中国医药生物技术协会生物医学信息技术专业委员会委员
科技部中小企业创新基金评审专家
西安交通大学教学委员会委员 (2009-2012)
陕西省生物医学工程学会生物信息专业委员会主任委员
陕西省生物产业发展专家咨询委员会委员(2008-2010)
陕西省生物化工专业委员会委员
西安市高新区管理委员会首批产业顾问
世界华人消化杂志编委
工作经历
1989.5-1992.9 第四军医大学药学系药物化学教研室 助教
1992.9-2004.9 第四军医大学药学系药物化学教研室讲师,副教授，
2000.9-2004.9 教研室副主任
2004.9- 西安交通大学生物医学工程系 教授，博士生导师
其中2004.9-2005.2 在新疆大学生命科学与技术学院挂职副院长、教授。
2006.6- 2011. 6西安交通大学生命科学与技术学院副院长
2011.6- 西安交通大学生命学院，教授，博士生导师,生物信息中心主任
2016.12- 西安交通大学生命学院生物医学工程系主任
联系方式
联系方法:电话 86-（办）（传真）
E-mail: wudaocheng@mail.xjtu.edu.cn
站点计数器
教学情况 - 吴 道澄讲授课程
岗位职责
负责国家生命科学与技术人才培养基地学生培养和建设工作等。2010年获得王宽诚育才奖 主讲课程
1.生物材料与组织工程 40 学时研究生课程(学位课) 秋季开课
2.材料科学基础与生物材料 32学时本科课程 春季开课
3.生物光谱48学时本科课程 春季开课
负责主讲全校核心课程“生命起源与生物进化”（秋季上课）
教学研究项目
1.吴道澄 “生命科学基地人才培养创新实验区” 陕西省人才培养模式创新实验区项目 陕教高〔2008〕46号
2.吴道澄“生命科学基地人才培养新机制的探索和实践”2007年陕西高等教育教学改革研究项目陕教高〔2007〕68号
3.国家级大学生创新实验计划 新型St/AAm/AA三元共聚高分子微球的合成与表征 (3.5万元) 2007-2009 指导老师 4. 国家级大学生创新实验计划 Lovd转酯酶定点突变分子动力学模拟及反应机理研究 (2万元) 2009-2011 指导老师
5.陕西省高等教育协会2019年度高等教育科学研究项目（XGH10079）
教材
副主编 蛋白质工程 普通高等学校'十二五"规划教材 2013年6月,科学出版社ISBN 978-7-03-037627-5
副主编基础化学科学出版社 2002年8月 21世纪教材
参编 医用化学化学工业出版社 2002年7月四所军医大学教材
参编 示范教案人民军医出版社 2002年6月
教学文章
1．吴道澄，吴红，陈长生。医学院校学员化学成绩与后续课程成绩的相关性研究。山西医科大学学报，2002;4(2):94-96
2．吴道澄，吴红，南鹏娟。大学化学教学中微机辅助教学模式（CAI）的应用。中国高校教育研究，2001，3：97-99
3．吴红，吴道澄。如何搞好医用化学的实验课教学。山西医科大学学报（基础医学教育版)，2002;4(1):48-50
4．吴红，吴道澄，孙晓莉。建立医学基础化学题库的尝试。西北医学教育，2001;9(4):212-213
5．吴红，吴道澄，刘鹏。医学院校化学实验课教学改革尝试。医学教育与管理，2001;4:9-10
6.吴道澄,张虎勤,刘颖 生命科学基地人才培养新机制的探索与实践 中国教育教学杂志 2010,22(174):23466-23427
该文章获得中国教育教学研究会科教论文一等奖
7.张虎勤，吴道澄，吴晓明，杜建强 生命基地学生探索性创新实验课程建设 西北医学教育 2010，18（2）：342-345
作为指导教师 学生获奖
1.动粒生物磁分离分析技术公司 2008年陕西省大学生创业计划大赛金奖
2.动粒生物磁分离分析技术有限公司商业计划书 2008年第六届"挑战杯"中国大学生创业计划大赛铜奖
n
吴宥伸、张哲、张楠、王博、杨飞龙 “生物磁分离分析用高磁响应超顺磁微球-基于PICA方法“获得第十一届“挑战杯”全国大学生课外学术科技作品竞赛一等奖2009.11( 北京 ) 指导教师 吴道澄
3.指导本科生获得第八届全国大学生“挑战杯”银奖一项【西安彼乐科技有限责任公司】
参赛作品：《彼乐生物科技创业项目》
参赛成员：郭静雅、黄秀丽、白骏、宝起东、崔智炜、李春晓、丁鑫、黄珍、刘昭伟、李艳
4.获得第八届全国大学生“挑战杯”网络虚拟运营专项竞赛三等奖:
【西安彼乐科技有限责任公司】
参赛作品：《彼乐生物科技创业项目》, 参赛成员：郭静雅、丁鑫、白骏、宝起东
科学研究 - 吴 道澄研究领域
1.纳米药物载体
2. 超声药物控释系统及其设备
3. 造影剂及其成像设备
4. 棉酚及其衍生物
代表性研究成果
1.棉酚及其衍生物的抗肿瘤作用
在天然产物棉酚及其衍生物的分离、提纯和衍生物抗肿瘤研究方面开展了大量研究，首次发现了棉酚衍生物具有肿瘤细胞自噬的作用机理，发现了棉酚衍生物衍生物和阿霉素对肿瘤的协同作用，将它们组装在桑葚状双药靶向自组装纳米药载体系中，其药物仅仅用1/5的量即可达到原来1.5倍的治疗效果，毒副作用大幅度降低。还发现了棉酚衍生物与其它药物的协同作用。在Adv Funct Mater,Biomaterials，Cancer biological and therapy Cancer，J Mater Chem B，J Control Release 等国际著名期刊发表论文20余篇。
2.超声药物控释系统与设备
设计、制备了明胶离子化修饰的具有可逆超声触发智能释药性能纳米凝胶，使其超声触发释药的响应时间达到1-2 min，恢复时间3~4 min，纳米凝胶可逆超声触发后平均粒径提高到2-3 μm，大大提高该系统的药物负载量。设计了聚多巴胺、近红外染料IR-780的高光热转化效率的体系，用于对全氟碳纳米液滴的修饰，使其具有灵敏的光热相变能力。在近红外激光的作用下，该体系温度从室温大幅提高至60 ℃以上，该温度足以实现对肿瘤细胞及组织的热疗。此外，全氟碳纳米液滴发生明显的相变(从液态转变为气态)，相变之后的全氟碳气体能够增强超声波造影效果，能可视化光热治疗的肿瘤部位，并且超声信号的强弱还指示了热疗的温度变化过程以及进行程度。该研究利用全氟碳纳米液滴实现了对动物体内的治疗，以及治疗状态的实时监控。在ACS Applied Materials & Interfaces，Current Medicinal Chemistry, Nanoscale, J Mater Chem B,C 等国际著名期刊发表论文10余篇。获得发明专利多项。
3 生物医学纳米温度计
研究了一种新方法将水溶性罗丹明F-127荧光染料和罗丹明B（参比）同时包裹于三聚氰胺纳米粒中形成荧光纳米温度计，其温度灵敏度高（7.6 %°C−1），能实现-20°C至150°C宽温度范围内温度测量，成功应用于微波加热细胞的温度测量。利用单链DNA分子无规卷曲大小Rg变化产生的荧光共振能量转移（FRET）变化来测定微环境温度。制成了基于单链DNA的比色荧光纳米温度计，其灵敏度高（7.04% °C-1）、测温范围宽（0-100 °C），具有稳定的温敏特性，已成功应用于凝胶和细胞内部温度的定量测量，还初步测定了荷瘤裸鼠肿瘤微波加热前后的温度变化。在ACS Applied Materials & Interfaces ，J Mater Chem B,C 等国际著名期刊发表论文10余篇。
科研项目
没有找到条目。
项目编号项目名称项目来源起讫时间承担角色项目类别
** 肿瘤靶向负载IR780的棉酚-Fe(Ⅲ)-绿茶多酚(EGCG) 无限配位聚合物纳米粒及其肿瘤光热/协同化疗 国家自然科学基金项目 2019-1~ 负责人 纵向项目
** 多功能桑葚状AQ4N/噻替哌纳米载体及其乏氧选择、双药协同抗肿瘤作用 国家自然科学基金项目 2015-1~ 负责人 纵向项目
** 肿瘤细胞与线粒体双靶向Bcl-2 蛋白抑制剂载体系统 国家自然科学基金项目 2013-1~ 负责人 纵向项目
** 双靶向棉酚/MicroDNAs 抗肿瘤体系 国家自然科学基金项目 2013-1~ 负责人 纵向项目
2011B DNA防伪染料与标志涂料的研制 广东省教育部产学研结合项目 2011-12~ 负责人 纵向项目
2011KTCL03-07 工业残渣皂脚中提取、分离棉酚与左旋棉酚的工艺研究 陕西省科技统筹创新工程计划项目 2011-12~ 负责人 纵向项目
无 飞秒时间分辨荧光共振能量转移研究CD44及抗体的相互作用 精密光谱科学与技术国家重点实验室重点基金 2010-9~ 负责人 纵向项目
** 用于干细胞研究的核-壳多功能免疫磁珠 国家自然科学基金项目 2010-1~ 负责人 纵向项目
** (-)棉酚肿瘤靶向超声控释微系统的制备与抗肿瘤作用 国家自然科学基金项目 2008-1~ 负责人 纵向项目
具有肿瘤靶向和超声触发释药特性的Bcl-2/Mcl-1抑制剂 国家自然科学基金国际合作项目 2008-1~ 负责人 纵向项目
** 兼有超声触发释药与超声示踪特性的载药微系统 国家自然科学基金项目 2006-1~ 负责人 纵向项目
200502 手性微乳液及其凝胶中脂肪酶催化性能研究 胶体与界面化学教育部重点实验室基金 2005-1~ 负责人 纵向项目
2001BA310A7 -7 纳米药物新剂型的研究及产业化 国家“十五”科技攻关项目 2003-1~ 负责人 纵向项目
2001AA- 218031 纳米微粒靶向诊断和治疗 “863”高科技项目 2002-1~ 负责人 纵向项目
** 智能化释药纳米凝胶的制备与性质 国家自然科学基金项目 2001-1~ 负责人 纵向项目
97003 阿霉素脂质体临床前综合研究 贵州省重大课题 1999-1~ 负责人 纵向项目
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文章专著
已出版刘有初、吴道澄、赵小宁编著《医用高分子化学概论》陕西科技出版社1995等著作3部，获得国家发明专利11项：
1.吴道澄 超声浓差酸碱法生产盐酸阿霉素脂质体注射剂 ZL**.9
2. 吴开春;师瑞;吴道澄胃癌特异性纳米疫苗的制备方法 ZL 4.9
3. 隋延仿;叶菁;吴道澄恶性肿瘤广谱基因工程纳米疫苗的制备方法 ZL**.X
4.吴道澄;贾光锋;徐 梁 一种从棉油皂脚中提取醋酸棉酚的方法 ZL 8.X
5.吴宥伸，张楠，吴道澄 一种制备核壳式高磁含量超顺磁微球的方法ZL2.X
6.吴道澄，刘永春，贺佑康，黄凯兵，钟铁山，李伟 一种DNA明胶纳米微凝胶防伪涂料的制备方法zl 8.9
7.吴道澄，李科，刘佳俊，刘浩，曾鋆 自组装法制备棉酚及其衍生物普朗尼克纳米粒子的方法 ZL 3.5
8. 吴道澄，马静文，吴宥伸,曾鋆，申世红。聚合法制备棉酚及其衍生物聚多巴胺纳米载体的方法 ZL7.1
9.吴道澄， 刘佳俊，吴宥伸 一种棉酚及其衍生物棕榈蜡固体脂药物载体的制备方法 ZL 6.4
10 吴道澄，申世红，杨翰、崔晓利，康磊，刘泽英，雒思远 一种双药配位聚合物抗结核纳米药物的制备方法
ZL0.1
11.吴道澄，唐鹏， 肖鹏，朱红瑞，甘震海，付涛 一种高效产热的石墨烯涂层电热针 ZL3.X
申请发明专利2项，发表论文120余篇。
近年来发表的代表性论文
2021年
83.???????Shuai Zhang, Shuo Zhang, Siyuan Luo, Daocheng Wu*，Therapeutic agent-based infinite coordination polymer nanomedicines for tumor therapy Coordination Chemistry Reviews 2021，DOI 10.1016/j.ccr.2021.214059
82.Dui Qin, Lei Zhang,Hongrui Zhu, Junjie Chen, Daocheng Wu,Minxi Wan*,?????????? Yi Feng* A Highly Efficient One-for-All Nanodroplet for Ultrasound Imaging-Guided and Cavitation-Enhanced Photothermal Therapy International Journal of Nanomedicine 2021,16,3105-3119
81.Peng Tang, Yongchun Liu, Yuan Gao, Ya Wang, Hui Zhang, Yiming Liu, Daocheng Wu* Study on thermal-responsive unfolding characteristics of acetylated amylose V-type helical complex using molecular dynamic simulation.Journal of Materials Chemistry B, 2021, 9, 3389 - 3400
???????80. Siyuan Luo, Ya Wang, Shihong Shen, Peng Tang, Zeying Liu, Shuai Zhang, and Daocheng Wu*, IR780-Loaded Hyaluronic Acid@Gossypol–Fe(III)–EGCG Infinite Coordination Polymer Nanoparticles for Highly Efficient Tumor Photothermal/Coordinated Dual Drugs Synergistic Therapy. Adv. Funct. Mater. 2021, **( https://doi.org/10.1002/adfm.).
2020年
??????? 79。Ya Wang, Siyuan Luo, Youshen Wu, Peng Tang, Jiajun Liu, Zeying Liu, Shihong Shen, Haozhe Ren, and Daocheng Wu*. Highly Penetrable and On-Demand Oxygen Release with Tumor Activity Composite Nanosystem for Photothermal/Photodynamic Synergetic Therapy. ACS nano 2020 ，14；17046-17062( https://dx.doi.org/10.1021/acsnano.0c06415)
78. Xiaoyun Wu, Daocheng Wu, Yongxu Mu, Yuxia Zhao andZhijie Ma* Serum-Free Medium Enhances the Therapeutic Effects of Umbilical Cord Mesenchymal Stromal Cells on a Murine Model for Acute Colitis.Front. Bioeng. Biotechnol., 26 June 2020 ( https://doi.org/10.3389/fbioe.2020.00586)
77.Weiqiu Jin, Changzi Dong, Dengtian Yang, Ruotong Zhang, Tianshu Jiang and Daocheng Wu* .Nano-Carriers of Combination Tumor Physical Stimuli-Responsive Therapies .Current Drug Delivery, 2020, 17 （11）；577-587 (DOI: 10.2174/**225 )
76 Zeying Liu, Lingze Zhang, Peng Xiaoa, Lingfeng Liu, Peng Tang, Ya Wang, Shihong Shen,Jiajun Liu, Zhenhai Gan, Daocheng Wu*.Magnetothermally responsive composite submicron particles for recyclable catalytic applications.Chemical Engineering Journal 2020,399:125554
75.Xiaoyun Wu,Zhijie Ma, Wu Daocheng* Derivation of Clinical-Grade Mesenchymal Stromal Cells from Umbilical Cord under Chemically Defined Culture Condition – Platform for Future Clinical Application. Cytotheapy 2020.22;377-387
74.Yang Yuexuan & Wu Daocheng* ,Research shortcomings of fluorescent nanothermometers in biological and medical fields, Nanomedicine(Lond.) 2020,15(8);735-738 ( DOI10.2217/nnm-2019-0416)
73.Lingze Zhang, Zeying Liu, Yiming Liu, Ya Wang, Peng Tang, Youshen Wu, Hengbo Huang, Zhenhai Gan, Jiajun Liu, Daocheng Wu? Ultrathin surface coated water-soluble cobalt ferrite nanoparticles with high magnetic heating e?ciency and rapid in vivo clearance 、Biomaterials 2020，230:119655
2019年
72.Hongrui Zhu, Zhenhai Gan, Dapeng Li, Jing Qin, Hongmei Zhang, Mingxi Wan, Daocheng Wu *. Sensitive detection of dopamine with ultrasound cavitation-enhanced fluorescence method. Microchemical Journal 2019, 150; 104199.
71.Yiming Liu, Ke Li, Youshen Wu, Jingwen Ma, Peng Tang, Yongchun Liua and Daocheng Wu*. PVA reinforced gossypolone and doxorubicin π–π stacking nanoparticles towards tumor targeting and ultralow dose synergistic chemotherapy. Biomaterials Science 2019,7. 3662-2674.
?????70 Hao Liu, Rebecca T. Marquez, Xiaoqing Wu, Ke Li, Shweta Vadlamani, Song Li, Ya Wang, Liang Xu * and Daocheng Wu *.A non-intrusive evaluation method for tumortargeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging.J. Mater. Chem B. 2019,7, 4751- 4757.
69 Yun Zeng, Jingwen Ma, Liang Xu*,Daocheng Wu*. Natural Product Gossypol and Its Derivatives in Precision Cancer.Current Medicinal Chemistry.2019,26; 1849-1873 (DOI:10.2174/ 655)68.Hui Zhang,Youshen Wu,Zhenhai Gan,,Yuexuan Yang,Yiming Liu,,Peng Tang and Daocheng Wu*.Accurate intracellular and in vivo temperature sensing based on CuInS2/ZnS QD micelles. J. Mater. Chem B. 2019,7,2835--2844.67.Jiajun Liu,Zeying Liu,Daocheng Wu*.Multifunctional hypoxia imaging nanoparticles: multifunctional tumor imaging and related guidedtumor therapy.International Journal of Nanomedicine 2019,14;707-719.66.Ya Wang, Youshen Wu,Ke Li , Shihong Shen, Zeying Liu, Daocheng Wu*. Ultralong Circulating Lollipop‐Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy. Advanced Functional Materials 2019,29(1);** doi.org/10.1002/adfm.65.Peng Tang , Yongchun Liu , Yiming Liu , Hongru Meng , Zeying Liu , Ke Li , Daocheng Wu* Thermochromism-induced temperature self-regulation and alternating photothermal nanohelix clusters for synergistic tumor chemo/photothermal therapy. Biomaterials. 2019, 88;12-232018年64.Hongrui Zhu, , Dui Qin, Youshen Wu, Bowen Jing, Jiajun Liu, David Hazlewood, Hongmei Zhang, Yi Feng, Xinmai Yang, Mingxi Wan,* and Daocheng Wu* Laser-Activated Bioprobes with High Photothermal Conversion Efficiency for Sensitive Photoacoustic/Ultrasound Imaging and Photothermal Sensing. ACS Appl. Mater. Inter 2018, 10:29251-29259.63.Ying Wang , Ya Wang , Ji Wang , Wan Lei , Ke Li , Daocheng Wu? , Xiaojuan Wang? Pharmacokinetics, biodistribution, and bioavailability of gossypol-loaded Pluronic ? F127 nanoparticles Journal of Drug Delivery Science and Technology 2018，45；388-39662. Ailiang Zhang*, Xumei Yang, Quanxiao Li, Yu Wang, Gan Zhao, Bin Wang, Daocheng Wu*. Immunostimulatory activity of wat er-extractable polysaccharides from Cistanchedeserticola as a plantadjuvant in vitro and in vivo. PlosOne 2018,13;1:e**61. Zeying Liu,Yongchun Liu,Shihong ShenandDaocheng Wu*. Progress of recyclable magnetic particles for biomedical applications. J. Mater. Chem. B 2018,6, 366-38060. Shihong Shen , Youshen Wu ,Ke Li, Ya Wang Jimin Wu Yun Zeng, Daocheng Wu*. Versatile hyaluornicacid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles:Mulitiple tumor targeting,highle efficient synergistic chemotherapy and real-time self-montoring.Biomaterials 2018,154:197-2122017年59 Yongchun Liu,Wei Gao,Chunghong Zhang,Peng Tang, Yuan Zhao,Daocheng Wu*.Sequenential molecule-triggered-release system based on acetylated amylose helix aggregates. Chem Comm 2017,53,10680-10683.58.Lu Lei, Peng Tang, Yongchun Liu, Ke Li, Jiajun Liu, Daocheng Wu*. Controlled thermo-triggered drug release system based on propionylated amylose helix nanoclusters. Journal of Controlled Release .2017,259 ;e89–e9057.Xiaoying lei, Ke li,Yan liu, Zhen Yu Wang, Ban Jun Ruan, Li Wang, An Xiang, Daocheng Wu*, Zifan lu*. Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and a-tocopheryl succinate enhance anti-tumor effect in vivo.International Journal of Nanomedicine 2017,12,5701-571555.Jiajun Liu,Youshen Wu,YaoYu, Ke Li, Yuanyuan Ji, Daocheng Wu*.Quantitative ratiometric phosphorescence hypoxia–sensing nanoprobes based on Quantum Dots/Ir(III) glycerol monoolein cubic-phase nanoparticles. Biosensors and Bioelectronics.2017 ,98:119-125.55.Yongchun Liu , Chunhong Zhang ,Xizhe LI,Daocheng Wu*.A self-monitored fluorescence.DNA anti-counterfeiting system based on silica coated SYBR Green I/DNA gelatin nanoparticles. J Mater, Chem C.2017, 5,5939-3948 (DOI: 10.1039/C7TC01380A ) (This article is part of the themed collection2017 Journal of Materials Chemistry C HOT Papers54.Yao Yu, Youshen Wu, Yongchun Liu ,,Liu Jiajunm,Daocheng Wu*.Highly efficient dual-modal phosphorescence/ computed tomography bioprobes based on iridium complex and AuNPs polyiohexol composite nanoparticles . Nanoscale, 2017, 9,9447-945653. Shihong Shen,Youshen Wu, Yongchun LIu,Daocheng Wu*. High drug-loading nanomedicine:progress, current statues, and prospects. Int J Nanomedicine 2017,12;4085-4109 ( invited Review)(2019 ESI 根据对应领域和出版年中的高引用阈值，到 十一月/十二月 2019 为止，本高被引论文受到引用的次数已将其归入Pharmacology & Toxicology学术领域同一出版年最优秀的 前1% 之列)。 52. Youshen Wu,Liu Jiajun, Ya Wang, Ke Li , Jianhua Xu ,Daocheng Wu*. Novel ratiomatric flourescence nanothermometers based onflouropores-labeled short single-stranded DNA.ACS Appl. Mater. Inter. 2017, 9(12):11073-11081.51.Jingwen Ma, Yun Zeng, Yongchun Liu andDaocheng Wu*.Thermostable polymeric nanomicelles ofiridium(III) complexes with aggregation-induced phosphorescence emission characteristics and their recyclable double-strand DNA monitoring.J. Mater. Chem B. 2017,5,123-13350.Wei Gao , Yongchun Liu , Guixia Jing , Ke Li , Yuan Zhao , Baoyong Sha Qiang Wang *,Daocheng Wu*.Rapid and efficient crossing blood-brain barrier: Hydrophobic drugdelivery system based on propionylated amylose helix nanoclusters.Biomaterials2017;113 :133-1442016年49.Haseeb Zubair, Shafquat Azim, Husain Khan, M Ullah,Daocheng Wu, Ajay Singh, S Hadi, Aamir Ahmad. * Mobilization of intracellular copper by gossypol and apogossypolone leads to reactive oxygen species-mediated cell death: putative anticancer mechanism.Int. J. Mol. Sci. 2016, 17, 973; (doi:10.3390/ijms**)48.Youshen Wu, Jiajun Liu, Jingwen Ma, Yongchun Liu, Ya Wang, andDaocheng Wu*.Ratiometric Nanothermometer Based on Rhodamine Dye-Incorporated F127-Melamine-Formaldehyde Polymer Nanoparticle:Preparation, Characterization, Wide-Range Temperature Sensing,and Precise Intracellular Thermometry.ACS Appl. Mater. Inter 2016,8(23):14396-14405.47.Yongxing Dua,Lingze Zhang,Lulu SangeandDaocheng Wu,*Temperature field simulation and phantom validation of a Two-armed Spiral Antenna for microwave thermotherapy.Technology and Health Care 2016,24S675–46. Yun Zeng, Jingwen Ma, Shaojuan Zhang, andDaocheng Wu,* Imaging Agents in Targeting Tumor Hypoxia. Current Medicinal Chemistry, 2016, 23(17), 1775-1800.45. Yao Yu, Youshen Wu, Jiajun Liu, Ke Li,Daocheng Wu* Metabolizable dopamine-coated gold nanoparticles aggregates: Preparation, characteristics, computed tomography imaging, acute toxicity, and metabolism in vivo Journal of Materials Chemistry B, 2016,4,1090-1099 (DOI: 10.1039/ C5TB02497H)44. Zhang X, Xi X, Li M ,Wu D*. Comparison of Impulse Radar and Spread-Spectrum Radar in Through-Wall Imaging IEEE Transactions on Microwave Theory and Techniques , 2016 ,64(3):699-706(DOI:10. 1109/ TMTT. 2015.**)43.Yiao Yu, Youshen Wu , Jiajun Liu, YonghuaZhan ,Daocheng Wu* Ultrasmall dopamine-coated nanogolds: preparation, characteristics, and CT imaging Journal of Experimental Nanoscience2016,11(Sup1):S1-S1142. Hao Liu andDaocheng Wu*.In vivo near-infrared fluorescence tumor imaging using DiR-loaded nanocarriers.Current Drug Delivery. 2016,13(1) :40-482015年401Yan Li,Youshen Wu,ChengLuo , Bo WangandDaocheng Wu*. Rewritable megnetic fluorescence-encoded microspheres:preparation, characterization, and recycling. J. Mater. Chem C. 2015,3 :8262-8271.40.Jinwen Ma, Youshen Wu, Yun Zeng,Yan Li andDaocheng Wu*. Thermo-stable hollow megnetic microspheres:preparation, characteristics and recycable catalytic applications. J. Mater. Chem A. 2015, 3:16762-16773.39.Daocheng Wu*,Mingxi Wan. A novel ultrasonic-triggered drug release and tracked drug delivery system based on gas-filled BSA microbubbles and gelatin nanogels. Journal of Controlled release 2015,213;e24 38. Gao wei, Sha Baoyong, Liu Yongchun,DaochengWu, Xin Shen,Guixia Jing. The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin。Artificial Cells, Nanomedicine, and Biotechnology 2015,43(3):196-20237.Yun Zeng, Yang Liu, Jin Shang, Jingwen Ma, Rong Wang, Lei Deng, Youmin Guo,Fan Zhong, Mingfeng Bai, Shaojuan Zhang,Daocheng Wu*.Phosphorescence Monitoring of Hypoxic Micro- environment in Solid-Tumors to Evaluate Chemotherapeutic Effects Using the Hypoxia-Sensitive Iridium (III) Coordination Compound. PLoS ONE. 2015,10(3): e**. doi:10.1371/ journal. pone. 0121296.Ke Li , Hao Liu , Wei Gao , Mu Chen, Yun Zeng , Jiajun Liu, Liang Xu ,Daocheng Wu*,Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. Biomaterials 2015,39,131-14435.Xue-fan Gu , Jing Huo , Rui-tao Wang，Dao-cheng Wu& Yong-li Yan. Synergism in Mixed Zwitterionic Surface Activity Ionic Liquid and Anionic Surfactant Solution: Analysis of Interfacial and Micellar Behaviorv. Journal of Dispersion Science and Technology 2015,36；334-3422014年34.Xuehui Zhang, Xiaoli Xi, Zhongguo Song, Supin Wang, Mingxi Wan, andDaocheng Wu*.Performance Analysis of Spread Spectrum Through Wall Radar IEEE TRANSACTIONS ON MAGNETICS 2014,50(11):**.33.Hao Liu , Ke Li, Liang Xu,Daocheng Wu*,Bilayered near-infrared fluorescent nanoparticles based on low molecular weight PEI for tumor-targeted in vivo imaging. J Nanopart Res 2014,16:278432.Youshen Wu, Yan Li, Jianhua Xu andDaocheng Wu*.Incorporating Fluorescent Dyes into Monodisperse Melamine-Formaldehyde Resin Microspheres via Organic Sol-Gel Process: Pre-polymer Doping Strategy.J. Mater. Chem. B, 2014,2（35），5837-584631.Hao Liu, Ke Li, Lan Lan, Jingwen Ma, Yun Zeng, Liang Xu*andDaocheng Wu*.Double-layered hyaluronic acid/stearic acidmodified polyethyleneimine nanoparticles encapsulating (-)-gossypol: a nanocarrier for chiral anticancer drugs.J. Mater. Chem. B, 2014 2,5238-524830.Xuefan Gu, Youshen Wu, Lingze Zhang，Yongchun Liu, Yan Li, Yongli YanandDaocheng Wu* Hybrid magnetic nanoparticle/nanogold cluster and its distance-dependent metal-enhanced fluorescence effect via DNA hybridization, Nanoscale, 2014，6，8681-86932013年29.Yun zeng,Shaojuan Zhang,Menghui Jia, Yang Liu, Jin Shang,Youmin Guo,Jianghua Xu andDaocheng Wu*Hypoxia-sensitive Bis(2-(2-Benzothienyl)-pyridinato-N,C3') Iridium[poly(n-butylcyanoa- crylate]/Chitosan nanoparticles and Their Phosphoresence Tumor Imageing In vitro and in vivo. Nanoscale 2013,5，12633-1264428.Yan Li,Youshen Wu, Cheng Luo, Feilong Yang, Lei Qin, Tao Fu, Guangquan Wei, Xiaowei Kang,Daocheng Wu*Preparation and characterization of narrow-dispersed magnetic colloidal nanoparticle cluster/silica microspheres with controlled sizes, high saturation magnetization and MRI enhancement effect. J. Mater. Chem. B, 2013,1:4644-4654.27. PCheng, ZNi, XDai, BWang, WDing, ARae Smith, LXu,DWu, FHe and JLian. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular cells.Cell Death and Disease, 2013;4, e489;doi:10.1038/cddis.26 Chen Zhao,Daocheng Wu* Rapid detection assay for the molecular imprinting of gossypol using a two-layer PMAA/SiO2 bulk structure with a piezoelectric imprinting sensor，Sensors & Actuators:B.Chemical, 2013,181；104-113。25.Youshen Wu, Yan Li, Lei Qin, Feilong Yang andDaocheng Wu*. Monodispersed or narrow-dispersed melamine–formaldehyde resin polymer colloidal spheres: Preparation, size-control, modification, bioconjugation, and particle formation mechanism. J Mater.Chem B.2013,1:204-2122012年24 W Tang, Y Qu, L Lan,D Wu, L Xu*. Novel molecular therapy targeting Mcl-1 and modulating autophagy in castration-resistant prostate cancer. Cancer Res 2012, 72(8 Supplement) :doi:1538-7445.AM2012-226023. Gan Z, Zhang T, Liu Y,Wu D*.Temperature-Triggered Enzyme Immobilization and Release Based on Cross-Linked Gelatin Nanoparticles. PLoSONE. 2012, 7(10): e47154. doi:10. 1371/ journal. pone. **22. Liu T,Wu D*High-performance liquid chromatographic determination of triclosan and triclocarban in cosmetic products. Int J Cosmet Sci. 2012 ,34:489-49421.Haseeb Zubair, Husain Y Khan, M.F. Ullah, Aamir Ahmad,Daocheng Wu, S.M.Hadi. Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. European Journal of Pharmaceutical Sciences, 2012 ,47:280-286.20.Wu Daocheng*, Wan Mingxi.Methylene diphosphonate-conjugated adriamycin liposomes: Preparation, characteristics, and targeted therapy for osteosarcomas invitro and in vivo. Biomedical Microdevices 2012,14:497-510.19.Ruifen Xu, Xuyang Feng, Xin Xie, Jin Zhang,Daocheng Wu*, Lixian Xu*.HIV-1 Tat protein increase the permeability of brain endothelial cells by both inhibiting Occludin expression and cleaving occludin via matrix metalloproteinase-9. Brain Research. 2012,1436:13-19.(Most Cited Brain Research Articles, The most cited articles published since 2012, extracted fromScopus）2011年
18.Lu XY,Wu DC, Li ZJ, Chen GQ. Polymer nanoparticles Prog Mol Biol Transl Sci. 2011; 104: 299-323.17.Chen L,Kong X,Liang Z,Ye F,Yu K,Dai W,Wu D*,Luo C*,Jiang H.Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli.J Phys Chem B 2011, 115 (44):13019–13025.16.Wei Gao, Baoyong Sha, Wei Zou, Xuan Liang, Xiangzhong Meng, Hao Xu, JunTang,DaochengWu,*Lixian Xu, Hui Zhang.Cationic Amylose-Encapsulated Bovine Hemoglobin as a Nanosized Oxygen Carrier. Biomaterials. 2011,32:9425-9433.15.Zhenhai Gan, Jianhui Ju, Ting Zhang, andDaocheng Wu*.Preparation of Rhodamine B Fluorescent Poly(methacrylic acid) Coated Gelatin Nanoparticles. J Nanomaterials 2011, Article ID 753705, 8 pages doi:10.1155/2011/753705.14.Liu T,Wu D.Simultaneous determination of some ultraviolet-absorbing chemicals in sunscreen cosmetics using a high-performance liquid chromatography method.Int J Cosmet Sci 2011, 33, 408–415.13.Xinghua Pan, Jianhui Ju, Jianjun Li andDaocheng Wu*. Poly(styrene-acrylamide-acrylic acid) copolymer fluorescent microspheres with improved hydrophilicity: preparation and influence on protein immobilization. High Performance Polymers 2011，22（3）；255-26212.Xinghua Pan , Rachel Thompson , Xiaojie Meng ,Daocheng Wu, Liang Xu. Tumor-targeted RNA-interference: functional non-viral nanovectors. Am J Cancer Res 2011;1(1):32-49(invited Review).
2010年11. Xinghua Pan, Jianhui Ju, Yonghua Zhan, andDaocheng Wu*.Preparation and Fluorescence Characteristics of Amido- functionalized Dual-fluorescent Microspheres with Core-shell Structure.Micromolecular Chemistry& Physics. 2010, 221 (21): 2347-235510.Xian-Qing Zhang, Xiao-Feng Huang, Xing-Bin Hu, Yong-Hua Zhan, Qun-Xing An, Shi-Ming Yang, Ai-Jun Xia,Jing Yi, Rui Chen, Shi-Jie Mu,Dao-Cheng Wu*.Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro. Asian Journal of Andrology.2010:12;697-708.9.Wu D*,Wan M.Preparation of the core-shell structure adriamycin lipiodol microemulsions and their synergistic anti-tumor effects with diethyldithiocarbamate in vivo. Biomedicine & Pharmacotherapy 2010, 64(9):615-23.8.Sun F,Wu D., Qiu, Z., Li, J. Development of real-time PCR systems based on SYBR Green for the specific detection and quantification of Klebsiella pneumoniae in infant formula, Food Control ,2010,21 (5):487-491. 7.Xian-Qing Zhang, Xiao-Feng Huang, Shi-Jie Mu, Qun-Xing An, Ai-Jun Xia, Rui Chen,Dao-Cheng Wu*Inhibition of proliferation of prostate cancer cell line, PC-3,in vitro and in vivo using (–)-gossypol. Asian Journal of Andrology 2010,12:390-399.
2009年6. Na Guo,Daocheng Wu*,Xinghua Pan, Maolin Lu.Magnetic Polymer Microspheres with AzidocarbonylGroups: Synthesis, Characterization and Application in Protein Immobilization. Journal of Applied Polymer Science 2009,112(4);2383-2390.5.Xinghua Pan, Maolin Lu,Daocheng Wu*,Lili Gai.Synthesis and Characterization of Double-layer Quantum Dots-Tagged Microspheres. IEEE Transactions on NanoBioscience, 2009 ,8(1);13-194. Maolin Lu,Daocheng Wu*，Na Guo.Novel functionalized ternary copolymer fluorescent nanopart- icles: synthesis, fluorescent characteristics and protein immobilization. J Mater Sci: Mater Med. 2009, 20(2); 563.-5723. Lili Gai，Daocheng Wu*.A Novel Reversible pH-Triggered Release Immobilized Enzyme System.Appl Biochem Biotechnol 2009,158(3):747-760 2. Guangfeng Jia,Daocheng Wu*,Yang Meng and Liang Xu.An Improved Ultrasound-Assisted Extraction Process of Gossypol Acetic Acid from Cottonseed Soapstock. American Institute of Chemical Engineers Journal 2009,55(3) :797-897.1.Yonghua Zhan ,GuangfengJia , Daocheng Wu*, YiqingXu and Liang Xu.Design and Synthesis of a Gossypol Derivative with Improved AntitumorActivities. Arch.Pharm.Chem.Life Sci. 2009,342,223–229.(*correspondence author)
学子丰采 - 吴 道澄历届研究生
博士研究生
序号
博士生
入学/毕业时间
专业
现状
1
孙飞龙
2004/2010
生物医学工程
西安工程大学工作副教授
2
贾光锋
2006/2010
生物医学工程
西安工业大学工作副教授
3
张献清
2006/2010
生物医学工程
第四军医大学西京医院输血科主任
4
詹勇华
2006/2010
生物医学工程
西安电子科技大学生命学院，教授
5
赵晨
2008/2013
生物医学工程
西安工业大学讲师
6
徐瑞芬
2008/2012
生物医学工程
陕西省人民医院麻醉科副教授
7
潘兴华
2009/2012
生物医学工程
美国北卡罗来那大学博士后,休斯顿工作
8
高巍
2009/2012
生物医学工程
西安交通大学第一附属医院麻醉科副教授
9
吴宥伸
2010/2016
生物医学工程
西安交通大学理学院 副教授
10
刘浩
2010/2015
生物医学工程
西南医科大学药学院讲师
11
顾雪凡
2010/2014
生物医学工程
西安石油大学副教授
12
李科
2011/2016
生物医学工程
西安医学院 副教授
13
张学辉
2012/2016
生物医学工程
北京航天部研究所
14
张令泽
2012/2020
生物医学工程
中国科学院纳米所 博士后
15
李艳
2012/2015
生物医学工程
江西宜春大学医学院讲师
16
马静文
2012/2017
生物医学工程
西安市第九人民医院放射科 助理研究员
17
曾鋆
2013/2016
生物医学工程
西安电子科技大学生命学院 讲师
18
刘永春
2013/2018
生物医学工程
陕西师范大学化学学院 讲师
19
刘佳俊
2014/2019
生物医学工程
加拿大卡尔加里大学MBA
20
余瑶
2014/2018
生物医学工程
武汉理工大学化工学院讲师
22
申世红
2015/2019
生物医学工程
西北大学化工学院
师资博士后
23
刘泽英
2016/2021
生物医学工程
西北大学生命学院
师资博士后
24
唐鹏
2017
生物医学工程
在读
25
刘怡茗
2017
生物医学工程
在读
26
张慧
2017
生物医学工程
在读
27
王雅
2018
生物医学工程
在读
28
朱红瑞
2018
生物医学工程
在读（美国堪萨斯大学联合培养）
29
杨月璇
2018
生物医学工程
在读
30
张帅
2019
生物医学工程
在读
31
骆思远
2019
生物医学工程
在读
32 张烁 2020 生物医学工程 在读
硕士研究生
序号
硕士生
入学/毕业时间
专业
现状
1
郭娜
2005/2008
生物医学工程
江苏天瑞仪器股份有限公司，北京办事处
2
吴倩
2006/2009
生物化学
北京宝洁公司（Procter&Gamble)
3
盖丽莉
2006/2009
生物化学
美国Penn State University博士后
西雅图工作
4
卢茂林
2006/2009
生物化学
美国德州大学助理教授
5
张婷
2007/2010
生物化学
西安交大二附院
6
邹扬帆
2007/2010
生物化学
陕西省卫生防役站
7
张晓宇
2008/2011
生物化学
苏州晶云药业
8
金风
2008/2011
生物医学工程
中兴通讯西安公司
9
巨建辉
2009/2012
生物化学
壳牌-延长石油公司
10
NGOSHALI HAULENGA
2009/2012
生物医学工程
毕业在纳米比亚工作,结婚后在美国
11
陈艳峰
2010/2013
生物化学
上海工作
12
陈牧
2011/2014
生物化学
陕西慈缘生物技术有限公司
13
雷璐
2014/2017
生物医学工程
德克萨斯奥斯丁大学研究生
14
肖鹏
2019/2020
生物医学工程
深圳凯利公司
15
刘凌风
2019
生物医学工程
在读
16
姜天舒
2020/2021
生物医学工程
香港理工大学博士研究生
社会服务 - 吴 道澄我的新闻
西安交通大学吴道澄《AFM》：聚合物纳米粒子，用于高效的肿瘤光热/协同双药协同治疗
2021-05-18
西安交大科研人员在肿瘤光热/光动力协同治疗纳米载体方面取得重要进展
2020-12-24
西安交大科研人员在可回收磁性生物催化体系方面取得重要进展
2020-07-03
生命学院举办《生命起源与生物进化》 基础通识类核心标杆课程建设研讨会
2020-01-03
西安交大在超长循环载体肿瘤协同化疗方面取得新进展
2018-11-20
高巍获得2015年校级优秀博士学位论文
2017-06-10
更多新闻>>
English Version - 吴 道澄(1.)Basic Information
CURRICULUM VITAE
Daocheng Wuwas born in
Currently he’s research is focused on the areas of biomaterials, bionanotechnology, and related topics that include drug delivery system, nanoparticles for diagnosis and therapy, as well as functional nanoparticles and their applications in the biomedical field. In recent 10 years, he has published over 120 papers in many peer-review journals. He has published more than 70 research papers in advanced functional materials (IF 15.7), biomaterials (IF 10.3), J material Chem a (IF10.4), nanoscale (IF7.3), autophagy (IF11.3), ACS appl. Material. Inter (IF8.1) and other famous SCI journals. His cittation is more than 7500 times in total and H factor 24. Among them, there are more than 60 articles written by the first and corresponding authors. He has published more than 100 articles in core journals in China. More than 30 doctoral and master degree students have been trained.
Research fields:
1.Antitumor effects of gossypol and its derivatives
A lot of studies have been carried out on the separation and purification of gossypol and its derivatives as well as the anti-cancer research of its derivatives. For the first time, gossypol derivatives have been found to have the mechanism of autophagy of tumor cells, and the synergistic effect of gossypol derivatives and adriamycin on tumors has been found. They are assembled into mulberry-like double-drug targeting self-assembly. In the assembled nano-drug carrier system, only 1/5 dosage of the drug can achieve 1.5 times the original therapeutic effect, and the toxicity and side effects are greatly reduced. The synergistic effect of gossypol derivatives with other drugs was also found. More than 20 papers hace been published in Adv Funct Mater, Biomaterials, Cancer Biology and Treatment Cancer, J Mater Chem B, J Control Release and other international well-known journals ,
2. Ultrasound Drug Controlled Release System and Equipment
A gelatin ionized nanogel with reversible ultrasound triggered intelligent drug release was designed and prepared. The response time and recovery time of the gelatin ionized nanogel were 1-2 min and 3-4 min， respectively. The average particle size of the gelatin ionized nanogel was increased to 2-3 micron after reversible ultrasound triggered, which greatly increased the drug load of the system. A high photothermal conversion efficiency system of polydopamine and near infrared dye IR-780 was designed to modify perfluorocarbon nanodroplets with sensitive photothermal phase transition ability. Under the action of near infrared laser, the temperature of the system has been greatly increased from room temperature to above 60 C, which is enough to realize the hyperthermia of tumor cells and tissues. In addition, perfluorocarbon nanodroplets undergo obvious phase transition (from liquid to gaseous). The perfluorocarbon gas after phase transition can enhance the contrast effect of ultrasound, visualize the tumor site of photothermal therapy, and the intensity of ultrasound signal also indicates the temperature change process and degree of hyperthermia. In this study, perfluorocarbon nanodroplets were used to achieve in vivo treatment of animals and real-time monitoring of treatment status. More than 10 papers have been published in ACS Applied Materials & Interfaces, Current Medicinal Chemistry, Nanoscale, J Mater Chem B, C and other well-known international journals. A number of invention patents have been also granted.
3 Nanothermometer for biomedical applications
A new method for the formation of fluorescent nanothermometer by encapsulating water-soluble rhodamine F-127 fluorescent dye and Rhodamine B (reference) in melamine nanoparticles at the same time was studied. The temperature sensitivity of the fluorescent nanothermometer is high (7.6%C-1). It can measure temperature in a wide temperature range from -20 C to 150 C. It has been successfully applied to microwave heating of cells measurement. The fluorescence resonance energy transfer (FRET) of random curl size Rg of single stranded DNA molecule was used to measure the microenvironment temperature. A colorimetric fluorescent nanometric thermometer based on single stranded DNA has been developed. It has high sensitivity (7.04% degree C-1) and wide temperature range (0-100 degrees C). It has a stable thermo sensitive property and successfully applied to the quantitative measurement of gel and intracellular temperature. More than 10 papers have been published in ACS Applied Materials & Interfaces, J Mater Chem B, C and other well-known international journals.
Work Address
School of Life Science and Technology,Xi’an Jiaotong University, P.R.China.
28 West Changle Road, Xi’an710049.
Tel: 86- Fax: 86-
e-mail: wudaocheng@mail.xjtu.edu.cn
Home Address: 5 Jinhua Road, Xi’an 710048, Tel: 86-
Research Grants:
1. Bifunctional drug delivery micro-system with the characteristics of ultrasound- triggered release and ultrasound tracking
(National Natural Science Foundation of China, **)
Role: Principal Investigator
2.Systemic pre-clinic research of adriamycin liposomes
(Major Program of science and technology of Guizhou Province of China, 97003)
Role: Principal Investigator
3. The preparation and characteristics of Intelligence release nanogel
(National Natural Science Foundation of China, **)
Role: Principal Investigator
4. Nanosized particles for medical diagnosis and therapy
( National Medical Science and Technique Foundation during the 10th Five-Year Plan Period, No. 2001AA-218031).
Role: Principal Investigator
5.Novel nanosized drug delivery system and their industrialization
(National High Technology Research and Development Program of China, 2001BA310A7 -7)(863 Program ).
Role: Principal Investigator
6. The preparation and anti-tumor mechanism of (-) gossypol micro-system with the characteristics of ultrasonic controlled release and tumor targeting
( National Natural Science Foundation of China,**).
Role: Principal Investigator
7. Bcl-2/Mcl-1 protein inhibitor with the characteristics of ultrasonic controlled release and tumor targeting.
(Projects of International Cooperation and Exchanges NSFC, )
Role: Principal Investigator
8. Study on the Chiral microemulsion and related hydrogel and their characteristics of lipase catalyse.
(Key Laboratory Project on Key Laboratory of Colloid Interface Chemistry, Ministry of Education)
Role: Principal Investigator
9.Multi-functional core-shell immunomagnetic bead for the research of cancer stem cells.
( National Natural Science Foundation of China,**).
Role: Principal Investigator
10. Extract process of Gossypol acetic acid from cottonseed soapstock and(-)Gossypol separation
(Shaanxi province science and technology innovation project , 2011KTCL03-07)
Role: Principal Investigator
11.Dual- targeting of Bcl-2 proteins inhibitor delivery system to the tumor cells and their mitochondrions ( National Natural Science Foundation of China,**).
Role: Principal Investigator
12．Gossypol/MicroDNAs antitumor system with the characteristics of tumorcells and their nucleus dual-targeting（Overseas, Hong Kong & Macao Scholars Collaborated Researching Fund of National Natural Science Foundation of China.**）.
Role: Co-Principal Investigator
13.Multi-functional mulberry like AQ4N∕thiotepa nanocarrier with the characteristics of hypoxia phosphorescence indication for drug release,hyaluronic acid tumor targeting, AQ4N hypoxia-selective reduction and combined therapy,
Natural Science Foundation of China,**).
Role: Principal Investigator
14.Tumor targeting IR780-loaded Gossypol-Fe (Ⅲ)-EGCG infinite coordination polymer nanoparticles and their tumor photothermal /synergistic chemotherapy
Natural Science Foundation of China, **
Role: Principal Investigator
Publications:
Over 120 papers have been published in: Adv Funct Mater, Biomaterials, Clinic Chem, J Phy Chem,J Pharm PharmaceutSci,J Mater Chem, Nanoscale，IEEE Transactions on NanoBioscienc, Sensors & Actuators:B.Chemical, American Institute of Chemical Engineers Journal, Chem. Commun, CancerImmunol Immunother, JBiotechnol，and so on.
Some of them are shown as following:
1.Daocheng Wu*, Mingxi Wan，Yongfeng Du Enhancing the AntitumorEffect of Adriamycin Nanoparticle Lipiodol Emulsion by Pretreating Liver Cancer with Diethyldithiocarbamate. International Journal of Nonlinear and Numericalsimulation 2002,3(3-4):181-184.
2.Wu Daocheng*, Wan Mingxi，Mo Jian ,Wu Hong. Enhancing the Antitumor Effect of Adriamycin nanoparticle by pretreating liver Cancer with Diethyldithiocarbamate. J Chin Pharm Sci 2002, 11(3):24-29
3.H. WU, Z. X. ZHANG, H. P. ZHAO, D. C. Wu, B. L. Wuz Preparation of sodium fluoride-loaded gelatin microspheres, characterization and cariostatic studies. Journal of Microencapsulation 2004,21(8): 889-903.
4.Guo-Ping Wang, Er-Qun Song,a Hai-Yan Xie,Zhi-Ling Zhang, Zhi-Quan Tian, Chao Zuo,Dai-Wen Pang, Dao-Cheng Wu and Yun-Bo Shi.Biofunctionalization of fluorescent- magnetic-bifunctional nanospheres and their applications. Chem. Commun. 2005, 4276–4278
5.Ge W, Sui YF, Wu DC, Y.J. SunGuang-Sheng Chen,Zeng-Shan Li ,Shao-Yan Si,Pei-Zhen Hu ,Yang Huang,Xiu-Min Zhang.MAGE-1/Heat shock protein 70/MAGE-3fusion protein vaccine innanoemulsionenhances cellular and humoral immune responses to MAGE-1 or MAGE-3 in vivo. CancerImmunol Immunother，2005,55（7）：841-849
6.Shi R, Hong L, Wu D, Ning X, Chen Y, Lin T, Fan D, Wu K.Enhanced Immune Response to GastricCancer Specific Antigen Peptide by Co-encapsulation with CpOligodeoxynucleotides Nanoemulsion. Cancer biological and therapy 2005, 4(2): 218-224
7. Hong Wu, Zhenxi Zhang, Daocheng Wu , Hongping Zhao, Kaitao Yu, Zhenqing Hou. Preparation anddrug release characteristics of Pingyangmicin-loaded dextran cross-linked gelatin microspheresforembolization therapy.Journal of Biomedical Materials Research part B: Applied Biomaterials 2006,78 (1):56-62.
8. Lan J, Huang X, Hu M, Li Y, Qu Y, Gao P,Wu DC . High efficient degradation of dyes with lignin peroxidase coupled with glucose oxidase. J Biotechnol. 2006,123(4):483-90
9.Er-Qun Song, Guo-Ping Wang, Dao-Cheng Wu, Dai-Wen Pang.Visual Recognition and Efficient Isolation of Apoptotic Cells with Fluorescent- Magnetic- Biotargeting Multifunctional Nanospheres.Clin. Chem. 2007,53(12):2177-2185.
10. Wu Daocheng*, Wan Mingxi. A Novel Fluoride Anion Modified Gelatin Nanogel System for Ultrasound-Triggered Drug Release. J Pharm Pharmaceut Sci2008；11 (4): 32-45,
11. Shuqiang M, Kunzheng W, Xiaoqiang D, Wei W, Mingyu Z, Daocheng W. Osteogenic growth peptide incorporated into PLGA scaffolds accelerates healing of segmental long bone defects in rabbits. J Plast Reconstr Aesthet Surg. 2008 ;61(12):1558-1560.
12.Fei Z, Hu Y, Wu D, Wu H, Lu R, Bai J, Song H. Preparation and property of a novel bone graft composite consisting of rhBMP-2 loaded PLGA microspheres and calcium phosphate cement.J Mater Sci Mater Med. 2008,19(3):1109-1116
13.Na Guo, Daocheng Wu*, Xinghua Pan, Maolin LuMagnetic Polymer Microspheres with AzidocarbonylGroups: Synthesis, Characterization and Application in Protein Immobilization. Journal of Applied Polymer Science 2009,112(4);2383-2390
14. Xinghua Pan, Maolin Lu, Daocheng Wu*, Lili Gai. Synthesis and Characterization of Double-layer Quantum Dots- Tagged Microspheres. IEEE Transactions on NanoBioscience, 2009 ,8(1);13-19
15. Maolin Lu, Daocheng Wu*， Na Guo. Novel functionalized ternary copolymer fluorescent nanopart- icles: synthesis, fluorescent characteristics and protein immobilization. J Mater Sci: Mater Med 2009, 20(2); 563.-572
16. Lili Gai，Daocheng Wu*.A Novel Reversible pH-Triggered Release Immobilized Enzyme System. Appl Biochem Biotechnol 2009,158(3):747-760 (2008On Line , DOI 10.1007/s12010-008-8373-2).
17. Guangfeng Jia, Daocheng Wu*, Yang Meng and Liang Xu. An Improved Ultrasound-Assisted Extraction Process of Gossypol Acetic Acid from Cottonseed Soapstock. American Institute of Chemical Engineers Journal 2009,55,(3) :797-897
18.YonghuaZhan ,GuangfengJia , Daocheng Wu*, YiqingXu ,and LiangXu. Designand Synthesis of a Gossypol Derivative with Improved AntitumorActivities. Arch.Pharm.Chem.Life Sci.2009,342,223–229.
19. Sun F, Wu D., Qiu, Z., Li, J., Development of real-time PCR systems based on SYBR Green for the specific detection and quantification of Klebsiella pneumoniae in infant formula, Food Control ,2010, 21 (5):487-491.
20.Daocheng Wu* , Mingxi Wan, HongWu .Ultrasonic triggered release drug delivery system of Pluronic micelle.Nanoscience, 2006,11(3):210-218
21.Xian-Qing Zhang, Xiao-Feng Huang, Shi-Jie Mu, Qun-Xing An, Ai-Jun Xia, Rui Chen, Dao-Cheng Wu* Inhibition of proliferation of prostate cancer cell line, PC-3,in vitro and in vivo using (–)-gossypol. AsianJournal of Andrology 2010,12:390-399.
22.Wu D*, Wan M. Preparation of the core-shell structure adriamycin lipiodol microemulsions and theirsynergistic anti-tumor effects with diethyldithiocarbamate in vivo. Biomedicine & Pharmacotherapy 2010, 64(9):615-23.
23.Xian-Qing Zhang, Xiao-Feng Huang, Xing-Bin Hu, Yong-Hua Zhan, Qun-Xing An, Shi-Ming Yang, Ai-Jun Xia,Jing Yi, Rui Chen, Shi-Jie Mu, Dao-Cheng Wu*. Apogossypolone, a novel inhibitor of antiapoptotic Bcl-2 family proteins, induces autophagy of PC-3 and LNCaP prostate cancer cells in vitro.Asian Journal of Andrology.2010;12:697-708.
24.Xinghua Pan, Jianhui Ju, Yonghua Zhan, and Daocheng Wu*. Preparation and Fluorescence Characteristics of Amido- functionalized Dual-fluorescent Microspheres with Core-shell Structure Micromolecular Chemistry & Physics. 2010, 221 (21) ;2347-2355 .
25.Xinghua Pan , Rachel Thompson , Xiaojie Meng , Daocheng Wu , Liang Xu. Tumor-targeted RNA-interference: functional non-viral nanovectors. Am J Cancer Res 2011;1(1):32-49(invited Review)
26.Xinghua Pan, Jianhui Ju, Jianjun Li and Daocheng Wu*. Poly(styrene-acrylamide- acrylic acid) copolymer fluorescent microspheres with improved hydrophilicity: preparation and influence on protein immobilization. High Performance Polymers 2011，22（3）；255-262
27.Liu T, Wu D. Simultaneous determination of some ultraviolet-absorbing chemicals in sunscreen cosmetics using a high-performance liquid chromatography method. Int J Cosmet Sci. 2011, 33, 408–415.
28.Zhenhai Gan, Jianhui Ju, Ting Zhang, and Daocheng Wu*. Preparation of Rhodamine B Fluorescent Poly(methacrylic acid) Coated Gelatin Nanoparticles. J Nanomaterials 2011, Article ID 753705, 8 pages doi:10.1155/2011/753705.
29.Wei Gao, Baoyong Sha, Wei Zou, Xuan Liang, Xiangzhong Meng, Hao Xu, JunTang, DaochengWu,*Lixian Xu, Hui Zhang.Cationic Amylose-Encapsulated Bovine Hemoglobin as a Nanosized Oxygen Carrier. Biomaterials 2011,32:9425-9433.
30.Chen L, Kong X, Liang Z, Ye F, Yu K, Dai W, Wu D*, Luo C*, Jiang H. Theoretical Study of the Mechanism of Proton Transfer in the Esterase Estb from Burkholderia Gladioli. Journal ofPhysical Chemistry B. 2011, 115 (44):13019–13025.
31.Lu XY, Wu DC, Li ZJ, Chen GQ. Polymer nanoparticles. Prog Mol Biol Transl Sci. 2011;104:299-323.
32. Ruifen Xu, Xuyang Feng, Xin Xie, Jin Zhang, Daocheng Wu*, Lixian Xu*.HIV-1 Tat protein increase the permeability of brain endothelial cells by both inhibiting Occludin expression and cleaving occludin via matrix metalloproteinase-9. Brain Research 2012,1436:13-19.
33.Wu Daocheng*, Wan Mingxi. Methylene diphosphonate-conjugated adriamycin liposomes: Preparation, characteristics, and targeted therapy for osteosarcomas invitro and in vivo. Biomedical Microdevices 2012,14:497-510
34.Haseeb Zubair, Husain Y Khan, M.F. Ullah, Aamir Ahmad, Daocheng Wu, S.M.Hadi. Apogossypolone, derivative of gossypol, mobilizes endogenous copper in human peripheral lymphocytes leading to oxidative DNA breakage. European Journal of Pharmaceutical Sciences, 2012 ,47:280-286.
35. Liu T, Wu D*High-performance liquid chromatographic determination of triclosan and triclocarban in cosmetic products. Int J Cosmet Sci. 2012 ,34:489-494
36. Gan Z, Zhang T, Liu Y, Wu D*. Temperature-Triggered Enzyme Immobilization and Release Based on Cross-Linked Gelatin Nanoparticles. PLoSONE. 2012, 7(10): e47154. doi:10.1371/journal.pone.**.
37.Youshen Wu, Yan Li, Lei Qin, Feilong Yang and Daocheng Wu*. Monodispersed or narrow-dispersed melamine–formaldehyde resin polymer colloidal spheres: Preparation, size-control, modification, bioconjugation, and particle formation mechanism. JournalofMaterials.Chemistry. 2013,1:204-212 (doi 10.1039/C2TB00043A).
38.Chen Zhao, Daocheng Wu* Rapid detection assay for the molecular imprinting of gossypol using a two-layer PMAA/SiO2 bulk structure with a piezoelectric imprinting sensor，Sensors & Actuators:B.Chemical, 2013,181；104-113.
39.PCheng, ZNi, XDai, BWang, WDing, ARae Smith, LXu, DWu, FHe and JLian. The novel BH-3 mimetic apogossypolone induces Beclin-1- and ROS-mediated autophagy in human hepatocellular cells.Cell Death and Disease, 2013；4, e489;doi:10.1038/cddis.2013.17
40. Yan Li,Youshen Wu, Cheng Luo, Feilong Yang, Lei Qin, Tao Fu, Guangquan Wei, XiaoweiKang,Daocheng Wu* Preparation and characterization of narrow-dispersed magnetic colloidal nanoparticle cluster/silica microspheres with controlled sizes, high saturation magnetization and MRI enhancement effect. Journal of Materials. Chemistry. B, 2013,1:4644-465 .
41.Yun zeng,Shaojuan Zhang,Menghui Jia, Yang Liu, Jin Shang,Youmin Guo,Jianghua Xu and Daocheng Wu*Hypoxia-sensitive Bis(2-(2-Benzothienyl)-pyridinato-N,C3') Iridium[poly(n-butylcyanoacrylate]/Chitosan nanoparticles and Their Phosphoresence Tumor Imageing In vitro and in vivo.Nanoscale2013,5,12633 —12644
42.Xuefan Gu, Youshen Wu, Lingze Zhang，Yongchun Liu, Yan Li, Yongli Yanand Daocheng Wu*Hybrid magnetic nanoparticle/nanogold cluster and its distance-dependent metal-enhanced fluorescence effect via DNA hybridization, Nanoscale, 2014，6，8681-8693.
43.Youshen Wu, Yan Li, Jianhua Xu and Daocheng Wu*.Incorporating Fluorescent Dyes into Monodisperse
Melamine-Formaldehyde Resin Microspheres via Organic Sol-Gel Process: Pre-polymer Doping Strategy.J. Mater. Chem. B,2014,2（35），5837-5846 .
44.Hao Liu, Ke Li, Lan Lan, Jingwen Ma, Yun Zeng, Liang Xu*and Daocheng Wu*.Double-layered hyaluronic acid/stearic acidmodified polyethyleneimine nanoparticles encapsulating (-)-gossypol: a nanocarrier for chiral anticancer drugs.J. Mater. Chem. B, 2014 2,5238-5248.
45.Ke Li , Hao Liu , Wei Gao , Mu Chen, Yun Zeng , Jiajun Liu, Liang Xu ,Daocheng Wu*,Mulberry-like dual-drug complicated nanocarriers assembled with apogossypolone amphiphilic starch micelles and doxorubicin hyaluronic acid nanoparticles for tumor combination and targeted therapy. Biomaterials 2015,39,131-144
46.Hao Liu , Ke Li, Liang Xu, Daocheng Wu*, Bilayered near-infrared fluorescent nanoparticles
based on low molecular weight PEI for tumor-targeted in vivo imaging.Journal Nanopart Research2014, 16: 2784
47. Xuehui Zhang, Xiaoli Xi, Zhongguo Song, Supin Wang, Mingxi Wan, and Daocheng Wu*. Performance Analysis of Spread Spectrum Through Wall Radar IEEE TRANSACTIONS ON MAGNETICS 2014,50(11):**
48.Yun Zeng, Yang Liu, Jin Shang, Jingwen Ma, Rong Wang, Lei Deng, Youmin Guo,Fan Zhong, Mingfeng Bai, Shaojuan Zhang, Daocheng Wu*.Phosphorescence Monitoring of Hypoxic Microenvironment in Solid-Tumors to Evaluate Chemotherapeutic Effects Using the Hypoxia-Sensitive Iridium (III) Coordination Compound. PLoS ONE. 2015,10(3): e**. doi:10.1371/ journal.pone.**
49. Wei Gao , Baoyong Sha , Yongchun Liu , Daocheng Wu , Xin Shen , Guixia Jing
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
Wei Gao , Baoyong Sha , Yongchun Liu , Daocheng Wu , Xin Shen , Guixia Jing
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
Wei Gao , Baoyong Sha , Yongchun Liu , Daocheng Wu , Xin Shen , Guixia Jing
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
Wei Gao , Baoyong Sha , Yongchun Liu , Daocheng Wu , Xin Shen , Guixia Jing
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
Wei Gao , Baoyong Sha , Yongchun Liu , Daocheng Wu , Xin Shen , Guixia Jing
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/pdf/10.3109/**.2015.**
Gao wei, Sha Baoyong, The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/abs/10.3109/**.2015.**
Liu Yongchun, DaochengWu, Xin Shen,Guixia Jing. The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/abs/10.3109/**.2015.**
The effect of cationic starch on hemoglobin, and the primary attempt to capsulate hemoglobin. The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/abs/10.3109/**.2015.**
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/abs/10.3109/**.2015.**
The effect of cationic starch on hemoglobin, and the primary attempt to encapsulate hemoglobin
Read More: http://informahealthcare.com/doi/abs/10.3109/**.2015.**
Artificial Cells, Nanomedicine, and Biotechnology 2015,43(3):196-202
50.Yan Li,Youshen Wu,ChengLuo , Bo WangandDaocheng Wu*. Rewritable megnetic fluorescence-encodeed microspheres:preparation, characterization, and recycling.J. Mater. Chem C. 2015,3:8262-8271.
51.Jinwen Ma, Youshen Wu, Yun Zeng,Yan Li andDaocheng Wu*. Thermo-stable hollow megnetic microspheres:preparation, characteristics and recycable catalytic applications. J. Mater. Chem A.2015,3:16762-16773.
52. Daocheng Wu*,Mingxi Wan. A novel ultrasonic-triggered drug release and tracked drug
delivery system based on gas-filled BSA microbubbles and gelatin nanogels. Journal of Controlled release 2015,213;e24 (doi:10.1016/j.jconrel.2015.05.036) 53.Yiao Yu, Youshen Wu , Jiajun Liu, Yonghua Zhan ,Daocheng Wu* Ultrasmall dopamine-coated nanogolds: preparation, characteristics, and CT imaging Journal of Experimental Nanoscience2016,11(Sup1):S1-S11 (DOI:10.1080/ **. 2015.**)
54.Yao Yu, Youshen Wu, Jiajun Liu, Ke Li, Daocheng Wu* Metabolizable dopamine-coated gold nanoparticles aggregates: Preparation, characteristics, computed tomography imaging, acute toxicity, and metabolism in vivo Journal of Materials Chemistry B, 2016, 4,1090-1099(DOI: 10.1039/C5TB02497H )
55. Zhang X, Xi X, Li M , Wu D*. Comparison of Impulse Radar and Spread-Spectrum Radar in Through-Wall Imaging IEEE Transactions on Microwave Theory and Techniques , 2016 ,64(3):699-706(DOI:10.1109/TMTT.2015.**).
56.Hao Liu andDaocheng Wu*.In vivo near-infrared fluorescence tumor imaging using DiR-loaded nanocarriers.Current Drug Delivery 2016,13(1):40-48 (DOI: 10.2174/**66**8.)
57. Yun Zeng, Jingwen Ma, Shaojuan Zhang, and Daocheng Wu,* Imaging Agents in Targeting Tumor Hypoxia. Current Medicinal Chemistry, 2016(17), 23, 1775-1800.
58..Yongxing Dua,Lingze Zhang,Lulu Sangeand Daocheng Wu,*Temperature field simulation and phantom validation of a Two-armed Spiral Antenna for microwave thermotherapy.Technology and Health Care 2016,24 S675–S682.
59.Youshen Wu, Jiajun Liu, Jingwen Ma, Yongchun Liu, Ya Wang, and Daocheng Wu*.Ratiometric Nanothermometer Based on Rhodamine Dye-Incorporated F127-Melamine-Formaldehyde Polymer Nanoparticle:Preparation, Characterization, Wide-Range Temperature Sensing,and Precise Intracellular Thermometry.ACS Appl. Mater. Inter 2016,8(23):14396-14405.
60.Wei Gao , Yongchun Liu , Guixia Jing , Ke Li , Yuan Zhao , Baoyong Sha Qiang Wang *,Daocheng Wu*.Rapid and efficient crossing blood-brain barrier: Hydrophobic drugdelivery system based on propionylated amylose helix nanoclusters.Biomaterials2017;113 :133-144 (DOI : 10.1016/ j.biomaterials.2016.10.045
61.Jingwen Ma, Yun Zeng, Yongchun Liu andDaocheng Wu*.Thermostable polymeric nanomicelles ofiridium(III) complexes with aggregation-inducedphosphorescence emission characteristics and their recyclable double-strand DNA monitoring.J. Mater. Chem B. 2017,5,123-133.
62. Youshen Wu,Liu Jiajun, Ya Wang, Ke Li , Jianhua Xu ,Daocheng Wu*. Novel ratiomatric flourescence nanothermometers based onflouropores-labeled short single-stranded DNA.ACS Appl. Mater. Inter 2017,9(12):11073-11081.
63. Shihong Shen,Youshen Wu, Yongchun LIu,Daocheng Wu*. High drug-loading nanomedicine:progress, current statues, and prospects. Int J Nanomedicine 2017,12;4085-4109( invited Review)
64.Yongchun Liu ,Chunhong Zhang ,Xizhe LI,Daocheng Wu*.A self-monitored fluorescence.DNA anti-counterfeiting system based on silica coated SYBR Green I/DNA gelatin nanoparticles. J Mater, Chem C,2017, 5,5939-3948 (DOI: 10.1039/C7TC01380A ) (This article is part of the themed collection2017 Journal of Materials Chemistry C HOT Papers)
65.Jiajun Liu,Youshen Wu,YaoYu, Ke Li, Yuanyuan Ji,Daocheng Wu*.Quantitative ratiometric phosphorescence hypoxia–sensing nanoprobes based on Quantum Dots/Ir(III) glycerol monoolein cubic-phase nanoparticles. Biosensors and Bioelectronics2017 ,98:119-125.
66.Yao Yu, Youshen Wu, Yongchun Liu ,,Liu Jiajunm,Daocheng Wu*.Highly efficient dual-modal phosphorescence/ computed tomography bioprobes based on iridium complex and AuNPs polyiohexol composite nanoparticles ,Nanoscale, 2017, 9,9447-9456
67.Xiaoying lei, Ke li,Yan liu, Zhen Yu Wang, Ban Jun Ruan, Li Wang, An Xiang, Daocheng Wu*,Zifan lu*.Co-delivery nanocarriers targeting folate receptor and encapsulating 2-deoxyglucose and a-tocopheryl succinate enhance anti-tumor effect in vivo.International Journal of Nanomedicine 2017,12,5701-5715.
68.Lu Lei, Peng Tang, Yongchun Liu, Ke Li, Jiajun Liu,Daocheng Wu*. Controlled thermo-triggered drug release system based on propionylated amylose helix nanoclusters. Journal of Controlled Release ,2017,259 ;e89–e90
69. Yongchun Liu,Wei Gao,Chunghong Zhang,Peng Tang, Yuan Zhao,Daocheng Wu*.Sequenential molecule-triggered-release system based on acetylated amylose helix aggregates. Chem Comm 2017,53,10680-10683.
70. Shihong Shen ,Youshen Wu ,Ke Li, Ya Wang Jimin Wu Yun Zeng,Daocheng Wu*. Versatile hyaluornic acid modified AQ4N-Cu(II)-gossypol infinite coordination polymer nanoparticles:Mulitiple tumor targeting,highle efficient synergistic chemotherapy and real-time self-montoring.Biomaterials 2018,154:197-212
71.Zeying Liu,Yongchun Liu,Shihong ShenandDaocheng Wu*.Progress of recyclable magnetic particlesfor biomedical applications.J. Mater. Chem. B, 2018,6, 366-380
72.Ying Wang , Ya Wang , Ji Wang , Wan Lei , Ke Li , Daocheng Wu? , Xiaojuan Wang? Pharmacokinetics, biodistribution, and bioavailability of gossypol-loaded Pluronic ? F127 nanoparticles Journal of Drug Delivery Science and Technology 2018，45；388-39673. Ailiang Zhang*, Xumei Yang, Quanxiao Li, Yu Wang, Gan Zhao, Bin Wang, Daocheng Wu*. Immunostimulatory activity of wat er-extractable polysaccharides from Cistanchedeserticola as a plant adjuvant in vitro and in vivo. PlosOne 2018,13;1:e**74. Peng Tang , Yongchun Liu , Yiming Liu , Hongru Meng , Zeying Liu , Ke Li , Daocheng Wu* Thermochromism-induced temperature self-regulation and alternating photothermal nanohelix clusters for synergistic tumor chemo/photothermal therapy. Biomaterials 2019,88;12-23
75 Ya Wang, Youshen Wu,Ke Li , Shihong Shen, Zeying Liu, Daocheng Wu*. Ultralong Circulating Lollipop‐Like Nanoparticles Assembled with Gossypol, Doxorubicin, and Polydopamine via π–π Stacking for Synergistic Tumor Therapy. Advanced Functional Materials 2019,29(1);** doi.org/10.1002/adfm.
76.Jiajun Liu,Zeying Liu,Daocheng Wu*.Multifunctional hypoxia imaging nanoparticles:multifunctional tumor imaging and related guidedtumor therapy.International Journal of Nanomedicine 2019,14;707-719.
77. Hui Zhang,Youshen Wu,Zhenhai Gan,,Yuexuan Yang,Yiming Liu,,Peng Tang and Daocheng Wu*.Accurate intracellular and in vivo temperature sensing based on CuInS2/ZnS QD micelles.J. Mater. Chem B. 2019,7,2835--2844.
78.Hongrui Zhu, Zhenhai Gan, Dapeng Li, Jing Qin, Hongmei Zhang, Mingxi Wan, Daocheng Wu *. Sensitive detection of dopamine with ultrasound cavitation-enhanced fluorescence method. Microchemical Journal 2019, 150; 104199.79.Yiming Liu, Ke Li, Youshen Wu, Jingwen Ma, Peng Tang, Yongchun Liua and Daocheng Wu*. PVA reinforced gossypolone and doxorubicin π–π stacking nanoparticles towards tumor targeting and ultralow dose synergistic chemotherapy. Biomaterials Science 2019,7. 3662-2674. 80 Hao Liu, Rebecca T. Marquez, Xiaoqing Wu, Ke Li, Shweta Vadlamani, Song Li, Ya Wang, Liang Xu * and Daocheng Wu *.A non-intrusive evaluation method for tumortargeting characteristics of nanomedicines based on in vivo near-infrared fluorescence imaging.J. Mater. Chem B. 2019,7, 4751- 4757.81 Yun Zeng, Jingwen Ma, Liang Xu*,Daocheng Wu*. Natural Product Gossypol and Its Derivatives in Precision Cancer.Current Medicinal Chemistry.2019,26; 1849-1873 (DOI:10.2174/ 655)82.Lingze Zhang, Zeying Liu, Yiming Liu, Ya Wang, Peng Tang, Youshen Wu, Hengbo Huang, Zhenhai Gan, Jiajun Liu, Daocheng Wu? Ultrathin surface coated water-soluble cobalt ferrite nanoparticles with high magnetic heating e?ciency and rapid in vivo clearance 、Biomaterials 2020，230:119655
83.Yang Yuexuan & Wu Daocheng* ,Research shortcomings of fluorescent nanothermometers in biological and medical fields, Nanomedicine(Lond.) (Epub ahead of print) 2020 DOI10.2217/nnm-2019-0416
84 Zeying Liu, Lingze Zhang, Peng Xiaoa, Lingfeng Liu, Peng Tang, Ya Wang, Shihong Shen,Jiajun Liu, Zhenhai Gan, Daocheng Wu*.Magnetothermally responsive composite submicron particles for recyclable catalytic applications.Chemical Engineering Journal 2020,399:125554
?????85.Weiqiu Jin, Changzi Dong, Dengtian Yang, Ruotong Zhang, Tianshu Jiang and Daocheng Wu* .Nano-Carriers of Combination Tumor Physical Stimuli-Responsive Therapies .Current Drug Delivery, 2020, 17 （11）；577-587(DOI: 10.2174/**225 )
???????86. Ya Wang, Siyuan Luo, Youshen Wu, Peng Tang, Jiajun Liu, Zeying Liu, Shihong Shen, Haozhe Ren, and Daocheng Wu*. Highly Penetrable and On-Demand Oxygen Release with Tumor Activity Composite Nanosystem for Photothermal/Photodynamic Synergetic Therapy. ACS nano 2020 ，14；17046-17062( https://dx.doi.org/10.1021/acsnano.0c06415)
???????87. Siyuan Luo, Ya Wang, Shihong Shen, Peng Tang, Zeying Liu, Shuai Zhang, and Daocheng Wu*, IR780-Loaded Hyaluronic Acid@Gossypol–Fe(III)–EGCG Infinite Coordination Polymer Nanoparticles for Highly Efficient Tumor Photothermal/Coordinated Dual Drugs Synergistic Therapy. Adv. Funct. Mater. 2021, **( https://doi.org/10.1002/adfm.).
???????88.Peng Tang, Yongchun Liu, Yuan Gao, Ya Wang, Hui Zhang, Yiming Liu, Daocheng Wu* Study on thermal-responsive unfolding characteristics of acetylated amylose V-type helical complex using molecular dynamic simulation.Journal of Materials Chemistry B, 2021, 9, 3389 - 3400
(*correspondence author)
吴道澄的个人主页空间 - 吴 道澄招生信息
一、博士研究生招生
专业代码、名称与研究方向
指导教师
考试科目
参考教材
013生命科学学院
083100生物医学工程
13生物信息技术
14生物材料及组织工程
15生物大分子与药物载体
吴道澄
教授
① 1101英语 ② 2210生物化学或 2247医用电子学 ③ 3316分子生物学或 3358医学成像原理
2247医用电子学，王保华主编 高等教育出版社 1988年
2210生物化学 1.《生物化学》（影印版） B.D Hames,N.M.Hooper, J.D.Houghton
科学技术出版社 2. 《生物化学》(第三版) 王镜岩等高等教育出版社 2002年
3358医学成像原理 《医学成像的物理原理》 黄饴焯 高等教育出版社 1993年
二、硕士研究生招生
专业代码、名称与研究方向
指导教师
考试科目
013生命科学学院
083100 生物医学工程
17 生物材料及组织工程
吴道澄
教授
① 101 思想政治理论
② 201 英语一
③ 301 数学一
④ 815 信号与系统（含数字信号处
理）或
822 普通物理学或
833 生物化学或
834 微机原理与应用
013生命科学学院
071010 生物化学与分子生物学
吴道澄
教授
① 101 思想政治理论
② 201 英语一
③ 302 数学二或
714 生物综合
④ 833 生物化学
815信号与系统（含数字信号处理）《信号与线性系统》 阎鸿森等 西安交大出版社1999年版
822普通物理学 《普通物理学》第五版程守洙，江之永编 高等教育出版社
833.《生物化学》(第三版) 王镜岩等 高等教育出版社 2002年
834 微机原理与应用 《微型计算机原理与接口技术》 周荷琴 中国科学技术大学出版社 2004年
714生物综合
《生理学》（第二版）
王庭槐
高等教育出版社
2008年
《生物化学》（第七版）
查锡良
人民卫生出版社
2008年
《医学生物学》（第七版）
傅松滨
人民卫生出版社
2008年
《医学免疫学》（第四版）
陈慰峰
人民卫生出版社
2004年
《医学遗传学》（第四版）
左伋
人民卫生出版社
2005年
说明
西安交通大学吴道澄《AFM》：聚合物纳米粒子，用于高效的肿瘤光热/协同双药协同治疗
2021-05-18
西安交大科研人员在肿瘤光热/光动力协同治疗纳米载体方面取得重要进展
2020-12-24
西安交大科研人员在可回收磁性生物催化体系方面取得重要进展
2020-07-03
生命学院举办《生命起源与生物进化》 基础通识类核心标杆课程建设研讨会
2020-01-03
西安交大在超长循环载体肿瘤协同化疗方面取得新进展
2018-11-20
高巍获得2015年校级优秀博士学位论文
2017-06-10
更多新闻>>
核心课程 - 吴 道澄我的家庭
我的课程
生命的起源与生物进化”课程简介
前面的话
进化论孰是孰非？
它在社会学、经济学、人工智能等领域
又能得到怎样的发挥？ 中国人究竟是谁？
从何而来，去往何方？
当我们对“昨天”的追寻
超越了符号记载，超越了化石镌刻
DNA为我们提供了什么？
它扮演着主义的角色？
故事从寒武纪开始
这场“地球上最伟大的表演”
充满未解之谜的20亿年
你我都身处这舞台
快到《生命起源与生物进化》的课堂上
打开脑洞，让“未知”启迪你吧
您理想中的《生命起源与生物进化》课堂是什么样的？当初开设这样一门课程的初衷是怎么样的呢？
开设这样一门课首先来自于我所意识到的我们教育中的问题，我们的大多数同学在从小学到高中，乃至到大学学习的过程中，不断地进入到一种充满限制的思维模式，很难发散思维，很难大胆想象。
在科学领域我们强调这样几个方面的思维：批判性思维、逻辑性思维以及想象力。
那么，就我个人所见，我们的学生逻辑性思维或许有余，批判性思维和想象力却实在不足。
在开课之初，我们的课程团队商讨选题，最终确定了“生命起源”与“生物进化”这两个方向、两条线索。希望以此从生物科学、生命科学的角度上引导同学们做各种大胆的想象，进行思维的发散，再去寻找历史与科学世界中的蛛丝马迹为此求证，从中得到启迪。
这门课所探讨的话题有几个特点。一是周期长；二是未解之谜特别多；三是有趣的科学故事特别多。
就生命起源与进化的题域而言，时间横跨20亿年之长，我在课上常和大家说“让未知来启迪你”，我们的课题就充满了未知。这也是一个巨大的舞台，留待同学们去尽情发挥，“随便”想象。
时而在课堂上，我提出某些观点，同学们会觉得很震惊，说“老师你这是逆天的想法”！我说不是我逆天，是你们的思想太受限制。
我们的学生太需要“relax”的思维。
所谓批判性思维，第一步一定是敢于质疑，放下质疑的心理门槛。我在课堂上跟同学们说，你随便质疑！可以质疑任何人！
达尔文著《物种起源》，提出相对论，被全世界的科学家所质疑。比如说，就“寒武纪”生命大爆发来看，为什么在寒武纪时期以前了无痕迹的生物突然出现了，这明显不符合进化论，如何解释才好？一代一代的理论在不断地推翻和重构，而敢想就是创新的前提。
《生命起源与生物进化》的课程内容可以如何来概括呢？
总的来说这门课可以分为这几个板块：生命的起源；生物的进化；人类文明的产生和人类的未来。
简要而言，生命的过去、现在和未来。这既是一幅波澜壮阔的历史画卷，又是一系列引人入胜的有趣故事。
这话题听起来就十足宏大，《生命起源与生物进化》是一个启发型课堂，我们为大家起一个头，告诉同学们其中包罗万象，未来自由探索。
针对某一个具体问题，我会向大家从正面的、直接的角度来进行讲述和分析，刘晓刚老师则会站在分子生物学的层面上，从侧面来对问题进行探讨和论证。
这个分子生物学我们怎么理解呢？
我们说“生命不是永恒的，但DNA是永恒的”，分子生物学就是在DNA的层面研究生物，将生命现象乃至社会问题牵引到基因遗传的本质上探究。
比方说，复旦大学有一个非常著名的分子人类学研究所。他们可以把方言问题、诗歌都和基因、生物分子相结合。当然，这看似毫无关系的两者如何搭建联系？需要靠想象力，需要发散思维。
我们在课堂上还会讨论“中国人从哪里来走到哪里？”“为什么我们观察到古人类走出非洲，又一次走出非洲？”
很多用“历史痕迹”所无法解释的，我们必须要从分子的角度去挖掘。分子的保存本质就是信息的保存。
听同学们的反馈，老师您布置的作业往往是一些“怪题”？能与同学们说说吗？
是的，我出的作业题都特别怪，是你在书上也好网上也好，都找不到答案的那种。它们都是我长期以来对这一课题的思考成果。
比方说，猴子的打架和人类有什么关系？
我要在课堂上打破几个概念。我们常说科学是追求真理的学科，我要告诉同学们，科学没有绝对真理。就如同这些怪题，没有所谓标准答案，甚至说不出谁对谁错，重点就在于思考，在于同学们如何进行合理想象，怎么提出质疑，怎么自圆其说。
我认为我们的许多学生缺乏“大科学”的概念，并未建立起对科学的真正兴趣，又谈何对科学的敬畏呢？
因此我还会在课堂上向同学们推荐一系列的书籍，很多是科普性质的读物。“科普”听起来简单，往往我们就缺乏这个，我们多的是教科书，科研文章，这样一来热情在哪里？真正建立在问题之上的求知欲在哪里？
课程编码：
学分：2
授课学时：32
课程内容简介（200字以内，含实验内容）
生物进化论是生物学中最大的统一理论,进化思想和进化理论是生物科学对于整个自然科学最值得骄傲的贡献，生命科学的各个分支或各个层次的研究都是建立在生物进化的理论上，生命的起源则是生物进化的起点，两者之间存在着必然的联系。通过探索生命的起源可以丰富生物进化理论，而生物进化理论可以推动生命起源的探索。所以，本课程将这两个部分联合在一起进行授课，力图从整体上把握生命起源和生物进化的规律和特点，使同学们理解它们独特的思维方式，开阔科学视野，更深层次地了解生物世界和人类本身。同时，由于生命起源和生物进化理论的发展吸收了哲学、化学、物理学、数学、考古学、地质学、天文学等多学科的研究成果。因此，生命的起源和生物进化是一门综合性很强的课程。
先修课：无
课程水平：全校所有年级
教学手段：课堂讲授
参考书目:
《生物进化》张昀著 北京大学出版社ISBN:57
电子教案下载 大学生个人规划 2019大学生个人规划.pdf
1.生命起源和生物进化 生命的起源 第一章.pdf
2.生命起源与生物进化 第二章课件.pdf? pdf
3. 生命起源与生物进化第三章第三章1.pdf
4. 生命起源与生物进化第三章第三章 2.pdf
5. 生命起源与生物进化第四章第四章.pdf Pdf
6 生命起源与生物进化第五章第五章人类的起源.pdf Pdf
中文文章 - 吴 道澄
