西安交通大学生命科学与技术学院导师教师师资介绍简介-张红梅

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个人主页 - 张红梅基本信息
张红梅，副教授，博士生导师主要论著：发表第一作者学术论文23篇，其他作者学术论文若干，参与编写教材一部。
科研项目：承担国家自然科学基金面上项目2项，国家自然科学青年基金1项，校级基金3项，参与973和多项国家重点项目，参与Mayo clinic的国际合作科研项目。

研究领域
软物质力学与超声黏弹性成像（Soft matter mechanics and ultrasonic viscoelastic imaging）研究软材料（如仿生体、组织、细胞等）的黏弹性力学性质以及描述软材料的黏弹性模型。并将模型使用于超声黏弹性成像中，提取所成像区域的黏弹性信息，发展先进超声功能成像技术。
多源多模态影像数据与颈动脉易损斑块黏弹性成像的早期风险评估（Statistical and deep reinforcement learning of multisource and multimode imaging datafor early risk evaluation on vulnerable carotid plaque ）基于多源多模态影像数据统计学习，结合颈动脉斑块超声黏弹性成像对易损斑块进行早期风险评估。
细胞和软组织材料黏弹性力学与疾病早期诊断应用研究（Viscoelastic mechanics of cell and soft tissue and its application in early diagnosis of diseases）基于软物质黏弹性力学的研究，建立细胞、组织黏弹性力学参数与生理、病理信息的关联，拓展应用于细胞、组织的力学手段诊断疾病的方法。
医学图像与信息分析-基于医学影像大数据的机器学习与智能诊疗（Medical image and information analysis-machine learning and intelligent diagnosis and treatment based on medical image data）采用大数据、机器学习等技术，对包括医学影像数据、临床数据在内的海量医学数据进行分析，建立多源数据集对疾病的辅助诊断技术。

教育经历
访学：伊利诺伊州立大学香槟分校（UIUC）访问****（2014-2015）
博士：西安交通大学生物医学工程（2000-2004）
论文题目：基于变分法的医学图像分割研究

主要任职
博士，副教授，博士生导师
生物医学信息工程教育部重点实验室
西安交通大学生命科学与技术学院生物医学工程

联系方式
电话： (029)**
手机：**
传真：(029)**-801
邮箱：claramei@mail.xjtu.edu.cn
地址：陕西省西安市碑林区-咸宁西路28号-西安交通大学-生命科学与技术学院

科研项目
研究经费支持项目名称: “分数阶黏弹性和流性参量表征颈动脉粥样硬化斑块易损性的超声成像
方法和实验研究”
资金来源: 国家自然科学基金面上项目(No.**)
项目名称: 超声黏弹性参数表征在早期乳腺肿瘤筛查中的应用研究
资金来源:重点研发计划专项和科技重大专项培育项目2016YFC**
项目名称: “超分辨超声血管应变估计和弹性成像方法和实验研究”
资金来源: 国家自然科学青年基金(No.**)
项目名称: “超分辨超声血管应变估计和弹性成像实验研究”
资金来源:西安交通大学校长基金 (No.xjj**)
项目名称: “颈动脉血管壁斑块特性的超声弹性成像评估”
资金来源: 西安交通大学国际合作项目 (No. 2012jdhz50)
项目名称: “超分辨率成像心脑血管易损斑块和风险估计预报系统研究的核心问题基础研究”
资金来源: 国家重点基础研究发展计划 (973项目)

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研究方向
软物质力学与超声黏弹性成像
Soft matter mechanics and ultrasonic viscoelastic imaging

颈动脉斑块力学计算仿真
Mechanical simulation of carotid plaque

细胞和软组织材料黏弹性力学与疾病早期诊断应用研究
Viscoelastic mechanics of cell and soft tissue materials and its application in early diagnosis of diseases

医学图像信息分析-基于医学影像大数据机器学习与智能诊疗
Medical image and information analysis machine learning and intelligent diagnosis and treatment based on medical image big data

学术成果 - 张红梅发表的学术成果

Hongmei Zhang, Tongqing Lu, Qingzhe Zhang, Yan Zhou, Hongrui Zhu, Joseph Harms, Xiaofeng Yang, Mingxi Wan*, Michael F. Insana*, Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling, Mechanics of Materials, 2020, 148 (103431):1-15. DOI: 10.1016/j.mechmat.2020.103431
HONGMEI ZHANG, LEI XU, ZHIHUI LIU, SHUKUAN LU, JICHAO YIN, SIBO TIAN, XIAOFENG YANG, MINGXI WAN*. Statistical and Texture Descriptors of Symptomatic Plantar Fasciitis Using Ultrasound Shear Wave Elastography. IEEE Access. 2020:8,120146-120159. DOI: 1-1. 10.1109/ACCESS.2020.**.
Hongmei Zhang , Ying Guo , Yan Zhou, Hongrui Zhu, Manman Song, Kai Wang, Meili Gao, Litao Ruan, Mingxi Wan, Michael F. Insana*, Fluidity and elasticity form a concise set of viscoelastic biomarkers for breast cancer diagnosis based on Kelvin–Voigt fractional derivative modeling, Biomechanics and Modeling in Mechanobiology , Biomechanics and Modeling in Mechanobiology, 2020,19:19:2163–2177 (DOI:10.1007/s10237-020-01330-7)
HONGMEI ZHANG, MANMAN SONG,LITAO RUAN,FURONG ZHANG, AIFENG ZHANG, ANDREW M. SIEDLECKI, MINGXI WAN. Von Mises Strain as a Risk Marker for Vulnerability of Carotid Plaque: Preliminary Clinical Evaluation of Cerebral Infarction. Ultrasound Med Biol 2019, 45:1221-1233. DOI: 10.1016/j.ultrasmedbio.2019.01.007
Hongmei Zhang, Qingzhe Zhang，Litao Ruan, Mingxi Wan, Michael F.Insana. Modeling Ramp-hold Indentation Measurements based on Kelvin-Voigt Fractional Derivative Model. Measurement Science and Technology. 2018, 29(3), 1-16. DOI: 10.1088/1361-6501/aa9daf.
Hongmei Zhang, Yue Wang, Mostafa Fatemi , Michael Insana. Assessing composition and structure of soft biphasic media from Kelvin-Voigt fractional derivative model parameters", Measurement Science and Technology. 2017, 28 (2017) 035703 (12pp) doi:10.1088/1361-6501/aa5531.
HongMei Zhang^1,2, Yue Wang², Michael F. Insana², Ramp-hold relaxation solutions for the KVFD model applied to soft viscoelastic media. Measurement Science and Technology, 27 (2016) :1-11.
Zhang HM, Song MM, Yang M, Ruan LT, Wan MX. Fast Von Mises Strain Imaging on Ultrasound Carotid Vessel Wall by Flow Driven Diffusion Method,AUSTRALAS PHYS ENG S 2018: 1-18.
HongMeiZhang, Yue Wang, LiTao Ruan, Junbo Duan, MingXi Wan,Non-invasive Von Mises Strain imaging for Longitudinal Artery Wall. Journal of Medical Imaging and Health Informatics, 2016,6(4):906-915.
HongMei Zhang, HuiE Zhang, JunFeng Wu, et al. "Detection of thin structure defects in radiographic images using an improved Gabor filter."Insight - Non-Destructive Testing and Condition Monitoring59.10(2017):531-536.
Zhang Hongmei, Wan Mingxi, Bian Zhengzhong. Complementary tensor-driven image coherence diffusion for oriented structure enhancement. EURASIP Journal on Advances in Signal Processing 2011, 2011:70http://asp.eurasipjournals.com/content/2011/1/70.
HongMei Zhang, MingXi Wan, JinJin Wan,XuLei Qin. Super-Resolution Reconstruction of Deformable Tissue from Temporal Sequence of Ultrasound Images, 2010 International conference on artificial Intelligence and Computational Intelligence. Vol. 1, pp.337-342.
Hongmei Zhang，Mingxi Wan, Bo Shen, Xiaodong Wang, Mingzhu Lu. Volume estimation in a sequence of freehand ultrasound images. Measurement Science and Technology. 2006, 17 (11): 2927-2937.
Zhang Hongmei，Wan Mingxi. Improved Mumford-Shah Functional for Coupled Edge-Preserving Regularization and Image Segmentation. EURASIP Journal on Applied Signal Processing. 2006 Art. No. 37129 : 1-9
Zhang Hongmei，Bian Zhengzhong, Guo Youmin, Ye Min, Miao Yalin. Region information-based ROI extraction by multi-initial fast marching algorithm. EURASIP Journal on Applied Signal Processing，2004,11:1739-1749.
Zhang Hongmei, Bian Zhengzhong, Yuan Zejian, Ye Min, Ji Feng. A novel multiresolution fuzzy segmentation method on MR image. Journal of Computer Science and Technology, 2003, 18(5): 659-666.
Zhang Hong-mei，Bian Zheng-zhong ,Guo You-min, Ye Min. Efficient approach to extraction of region of interest, Journal of Software, 2005, 16(1): 77-88.
Zhang Hongmei, Bian Zhengzhong, Jiang Dazong, Yuan Zejian, Ye Min. Level set method for pulmonary vessels extraction. IEEE International Conference on Image Processing, Barcelona, Spain, 14-17 September 2003, 2:1105-1108.
Hongmei Zhang, Zhengzhong Bian, Youmin Guo, Baowei Fei, Min Ye. An efficient multiscale approach to level set evolution. The 25th Silver Anniversary International conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 17-21 Sept. 2003, 694-697.
Zhang Hong-mei, Yuan Ze-jian, Cai Zhong-min, Bian Zheng-zhong. Segmentation of MRI Using Hierarchical Markov Random Field. Journal of Software, 2002, 13(9): 1779-1786.
Zhang Hong-mei, Bian Zheng-zhong, Guo You-min, Yuan Ze-jian. An Efficient Approach to Pulmonary Vessels Extraction Based on Curve Evolution. Chinese Journal of Biomedical Engineering (English edition), 2004, 13(1): 39-46.
Hongmei Zhang, Yalin Miao, Youmin Guo, Jiang Yang, Zhengzhong Bian, Vascular enhancement by anisotropic diffusion-reaction PDE. Microellectronics & Computer, 2004,21(3):25-27.(In Chinese)
Hongmei Zhang, Donglang Chai, Zhengzhong Bian, a fast subdivision method for grid of composite material. Journal of Applied Mechanics, 2002,19(4):147-149. (In Chinese)
(Chinese National Invention patent)
Zhang Hongmei, Ruan Litao, Zhang qingzhe, Guo Youmin, Wan Mingxi, Shan Baowen. A novel and high accuracy noninvasive elastic imaging of vascular wall. Authorized, ZL 20**191.

Zhang Hongmei, Wang Kai, Liu Zhihui, Zhang Kehao, Zhou Yan, Yang Fan, Wang Jiong, Wan Mingxi. Machine learning optimization method of fractional order KVFD parameters for Viscoelastic characterization of soft matter, CN 7.4 (publicizing)

Book Chapter (In Chinese)
Hongmei Zhang, Chapter 7 Elasticity reconstruction of Vascular (Mingxi Wan et al, Computational Ultrasonic imaging), 2019-01, 978-7-03-059103-6Chinese Science Press.
Hongmei Zhang, Chapter 8 Fractional derivative model based viscoelastic measurement of biological tissue (Mingxi Wan et al, Computational Ultrasonic imaging ) 2010-05,978-7-03-027204-1Chinese Science Press
Hongmei Zhang, Chapter 10 Ultrasound medical image processing (Mingxi Wan et al, Biomedical Ultrasonics), 2010-05,978-7-03-027204-1, Chinese Science Press.

(Software Copyright)
Hongmei Zhang ,Litao Ruan, Zhengzhong Bian, Youmin Guo, Mingxi Wan, Variational and d PDE base evolution methods for image analysis. (corpyright No. 2014SR080747)
Hongmei Zhang , Mingxi Wan, Litao Ruan, Volume measurement from free hand Ultrasound images (copyright 2014SR080401)
( Publication as co-corresponding author )
Yan Song, Ying Dang, Jichang Wang, Hui Cai, Jun Feng, Hongmei Zhang*, Litao Ruan. Carotid intraplaque neovascularization predicts Ischemic Stroke Recurrence in Patients with Carotid Atherosclerosis. Gerontology. 2020. (In Press)
( Publication as co-author )
Hongrui Zhu, Dui Qin, Youshen Wu, Bowen Jing, Jiajun Liu, David Hazlewood, Hongmei Zhang, Yi Feng, Xinmai Yang, Mingxi Wan,* , andDaocheng Wu* Laser-Activated Bioprobes with High Photothermal Conversion Efficiency for Sensitive Photoacoustic/Ultrasound Imaging and Photothermal Sensing.ACS Appl. Mater. Inter 2018, 10:29251-29259.
Zhu, H., Gan, Z., Li, D., Qin, J., Zhang, H., Wan, M., & Wu, D. (2019). Sensitive detection of dopamine with ultrasound cavitation-enhanced fluorescence method. Microchemical Journal, 150, 104199.
Jinjin Wan, Fangli He, Yongfeng Zhao, Hongmei Zhang, Xiaodong Zhou, Mingxi Wan. Non-invasive Vascular Radial/Circumferential Strain Imaging and Wall Shear Rate Estimation Using Video Images of Diagnostic Ultrasound. UltrasoundinMedicine&Biology,2014,40(3),622-636.

国际合作 - 张红梅与Michael F. Insana教授团队的合作
本人与导师——伊利诺伊州立大学香槟分校（UIUC）著名****Michael F. Insana教授有密切的科研合作，致力于解决软材料黏弹性力学与超声黏弹性成像相关的问题。Michael F. Insana教授具有前沿的研究视角、扎实的学术功底和开拓创新的精神，与Michael F. Insana教授的国际合作让课题组的研究工作更加精彩！

Michael F. Insana教授于2015年被评为西安交通大学荣誉教授

English - 张红梅Basic Information
??????????????
Hong-Mei Zhang , PhD
???????
Associate Professor of Biomedical Information Engineering
Key Laboratory of Biomedical Information Engineering, Ministry of Education
Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University
28 Xian Ning West Avenue, 710049
P. R. China
Tel: (029)**; Fax: (029)**-801
Mobile: **
Email: claramei@mail.xjtu.edu.cn
Hongmei Zhangreceived herPhD degree in Biomedical Science and Technology from Xi’an Jiaotong University, in 2004. She is currently an Associate Professor in the Key Laboratory of Biomedical Information Engineering, Ministry of Education, the Department of Biomedical Engineering, Xi’an Jiaotong University. Herresearch work is to develop novel methods to characterize the viscoelastic property of the soft tissue.Her multidisciplinary broad research interests include fractional derivative model based viscoelastic biomarkers for early disease;Machine learning of multi-mode medical imaging data on early diagnosis of major disease.She has more than 30 publications. She is an IEEE member and a member of the Chinese Institute of Electronics.
EDUCATION:
Visiting Scholar: University of Illinois at Urbana-Champaign. (2014.9-2015.9)
Ph.D. Biomedical Engineering, Xi’an Jiaotong University, P.R. China, (2000-2004)
M.S. Material Science, Xi’an Jiaotong University, P.R. China, (1997-2000)
B.S. Material Science, Nanjing University of Science and Technology, P. R. China (1992-1996)

Research Interests
?Nanoindentation of soft tissue based on Fractional derivative models.
?Fractional derivative model basedviscoelastic imaging and deep learning of imaging parameters.
?Machine learning of multi-mode medical imaging data on early diagnosis of major disease (Vulnerability evaluation for Carotid plaque, breast cancer and other clinic symptom)???????????????????????

Teaching Activity
Medical image processing, 2 credit hours/semester ( for undergraduate student)
Medical image information Analysis, 2 credit hours/semester ( for postgraduate student)

Funding

(1) Project Title: “Ultrasound Viscoelasticity and fluidity biomarkers for vulnerability of carotid plaque by Fractional derivative model”
PI: Hong-Mei Zhang
Funding support: National Natural Science Fundation of China under Grant (No. **)
Research Time: 1/01/2019-12/31/2022
Total cost: RMB:630,000

(2) Project Title: “Super-resolution ultrasound elasticity imaging on carotid plaque-Theroetical methods and experiments”
PI: Hong-Mei Zhang
Funding support: National Natural Science Fundation of China under Grant (No.**)
Research Time: 1/01/2009-12/31/2011
Total cost: RMB:200,000

(3) Project Title: “Carotid strain estimation and elasticity imaging”
PI: Hong-Mei Zhang
Funding support: President Science Fundation of Xi an Jiaotong University under Grant (No.xjj**)
Research Time: 10/01/2008-9/31/2010
Total cost: RMB:10,000

(3) Project Title: “Super-resolution strain estimation and elasticity imaging to evaluate the risk of vulnerability of Carotid plaque”
PI: Hong-Mei Zhang
Funding support: International cooperation Science Fundation of Xi an Jiaotong University under Grant (No. 2012jdhz50)
Research Time: 10/01/2010-9/31/2012.
Total cost: RMB:40,000

(4) Project Title: “Fractional based model for Viscoelastic imaging and application on early sifting of breast cancer”
PI: Hong-Mei Zhang
Funding support: Major and Cultivation Project of Xi’an JiaoTong University(Grant No: zdyf**).
Research Time: 10/01/2017-9/31/2019.
Total cost: RMB:150,000

(Participated Fundings as primary members)
(5) Project Title: "Fundamental Research on the Key Problem of Super-Resolution Imaging for Cardiocerebral Vulnerable Plaque and Risk Forecasting System”
PI: Yuanting Zhang, Lei Song, Da Xing, Ming-Xi Wan, et al
Funding support: National Basic Research Program of China (973 Program)
Research Time: 1/01/2010-8/31/2014
Total cost: RMB:3,000,000
Role: Principal investigator, 5％???????

Publications
Hongmei Zhang, Tongqing Lu, Qingzhe Zhang, Yan Zhou, Hongrui Zhu, Joseph Harms, Xiaofeng Yang, Mingxi Wan*, Michael F. Insana*, Solutions to ramp-hold dynamic oscillation indentation tests for assessing the viscoelasticity of hydrogel by Kelvin-Voigt fractional derivative modeling, Mechanics of Materials, 2020, 148 (103431):1-15. DOI: 10.1016/j.mechmat.2020.103431
HONGMEI ZHANG, LEI XU, ZHIHUI LIU, SHUKUAN LU, JICHAO YIN, SIBO TIAN, XIAOFENG YANG, MINGXI WAN*. Statistical and Texture Descriptors of Symptomatic Plantar Fasciitis Using Ultrasound Shear Wave Elastography. IEEE Access. 2020:8,120146-120159. DOI: 1-1. 10.1109/ACCESS.2020.**.
Hongmei Zhang , Ying Guo , Yan Zhou, Hongrui Zhu, Manman Song, Kai Wang, Meili Gao, Litao Ruan, Mingxi Wan, Michael F. Insana*, Fluidity and elasticity form a concise set of viscoelastic biomarkers for breast cancer diagnosis based on Kelvin–Voigt fractional derivative modeling, Biomechanics and Modeling in Mechanobiology , Biomechanics and Modeling in Mechanobiology, 2020,19:19:2163–2177 (DOI:10.1007/s10237-020-01330-7)
HONGMEI ZHANG, MANMAN SONG,LITAO RUAN,FURONG ZHANG, AIFENG ZHANG, ANDREW M. SIEDLECKI, MINGXI WAN. Von Mises Strain as a Risk Marker for Vulnerability of Carotid Plaque: Preliminary Clinical Evaluation of Cerebral Infarction. Ultrasound Med Biol 2019, 45:1221-1233. DOI: 10.1016/j.ultrasmedbio.2019.01.007
Hongmei Zhang, Qingzhe Zhang，Litao Ruan, Mingxi Wan, Michael F.Insana. Modeling Ramp-hold Indentation Measurements based on Kelvin-Voigt Fractional Derivative Model. Measurement Science and Technology. 2018, 29(3), 1-16. DOI: 10.1088/1361-6501/aa9daf.
Hongmei Zhang, Yue Wang, Mostafa Fatemi , Michael Insana. Assessing composition and structure of soft biphasic media from Kelvin-Voigt fractional derivative model parameters", Measurement Science and Technology. 2017, 28 (2017) 035703 (12pp) doi:10.1088/1361-6501/aa5531.
HongMei Zhang^1,2, Yue Wang², Michael F. Insana², Ramp-hold relaxation solutions for the KVFD model applied to soft viscoelastic media. Measurement Science and Technology, 27 (2016) :1-11.
Zhang HM, Song MM, Yang M, Ruan LT, Wan MX. Fast Von Mises Strain Imaging on Ultrasound Carotid Vessel Wall by Flow Driven Diffusion Method,AUSTRALAS PHYS ENG S 2018: 1-18.
HongMeiZhang, Yue Wang, LiTao Ruan, Junbo Duan, MingXi Wan,Non-invasive Von Mises Strain imaging for Longitudinal Artery Wall. Journal of Medical Imaging and Health Informatics, 2016,6(4):906-915.
HongMei Zhang, HuiE Zhang, JunFeng Wu, et al. "Detection of thin structure defects in radiographic images using an improved Gabor filter."Insight - Non-Destructive Testing and Condition Monitoring59.10(2017):531-536.
Zhang Hongmei, Wan Mingxi, Bian Zhengzhong. Complementary tensor-driven image coherence diffusion for oriented structure enhancement. EURASIP Journal on Advances in Signal Processing 2011, 2011:70http://asp.eurasipjournals.com/content/2011/1/70.
HongMei Zhang, MingXi Wan, JinJin Wan,XuLei Qin. Super-Resolution Reconstruction of Deformable Tissue from Temporal Sequence of Ultrasound Images, 2010 International conference on artificial Intelligence and Computational Intelligence. Vol. 1, pp.337-342.
Hongmei Zhang，Mingxi Wan, Bo Shen, Xiaodong Wang, Mingzhu Lu. Volume estimation in a sequence of freehand ultrasound images. Measurement Science and Technology. 2006, 17 (11): 2927-2937.
Zhang Hongmei，Wan Mingxi. Improved Mumford-Shah Functional for Coupled Edge-Preserving Regularization and Image Segmentation. EURASIP Journal on Applied Signal Processing. 2006 Art. No. 37129 : 1-9
Zhang Hongmei，Bian Zhengzhong, Guo Youmin, Ye Min, Miao Yalin. Region information-based ROI extraction by multi-initial fast marching algorithm. EURASIP Journal on Applied Signal Processing，2004,11:1739-1749.
Zhang Hongmei, Bian Zhengzhong, Yuan Zejian, Ye Min, Ji Feng. A novel multiresolution fuzzy segmentation method on MR image. Journal of Computer Science and Technology, 2003, 18(5): 659-666.
Zhang Hong-mei，Bian Zheng-zhong ,Guo You-min, Ye Min. Efficient approach to extraction of region of interest, Journal of Software, 2005, 16(1): 77-88.
Zhang Hongmei, Bian Zhengzhong, Jiang Dazong, Yuan Zejian, Ye Min. Level set method for pulmonary vessels extraction. IEEE International Conference on Image Processing, Barcelona, Spain, 14-17 September 2003, 2:1105-1108.
Hongmei Zhang, Zhengzhong Bian, Youmin Guo, Baowei Fei, Min Ye. An efficient multiscale approach to level set evolution. The 25th Silver Anniversary International conference of the IEEE Engineering in Medicine and Biology Society, Cancun, Mexico, 17-21 Sept. 2003, 694-697.
Zhang Hong-mei, Yuan Ze-jian, Cai Zhong-min, Bian Zheng-zhong. Segmentation of MRI Using Hierarchical Markov Random Field. Journal of Software, 2002, 13(9): 1779-1786.
Zhang Hong-mei, Bian Zheng-zhong, Guo You-min, Yuan Ze-jian. An Efficient Approach to Pulmonary Vessels Extraction Based on Curve Evolution. Chinese Journal of Biomedical Engineering (English edition), 2004, 13(1): 39-46.
Hongmei Zhang, Yalin Miao, Youmin Guo, Jiang Yang, Zhengzhong Bian, Vascular enhancement by anisotropic diffusion-reaction PDE. Microellectronics & Computer, 2004,21(3):25-27.(In Chinese)
Hongmei Zhang, Donglang Chai, Zhengzhong Bian, a fast subdivision method for grid of composite material. Journal of Applied Mechanics, 2002,19(4):147-149. (In Chinese)
(Chinese National Invention patents) ??????????????
1. Zhang Hongmei, Ruan Litao, Zhang qingzhe, Guo Youmin, Wan Mingxi, Shan Baowen. A novel and high accuracy noninvasive elastic imaging of vascular wall. Authorized, ZL 20**191.
??????????????
2. Zhang Hongmei, Wang Kai, Liu Zhihui, Zhang Kehao, Zhou Yan, Yang Fan, Wang Jiong, Wan Mingxi. Machine learning optimization method of fractional order KVFD parameters for Viscoelastic characterization of soft matter, CN 7.4 (publicizing)

Book Chapters (In Chinese)
Hongmei Zhang, Chapter 7 Elasticity reconstruction of Vascular (Mingxi Wan et al, Computational Ultrasonic imaging), 2019-01, 978-7-03-059103-6Chinese Science Press.
Hongmei Zhang, Chapter 8 Fractional derivative model based viscoelastic measurement of biological tissue (Mingxi Wan et al, Computational Ultrasonic imaging ) 2010-05,978-7-03-027204-1Chinese Science Press
Hongmei Zhang, Chapter 10 Ultrasound medical image processing (Mingxi Wan et al, Biomedical Ultrasonics), 2010-05,978-7-03-027204-1, Chinese Science Press.

(Software Copyright)
Hongmei Zhang ,Litao Ruan, Zhengzhong Bian, Youmin Guo, Mingxi Wan, Variational and d PDE base evolution methods for image analysis. (corpyright No. 2014SR080747)
Hongmei Zhang , Mingxi Wan, Litao Ruan, Volume measurement from free hand Ultrasound images (copyright 2014SR080401)
( Publication as co-corresponding author )
Yan Song, Ying Dang, Jichang Wang, Hui Cai, Jun Feng, Hongmei Zhang*, Litao Ruan. Carotid intraplaque neovascularization predicts Ischemic Stroke Recurrence in Patients with Carotid Atherosclerosis. Gerontology. 2020. (In Press)
( Selected Publications as co-author )
Hongrui Zhu, Dui Qin, Youshen Wu, Bowen Jing, Jiajun Liu, David Hazlewood, Hongmei Zhang, Yi Feng, Xinmai Yang, Mingxi Wan,* , andDaocheng Wu* Laser-Activated Bioprobes with High Photothermal Conversion Efficiency for Sensitive Photoacoustic/Ultrasound Imaging and Photothermal Sensing.ACS Appl. Mater. Inter 2018, 10:29251-29259.
Zhu, H., Gan, Z., Li, D., Qin, J., Zhang, H., Wan, M., & Wu, D. (2019). Sensitive detection of dopamine with ultrasound cavitation-enhanced fluorescence method. Microchemical Journal, 150, 104199.
Jinjin Wan, Fangli He, Yongfeng Zhao, Hongmei Zhang, Xiaodong Zhou, Mingxi Wan. Non-invasive Vascular Radial/Circumferential Strain Imaging and Wall Shear Rate Estimation Using Video Images of Diagnostic Ultrasound. UltrasoundinMedicine&Biology,2014,40(3),622-636.