| 吴浩浩 | 博士 | 副教授 | 硕士研究生导师 | |
| 团队 | 水产品高值化利用研究室 | |||
| 办公电话： | 0532-82032 400 | 电子邮箱： | wuhaohao@ouc.edu.cn | |
| 联系地址： | 青岛市市南区鱼山路 5 号 | |||
| 研究方向： | 1. 矿物质营养素的纳米递送 2. 矿物质营养素的稳态代谢 3. 海洋微藻营养功能与加工 | |||
| 个人简介 | ||||
| 近年来主要围绕海洋食品（鱼虾贝藻）稳态化递送矿物质营养素（钙、铁和锌）开展科研工作，在海洋微藻营养功能特性及相关食品开发方面也有一定的科研积累，已在国内外知名期刊发表学术论文 30 余篇，他引次数达 300 余次。迄今（-2020/04）以第一或通讯（含共同）作者发表 SCI 论文 22 篇，其中一区 12 篇、二区 8 篇（按发表当年中科院大类期刊分区）。 承担了本科生核心课程《食品工程原理》的教学工作，是国家精品在线开放课程《食品保藏探秘》课程团队主要成员，担任了食品科学与工程专业 2016 级班主任，曾指导本科生获得了全国大学生食品 工程虚拟仿真大赛总决赛一等奖。讲授多门本专业研究生课程，已指导多名研究生获得了国家奖学金。 | ||||
| 教育背景 | ||||
| 2009.09~2015.01 | 中国海洋大学 | 水产品加工及 贮藏工程 | 博士 | |
| 2013.8~2014.12 | 马 里 兰 大 学 （University of Maryland, College Park）和美国食品药品监管局/食品安全与应用营养中心 （FDA/CFSAN） | 纳米材料生物学效应 | CSC 联合培养 | |
| 2005.09~2009.07 | 陕西师范大学 | 食品工艺教育 | 学士 | |
| 工作经历 | ||||
| 2015.05 至今 | 中国海洋大学 食品科学与工程学院 | 副教授 | “青年英才工程”第三层次 | |
| 学术兼职 | ||||
| 中国食品工业协会理事，美国食品科学技术学会（IFT）会员，华美食品学会（CAFS）会员，Food & Function、 International Journal of Nanomedicine 等 SCI 期刊的特约审稿人 | ||||
| 奖励荣誉 | ||||
| 科研成果“纳米技术在鳀鱼多肽促铁吸收中的应用”获得了 2015 年山东省研究生优秀科技创新成果奖二等奖 | ||||
| 承担课程（含本科及研究生） | ||||
| 主讲《食品工程原理》、《食品工程原理实验》和《认知实习》等本科生课程；讲授《食品纳米技术》（矿物质纳米递 送部分）、中英文《食品营养专题》（矿物质部分）等研究生课程。 |
| 研究进展 |
| 1. 矿物质营养素的纳米递送：利用水产蛋白、磷脂、酸性多糖和核酸作为天然聚阴离子模板，进行了钙、铁和锌纳米营养补充/强化剂的绿色制备和生物可利用性评价；利用海洋微藻作为细胞工厂，进行了多聚磷酸钙、铁和锌盐纳米颗粒的生物制备和生物可利用性评价。 2. 矿物质营养素的稳态代谢：研究了胶原肽调控机体铁稳态的作用及分子机制，主要从细胞和动物水平上评价了胶原肽及其主要降解产物对肠上皮细胞铁吸收转运相关蛋白的表达、肝细胞铁稳态相关激素的分泌以及脯氨酸羟化酶-低氧诱导因子信号通路等的影响。 3. 海洋微藻营养功能与加工：围绕海洋聚球藻的规模化培养、藻体收集、营养组成和安全性评价等开展 了研究，并评价了微藻中纳米多聚磷酸体、藻蓝蛋白和多糖等成分在维持肠道健康方面的功能活性。 |
| 代表性论文 |
| 1. Guangxin Feng, Shuwei Tang, Yuxin Gang, Mingyong Zeng, Haohao Wu*. Chondroitin sulfate and its nanocomposites with protamine or chitosan stabilize and deliver available nanosized iron. International Journal of Biological Macromolecules, 2020, 150, 501-508. 2. Tengjiao Guo, Yisheng Yang, Jiayou Zhang, Yu Miao, Feifei Lin, Suqin Zhu, Caili Zhang, Haohao Wu*. Ascorbate exacerbates iron toxicity on intestinal barrier function against Salmonella infection. Journal of Environmental Science and Health, Part C, 2020, doi: 10.1080/**.2020.** 3. Yinong Feng, Jiayou Zhang, Yu Miao, Wei Guo, Guangxin Feng, Yisheng Yang, Tengjiao Guo, Haohao Wu*, Mingyong Zeng*. Prevention of Zinc Precipitation with Calcium Phosphate by Casein Hydrolysate Improves Zinc Absorption by Mouse Small Intestine Ex Vivo via a Nanoparticle-Mediated Mechanism. Journal of Agricultural and Food Chemistry, 2020, 68, 652−659. 4. Wei Guo, Suqin Zhu, Guangxin Feng, Lingyu Wu, Yinong Feng, Tengjiao Guo, Yisheng Yang, Haohao Wu*, Mingyong Zeng*. Microalgae Aqueous Extracts Exert Intestinal Protective Effects in Caco‐2 Cells and Dextran Sodium Sulphate-Induced Mouse Colitis. Food & Function, 2020, 11, 1098-1109. 5. Suqin Zhu, Mingyong Zeng, Guangxin Feng, Haohao Wu*. Platinum nanoparticles as a therapeutic agent against dextran sodium sulfate-induced colitis in mice. International Journal of Nanomedicine, 2019, 14, 8361–8378. 6. Yisheng Yang, Suqin Zhu, Wei Guo, Yinong Feng, Tengjiao Guo, Haohao Wu*. Formation of Calcium Phosphate Nanoparticles Mediated by Animal Protein Hydrolysates Enhances Calcium Absorption by Murine Small Intestine Ex Vivo. Food & Function, 2019, 10, 6666– 6674. 7. Lingyu Wu, Yaqun Zou, Yu Miao, Jiayou Zhang, Suqin Zhu, Mingyong Zeng, Haohao Wu*. |
| Dietary gelatin enhances non-heme iron absorption possibly via regulation of systemic iron homeostasis in rats. Journal of Functional Foods, 2019, 59, 272-280. 8. Suqin Zhu, Mingyong Zeng, Wei Guo, Guangxin Feng, Haohao Wu*. Catalase-mimetic gold nanoparticles inhibit the antagonistic action of Lactobacillus gasseri toward foodborne enteric pathogens in associative cultures. Journal of Environmental Science and Health, Part C, 2019, 37(2), 55–66. 9. Guangxin Feng, Mingyong Zeng, Min Huang, Suqin Zhu, Wei Guo, Haohao Wu*. Protective Effect of Biogenic Polyphosphate Nanoparticles from Synechococcus sp. PCC 7002 on Dextran Sodium Sulphate-Induced Colitis in Mice. Food & Function, 2019, 10, 1007-1016. 10. Suqin Zhu, Xiumei Jiang, Mary D. Boudreau, Guangxin Feng, Yu Miao, Shiyuan Dong, Haohao Wu*, Mingyong Zeng*, Jun-Jie Yin. Orally administered gold nanoparticles protect against colitis by attenuating Toll-like receptor 4- and reactive oxygen/nitrogen species-mediated inflammatory responses but could induce gut dysbiosis in mice. Journal of Nanobiotechnology, 2018, 16, 86. 11. Guangxin Feng, Shiyuan Dong, Min Huang, Mingyong Zeng, Zunying Liu, Yuanhui Zhao, Haohao Wu*. Biogenic Polyphosphate Nanoparticles from a Marine Cyanobacterium Synechococcus sp. PCC 7002: Production, Characterization, and Anti-Inflammatory Properties In Vitro. Marine Drugs, 2018, 16, 322. 12. Guangxin Feng, Yinong Feng, Tengjiao Guo, Yisheng Yang, Wei Guo, Min Huang, Haohao Wu*, Mingyong Zeng*. Biogenic Polyphosphate Nanoparticles from Synechococcus sp. PCC 7002 Exhibit Intestinal Protective Potential in Human Intestinal Epithelial Cells In Vitro and Murine Small Intestine Ex Vivo. Journal of Agricultural and Food Chemistry, 2018, 66(30), 8026–8035. 13. Yuhong Yang#, Haohao Wu#, Shiyuan Dong*, Weiya Jin, Kaining Han, Yanmei Ren, Mingyong Zeng. Glycation of fish protein impacts its fermentation metabolites and gut microbiota during in vitro human colonic fermentation. Food Research International, 2018, 113, 189-196. 14. Feifei Lin, Haohao Wu*, Mingyong Zeng*, Guangli Yu, Shiyuan Dong, Huicheng Yang. Probiotic/prebiotic correction for adverse effects of iron fortification on intestinal resistance to Salmonella infection in weaning mice. Food & Function, 2018, 9, 1070-1078. 15. Suqin Zhu, Min Huang, Guangxin Feng, Yu Miao, Haohao Wu*, Mingyong Zeng*, Y. Martin Lo. Gelatin versus its two major degradation products, prolyl-hydroxyproline and glycine, as supportive therapy in experimental colitis in mice. Food Science & Nutrition, 2018, 6(4), 1023-1031. 16. Yaqun Zou, Liang Zhao, Guangxin Feng, Yu Miao, Haohao Wu*, Mingyong Zeng*. Characterization of Key Factors of Anchovy (Engraulis japonicus) Meat in the Nanoparticle-Mediated Enhancement of Non-Heme Iron Absorption. Journal of |
| Agricultural and Food Chemistry, 2017, 65(51), 11212-11219. 17. Liang Zhao, Haohao Wu*, Mingyong Zeng*, Hai Huang. Nonheme Iron-Loading Capacities of Anchovy (Engraulis japonicus) Meat Fractions under Simulated Gastrointestinal Digestion. Journal of Agricultural and Food Chemistry, 2017, 65(1), 174-181. 18. Haohao Wu, Yi Liu, Meng Li, Yu Chong, Mingyong Zeng, Y. Martin Lo, Jun-Jie Yin*. Size-dependent tuning of horseradish peroxidase bioreactivity by gold nanoparticles. Nanoscale, 2015, 7(10), 4505-4513. 19. Haohao Wu, Suqin Zhu, Mingyong Zeng*, Zunying Liu, Shiyuan Dong, Yuanhui Zhao, Hai Huang. Enhancement of non-heme iron absorption by anchovy (Engraulis japonicus) muscle protein hydrolysate involves a nanoparticle-mediated mechanism. Journal of Agricultural and Food Chemistry, 2014, 62(34), 8632-8639. 20. Haohao Wu, Jun-Jie Yin, Wayne G. Warmer, Mingyong Zeng, Y. Martin Lo. Reactive oxygen species-related activities of nano-iron metal and nano-iron oxides. Food and Drug Analysis, 2014, 22(1), 86-94. 21. Haohao Wu, Zunying Liu, Shiyuan Dong, Yuanhui Zhao, Hai Huang, Mingyong Zeng*. Formation of ferric oxyhydroxide nanoparticles mediated by peptides in the anchovy (Engraulis japonicus) muscle protein hydrolysate. Journal of Agricultural and Food Chemistry, 2013, 61(1), 219-224. 22. Haohao Wu, Zunying Liu, Yuanhui Zhao, Mingyong Zeng*. Enzymatic preparation and characterization of iron-chelating peptides from anchovy (Engraulis japonicus) muscle protein. Food Research International, 2012, 48(2), 435-441. |
| 出版著作 |
| 专利 |
| 1. 一种规模化高效培养聚球藻 7002 的方法. 授权公告号：CN**7B；授权公告日：2020.04.03 2. 高产纳米多聚磷酸体的转基因藻株及其制备方法. 授权公告号：CN**5B；授权公告日： 2020.03.17 |
| 项目课题 |
| 1. 国家重点研发计划子课题，2019YFC**，水产品危害因子非靶向筛查技术集成与示范，2019/12-2022/12， 在研，主持 2. 国家自然科学基金青年基金，**，海洋聚球藻源纳米多聚磷酸体中钙、铁和锌的生物可利用性研究， |
| 2017/01-2019/12，已结题，主持 3. 中国博士后科学基金面上资助， 2015M582142 ，食物铁强化对肠道抵抗力的负面影响及其矫正实验研究， 2016/01-2017/12，已结题，主持 4. 山东省自然科学基金博士基金，ZR2016CB30，海洋聚球藻源纳米多聚磷酸体的益生作用研究，2016/11-2018/11， 已结题，主持 5. 青岛市应用基础研究项目，16-5-1-16-jch，海洋聚球藻源纳米多聚磷酸体的益生作用研究，2016/09-2018/8，已 结题，主持 |
