蒋晓燕 教授
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：医学院
联系方式：xiaoyanjiang001@163.com，xiaoyanjiang@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

蒋晓燕，同济大学医学院心律失常教育部重点实验室教授，博士生导师。2013年～至今任同济大学医学院病理与病理生理学系主任助理。研究方向：心血管与代谢性疾病分子遗传流行病学。为如皋衰老纵向队列的主要建设者（Rugao Longevity and Ageing Study, RuLAS）Co-PI，建立队列数据库。长期从事心血管代谢性疾病及衰弱的分子遗传流行病学研究，并有多年的多基因病与药物遗传学咨询、心血管药理学及病理生理学研究教学经历。主持国家自然科学基金面上项目、国家自然科学基金青年基金、国家教育部博士点新教师基金、上海市自然科学基金、中央高校基本科研业务费专项基金等项目。为国家重点研发计划“主动健康和老龄化科技应对”专项“老年衰弱快速筛查评估量表的研发与建立”任务责任人。在国内外学术刊物上发表六十多篇论文，其中以通讯或第一作者（含并列）名义发表SCI论文20篇。获济南市科技进步二等奖（2015，排名第二）。是国家自然科学基金及教育部博士学位论文评审专家以及MolecularBiology Reports、PsychiatryResearch 、J NutrHealth Aging等国际SCI期刊的审稿人。
Xiao-Yan Jiang, Ph.D., Professor (Ph.D.Supervisor) of the key laboratory of arrhythmiasof ministry of Education of China and the assistant director of the departmentof pathology and pathophysiology. Research field: molecular epidemiology incardiology and metabolic disease. Reviewer of the National Natural ScienceFoundation, the Doctoral Dissertation of the Ministry of Education, and the SCIjournals (Molecular Biology Reports, PsychiatryResearch，J Nutr Health Aging). Grants: theNational Key R&D Program of China；the NationalNatural Science Foundation; the Research Fund for the Doctoral Program ofHigher Education of China; the Shanghai Municipal Natural Science Foundation;the Fundamental Research Funds for the Central Universities. Awards: theSecond Prize of Jinan Science and Technology Progress Award (2015, rank second).

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发表文章(Publication)：*通讯作者(corresponding author)，#并列第一(co-firstauthor)
1. Sun XH#, Ma T#, Yao S1,Chen ZK, Xu WD, Jiang XY*, Wang XF*. Associations of sleepquality and sleep duration with frailty and pre-frailty in an elderlypopulation Rugao longevity and ageing study. BMC Geriatr. 2020 Jan 6;20(1):9.doi: 10.1186/s12877-019-1407-5.. （并列通讯、co-corresponding author)
2. Ma T#, Sun XH#, Yao S,Chen ZK, Zhang JF, Xu WD, Jiang XY*, Wang XF*. Genetic Variantsof Homocysteine Metabolism, Homocysteine, and Frailty - Rugao Longevity andAgeing Study.J Nutr Health Aging. 2020;24(2):198-204. doi:10.1007/s12603-019-1304-9. （并列通讯、co-corresponding author)
3. Li YX#, Jiang XY#, Stone C, Ma YJ, Liu Q, Hu ZH, Li XD, Wang XF, Li SJ. A newphysical-cognitive scale for assessment of frailty in Chinese Han elderly. NeurolRes. 2019 Aug;41(8):728-733. doi: 10.1080/**.2019.**. Epub 2019 Apr28. （并列第一，co-first author）
4. Shi GP, Ma T, Zhu YS, Wang ZD, Chu XF, Wang Y,Chen ZK, Xu WD, Wang XF, Guo JH, Jiang XY*. Frailty phenotype, frailty indexand risk of mortality in Chinese elderly population- Rugao longevity and ageingstudy. Arch Gerontol Geriatr. 2019 Jan - Feb;80:115-119. doi:10.1016/j.archger.2018.11.001. Epub 2018 Nov 6.（并列通讯、co-corresponding author、last author）
5. Ma T #, Cai J#, Zhu Y, Chu X, Wang Y, Shi G,Wang Z, Yao S, Wang X*, Jiang X*. Association between a frailtyindex based on common laboratory tests and QTc prolongation in older adults:the rugao longevity and Ageing study. Clin Interv Aging. 2018;13:797-804.eCollection 2018. （并列通讯、co-corresponding author、last author）
6. Zheng HX#, Li L#, Jiang XY#, YanS, Qin Z, Wang X, Jin L. MtDNA genomes reveal a relaxation of selectiveconstraints in low-BMI individuals in a Uyghur population. Hum Genet (2017) 136:1353–1362. （并列第一，co-first author）
7. Wang Y, Ma T, Zhu YS, Chu XF, Yao S, Wang HF,Cai J, Wang XF*, Jiang XY*. The KSR2-rs**Polymorphism is Associated with Metabolic Phenotypes, but Not PsychologicalPhenotypes, in Chinese Elders. Genet Test Mol Biomarkers. 2017Jul;21(7):416-421. （并列通讯、co-corresponding author、last author）
8. Zhi TF, Sun XM, Li SJ, Wang QS, Cai J, Li LZ, LiYX, Xu MJ, Wang Y, Chu XF, Wang ZD, Jiang XY*. Associations ofsleep duration and sleep quality with life satisfaction in elderly Chinese: Themediating role of depression. Arch Gerontol Geriatr. 2016 Jul-Aug; 65:211-7.doi: 10.1016/j.archger.2016.03.023. Epub 2016 Mar 30. (corresponding author)
9. Zhi T, Wang Q, Liu Z, Zhu Y, Wang Y, Shi R, WangZ, Chu X, Wang X, Jiang X*. Body mass index, waist circumferenceand waist-hip ratio are associated with depressive symptoms in older Chinesewomen: results from the Rugao Longevity and Ageing Study (RuLAS). Aging MentHealth. 2017 May;21(5):518-523. doi: 10.1080/**.2015.**. Epub 2015Dec 21. (corresponding author)
10. Liu Z, Wang Q, Zhi T, Zhu Y, Wang Y, Wang Z, ShiJ, Xie X, Chu X, Wang X, Jiang X*. Frailty Index and Its Relationto Falls and Overnight Hospitalizations in Elderly Chinese People: APopulation-based Study. J Nutr Health Aging. 2016;20(5):561-8. doi:10.1007/s12603-015-0625-6. (corresponding author)
11. Ma Q, Wang L, Yao H*, Wang TT, Ma Y, Su YX, WangZQ, Zhu J, Wang SX, Zhang ZX, Hou QQ, Cai R, Gong XL, Jiang XY*.Association between KCNQ1 genetic variants and type 2 diabetes in the UyghurPopulation. Genetic Testing and Molecular Biomarkers.2015 Dec;19(12):698-702.doi: 10.1089/gtmb.2015.0146. Epub 2015 Nov 5. （并列通讯co-corresponding author、last author）
12. Li L, Li X, The E, Wang LJ, Yuan TY, Wang SY,Feng J, Wang J, Liu Y, Wu YH, Ma XE, Ge J, Cui YY*, Jiang XY*.Low Expression of lncRNA-GAS5 Is Implicated in Human Primary Varicose GreatSaphenous Veins. PLoS One. 2015 Mar 25;10(3):e**.doi:10.1371/journal.pone.**. e Collection 2015. （并列通讯、co-correspondingauthor、last author）
13. Jiang XY*,Cai J, Wang HB, Li X, Chen Y, Wang J, Lin RY. TNFRSF11B polymorphisms areassociated with metabolic traits in Uyghur and Han ethnic groups. Endocr Res.2014;39(1):34-8. (通讯作者，corresponding author)
14. Li X#, Jiang XY#, Ge J, Wang J,Chen GJ, Xu L, Xie DY, Yuan TY, Zhang DS, Zhang H, Chen YH. Aberrantlyexpressed lncRNAs in primary varicose great saphenous veins. PLoS One. 2014 Jan31;9(1):e86156. (并列第一，co-first author)
15. Jiang XY,Zhang Q, Chen P, Li SY, Zhang NN, Chen XD, Wang GC, Wang HB, Zhuang MQ, Lu M. CYP7A1polymorphism influences the LDL cholesterol-lowering response to atorvastatin.JClin Pharm Ther. 2012;37(6):719-23.
16. Jiang XY,Chen Y, Xu L, Li X, Cao FF, Li L, Lu M, Jin L, Wang XF. Association of LPR5Polymorphism with Bone Mass Density and Cholesterol Level in Population ofChinese Han. Experimental and Clinical Endocrinology Diabetes.2010;118(6):388-391.
17. Jiang XY,Chen HH, Cao FF, Li L, Lin RY, Wen H, Jin L, Wang XF. A polymorphism nearosteoprotegerin gene confer risk of Obesity in Uyghurs. Endocrine, 2010,37(3):383-388.
18. Chen Y#, Jiang XY#, Xu L, Li X,Cao FF, Li L, Lu M, Jin L, Wang XF. Association of ER-Alpha Gene Polymorphismwith Metabolic Phenotypes in Chinese Hans. Lipids.2009,44:719-723. (并列第一，co-first author)
19. Jiang X, NieB, Fu S, Hu J, Yin L, Lin L, Wang X, Lu P, Xu XM. EGb761 protects hydrogenperoxide-induced death of spinal cord neurons through inhibition ofintracellular ROS production and modulation of apoptotic regulating genes. JMOL NEUROSCI, 2009, 38:103-113.
20. Jiang XY,Fu SL, Nie BM, Li Y, Lin L, Yin L, Wang YX, Lu PH, Xu XM. Methods for isolatinghighly-enriched embryonic spinal cord neurons: A comparison between enzymaticand mechanical dissociations. J Neurosci Meth, 2006,158 (1)13-18.
21. Nie BM, Jiang XY, Cai JX, Fu SL,Yang LM, Lin L, Hang Q, Lu PL, Lu Y. Panaxydol and panaxynol protect culturedcortical neurons against Aβ25-35-induced toxicity. Neuropharmacology 2008,54(5):845-853.
22. Liu NK, Zhang YP, Titsworth WL, Jiang X,Han S, Lu PH, Shields CB, Xu XM. A Novel Role of Phospholipase A2 in MediatingSpinal Cord Secondary Injury. Annal Neurol, 2006, 59:606-619.
23. Nie BM, Yang LM, Fu SL, Jiang XY,Lu PH, Lu Y. Protective effect of panaxydol and panaxynol on sodiumnitroprusside-induced apoptosis in cortical neurons. Chemico-biologicalInteraction, 2006, 160(3):225-231.
24. Hu JG, Fu SL, Wang YX, Li Y, Jiang XY,Wang XF, Qiu MS, Lu PH, Xu XM.Platelet-derived growth factor-AA mediatesoligodendrocyte lineage differentiation through activation of extracellularsignal-regulated kinase signaling pathway. Neurosci, 2008,151 (1)138-147
25. Wang XF, Yin L, Hu JG, Huang LD, Yu PP, JiangXY, Xu XM, Lu PH. Expression and localization of p80 interleukin-1receptor protein in the rat spinal cord. J MOL NEUROSCI, 2006, 29(1):45-53
26. Wang X, Wang S, Lin R, Jiang X,Cheng Z, Turdi J, Ding J, Wu G, Lu X, Wen H. GNB3 gene C825T and ACE gene I/Dpolymorphisms in essential hypertension in a Kazakh genetic isolate. J HumHypertens. 2004 Sep;18(9):663-8.
27. Xu L, Pan L, Li J, Huang B, Feng J, Li C, WangS, The E, Liu Y, Yuan T, Zhen L, Liang D, Liu Y, Li L, Cui Y, Jiang X,Peng L, Chen YH. Nucleoporin 35 regulates cardiomyocyte pH homeostasis bycontrolling Na+-H+ exchanger-1 expression. J Mol Cell Biol. 2015Oct;7(5):476-85.
28. Ma T, Lu D, Zhu Y, Chu X, Wang Y, Shi G, Wang Z,Yu L, Jiang X, Wang X*. ACTN3 genotype and physical function andfrailty in an elderly Chinese population: the Rugao Longevity and Ageing Study.Age Ageing. 2018 May 1;47(3):416-422. doi: 10.1093/ageing/afy007.
29. Liu Q^#, Li Y, Hu Z, Jiang X,Li S*, Wang X*. Comparing associations of different metabolic syndromedefinitions with ischemic stroke in Chinese elderly population. Eur J InternMed. 2018;47:75-81.
30. Ma T^#, Shi G^#, Zhu Y, WangY, Chu X, Jiang X, Liu Z, Cai J, Wang H, Jin L, Wang Z*, Wang X*.Sleep disturbances and risk of falls in an old Chinese population-RugaoLongevity and Ageing Study. ArchGerontol Geriatr. 2017;73:8-14.
31. Liu Q^#, Li Y, Hu Z, Jiang X,Li S*, Wang X*. Reduced estimated glomerular filtration rate is associated withdepressive symptoms in elder Chinese: a population-based cross-sectional study.Neuroscience Letters. 2017;666:127-132.
32. Li WP, Ma K, Jiang XY, Yang R, LuPH, Nie BM, Lu Y. Molecular mechanism of panaxydol on promoting axonal growthin PC12 cells. Neural Regen Res. 2018 Nov;13(11):1927-1936. doi:10.4103/1673-5374.239439.
33. Liu Z^#, Shen Y^#, Ji L, JiangX, Wang X, Shi Y*. Association between serum β2-microglobulin levels andfrailty in an elderly Chinese population: results from RuLAS. Clin IntervAging. 2017;12:1725-1729.
34. Liu ZY#, Wei YZ#, Wei LQ#, Jiang XY,Wang XF, Shi Y, Hai H. Frailty transitions and types of death in Chinese olderadults: a population-based cohort study. Clin Interv Aging. 2018 May16;13:947-956. doi: 10.2147/CIA.S157089. eCollection 2018.
35. Yao S, Guo J, Shi G, Zhu Y, Wang Y, Chu X, JiangX, Jin L, Wang Z, Wang X. Association of BNP with Frailty in ElderlyPopulation: Rugao Longevity and Ageing Study. J Nutr Health Aging.2019;23(1):73-78. doi: 10.1007/s12603-018-1112-7.
36. Wang ZD, Yao S, Shi GP, Wang Y, Shi JM, Guo JH,Zhu YS, Jiang XY, Chu XF, Wang XF. Frailty index is associatedwith increased risk of elevated BNP in an elderly population: the RugaoLongevity and Ageing Study. Aging Clin Exp Res. 2019 Apr 19. doi:10.1007/s40520-019-01189-4. [Epub ahead of print]
37. Zhang N, Shi GP, Wang Y, Chu XF, Wang ZD, ShiJM, Guo JH, Wang YC, Yao S, Jiang XY, Zhu YS, Wang XF. Depressivesymptoms are associated with incident frailty in a Chinese population: theRugao Longevity and Aging Study. Aging Clin Exp Res. 2019 Nov 30. doi:10.1007/s40520-019-01409-x. [Epub ahead of print]