吕立夏 教授
硕士招生类型：学术型
硕士招生专业：生物医学工程
博士招生类型：学术型
博士招生专业：临床医学(基础医学方向)
所在院系：医学院
联系方式：lulixia@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩


视网膜变性的分子机制研究及相关的细胞干预和基因治疗。
Mechanistic study on retinal degenerationand its relevant cell therapy and gene therapy




ARVO 会员
中国生物化学与分子生物学学会会员会员
ARVO member
Chinese society of Biochemistry and molecular biology （CSBMB）member



承担课题：
1.国家重点研发计划（开发人胚胎干细胞向视网膜细胞分化和辅基的关键技术、种子细胞优化及组织工程化视网膜片构建（2017YFA**）2017-2021 （骨干）
2上海市自然科学基金（17ZR**）胶质成熟因子beta在早期糖尿病视网膜病变的作用机制及干预策略研究 2017-2019
4.863课题骨干（2011AA020109）临床级干细胞分离培养、扩增诱导和保存运输等产业化关键技术研发 92万（2013-2015）
5.973课题骨干（2011CB965102）ES和iPS细胞向RPE分化，治疗视网膜变性眼病有效性和临床安全性间的差异及预编程机制 121万（2011-2015)
6.课题骨干（2011DFB30010） 科技部国际合作干细胞治疗的基础与临床前研究及产品研发 90万（2011-2013)
发表论文：
1. Cui L, Lyu Y, Jin X, Wang Y, Li X, Wang J,Zhang J, Deng Z, Yang N, Zheng Z, Guo Y, Wang C, Mao R, Xu J, Gao F, Jin C,Zhang J, Tian H*, Xu GT*, Lu L*. miR-194 suppressesepithelial-mesenchymal transition of retinal pigment epithelial cells bydirectly targeting ZEB1，Annals oftranslational Medicine, 2019 Dec;7(23):751.doi: 10.21037/atm.2019.11.90 (Corresponding author)
2.Lian C, Lou H, Zhang J, Tian H, Ou Q,Xu JY, Jin C, Gao F, Zhang J, Wang J, Li W, Xu G*, Lu L*, Xu GT*.MicroRNA-24 protects retina from degeneration in rats by down-regulatingchitinase-3-like protein 1. Exp Eye Res. 2019 Nov;188:107791. doi:10.1016/j.exer.2019.107791. Epub 2019 Sep
3. Wang J, Xu D, Zhu T, Zhou Y, Chen X, WangF, Zhang J, Tian H, Gao F, Zhang J, Jin C, Xu J, Lu L*, Liu Q*,Xu GT*. Identification of two novel RHO mutations in Chinese retinitispigmentosa patients. Exp Eye Res. 2019 Nov;188:107726. doi:10.1016/j.exer.2019.107726. (co-corresponding)
4.Chengyu Hu,1,2 Huanzhi La,1,2 XuanchengWei,1,2 Yue Zhou,1,2 Qingjian Ou,1,2 Zhiyang Chen,1,2 Xiaoman Zhu,1,2 Jing-YingXu,1,2 Caixia Jin,1,2 Furong Gao,1,2 Juan Wang,1,2 Jingfa Zhang,1,2 JiepingZhang,1,2,3 Lixia Lu* ,1,2,4,5 Guo-Tong Xu* ,1,2,3,4,5 and HaibinTian *1,2 Transplantation site affects the outcomes of adipose-derivedstem cell-based therapy for retinal degeneration；Stemcells international, accepted （co-corresponding）
5. Lyu Y, Xu W, Zhang J, Li M, Xiang Q, Li Y,Tan T, Ou Q, Zhang J, Tian H, Xu JY, Jin C, Gao F, Wang J, Li W, Rong A*,Lu L*, Xu GT*. Protein Kinase A Inhibitor H89 Attenuates ExperimentalProliferative Vitreoretinopathy. Invest Ophthalmol Vis Sci. 2020 Feb 7;61(2):1.doi: 10.1167/iovs.61.2.1.
6. Jin C, Ou Q, Li Z, Wang J, Zhang J, Tian H,Xu JY, Gao F, Lu L*, Xu GT*.The combination of bFGF and CHIR99021maintains stable self-renewal of mouse adult retinal progenitor cells.Stem CellRes Ther. 2018 Dec 13;9(1):346. doi: 10.1186/s13287-018-1091-y.
7.Tian H, Xu JY, Tian Y, Cao Y, Lian C, Ou Q,Wu B, Jin C, Gao F, Wang J, Zhang J, Zhang J, Li W, Lu L*, Xu GT*.A cell culture condition that induces the mesenchymal-epithelial transition ofdedifferentiated porcine retinal pigment epithelial cells. Exp Eye Res. 2018Aug 8;177:160-172. doi: 10.1016/j.exer.2018.08.005. (co-corresponding author)
8.Chen S, Li R, Cheng C, Xu JY, Jin C, Gao F,Wang J, Zhang J, Zhang J, Wang H, Lu L*, Xu GT*, Tian H*. Pseudomonasaeruginosa infection alters the macrophage phenotype switching process duringwound healing in diabetic mice. Cell Biol Int. 2018 Jul;42(7):877-889. doi:10.1002/cbin.10955. (co-corresponding author)
9.Wang J, Zhang J, Chen X, Yang Y, Wang F, LiW, Awuti M, Sun Y, Lian C, Li Z, Wang M, Xu JY, Jin C, Tian H, Gao F, Zhang J,Sinha D, Lu L*, Xu GT*. miR-365 promotes diabetic retinopathythrough inhibiting Timp3 and increasing oxidative stress.Exp Eye Res. 2018Mar;168:89-99. doi: 10.1016/j.exer.2017.11.006. Epub 2017 Nov 28. (co-correspondingauthor)
10. Ou Q, Zhu T, Li P, Li Z, Wang L, Lian C,Xu H, Jin C, Gao F, Xu JY, Wang J, Zhang J, Li W, Tian H*, Lu L*,Xu GT*. Establishment of Retinal Degeneration Model in Rat and Monkey byIntravitreal Injection of Sodium Iodate.Curr Mol Med. 2018;18(6):352-364. doi:10.2174/**66**3 (co-corresponding)
11.Wang L, Li P, Tian Y, Li Z, Lian C, Ou Q,Jin C, Gao F, Xu JY, Wang J, Wang F, Zhang J, Zhang J, Li W, Tian H, Lu L*,Xu GT*. Human umbilical cord mesenchymal stem cells: subpopulations and theirdifference in cell biology and effects on retinal degeneration in RCS rats. CurrMol Med. 2017 Dec 5. doi: 10.2174/**66**6. （Co-corresponding）
12. Zhang J, Wang J, Zheng L, Wang M, Lu Y, LiZ, Lian C, Mao S, Hou X, Li S, Xu J, Tian H, Jin C, Gao F, Zhang J, Wang F, LiW, Lu L, Xu GT.miR-25 mediates retinal degeneration via inhibiting ITGAV andPEDF in rat. Curr Mol Med. 2017 Dec 5. doi: 10.2174/**66**0. （Co-corresponding）
13.Li Z, Wang J, Gao F, Zhang J, Tian H, ShiX, Lian C, Sun Y, Li W, Xu JY, Li P, Zhang J, Gao Z, Xu J, Wang F, Lu L*,Xu GT*. Human Adipose-derived Stem Cells Delay Retinal Degeneration in RoyalCollege of Surgeons Rats through Anti-apoptotic and VEGF-mediatedNeuroprotective Effects. Curr Mol Med. 2016;16(6):553-66.2016 Jun 6. [Epubahead of print] PMID: ** (co-corresponding author)
14. Li P, Tian H, Li Z, Wang L, Gao F, Ou Q,Lian C, Li W, Jin C, Zhang J, Xu JY, Wang J, Zhang J, Wang F, Lu L*,Xu GT*. Subpopulations of bone marrow mesenchymal stem cells exhibitdifferential effects in delaying retinal degeneration. Curr Mol Med.2016;16(6):567-81.2016 Jun 6. [Epub ahead of print] PMID: ** (co-corresponding)
15 Zeng Y, Yang K, Wang F, Zhou L, Hu Y, TangM, Zhang S, Jin S, Zhang J, Wang J, Li W, Lu L*, Xu GT*. Theglucagon like peptide 1 analogue, Exendin-4, attenuates oxidativestress-induced retinal cell death in early diabetic rats through promotingSirt1 and Sirt3 expression. Exp Eye Res. 2016 May 19. pii:S0014-4835(16)30105-1. doi: 10.1016/j.exer.2016.05.002. [Epub ahead of print]PMID: ** (co-corresponding author)
16. Wang J, Chen X, Wang F, Zhang J, Li P, LiZ, Xu J, Gao F, Jin C, Tian H, Zhang J, Li W, Lu L*, Xu GT*.OFD1,as a Ciliary Protein, Exhibits Neuroprotective Function in Photoreceptor DegenerationModels。PLoS One. 2016 May19;11(5):e**. doi: 10.1371/journal.pone.**. eCollection 2016.PMID:** (co-corresponding)
17. Gu H, Huang Z, Yin X, Zhang J, Gong L,Chen J, Rong K, Xu J, Lu L, Cui L. Role of c-Jun N-terminal kinase in theosteogenic and adipogenic differentiation of human adipose-derived mesenchymalstem cells.Exp Cell Res. 2015 Aug 10. pii: S0014-4827(15)30067-7. doi:10.1016/j.yexcr.2015.08.005. [Epub ahead of print] (co-corresponding author)PMID: ** (co-corresponding)
18. Zhuge CC, Xu JY, Zhang J, Li W, Li P, LiZ, Chen L, Liu X, Shang P, Xu H, Lu Y, Wang F, Lu L*, Xu GT*. Fullerenolprotects retinal pigment epithelial cells from oxidative stress-inducedpremature senescence via activating SIRT1.Invest Ophthalmol Vis Sci. 2014 May20;55(7):4628-38. doi: 10.1167/iovs.13-13732 (co-corresponding).
19. Erythropoietin exerts neuroprotectivefunction against glutamate neurotoxicity in experimental diabetic retina.Gu L,Xu H, Wang F, Xu G, Sinha D, Wang J, Xu J, Tian H, Gao F, Li W, Lu L*,Zhang J*, Xu GT*. Invest Ophthalmol Vis Sci. 2014 Oct 21. pii: IOVS-14-14435.doi: 10.1167/iovs.14-14435. [Epub ahead of print] （Co-corresponding author）
20.Lu L,Neff F, Fischer DA,Henze C, Hirsch EC, Oertel WH, Schlegel J, HartmannA.Regional vulnerability ofmesencephalic dopaminergic neurons prone todegenerate in Parkinson's disease: apost-mortem study in human control subjects. Neurobiol Dis. 2006Aug;23(2):409-21. (First author)
21.Lu L, Neff F, Alvarez-FischerD, Henze C, Xie Y, Oertel WH, Schlegel J,Hartmann A.Gene expression profilingof Lewy body-bearing neurons in Parkinson's disease.Lu L, Neff F,Alvarez-Fischer D, Henze C, Xie Y,Oertel WH, Schlegel J, Hartmann A. ExpNeurol. 2005 Sep;195(1):27-39.
22.Lu L,Neff F, Dun Z, Hemmer B,Oertel WH, Schlegel J, Hartmann A. Gene expression profiles derived from singlecells in human postmortem brain. Brain Res Brain Res Protoc. 2004Apr;13(1):18-25.