张海 副教授，副主任药师
硕士招生类型：学术型
硕士招生专业：药学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：附属第一妇婴保健院
联系方式：zhxdks2005@126.com
课题组链接：
研究方向
主要任职
科研业绩

药效成分筛选与作用靶点的确证；药物相互作用研究
Screeningand identification of effective components of Chinese Medicinal Herbs;Drug-drug interactions




中国妇幼保健协会药事管理专业委员会副主任委员；国家远程医疗与互联网医学中心精益诊疗专家委员会儿童药物治疗分会秘书长；上海市药理学会药物临床试验专委会委员
Thedeputy director of the pharmacy administration, Specialized Committee, Chinesematernal and child health care association; The Secretary General of thechildren's medical treatment branch of the National Center for telemedicine andInternet Medical Center; The committee member of the pharmaceutical clinicaltrial of Shanghai Pharmacological Society




从事基于药物代谢酶、转运体和靶蛋白的药物相互作用、中药药效成分筛选与作用靶点验证等研究工作，作为第一负责人先后完成和在研国家自然科学基金青年和面上项目，上海市科委的基金课题3项包括自然科学基金、国际合作项目及产学研医结合项目，上海市卫计委面上项目1项，中央高校学科交叉研究课题1项；获得专利和软件著作权4项；另在国内外期刊上发表学术论文100余篇，其中第一或通讯作者SCI论文30余篇。
The research focused ondrug-drug interactions based on metabolic enzymes, transporters and targetproteins, screening of the efficacy components of Chinese medicinal herbs andverification of the active targets. The research projects completed or understudy as PI are as follows: 2projects of National Natural Science Foundation of China, 3 projects of Shanghai Science andTechnology Commission Foundation, 1 project of Shanghai Municipal PlanningCommission of science and Research Fund and 1 project of interdisciplinaryresearch in central colleges and universities. In addition, the researcher haveobtained 4 patents or software copyright, and published more than 100 academicpublications, in which over 30 SCI papers published as first author orcorresponding author.
第一负责人基金：
1. 五味子乙素结合CB2受体抗肝纤维化作用的分子机制研究，**，2018.1-2021.12，国家自然科学基金；63.5万，第1；
2. 中药五味子木脂素类成分抗肝损伤、抗肝纤维化作用评价与机理研究，**，2014.1-2016.12，国家自然科学基金；23万，第1；
3. 基于网络药理学和药物代谢动力学的“参附汤”配伍机制研究，2018.6.1-2021.5.30，18ZR**，上海市自然科学基金，20万，第1；
4. 基于Hsp90-Cdc37蛋白交互作用的雷公藤红素结构修饰物抗胰腺癌作用评价与作用机理研究, , 2012.10-2014.9, 上海市科委“科技创新行动计划”国际合作项目；30万，第1；
5. 养心氏片的二次创新开发，15DZ**，2015.5-2018.4，上海市科委“科技创新行动计划”生物医药领域产学研医合作项目；110万，第1；
6. 红色诺卡氏菌细胞壁骨架抗宫颈癌作用药效成分筛选与作用机理研究，，2018.1.1-2020.12，上海市卫生计生委面上项目；10万，第1；
7. 基于生物信息学的妇女生殖系统防治中药复方“成分-靶点”智能分析系统的构建，，2017.9-2019.8，同济大学“中央高校基本科研业务费专项资金”学科交叉一般类项目；20万，第1。
获奖情况：
1. 药物代谢酶CYP450及转运体ABC在个体化用药中的基础和应用研究，上海市医学科技奖和药学科技奖，三等奖，第4，2014；
专利：
1. 五味子乙素、五味子丙素在制备抗肝纤维化药物中的应用，发明专利，专利号：ZL1.X，第1；
2. 一种用于治疗心血管疾病的中药提取物组合物及其制备方法，发明专利，专利号ZL 2015 1 **.1，第2；
3. 奇蒿提取物4’,5,7-三羟基黄酮的制备与应用，发明专利，专利号：ZL6.9，第4；
4. 五味子醇提物及其在制备抗肝纤维化药物中的应用，发明专利，受理号1.0，第1；
5. 一种用于治疗心血管疾病的天然药物组合物，发明专利，受理号8.1，第2；
6. 一种用于治疗脑卒中的中药提取物组合物及其制备方法与应用，发明专利，申请号**Z，第2；
7. 中药复方“成分-靶点”智能分析系统，软件著作权，2018SR329709。
近三年发表论文：
1. HaiZhang#, Shifan Ma#, Zhiwei Feng#, Dongyao Wang#, Chengjian Li, Yan Cao, XiaofeiChen, Aijun Liu, Zhenyu Zhu, Junping Zhang, Guoqing Zhang, Yifeng Chai*, LirongWang*, Xiangqun Xie*, Scientific Report. Cardiovascular Disease ChemogenomicsKnowledgebase-guided Target Identification and Drug Synergy Mechanism Study ofan Herbal Formula, Scientific Report, 2016, 6:33963. (IF:4.259)
2. HaiZhang#, Sen Sun#, Wen Zhang, Xiangqun Xie, Zhenyu Zhu, Yifeng Chai, GuoqingZhang*, Biological activities and pharmacokinetics of aconitine, benzoylaconineand aconine after oral administration in rats, Drug testing and analysis, 2016,8, 839-846. (IF:3.469)
3. HaiZhang#, Yahong Zhao#, Hongli Du, Yue Gao, Dan Xue, Zhenyu Zhu*, Yifeng Chai*,Metabolic profiles revealed anti-ischemia-reperfusion injury of Yangxinshitablet in Rats, Journal of Ethnopharmacology, 2018, 214: 124-133. (IF:3.115)
4. LiwenWei, Qingshan Chen, Aijie Guo, Jie Fan, Rong Wang, Hai Zhang*. Asiatic acidattenuates CCl4-induced liver fibrosis in rats by regulating the PI3K/AKT/mTORand Bcl-2/Bax signaling pathways. International Immunopharmacology，2018；60, 1-8. (IF:3.118)
5. RongWang#, Hai Zhang#, Sen Sun, Yujie Wang, Yifeng Chai, Yongfang Yuan*, Effect ofGinkgo Leaf Tablets on the Pharmacokinetics of Amlodipine in Rats.Eur J DrugMetab Pharmacokinet. 2016, 41(6):825-833. (co-author) (IF: 2.146)
6. HaiZhang#, Min Liu#, Wen Zhang, Jun Chen, Zhenyu Zhu, Hong Cao and Yifeng Chai*,Comparative pharmacokinetics of three monoester-diterpenoid alkaloids afteroral administration of Acontium carmichaeli extract and Sini decoction to rats.Biomedical Chromatography. 2015, 29(7): 1076-1083. (IF:1.729)
7. HaiZhang, Sen Sun, Qingshan Chen, Guoqing Zhang, Duxin Sun*, Wenpeng Zhang*, AScreening Method for Potential Anti- pancreatic Cancer Candidate CompoundsBased on Hsp90-Cdc37 Interaction Model in vitro, Letters in Drug Discovery,2015, 12, 66-71. (IF:0.974)
8. HaiZhang, Sen Sun, Qingshan Chen, Yifeng Chai, Duxin Sun, Guoqing Zhang*, Analysisof sulforaphane by HPLC-MS/MS in vitro and in vivo: Chemical stability,metabolic rate and Metabolites, Asian Journal of Chemistry, 2015, 7(23):1045-1048.
9. WangRong#, Zhang Hai#, Wang Yujie, Yu X, Yuan Yongfang*, Effects of salvianolicacid B and tanshinone IIA on the pharmacokinetics of losartan in rats byregulating the activities and expression of CYP3A4 and CYP2C9, JEthnopharmacology. 2016, 180: 87-96. (co-author) (IF:3.055)
10. Yongfang Yuan#, HaiZhang#, Fengfeng Sun, Sen Sun, Zhenyu Zhu, Yifeng Chai*, Biopharmaceutical andpharmacokinetic characterization of Asiatic Acid in Centella Asiatica asdetermined by a sensitive and robust HPLC-MS method, Journal ofethnopharmacology, 2015, 163: 31-38. (co-author) (IF:3.055)
11. Qingshan Chen(#),Hai Zhang(#), Yan Cao, Ying Li, Sen Sun, Junping Zhang, Guoqing Zhang*,Schisandrin B attenuates CCl4-induced liver fibrosis in rats by regulation ofNrf2-ARE and TGF-β/Smad signaling pathways, Drug Design, Development andTherapy, 2017, 11: 2179-2191. (Co-author, IF: 2.935)
12. Liwen Wei#,Qingshan Chen#, Aijie Guo, Jie Fan, Rong Wang*, Hai Zhang*, Asiatic acidattenuates CCl4-induced liver fibrosis in rats by regulating the PI3K/AKT/mTORand Bcl-2/Bax signaling pathways, International Immunopharmacology. 2018.(Accepted, IF:3.118)
13. Jian Zhang, QiqiangZhang, Xiaofei Chen, Yan liu, Jiyang Xue, Arik Dahan, Hai Zhang*, Yifeng Chai*,Revealing synergistic mechanism of multiple components in Gandi capsule fordiabetic nephropathy therapeutics by network pharmacology, Evidence-basedcomplementary and alternative medicine, 2018. (Accepted, IF：2.064)
14. Sen Sun#, RongWang#, Jie Fan, Guoqing Zhang, Hai Zhang*, Effects of Danshen tablets onpharmacokinetics of atorvastatin calcium in rats and its potential mechanism,Pharmaceutical Biology, 2018, 56(1):104-108. (IF: 1.918)
15. Sen Sun(#)，Qingshan Chen(#)，Jiyun Ge，Xiang Liu，Xinxia Wang，Qi Zhan，Hai Zhang(*)，Guoqing Zhang(*)，Pharmacokineticinteraction of aconitine, liquiritin and 6-gingerol in a traditional Chineseherbal formula, Sini Decoction，Xenobiotica, 2018; 48(1):45-52. (Co-corresponding author, IF: 1.857)
16. Qingshan Chen (#)，Qi Zhan (#)，Ying Li，Sen Sun，Liang Zhao，Hai Zhang(*)，Zhang,Guoqing(*), SchisandraLignan Extract Protects against CarbonTetrachloride-Induced Liver Injury inMice by Inhibiting Oxidative Stress andRegulating the NF-κB and JNK SignalingPathways，Evidence-BasedComplementary and Alternative Medicine, 2017; 2017: **. (Co-correspondingauthor, IF: 2.064)
17. Min Liu (#), YanCao (#), Diya Lv (#), Wen Zhang, Zhenyu Zhu, Hai Zhang(*), Yifeng Chai(*),Effect of Processing on the Alkaloids in Aconitum Tubers by HPLC-TOF/MS,Journal of Pharmaceutical Analysis, 2017, 7(3): 170-175. (Co-correspondingauthor)
18. Rong Wang(#), HaiZhang(#), Yuanyuan Wang, Fuxing Song, Yongfang Yuan*, Inhibitory Effects ofQuercetin on the Progression of Liver Fibrosis through the Regulation ofNF-кB/IкBα, p38 MAPK, and Bcl-2/Bax Signaling, InternationalImmunopharmacology, 2017, 47: 126-133. (Co-author, IF: 3.118).
19. Yongsheng Hu#,Xuexue Zhou#, Hui Shi, Wenyu Shi, Shengjie Ye*, Hai Zhang*, The effect oftripterygium glucoside tablet on pharmacokinetics of losartan and itsmetabolite EXP3174 in rats, Biomedical Chromatography, 2017, 31(10): 1-7.(corresponding author, IF: 1.688).
20. Yang Li#, ChengjianLi#, Jing Yu#, Yue Gao, Yahong Zhao, Dan Xue, Guoqing Zhang, Yifeng Chai, YingKe*, Hai Zhang*, Rapid separation and characterization of comprehensiveingredients in Yangxinshi Tablet and rat plasma by ultra-high performanceliquid chromatography quadrupole time-of-flight mass spectrometry, Journal ofliquid chromatography & Related Techonologies, 2017, 40(12): 616-634.(Corresponding Author, IF: 0.827)
21. Jing Yu (#), HaiZhang (#), Ying Li, Sen Sun, Jie Gao, Yanqiang Zhong, Duxin Sun*, GuoqingZhang*, Metabolomics revealed the toxicity of cationic liposomes in HepG2 cellsusing UHPLC-Q-TOF/MS and multivariate data analysis, Biomedical Chromatography,2017. (Co-author, IF: 1.688)
22. Hongli Du (#), HaiZhang (#), Yahong Zhao , Min Liu , Anni Chen, Shiyu Liu, Dan Xue, Yanjun Liu*,Guoqing Zhang*, Metabolic -Analysis of the anti-depressive effects ofYangxinshi Tablet in a vascular depression model in mice, BiomedicalChromatography, 2017. (Co-author, IF: 1.688).
23. Wen Zhang#, HaiZhang#, Sen Sun, Fengfeng Sun, Jun Chen, Liang Zhao, Guo-Qing Zhang*,Comparative pharmacokinetics of hypaconitine after oral administration of purehypaconitine, Aconitum carmichaelii extract and Sini decoction to rats,Molecules, 2015, 20, 1560-1570; (co-author, IF: 2.465)