曹颖瑛 教授
硕士招生类型：
硕士招生专业：
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：皮肤病医院
联系方式：caoyingying608@163.com
课题组链接：
研究方向
主要任职
科研业绩

真菌致病及耐药机制


皮肤病医院中心实验室教授



本人长期从事抗真菌研究，一方面聚焦病原真菌致病及耐药新靶点的发现，另一方面致力于筛选开发新型抗真菌活性化合物，相关研究成果发表SCI论著四十余篇，参编专著8部，获得国家发明专利授权12项。作为负责人承担国家新药创制科技重大专项1项，国家自然科学基金面上项目4项，上海市人才计划项目1项。入选上海市青年科技启明星，荣获上海药学科技奖二等奖、中国药学会科学技术奖二等奖等科技奖。
发表论文（第一或通讯作者）：
(1) Xing XR,Liao ZB, Tan Fei, Zhu ZY, Jiang YY, Cao YY. Effect of Nicotinamide AgainstCandida albicans. Front. Microbiol. 2019; 10:595. doi: 10.3389/fmicb.2019.00595
(2) Yan Y, Tan F, Miao H, Wang H, Cao YY. Effect of ShikoninAgainst Candida albicans Biofilms. Front. Microbiol. 2019; 10:1085. doi:10.3389/fmicb.2019.01085.
(3) Liao Z, Yan Y, Dong H, Jiang YY, Cao YY*.Endogenous nitric oxide production is involved in the antifungalactivity of Shikonin against Candida albicans. Emerg MicrobesInfec. 2016; 5: e88
(4) Lu H, Xiong J, Shang QH, Jiang YY, Cao YY*. Roles ofRPS41 in Biofilm Formation, Virulence, and Hydrogen Peroxide Sensitivity inCandida albicans. Curr Microbiol. 2016;72(6):783-7.
(5) Zhao LY, Jiang JC, Zhu ZY, Liao ZB, Yao XW, Yang Y, CaoYY*, JIang YY. Lysine enhances the effect of amphotericin B against Candidaalbicans in vitro. Acta Biochim Biophys Sin. 2016; 48:182-193.
(6) Liao ZB, ZhangGuan XZ, Zhu ZY, Yao XW, Yang Y, JiangYY, Cao YY*. Enhancement of the antibiofilm activity of amphotericin B bypolyamine biosynthesis inhibitors. Int J Antimicrob Agents. 2015; 46:45-52.
(7) Lu H, Xiong J, Shang QH, Jiang YY, Cao YY. Loss of RPS41but not its paralog RPS42 results in altered growth, filamentation andtranscriptome changes in Candida albicans. Fungal Genet Biol. 201; 80: 31-42
(8) Chen XF, Wu HT, Cao Y, Yao XW, Zhao L, Wang TQ, Yang Y, LvDY, CHai YF, Cao YY*, Zhu ZY. Ion-pairing chromatography on a porousgraphitic carbon column coupled with time-of-flight mass spectrometry fortargeted and untargeted profiling of amino acid biomarkers involved in Candida albicansbiofilm formation. MolBiosyst. 2014; 10:74-85
(9) Zhu ZY, Wang H, Shang QH, Jiang YY, Cao YY*, ChaiYF. Time course analysis of Candida albicans metabolites during biofilmdevelopment. J Proteome Res. 2013; 12:2375-2385.
(10) Cao YY, Zhu ZY, Chen X, Yao XW, Zhao LY, Wang H, Yan L, WuHT, Chai YF, Jiang YY. Effect of amphotericin B on the metabolic profilesof Candida albicans. J Proteome Res. 2013; 12:2921-2932
(11) Sun WR, Lu H, Jiang YY, Cao YY*. CaIPF19998 Reduces drugsusceptibility by enhancing the ability of biofilm formation and regulatingredox homeostasis in Candida albicans. Curr Microbiol. 2013; 67:322-326
(12) Lu H, Zhu ZY, Dong LL, Jia XM, Sun XR, Yan L, Chai YF, JiangYY, Cao YY*. Lack of trehalose accelerates H2O2-induced Candidaalbicans apoptosis through regulating Ca2+ signaling pathway andcaspase activity. Plos One.2011; 6: e15808
(13) Fu ZJ, Lu H, Zhu ZY, Yan L, Jiang YY, Cao YY*.Combination of baicalein and amphotericin B accelerates Candidaalbicans apoptosis. Biol Pharm Bull.2011; 34: 214-218
(14) Cao YY, Huang S, Dai BD, Zhu ZY, Lu H, Dong LL, Cao YB, WangY, Gao PH, Chai YF, Jiang YY. Candida albicans cellslacking CaMCA1-encoded metacaspase show resistance to oxidativestress-induced death and change in energy metabolism. Fungal GenetBiol. 2009; 46: 183-189
(15) Cao YY, Dai BD, Wang Y, Huang S, Xu YG, Cao YB, Gao PH, ZhuZY, Jiang YY. In vitro Activity of Baicalein against Candidaalbicans Biofilms. Int J Antimicrob Agents. 2008; 32:73-77
(16) Cao YY, Wang Y, Dai BD, Wang B, Zhang H, Zhu ZY, Xu YG, CaoYB, Jiang YY, Zhang GQ. Trehalose is an important mediator of Cap1p oxidativestresss response in Candida albicans. Biol Pharm Bull. 2008; 31，421-425
(17) Cao YY, Cao YB, Xu Z, Ying K, Li Y, Xie Y, Zhu ZY, ChenWS, Jiang YY. cDNA microarray analysis of differential gene expressionin Candida albicansbiofilm exposed to farnesol. Antimicrob AgentsChemother. 2005, 49:584-589
国家发明专利：
(1)曹颖瑛，赵柳娅，高越，朱臻宇，姜远英.赖氨酸作为增效剂在制备抗真菌药物中的作用（专利号：ZL7.5）
(2)曹颖瑛，朱臻宇，郑泽宇，徐铮，柴逸峰，姜远英.山奈酚作为抗真菌药物增效剂的用途 （专利号：ZL9.3）
(3)曹颖瑛，郑泽宇，朱臻宇，徐铮，姜远英，柴逸峰.，芒果苷作为抗真菌药物增效剂的用途 （专利号：2.X）
(4)曹颖瑛， 戴宝娣，王彦，曹永兵，朱臻宇，徐勇刚，姜远英.黄芩素作为抗真菌药物增效剂的用途 （专利号：ZL8.8）
(5)曹颖瑛，商庆华，朱臻宇，鹿辉，傅子晋，柴逸峰，姜远英. 鱼腥草素钠作为抗真菌药物增效剂的用途（专利号：ZL8.X）