张文 教授
硕士招生类型：学术型
硕士招生专业：药学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：医学院
联系方式：wenzhang1968@163.com
课题组链接：
研究方向
主要任职
科研业绩

海洋药用功能分子研究
Marine-derivedmolecules and medicinal properties


同济大学医学院教授、博士生导师。兼任上海海洋药物工程技术研究中心主任，中国药学会海洋药物专业委员会副主任委员、中国生化与分子生物学会海洋生化与分子生物学分会副理事长、上海市海洋湖沼学会海洋生物技术专业委员会主任委员， 18种SCI杂志的特约审稿人，国内外6种专业杂志的编委。
Full professor and doctoralsupervisor at School of Medicine, Tongji University. Director of Shanghai Engineering Research Center of Marine Drugs. ViceChairman of Committee for Marine Drugs, ChinesePharmaceutical Association; Vice Chairman of MarineChapter of the Chinese Society of Biochemistry and Molecular Biology; Chairmanof Committee forMarine Biotechnology, Shanghai Society for Oceanology and Limnology. Peerreviewers for 18 SCI journals, and editorial board members for 6 scientificjournals.



致力于海洋天然药物先导化合物的发现及关键技术研究。获得国家自然科学基金项目、科技部“863”项目、上海市优秀学科带头人计划、山东省泰山****领军人才计划等多项基金支持，研究成果发表SCI论文70余篇，获授权专利18项，形成在研新药3项，获上海市药学科技一等奖及国家海洋局海洋科学技术一等奖各1项。应邀撰写上海“海洋药物学科发展报告”，主编研究生教材《海洋药物导论》。着力推动海洋药物研究关键技术创新与推广，获批上海海洋药物工程技术研究中心。
His research interests focus on the investigation of lead compoundfrom marine sources and related key technology as well. The researches were financiallysupported by the National Natural Science Foundation of China, NationalHigh-tech R&D Programs of China (863 Programs), the Program of ShanghaiSubject Chief Scientists, and Leading Talent Project of Taishan Scholar ofShandong Province, resulting in more than 70 papers in reputed journals, 18authorized patents, 3 drug candidates in development, as well as the “Award of Shanghaipharmaceutical Science and Technology” and the “Marine Science andTechnology Award of State Oceanic Administration”. He was invited by ShanghaiAssociation of Science and Technology to write the “Subject Development Reportof Marine Drugs”. A teaching material monograph for graduated students, Introductionof Marine Drugs, was issued under his general editorship. He devotedhimself in innervation and promotion of key technology regarding marine drug development,leading to the approval of the “Shanghai Engineering Research Center of MarineDrugs”.
近期基金：
1. 自然基金重点国际合作项目（）：海洋来源新型肿瘤免疫治疗活性小分子的发现及作用靶标研究，240万元（主持）
2. 自然基金地区联合重点项目（U**）：东沙珊瑚共生微生物中药用活性菌株的筛选及相关功能基因研究，255万元（主持）
3. 自然基金面上项目（**）：海洋无脊椎动物及共附生菌中抗肿瘤干细胞活性物质的发现及靶点研究，70万元（主持）
4. 科技部863项目（2014AA093603）：调血脂新药海洋贻贝多糖制备中试及产业化研究，474万元（主持）
5. 上海市优秀学科带头人（15XD**），40万元（主持）
6. 泰山****蓝色领军人才团队支撑计划（鲁政办字〔2016〕5号），2600万元（主持）

近期论文：
1. D.-H.Liu,^# Y.-Z. Sun,^# T. Kurtán, A. Mándi, H. Tang, J. Li,L. Su, C.-L. Zhuang, Z.-Y. Liu,* W. Zhang.^* Osteoclastogenesis RegulateMetabolites from the Coral-associated Fungus Pseudallescheria boydii TW-1024-3. J. Nat. Prod. 2019,82, 1274-1282.
2. P. Sun,^# F.-Y. Cai,^# G. Lauro,^# H. Tang, L. Su,H.-L. Wang, H.-H.Li, A. Mándi, T.Kurta?n, R.Riccio, G. Bifulco,^* W. Zhang.^* Immunomodulatory biscembranoids and assignment of their relative andabsolute configurations: data set modulation in the density functionaltheory/nuclear magnetic resonance approach. J. Nat. Prod. 2019, 82,1264-1273.
3. J. Li, ^# H. Tang, ^# T. Kurtán, A. Mándi, C.-L.Zhuang, L. Su, G.-L. Zheng,* W. Zhang.* Swinhoeisterols from the South ChinaSea Sponge Theonella swinhoei. J. Nat. Prod. 2018, 81,1645-1650.
4. Y.-Z.Sun, T. Kurtán, A. Mándi, H. Tang, Y. Chou, K. Soong, L. Su, P. Sun, C.-L.Zhuang, W. Zhang.^* Immunomodulatory polyketides from a Phoma-likefungus isolated from a soft coral. J. Nat. Prod. 2017, 80,2930–2940.
5. P.Sun,^# Q. Yu,^# J. Li, R. Riccio, G. Lauro, G. Bifulco, T. Kurtán, A. Mándi, H.Tang, T.-J. Li, C.-L. Zhuang, W. H. Gerwick, W. Zhang.* Bissubvilides A and B, cembrane-capnosaneheterodimers from the soft coral Sarcophyton subviride. J. Nat. Prod. 2016,79, 2552–2558.
6. J. Gong,P. Sun, N. Jiang, R. Riccio, G. Lauro, G. Bifulco, T.-J. Li, W. H. Gerwick, W.Zhang.* Newsteroids with a rearranged skeleton as (h)P300 Inhibitors from the sponge Theonellaswinhoei. Org Lett 2014, 16, 2224–2227.
7. D.-X.Xu, P. Sun, T. Kurtán, A. Mándi, H. Tang, B.-S. Liu, W. H. Gerwick, Z.-W. Wang,*W. Zhang.* Polyhydroxy cyclohexanols from a Dendrodochiumsp. fungus associated with the sea cucumber Holothuria nobilis Selenka.J. Nat. Prod. 2014, 77, 1179-1184.
8. M.Jiang, P. Sun, H. Tang, B.-S. Liu, T.-J. Li, C. Li, W. Zhang.* Steroids glycosylated with both D- and L-arabinoses from the South China Sea gorgonianDichotella gemmacea. J. Nat. Prod. 2013, 76, 764-768.
9. L.-F.Liang, T. Kurtán, A. Mándi,L.-G. Yao, J. Li, W. Zhang.* Y.-W. Guo.* Unprecedented diterpenoidsas a PTP1B Inhibitor from the Hainan soft coral Sarcophyton trocheliophorum.Org. Lett. 2013, 15, 274-277
P.Sun, D.-X. Xu, A. Mándi, T. Kurta?n, T.-J. Li, B. Schulz, W. Zhang.* Structure, absolute configuration,and conformational study of 12-membered macrolides from the fungus Dendrodochiumsp. associated with sea cucumber Holothuria nobilis Selenka. J. Org. Chem. 2013, 78,7030-7047.