林厚文 教授，主任药师
硕士招生类型：
硕士招生专业：
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：医学院
联系方式：franklin67@126.com
课题组链接：
研究方向
主要任职
科研业绩

1、 海洋底栖共生生物中活性天然产物的发现（Discovery of active naturalproducts in marine benthic symbionts）
2、 海洋新颖药源分子的靶标揭示与作用机制（Target identification and MOA ofnovel marine pharmaceutical molecules）
3、药物先导分子的化学/生物合成与结构优化（Chemical/biosynthesisand structural optimization of new drug leads



林厚文教授是国家****、****、上海市优秀学术带头人。长期聚焦海洋共生生物海绵及其共附生微生物活性分子的化学与生物学研究，通过整合“微生物生态-天然药物化学-分子生物学-合成生物学”研究平台，借助高分辨多级质谱-分子网络数据库分析（HRMSn-MNDA）等微量新颖天然产物的快速精准发现技术，解析了1500 余种复杂天然分子的结构，新化合物 528 个，国际热点化合物20余个，HipplachninA 被美国化学会评选为“海洋天然产物复兴”代表之一；构建临床肿瘤干细胞筛选平台，获得抗肺癌干细胞耐药、靶向 Chk1 新型小分子抑制剂等 10 个海洋抗肿瘤先导化合物，阐明了其作用机制；解析了重要药源分子抗肿瘤缩酚酞NAT的生物合成机制并构建其高效生物合成体系，并获得活性改良的新结构。

中国生化与分子生物学会海洋分会（2016-2020）侯任理事长
中国药学会海洋药物专业委员会（2016-2019）副主任委员
中国心胸血管麻醉学会心血管药学分会（2018-2020）副主任委员
上海市药学会（2016-2020）常务理事
上海市药学会海洋药物专业委员会（2016-2020）主任委员

主持国家重点研发计划、国家自然科学基金（面上、重点、国际合作）项目、国家863 重点项目、国家科技重大专项、上海市教委海洋药物协同创新团队等多项重大课题。发表SCI论文100 余篇，授权发明专利16 项，国际PCT 专利1 项，获2018年度海洋科技一等奖。近三年代表论文：
[1] Wei-HuaJiao,# Jing Li,# Meng-Meng Zhang, Jie Cui, Yu-Han Gui, Yun Zhang, Jing-Ya Li,Ke-Chun Liu, and Hou-Wen Lin*. Frondoplysins A and B, UnprecedentedTerpene-Alkaloid Bioconjugates from Dysidea frondosa. Organic Letters,2019, 21, 6190
[2] YuanGao#, Fan Yang#, Fan Sun, Lei Liu, Bo Liu, Shu-ping Wang, Chun-wei Cheng,Hongze Liao(*), Hou-Wen Lin(*). Total Synthesis of Aaptamine, Demethyloxyaaptamine,and Their 3?Alkylamino Derivatives. OrganicLetters, 2019, 21, 1430
[3] Yu-hanGui, Wei-hua Jiao(*), Mi Zhou, Yun Zhang, De-quan Zeng, Hong-rui Zhu, Ke-chunLiu, Fan Sun, Hai-feng Chen, Hou-Wen Lin(*), Septosones A?C, in VivoAnti-inflammatory Meroterpenoids with Rearranged Carbon Skeletons from theMarine Sponge Dysidea septosa. Organic Letters, 2019, 21, 767
[4] Yong-junZhou, Xiao Lin, Chunmin Xu, Yao-yao Shen, Shu-ping Wang, Hong-ze Liao, Lei Li,Hai Deng(*),Hou-Wen Lin(*),Investigation of Penicillin Binding Protein(PBP)-likePeptide Cyclase and Hydrolase in Surugamide Non-ribosomal Peptide Biosynthesis.Cell Chemical Biology 2019, 26, 737
[5] WeiWu, Li-yun Liu, Hong-rui Zhu, Ya-ting Sun, Ying Wu, Hong-ze Liao, Yu-han Gui,Lei Li, Lei Liu, Fan Sun*, Hou-Wen Lin *. Butyrolactone-I，anefficient α?glucosidase inhibitor, improves Type 2Diabetes with potent TNF-α-lowering properties through modulating gutmicrobiota in db/db mice. FASEB Journal 2019, 33, 12616
[6] Bin-binGu, Wei Wu, Fu-rong Jiao, Wei-hua Jiao, Lei Li, Fan Sun, Shu-ping Wang, FanYang, Hou-Wen Lin(*), Asperflotone, an 8(14→15)-abeo-Ergostane from theSponge-Derived Fungus Aspergillus flocculosus 16D-1. Journal of OrganicChemistry, 2019, 84, 300
[7] Wei-HuaJiao, Jing Li, Dan Wang, Meng-Meng Zhang, Li-Yun Liu, Fan Sun, Jing-Ya Li,Robert J. Capon*, Hou-Wen Lin*. Cinerols, Nitrogenous Meroterpenoids from theMarine Sponge Dysidea cinerea. Journal of Natural Products, 2019,82, 2586
[8] YingWu#, Lei Liu#, Hai-feng Chen, Wei-hua Jiao, Fan Sun, Li-yun Liu, Hong-rui Zhu,Shu-ping Wang(*), Hou-Wen Lin(*), Fuscasins A-D, Cycloheptapeptides from theMarine Sponge Phakellia fusca. Journal of Natural Products 2019,82, 970
[9] Li-yunLiu, Hong-rui Zhu, Wei Wu, Yao-yao Shen, Xiao Lin, Ying Wu, Li Liu, Jie Tang,Yong-jun Zhou, Fan Sun*, Hou-Wen Lin*. Neoantimycin F, a Streptomyces-DerivedNatural Product Induces Mitochondria-Related Apoptotic Death in Human Non-SmallCell Lung Cancer Cells. Frontiers in Pharmacology 2019, 10,1042
[10] XiaoLin, Yong-Jun Zhou, Li-Yun Liu, Hong-Rui Zhu, Ye-Ping Chen, Shu-Ping Wang, FanSun, Ling Chai, Bu-Ming Liu, Shi-Hai Xu(*), and Hou-Wen Lin(*). CompoundDiscovery and Structure-Activity Relationship Study of Neoantimycins AgainstDrug-Resistant Cancer Cells. Frontiers in Chemistry 2019, 7, 481
[11] Bin-binGu, Fu-rong Jiao, Wei Wu, Lei Liu, Wei-hua Jiao, Fan Sun, Shu-ping Wang, FanYang, Hou-Wen Lin(*), Ochrasperfloroid, an ochratoxin–ergosteroid heterodimerwith inhibition of IL-6 and NO production from Aspergillus flocculosus 16D-1. RSCAdvances, 2019, 9, 7251
[12] Yang-HuaTang#, Jing Wu#, Ting-Ting Fan, Hui-Hui Zhang, Xiao-Xia Gong, Zheng-Yu Cao,Jian Zhang(*), Hou-Wen Lin(*), Bing-Nan Han(*), Chemical and biological studyof aplysiatoxin derivatives showing inhibition of potassium channel Kv1.5.RSC Advances 2019, 9, 7594
[13] Wei-Hua Jiao#, Bao-Hui Cheng, Guo-DongChen, Guo-Hua Shi, Jing Li, Tian-Yong Hu, Hou-Wen Lin⁽*⁾, Dysiarenone, a Dimeric C21 Meroterpenoid withInhibition of COX-2 Expression from the Marine Sponge Dysidea arenaria. OrganicLetters 2018, 20, 3092
[14] Bin-Bin Gu, Wei Wu, Fu-Rong Jiao Wei-hua Jiao, LeiLi, Fan Sun, Shu-Ping Wang, Fan Yang, Hou-Wen Lin⁽*⁾, Aspersecosteroids A and B, Two11(9→10)-abeo-5,10-secosteroids with a Dioxatetraheterocyclic Ring System fromAspergillus flocculosus 16D-1. Organic Letters, 2018, 20, 7957
[15] Bing-Nan Han⁽*⁾, Ting-TingLiang, Lawrence Jordan Keen, Ting-Ting Fan, Xiao-Dan Zhang, Lin Xu, Qi Zhao,Shu-Ping Wang, Hou-Wen Lin⁽*⁾, Two MarineCyanobacterial Aplysiatoxin Polyketides, Neo-debromoaplysiatoxin A and B, withK⁺ Channel Inhibition Activity, Organic Letters 2018, 20,578
[16] Yongjun Zhou# , Xiao Lin#, Simon R.Williams, Liyun Liu, Yaoyao Shen, Shu-Ping Wang, Fan Sun, Shihai Xu, Hai Deng,Peter F. Leadlay, Hou-Wen Lin⁽*⁾，Directed Accumulation of Anticancer Depsipeptides byCharacterization of Neoantimycins Biosynthetic Pathway and an NADPH-DependentReductase. ACS Chem.Biol., 2018, 13, 2153
[17] Jingtang Liu, Binbin Gu, Lianjuan Yang, FanYang,* Hou-Wen Lin⁽*⁾，New Anti-inflammatory Cyclopeptides From a Sponge-Derived Fungus Aspergillusviolaceofuscus.Frontiers In Chemistry 2018, 14, 226
[18] Bin-Bin Gu, Fu-Rong Jiao, Wei Wu, Wei-huaJiao, Lei Li, Fan Sun, Shu-Ping Wang, Fan Yang, Hou-Wen Lin(*),Preussinswith Inhibition of IL?6 Expressionfrom Aspergillus flocculosus 16D-1, a Fungus Isolated from the Marine SpongePhakellia fusca. Journal of Natural Products 2018, 81, 2275
[19] Wei-Zhuo Tang, Zhong-Zhen Yang, Wei Wu, JieTang, Fan Sun, Shu-Ping Wang, Chun-Wei Cheng, Fan Yang(*), Hou-Wen Lin(*)，Imidazole Alkaloids and Their Zinc Complexes from theCalcareous Marine Sponge Leucetta chagosensis. Journal of NaturalProducts 2018, 81, 894
[20] Li Liu, Wei Wu, Jing Li, Wei-Hua Jiao,Li-Yun Liu, Jie Tang, Lei Liu, Fan Sun, Bing-Nan Han(*), Hou-Wen Lin(*)，Two sesquiterpene aminoquinones protect againstoxidative injury in HaCaT keratinocytes via activation ofAMPKα/ERK-Nrf2/ARE/HO-1 signaling. Biomedicine & Pharmacotherapy2018, 100, 417
[21] Jing Li, Fan Yang, Zhuo Wang, Wei Wu, LiLiu, Shu-Ping Wang, Bin-Xin Zhao,a Wei-Hua Jiao⁽*⁾, Shi-Hai Xu⁽*⁾ , Hou-Wen Lin(*),Unusualanti-inflammatory meroterpenoids from the marine sponge Dactylospongia sp. Organic& Biomolecular Chemistry 2018, 16, 6773
[22] Jie Tang, Wei Wu, Fan Yang, Liyun Liu, ZhenYang, Li Liu, Weizhuo Tang, Fan Sun⁽*⁾, Hou-WenLin⁽*⁾,Marinesponge-derived smenospongine preferentially eliminates breast cancer stem-likecells via p38/AMPKα pathways. Cancer Medicine 2018, 7, 3965
[23] Bin-Bin Gu^#, Wei Wu^#,Li-Yun Liu, Jie Tang, Ya-Jun Zeng, Shu-Ping Wang,Fan Sun, Lei Li, Fan Yang, Hou-WenLin⁽*⁾, 3,5-Dimethylorsellinic Acid DerivedMeroterpenoids from Eupenicillium sp. 6A-9, a Fungus Isolated from the MarineSponge Plakortis simplex. European Journal of Organic Chemistry2018, 48
[24] Li-Li Hong^(#), Hao-Bing Yu^(#),Jie Wang, Wei-Hua Jiao, Bao-Hui Cheng, Fan Yang, Yong-Jun Zhou, Bin-Bin Gu,Shao-Jiang Song^(*), Hou-Wen Lin.^(*) UnusualAnti-allergic Diterpenoids from the Marine Sponge Hippospongia lachne. Scientific Reports 2017, 7, 43138
[25] Wei-Hua Jiao, Bao-Hui Cheng, Guo-Hua Shi,Guo-Dong Chen, Bin-Bin Gu, Yong-Jun Zhou, Li-Li Hong, Fan Yang, Zhi-Qiang Liu,Shu-Qi Qiu, Zhi-Qiang Liu, Ping-Chang Yang^(*), Hou-Wen Lin^(*).Dysivillosins A–D, Unusual Anti-allergic Meroterpenoids from the Marine SpongeDysidea villosa. ScientificReports 2017, 21, 7, 8947
[26] Jie Wang^(#), Feng-Rong Mu^(#),Wei-Hua Jiao^(*), Jian Huang, Li-Li Hong, Fan Yang, Ying Xu,Shu-Ping Wang, Fan Sun, Hou-Wen Lin^(*). Meroterpenoids withProtein Tyrosine Phosphatase 1B Inhibitory Activity from a Hyrtios sp. MarineSponge. Journal ofNatural Products 2017, 80, 2509
[27] Jing Li^(#), Bin-Bin Gu^(#),Fan Sun, Jian-Rong Xu, Wei-Hua Jiao, Hao-Bin Yu, Bin-Nan Han, Fan Yang^(*),Xi-Chun Zhang^(*),Hou-Wen Lin^(*). SesquiterpeneQuinones/Hydroquinones from the Marine Sponge Spongia pertusa Esper. Journal of Natural Product 2017, 80, 1436-1445
[28] Li-Li Hong^(#), Jia-Bao Sun^(#),Fan Yang, Man Liu, Jie Tang, Fan Sun, Wei-Hua Jiao, Shu-Ping Wang, Wei Zhang^(*),Hou-Wen Lin^(*). New Diterpene Alkaloids from the MarineSponge Agelas mauritiana, RSC Advances 2017, 7, 23970
[29] Bin-Bin Gu, Jie Tang, Shu-Ping Wang, Fan Sun,Fan Yang, Lei Li, Ying Xu, Hou-Wen Lin^(*). Structure,Absolute Configuration, and Variable-Temperature 1H-NMR Study of(±)-Versiorcinols A-C, Three Racemates of Diorcinol Monoethers from theSponge-Associated Fungus Aspergillus versicolor 16F-11. RSC Advances, 2017, 7, 50254
[30] Wei-Hua Jiao^#, Li-Li Hong^#, Jia-Bao Sun^#, Shu-Juan Piao,Guo-Dong Chen, Hai Deng, Shu-Piing Wang, Fan Yang, Hou-Wen Lin⁽*⁾.(±)-HippolideJ, a Pair of Unusual Antifungal Enantiomeric Sesterterpenoids from the MarineSponge Hippospongia lachne. European Journal of Organic Chemistry 2017, 3421-3426.
[31] Ya-Ting Sun, Bin Lin, Sheng-Ge Li, Man Liu,Yong-Jun Zhou, Ying Xu^(*), Hui-Ming Hua^(*), Hou-WenLin.^(*)New bromopyrrole alkaloids from the marine sponge Agelassp. Tetrahedron, 2017, 73, 2786
Chi Zhang,Zhi-chun Gu, Long Shen, Xian-yan Liu, Hou-wen Lin(*). A Dual TargetingDrug Delivery System for Penetrating Blood-Brain Barrier and SelectivelyDelivering siRNA to Neurons for Alzheimer’s Disease Treatment. CurrentPharmaceutical Biotechnology 2017, 18, 1124