刘海鹏 研究员
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：附属肺科医院
联系方式：haipengliu@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

固有免疫与肺部疾病：研究围绕肺部感染与肿瘤，聚焦cGAS等固有免疫识别分子的新功能和调控机制，以期为肺部免疫相关疾病提供新型干预手段。
Wefocus on thenovel functions and regulatory mechanisms of innate immune sensors such as cGASin lung diseases including infection and cancer. Hopefully, the research willprovide strategic basis for clinical intervention and therapy of immune-relatedlung diseases.

上海市医学会结核病分会青年委员（2019）
上海市卫生计生系统优秀青年医学人才（2017）
上海市浦江人才计划（A类）（2016）

Member of The 3^rd YouthCommittee of TB Branch of Shanghai Medical Association (2019)
Shanghai Medical and Health ServicesOutstanding Youth Talent Program (2017)
Shanghai Pujiang Program (2016)


固有免疫分子不仅参与免疫应答，也可发挥其他重要的生物学功能。团队近年来聚焦目前DNA 受体环鸟苷酸-腺苷酸合成酶（cyclic GMP-AMP synthase，cGAS），系统阐释了cGAS细胞核内抑制DNA修复的全新功能与机制，为肿瘤治疗提供了理论基础与重要靶标（Nature，2018；Nature Reviews MolecularCell Biology等亮点报道）。此外，发现cGAS可识别细胞外环核苷二磷酸，激活固有免疫应答，从而将cGAS识别的病原相关分子模式从dsDNA拓展到CDNs，对于将CDNs应用于疫苗与癌症免疫治疗具有重要参考价值（EMBO Reports，2019；F1000推荐）。另外，还发现TLR3、雌激素相关受体β等调控结核分枝杆菌的感染发病（J Immunol 2017；Nat Commun 2018）。
目前，已在Nature、Nature Communications、EMBO Reports、The Journal of Immunology等发表第一作者、共同第一作者或共同通讯作者论文17篇。先后入选“上海市浦江人才”计划（A类）（2016年）及上海市卫生计生系统优秀青年医学人才计划（2017年）。研究获得国家自然科学基金（青年基金1项，面上项目2项）、上海市科委来源基金资助。
代表性论文
1. Liu H^#, Zhang H^#,Wu X^#, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R,Jungblut P,Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, ChenJ, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F,Yan D, Kaufmann SHE, Chen C, Mao Z^*, Ge B^*. NuclearcGAS suppresses DNA repair and promotes tumorigenesis. Nature 2018.563(7729):131-136.
2. Liu HP, Pedro MA,Pei G, Mollenkopf HJ, Hurwirz R, Wu XY, Wang F, Liu SY, Ma MT, Fei YY, Zhu CG,Keohler AB, Oberbeck-Meuller K, Hahnke K, Klemm M, Guhlich-Bornhof U, Ge B,Tuukkanen A, Kolbe M, Dorhoi A^*, Stefan HE Kaufmann^*.cGAS facilitates sensing of extracellular cyclic dinucleotides to activateinnate immunity. EMBO Reports 2019: e46293.
3. Zheng R, Li Z,He F, Liu H*, Chen J, Chen J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B,Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang X, Zhang L, Xu F, Wang J, FengY, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S*, Shi Y*, Ge B*.Genome-wide association study identifies two risk loci for tuberculosis in HanChinese. Nat Commun 2018. 9(1):4072.
4. Wang L^#,Zuo MY, Chen H, Liu SY, Wu XY, Cui ZL, Yang H, Liu HP^*, Ge BX^*.Mycobacterium tuberculosis lipoprotein MPT83 induces apoptosis ofinfected macrophages by activating TLR2/p38/COX-2 signaling pathway. JImmunol. 2017 Jun 15;198(12):4772-4780. doi: 10.4049/jimmunol.**.
5. Yang H^#, LiuHP^#, Chen H, Mo HP, Chen JX, Huang XC, Zheng RJ, Liu ZH, Feng YH,Liu F, Ge BX^*. G protein-coupled receptor160 regulates mycobacteriaentry into macrophages by activating ERK. Cell Signal. 2016Sep;28(9):1145-51. doi: 10.1016/j.cellsig.2016.05.022.

Innate immune moleculesexert multiple important functions beyond immune response. We have beenfocusing on innate immune sensors and achieved a series of findings. Firstly, weuncovered a novel nuclear function of DNA sensor cGAS in inhibition ofhomologous recombination (HR)-mediated DNA repair (Nature 2018), which has beenhighlighted by Nature Reviews Molecular Cell Biology, Cancer Discovery andScience Signaling. Secondly, we revealed that cGAS is a receptor for thesensing of extracellular cyclic dinucleotides (CDNs) and clarified itsregulatory mechanism (EMBO Report 2019), which has been recommended by F1000.Lastly, we have identified multiple innate immune sensors including toll-likereceptor 3 (TLR3) and estrogen-related receptor beta involving in the processof Mycobacterium tuberculosis (Mtb) infection (J Immunol 2017; NatureCommunications 2018).

Publications
1. Liu H^#, Zhang H^#,Wu X^#, Ma D, Wu J, Wang L, Jiang Y, Fei Y, Zhu C, Tan R,Jungblut P,Pei G, Dorhoi A, Yan Q, Zhang F, Zheng R, Liu S, Liang H, Liu Z, Yang H, ChenJ, Wang P, Tang T, Peng W, Hu Z, Xu Z, Huang X, Wang J, Li H, Zhou Y, Liu F,Yan D, Kaufmann SHE, Chen C, Mao Z^*, Ge B^*. NuclearcGAS suppresses DNA repair and promotes tumorigenesis. Nature 2018.563(7729):131-136.
2. Liu HP, Pedro MA,Pei G, Mollenkopf HJ, Hurwirz R, Wu XY, Wang F, Liu SY, Ma MT, Fei YY, Zhu CG,Keohler AB, Oberbeck-Meuller K, Hahnke K, Klemm M, Guhlich-Bornhof U, Ge B,Tuukkanen A, Kolbe M, Dorhoi A^*, Stefan HE Kaufmann^*.cGAS facilitates sensing of extracellular cyclic dinucleotides to activateinnate immunity. EMBO Reports 2019: e46293.
3. Zheng R, Li Z,He F, Liu H*, Chen J, Chen J, Xie X, Zhou J, Chen H, Wu X, Wu J, Chen B,Liu Y, Cui H, Fan L, Sha W, Liu Y, Wang J, Huang X, Zhang L, Xu F, Wang J, FengY, Qin L, Yang H, Liu Z, Cui Z, Liu F, Chen X, Gao S, Sun S*, Shi Y*, Ge B*.Genome-wide association study identifies two risk loci for tuberculosis in HanChinese. Nat Commun 2018. 9(1):4072.
4. Wang L^#,Zuo MY, Chen H, Liu SY, Wu XY, Cui ZL, Yang H, Liu HP^*, Ge BX^*.Mycobacterium tuberculosis lipoprotein MPT83 induces apoptosis ofinfected macrophages by activating TLR2/p38/COX-2 signaling pathway. J Immunol.2017 Jun 15;198(12):4772-4780. doi: 10.4049/jimmunol.**.
YangH^#, Liu HP^#, Chen H, Mo HP, Chen JX, Huang XC,Zheng RJ, Liu ZH, Feng YH, Liu F, Ge BX^*. G protein-coupledreceptor160 regulates mycobacteria entry into macrophages by activating ERK. CellSignal. 2016 Sep;28(9):1145-51. doi: 10.1016/j.cellsig.2016.05.022.