尹芝南 教授
硕士招生类型：
硕士招生专业：
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：附属第十人民医院兼职教授
联系方式：zhinan.yin@yale.edu
课题组链接：
研究方向
主要任职
科研业绩

1）gammadelta T 细胞治疗临床疗效与分子机制；
2）新生儿免疫系统形成的分子机制；
3）肥胖及代谢综合征的分子指征及转化医学研究；
4）分子免疫学与转化医学。
Research Interests
1)Clinical efficacy and mechanism of gammadelta T cell therapy;
2)Molecular mechanism of neonatal immune system formation;
3)Translational Medicine Research and Molecular Indications of Obesity andMetabolic Syndrome;
4)Molecular Immunology and Translational Medicine.

教育背景
1979.09—1984.07：湖北医科大学医疗系，学士
1985.09—1988.08：上海第二医科大学上海市免疫学研究所，硕士
1994.12—1997.12：德国柏林自由大学，博士
工作经历
1984.09—1985.08：郧阳医学院微生物免疫学教研室，助教
1988.09—1992.12：广州医学院微生物免疫学教研室，讲师
1992.12—1994.12：意大利国家肿瘤中心，访问****
1994.12—1997.12：德国柏林自由大学，博士
1997.12—1999.03：美国耶鲁大学医学院风湿科，博士后
1999.03—2001.06：美国耶鲁大学医学院风湿科，助理研究员
2001.07—2006.06：美国耶鲁大学医学院风湿科，助理教授
2006.07—2007.03：美国耶鲁大学医学院风湿科，副教授
2007.03—2011.11：南开大学生命科学学院院长，教授、博导
2011.11—2013.7：南开大学生命科学学院，教授
2013.07—至今：暨南大学生物医学转化研究院， 院长，教授，博导
2019.02—至今：同济大学，兼职教授，博导

Education:
1984 Hubei MedicalUniversity, P.R.China M.D.
1988 Shanghai SecondMedical University, P.R.China M.S.
1997 Free UniversityBerlin, Germany Ph.D.
Career
1984-1985 Department ofMicrobiology and Immunology, Yun Yan Medical College, Tong Ji MedicalUniversity, Yun Yan, People's Republic of China Teaching Assistant
1988-1992 Department of Microbiology andImmunology, Guangzhou Medical College, Guangzhou, People's Republic of China Assistant Professor
1992-1994 Division for ExperimentalOncology, Reference Centerfor Oncology, Aviano (PN), Italy ResearchFellow
1994-1997 Klinikum Benjamin Franklin, FreeUniv. Berlin Ph.D Candidate
1997-1999 Section of Rheumatology, YaleSchool of Medicine Postdoctoral Fellow
1999-2001 Department of Rheumatology, YaleUniversity Medical College USA Associate Research Fellow
2001-2006 Department of Rheumatology, YaleUniversity Medical College, USA Assistant Professor
2006-2007 Department of Rheumatology, YaleUniversity Medical College USA Deputy Professor
2007-2011 College of Life Sciences, NankaiUniversity Dean, Professor and Mentor
2011-2013 College of Life Sciences, NankaiUniversity Professor
2013-Present Institute of BiomedicalTransformation, Jinan University Dean, Professor and Mentor
2019-Present Shanghai Tenth People'sHospital Affiliated to Tongji University Adjunct Professorsand Mentor



专业荣誉
1. 国家或地区奖项
1）1988年全国硕士研究生优秀论文评选优秀论文一等奖（中国微生物学会）论文题目“β-D半乳糖苷酶/抗β-D半乳糖苷酶单克隆抗体复合体(GAG)及其在ELISA和免疫组化中的应用”；
2）2000年3月获美国国家风湿病基金会青年基金；
3）2000年成为耶鲁癌症中心会员；
4）2000年成为美国风湿病学会（ACR）会员；
5）2002年成为美国免疫学会（AAI）会员；
6）2002年成为美国癌症研究协会（AAC）会员；
7）2004年美国免疫学家协会（AAI）青年教授会议资助奖；
8）2006年美国耶鲁大学内科系科研成就奖；
9）2007年中国国家****基金获得者；
10）2007年中国教育部“****”****；
11）2009年天津市“创业领军人才”；
12）2010年国家人力资源和社会保障部“高层次海外留学归国创业人才”。
13) 2013年被评为国家人力资源和社会保障部新“百千万”人才工程“有突出贡献中青年专家”；
14）2013年广东省第四批引进创新创业团队带头人。
15）2014年中国侨联第五届中国侨界（创新人才）贡献奖。
2. 单位奖项
1) 1998耶鲁大学医学院“布朗核心奖学金”
2) 2001年荣获耶鲁癌症中心的癌症研究奖；
3) 2006年获耶鲁大学医学院内科系科研成就奖；
承担的基金项目
共22项。
发表的文章
第一作者及通讯作者文章
[1] YinZ, Gabriele E, Leprini A, et al. Differential cation regulation of the alpha 5beta 1 integrin-mediated adhesion of leukemic cells to the central cell-bindingdomain of fibronectin[J]. Cell Growth Differ, 1997, 8(12): 1339-1347.
[2] YinZ, Giacomello E, Gabriele E, et al. Cooperative activity of alpha4beta1 andalpha4beta7 integrins in mediating human B-cell lymphoma adhesion andchemotaxis on fibronectin through recognition of multiple synergizing bindingsites within the central cell-binding domain[J]. Blood, 1999, 93(4): 1221-1230.
[3] YinZ, Braun J, Neure L, et al. T cell cytokine pattern in the joints of patientswith Lyme arthritis and its regulation by cytokines and anticytokines[J].Arthritis Rheum, 1997, 40(1): 69-79.
[4] YinZ, Braun J, Neure L, et al. Crucial role of interleukin-10/interleukin-12balance in the regulation of the type 2 T helper cytokine response in reactivearthritis[J]. Arthritis Rheum, 1997, 40(10): 1788-1797.
[5] YinZ, Siegert S, Neure L, et al. The elevated ratio of interferongamma-/interleukin-4-positive T cells found in synovial fluid and synovialmembrane of rheumatoid arthritis patients can be changed by interleukin-4 butnot by interleukin-10 or transforming growth factor beta[J]. Rheumatology(Oxford), 1999, 38(11): 1058-1067.
[6] MullerB, Gimsa U, Mitchison N A, et al. Modulating the Th1/Th2 balance ininflammatory arthritis[J]. Springer Semin Immunopathol, 1998, 20(1-2): 181-196.
[7] YinZ, Craft J. gamma delta T cells in autoimmunity[J]. Springer SeminImmunopathol, 2000, 22(3): 311-320.
[8] YinZ, Zhang D H, Welte T, et al. Dominance of IL-12 over IL-4 in gamma delta Tcell differentiation leads to default production of IFN-gamma: failure todown-regulate IL-12 receptor beta 2-chain expression[J]. J Immunol, 2000,164(6): 3056-3064.
[9] YinZ, Bahtiyar G, Zhang N, et al. IL-10 regulates murine lupus[J]. J Immunol,2002, 169(4): 2148-2155.
[10] YinZ, Chen C, Szabo S J, et al. T-Bet expression and failure of GATA-3cross-regulation lead to default production of IFN-gamma by gammadelta Tcells[J]. J Immunol, 2002, 168(4): 1566-1571.
[11] GaoY, Yang W, Pan M, et al. Gamma delta T cells provide an early source ofinterferon gamma in tumor immunity[J]. J Exp Med, 2003, 198(3): 433-442.
[12] PanM, Kang I, Craft J, et al. Resistance to development of collagen-inducedarthritis in C57BL/6 mice is due to a defect in secondary, but not in primary,immune response[J]. J Clin Immunol, 2004, 24(5): 481-491.
[13] GaoY, Tao J, Li M O, et al. JNK1 is essential for CD8+ T cell-mediated tumorimmune surveillance[J]. J Immunol, 2005, 175(9): 5783-5789.
[14] GaoY, Zhang D, Sun B, et al. Active hexose correlated compound enhances tumorsurveillance through regulating both innate and adaptive immune responses[J].Cancer Immunol Immunother, 2006, 55(10): 1258-1266.
[15] YouX, Pan M, Gao W, et al. Effects of a novel tylophorine analog oncollagen-induced arthritis through inhibition of the innate immune response[J].Arthritis Rheum, 2006, 54(3): 877-886.
[16] ChenL, He W, Kim S T, et al. Epigenetic and transcriptional programs lead todefault IFN-gamma production by gammadelta T cells[J]. J Immunol, 2007, 178(5):2730-2736.
[17] TaoJ, Gao Y, Li M O, et al. JNK2 negatively regulates CD8+ T cell effectorfunction and anti-tumor immune response[J]. Eur J Immunol, 2007, 37(3):818-829.
[18] HaoJ, Wu X, Xia S, et al. Current progress in gammadelta T-cell biology[J]. CellMol Immunol, 2010, 7(6): 409-413.
[19] HeW, Hao J, Dong S, et al. Naturally activated V gamma 4 gamma delta T cells playa protective role in tumor immunity through expression of eomesodermin[J]. JImmunol, 2010, 185(1): 126-133.
[20] YinZ, Fujii H, Walshe T. Effects of active hexose correlated compound on frequencyof CD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosisfactor-alpha in healthy adults[J]. Hum Immunol, 2010, 71(12): 1187-1190.
[21] HaoJ, Dong S, Xia S, et al. Regulatory role of Vgamma1 gammadelta T cells in tumorimmunity through IL-4 production[J]. J Immunol, 2011, 187(10): 4979-4986.
[22] QianP, Zuo Z, Wu Z, et al. Pivotal role of reduced let-7g expression in breastcancer invasion and metastasis[J]. Cancer Res, 2011, 71(20): 6463-6474.
[23] TaoJ, Kamanaka M, Hao J, et al. IL-10 signaling in CD4+ T cells is critical forthe pathogenesis of collagen-induced arthritis[J]. Arthritis Res Ther, 2011,13(6): R212.
[24] ZhaoN, Hao J, Ni Y, et al. Vgamma4 gammadelta T cell-derived IL-17A negativelyregulates NKT cell function in Con A-induced fulminant hepatitis[J]. J Immunol,2011, 187(10): 5007-5014.
[25] LinY, Wen T, Meng X, et al. The mouse Mageb18 gene encodes a ubiquitouslyexpressed type I MAGE protein and regulates cell proliferation and apoptosis inmelanoma B16-F0 cells[J]. Biochem J, 2012, 443(3): 779-788.
[26] WangH, Wei J, Yang C, et al. The inhibition of tumor growth and metastasis byself-assembled nanofibers of taxol[J]. Biomaterials, 2012, 33(24): 5848-5853.
[27] WenT, Li Y, Wu M, et al. A novel tylophorine analog NK-007 ameliorates colitisthrough inhibition of innate immune response[J]. Int Immunopharmacol, 2012,14(4): 487-494.
[28] WenT, Li Y, Wu M, et al. Therapeutic effects of a novel tylophorine analog,NK-007, on collagen-induced arthritis through suppressing tumor necrosis factoralpha production and Th17 cell differentiation[J]. Arthritis Rheum, 2012,64(9): 2896-2906.
[29] ChenX, Wen T, Wei J, et al. Treatment of allergic inflammation and hyperresponsivenessby a simple compound, Bavachinin, isolated from Chinese herbs[J]. Cell MolImmunol, 2013, 10(6): 497-505.
[30] LiY, Wen T, Zhu M, et al. Glycoproteomic analysis of tissues from patients withcolon cancer using lectin microarrays and nanoLC-MS/MS[J]. Mol Biosyst, 2013,9(7): 1877-1887.
[31] MengX, Zhang Y, Jia Z, et al. A novel tylophorine analog W-8 up-regulates forkheadboxP3 expression and ameliorates murine colitis[J]. J Leukoc Biol, 2013, 93(1):83-93.
[32] WeiJ, Xia S, Sun H, et al. Critical role of dendritic cell-derived IL-27 inantitumor immunity through regulating the recruitment and activation of NK andNKT cells[J]. J Immunol, 2013, 191(1): 500-508.
[33] WuX, Zhang J Y, Huang A, et al. Decreased Vdelta2 gammadelta T cells associatedwith liver damage by regulation of Th17 response in patients with chronichepatitis B[J]. J Infect Dis, 2013, 208(8): 1294-1304.
[34] ZhangS, Liang R, Luo W, et al. High susceptibility to liver injury in IL-27 p28conditional knockout mice involves intrinsic interferon-gamma dysregulation ofCD4+ T cells[J]. Hepatology, 2013, 57(4): 1620-1631.
[35] ZhaoY, Zhao H, Sun Y, et al. IL-4 induces a suppressive IL-10-producing CD8+ T cellpopulation via a Cdkn2a-dependent mechanism[J]. J Leukoc Biol, 2013, 94(6):1103-1112.
[36] MaoX, Wu Y, Diao H, et al. Interleukin-6 promotes systemic lupus erythematosusprogression with Treg suppression approach in a murine systemic lupuserythematosus model[J]. Clin Rheumatol, 2014, 33(11): 1585-1593.
[37] XiaS, Wei J, Wang J, et al. A requirement of dendritic cell-derived interleukin-27for the tumor infiltration of regulatory T cells[J]. J Leukoc Biol, 2014. 95: 733-742
[38] ZhaoN, Ni Y, Zhao L, et al. [Protective role of gammadelta T cells in concanavalinA-induced liver injury][J]. Zhonghua Gan Zang Bing Za Zhi, 2014, 22(1): 58-62.
[39] ZhuE, Wang X, Zheng B, et al. miR-20b suppresses Th17 differentiation and thepathogenesis of experimental autoimmune encephalomyelitis by targetingRORgammat and STAT3[J]. J Immunol, 2014, 192(12): 5599-5609.
[40] ChenS, Wang J, Cheng H, et al. Targeted delivery of NK007 to macrophages to treatcolitis[J]. J Pharm Sci, 2015, 104(7): 2276-2284.
[41] LuanR, Cheng H, Li L, et al. Maternal Lipopolysaccharide Exposure Promotes ImmunologicalFunctional Changes in Adult Offspring CD4+ T Cells[J]. Am J Reprod Immunol,2015, 73(6): 522-535.
[42] WenT, Hou K, Li Z, et al. Silencing beta-linked N-acetylglucosamine transferaseinduces apoptosis in human gastric cancer cells through PUMA and caspase-3pathways[J]. Oncol Rep, 2015, 34(6): 3140-3146.
[43] CaoG, Li H B, Yin Z, et al. Recent advances in dynamic m6A RNA modification[J].Open Biol, 2016, 6(4).
[44] CaoG, Wang Q, Li G, et al. mTOR inhibition potentiates cytotoxicity of Vgamma4 gammadeltaT cells via up-regulating NKG2D and TNF-alpha[J]. J Leukoc Biol, 2016. 100(5):1181-1189
[45] Cao, G.,Q. Wang, W. Huang, J. Tong, D. Ye, Y. He, Z. Liu, X. Tang, H. Cheng, Q. Wen, D.Li, H. T. Chau, Y. Wen, H. Zhong, Z. Meng, H. Liu, Z. Wu, L. Zhao, R. A.Flavell, H. Zhou, A. Xu, H. Yang, and Z. Yin. 2017. Long-term consumption ofcaffeine-free high sucrose cola beverages aggravates the pathogenesis of EAE inmice. Cell Discov 3: 17020.
[46] Li, H.B., J. Tong, S. Zhu, P. J. Batista, E. E. Duffy, J. Zhao, W. Bailis, G. Cao, L.Kroehling, Y. Chen, G. Wang, J. P. Broughton, Y. G. Chen, Y. Kluger, M. D.Simon, H. Y. Chang, Z. Yin, and R. A. Flavell. 2017. m(6)A mRNA methylationcontrols T cell homeostasis by targeting the IL-7/STAT5/SOCS pathways. Nature548: 338-342.
[47] Meng,Z., J. Wang, Y. Yuan, G. Cao, S. Fan, C. Gao, L. Wang, Z. Li, X. Wu, Z. Wu, L.Zhao, and Z. Yin. 2017. gammadelta T cells are indispensable forinterleukin-23-mediated protection against Concanavalin A-induced hepatitis inhepatitis B virus transgenic mice. Immunology 151: 43-55.
[48] Zhang,H., Z. Li, L. Wang, G. Tian, J. Tian, Z. Yang, G. Cao, H. Zhou, L. Zhao, Z. Wu,and Z. Yin. 2017. Critical Role of Myeloid-Derived Suppressor Cells inTumor-Induced Liver Immune Suppression through Inhibition of NKT Cell Function.Front Immunol 8: 129.
[49] Sun, G.,S. Yang, G. Cao, Q. Wang, J. Hao, Q. Wen, Z. Li, K. F. So, Z. Liu, S. Zhou, Y.Zhao, H. Yang, L. Zhou, and Z. Yin. 2018. gammadelta T cells provide the earlysource of IFN-gamma to aggravate lesions in spinal cord injury. The Journal ofexperimental medicine 215: 521-535.
[50] AllogenicNatural Killer Cell Immunotherapy Combined with Irreversible Electroporationfor Stage IV Hepatocellular Carcinoma: Survival Outcome. Alnaggar M, Lin M,Mesmar A, Liang S, Qaid A, Xu K, Chen J, Niu L, Yin Z. Cell Physiol Biochem.2018;48(5):1882-1893. doi: 10.1159/.
[51] Aluminumhydroxide colloid vaccine encapsulated in yeast shells with enhanced humoraland cellular immune responses. Liu H, Jia Z, Yang C, Song M, Jing Z, Zhao Y, WuZ, Zhao L, Wei D, Yin Z, Hong Z. Biomaterials. 2018 Jun;167:32-43. doi:10.1016/j.biomaterials.2018.03.014.
[52] MohammedAlnaggar#, Yan Xu#, Jingxia Li, Junyi He, Jibing Chen, Man Li, Qingling Wu, LiLin, Yingqing Liang, Xiaohua Wang, Jiawei Li, Yi Hu, Yan Chen, Kecheng Xu*,Yangzhe Wu*, Zhinan Yin*. Allogenic Vγ9Vδ2 T Cell as New PotentialImmunotherapy Drug for Solid Tumor: A Case Report for Cholangiocarcinoma.Journal for Immunotherapy of Cancer, 2019, accepted. (Co-corresponding author)

Professional Honors orRecognition
1. Regionalor National
1) 1988 Honor Certificate(First Honor) from the Chinese Association of Microbiology, National ScienceFoundation, P.R. China, for thesis work: "β-D-galatosidase/anti β-D-galactosidasemonoclonal antibody complex (GAG) and its use in ELISA and immunohistochemistry"
2) 2000 NationalArthritis Foundation Fellowship (2000-03)
3) 2000 AssociateMember of Yale Cancer Center
4) 2000 Member of AmericanCollege of Rheumatology (ACR)
5) 2002 Member of AmericanAssociation of Immunologists (AAI)
6) 2002 Member of AmericanAssociation of Cancer Society (AAC)
7) 2004 American Associationof Immunologists (AAI) Junior Faculty Travel Award
8) 2006 Yale UniversityDepartment of Internal Medicine Research Achievement Award
9) 2007 China NationalOutstanding Youth Fund
10) 2007 Special Professor of"Yangtze River Scholars" of the Ministry of Education of China
11) 2009 “Leading Personnel inEntrepreneurship” of Tianjin
12) 2010 "High-levelOverseas Students Returning to Start-up Talents" of National Ministry ofHuman Resources and Social Security
13) 2013 Young and Middle-agedExperts with Outstanding Contributions to the New Millions of Talents Projectof the Ministry of Human Resources and Social Security
14) 2013 The Fourth Group ofLeaders of Innovation and Entrepreneurship Teams in Guangdong Province
15) 2014 Contribution Award ofthe Chinese Federation of Overseas Chinese (The Fifth China Overseas ChineseFederation)
16) 2018 14th Guangdong DingYing Science and Technology Award
17) 2018 The Second Prize ofthe Contribution Award of the Chinese Overseas Chinese Federation
2. Local
1) 1998 The Second Prize of the Contribution Award of the Chinese Overseas Chinese Brown-Coxe Fellowship, Yale School of Medicine
2) 2000 ArgallL. and Anna G. Hull Cancer Research Award, Yale Cancer Center (2000-01)
3) 2006 FacultyAward for Achievement in Research, Department of Internal Medicine, Yale Schoolof Medicine
Fund
The number of fund projects has beenobtained is 22.
Publications
[1] YinZ, Gabriele E, Leprini A, et al. Differential cation regulation of the alpha 5beta 1 integrin-mediated adhesion of leukemic cells to the central cell-bindingdomain of fibronectin[J]. Cell Growth Differ, 1997, 8(12): 1339-1347.
[2] YinZ, Giacomello E, Gabriele E, et al. Cooperative activity of alpha4beta1 andalpha4beta7 integrins in mediating human B-cell lymphoma adhesion andchemotaxis on fibronectin through recognition of multiple synergizing bindingsites within the central cell-binding domain[J]. Blood, 1999, 93(4): 1221-1230.
[3] YinZ, Braun J, Neure L, et al. T cell cytokine pattern in the joints of patientswith Lyme arthritis and its regulation by cytokines and anticytokines[J].Arthritis Rheum, 1997, 40(1): 69-79.
[4] YinZ, Braun J, Neure L, et al. Crucial role of interleukin-10/interleukin-12balance in the regulation of the type 2 T helper cytokine response in reactivearthritis[J]. Arthritis Rheum, 1997, 40(10): 1788-1797.
[5] YinZ, Siegert S, Neure L, et al. The elevated ratio of interferongamma-/interleukin-4-positive T cells found in synovial fluid and synovialmembrane of rheumatoid arthritis patients can be changed by interleukin-4 butnot by interleukin-10 or transforming growth factor beta[J]. Rheumatology(Oxford), 1999, 38(11): 1058-1067.
[6] MullerB, Gimsa U, Mitchison N A, et al. Modulating the Th1/Th2 balance ininflammatory arthritis[J]. Springer Semin Immunopathol, 1998, 20(1-2): 181-196.
[7] YinZ, Craft J. gamma delta T cells in autoimmunity[J]. Springer SeminImmunopathol, 2000, 22(3): 311-320.
[8] YinZ, Zhang D H, Welte T, et al. Dominance of IL-12 over IL-4 in gamma delta Tcell differentiation leads to default production of IFN-gamma: failure todown-regulate IL-12 receptor beta 2-chain expression[J]. J Immunol, 2000,164(6): 3056-3064.
[9] YinZ, Bahtiyar G, Zhang N, et al. IL-10 regulates murine lupus[J]. J Immunol,2002, 169(4): 2148-2155.
[10] Yin Z,Chen C, Szabo S J, et al. T-Bet expression and failure of GATA-3cross-regulation lead to default production of IFN-gamma by gammadelta Tcells[J]. J Immunol, 2002, 168(4): 1566-1571.
[11] Gao Y,Yang W, Pan M, et al. Gamma delta T cells provide an early source of interferongamma in tumor immunity[J]. J Exp Med, 2003, 198(3): 433-442.
[12] Pan M,Kang I, Craft J, et al. Resistance to development of collagen-induced arthritisin C57BL/6 mice is due to a defect in secondary, but not in primary, immuneresponse[J]. J Clin Immunol, 2004, 24(5): 481-491.
[13] Gao Y,Tao J, Li M O, et al. JNK1 is essential for CD8+ T cell-mediated tumor immunesurveillance[J]. J Immunol, 2005, 175(9): 5783-5789.
[14] Gao Y,Zhang D, Sun B, et al. Active hexose correlated compound enhances tumorsurveillance through regulating both innate and adaptive immune responses[J].Cancer Immunol Immunother, 2006, 55(10): 1258-1266.
[15] You X,Pan M, Gao W, et al. Effects of a novel tylophorine analog on collagen-inducedarthritis through inhibition of the innate immune response[J]. Arthritis Rheum,2006, 54(3): 877-886.
[16] Chen L,He W, Kim S T, et al. Epigenetic and transcriptional programs lead to defaultIFN-gamma production by gammadelta T cells[J]. J Immunol, 2007, 178(5):2730-2736.
[17] Tao J,Gao Y, Li M O, et al. JNK2 negatively regulates CD8+ T cell effector functionand anti-tumor immune response[J]. Eur J Immunol, 2007, 37(3): 818-829.
[18] Hao J,Wu X, Xia S, et al. Current progress in gammadelta T-cell biology[J]. Cell MolImmunol, 2010, 7(6): 409-413.
[19] He W,Hao J, Dong S, et al. Naturally activated V gamma 4 gamma delta T cells play aprotective role in tumor immunity through expression of eomesodermin[J]. JImmunol, 2010, 185(1): 126-133.
[20] Yin Z,Fujii H, Walshe T. Effects of active hexose correlated compound on frequency ofCD4+ and CD8+ T cells producing interferon-gamma and/or tumor necrosisfactor-alpha in healthy adults[J]. Hum Immunol, 2010, 71(12): 1187-1190.
[21] Hao J,Dong S, Xia S, et al. Regulatory role of Vgamma1 gammadelta T cells in tumorimmunity through IL-4 production[J]. J Immunol, 2011, 187(10): 4979-4986.
[22] Qian P,Zuo Z, Wu Z, et al. Pivotal role of reduced let-7g expression in breast cancerinvasion and metastasis[J]. Cancer Res, 2011, 71(20): 6463-6474.
[23] Tao J,Kamanaka M, Hao J, et al. IL-10 signaling in CD4+ T cells is critical for thepathogenesis of collagen-induced arthritis[J]. Arthritis Res Ther, 2011, 13(6):R212.
[24] Zhao N,Hao J, Ni Y, et al. Vgamma4 gammadelta T cell-derived IL-17A negativelyregulates NKT cell function in Con A-induced fulminant hepatitis[J]. J Immunol,2011, 187(10): 5007-5014.
[25] Lin Y,Wen T, Meng X, et al. The mouse Mageb18 gene encodes a ubiquitously expressedtype I MAGE protein and regulates cell proliferation and apoptosis in melanomaB16-F0 cells[J]. Biochem J, 2012, 443(3): 779-788.
[26] Wang H,Wei J, Yang C, et al. The inhibition of tumor growth and metastasis byself-assembled nanofibers of taxol[J]. Biomaterials, 2012, 33(24): 5848-5853.
[27] Wen T,Li Y, Wu M, et al. A novel tylophorine analog NK-007 ameliorates colitisthrough inhibition of innate immune response[J]. Int Immunopharmacol, 2012,14(4): 487-494.
[28] Wen T,Li Y, Wu M, et al. Therapeutic effects of a novel tylophorine analog, NK-007,on collagen-induced arthritis through suppressing tumor necrosis factor alphaproduction and Th17 cell differentiation[J]. Arthritis Rheum, 2012, 64(9):2896-2906.
[29] Chen X,Wen T, Wei J, et al. Treatment of allergic inflammation and hyperresponsivenessby a simple compound, Bavachinin, isolated from Chinese herbs[J]. Cell MolImmunol, 2013, 10(6): 497-505.
[30] Li Y,Wen T, Zhu M, et al. Glycoproteomic analysis of tissues from patients withcolon cancer using lectin microarrays and nanoLC-MS/MS[J]. Mol Biosyst, 2013,9(7): 1877-1887.
[31] Meng X,Zhang Y, Jia Z, et al. A novel tylophorine analog W-8 up-regulates forkheadboxP3 expression and ameliorates murine colitis[J]. J Leukoc Biol, 2013, 93(1):83-93.
[32] Wei J,Xia S, Sun H, et al. Critical role of dendritic cell-derived IL-27 in antitumorimmunity through regulating the recruitment and activation of NK and NKTcells[J]. J Immunol, 2013, 191(1): 500-508.
[33] Wu X,Zhang J Y, Huang A, et al. Decreased Vdelta2 gammadelta T cells associated withliver damage by regulation of Th17 response in patients with chronic hepatitisB[J]. J Infect Dis, 2013, 208(8): 1294-1304.
[34] Zhang S,Liang R, Luo W, et al. High susceptibility to liver injury in IL-27 p28conditional knockout mice involves intrinsic interferon-gamma dysregulation ofCD4+ T cells[J]. Hepatology, 2013, 57(4): 1620-1631.
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