占贞贞 研究员
硕士招生类型：学术型
硕士招生专业：基础医学
博士招生类型：学术型
博士招生专业：临床医学（基础医学方向）
所在院系：附属东方医院
联系方式：zhanzz@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

临床重大疾病发生发展中的免疫炎症调控

The regulation of immune inflammation in disease






上海市曙光****
上海市卫生系统学科带头人
上海市青年科技启明星
澳大利亚University of Newcastle访问****
中华医学会医学工程学分会干细胞工程学组委员
上海市免疫学会免疫遗传分会委员





作为项目负责人主持国家级和上海市等省部级项目共10余项，代表性发表论文如下：
(1) Zhou Qingqing^#, Zhang Yunkai^#, Wang Bo^#,Zhou Weihui, Bi Yong, Huai Wanwan, Chen Xi, Chen Yihan, Liu Zhongmin, LiuXingguang^*, Zhan Zhenzhen^*. KDM2B epigeneticallypromotes IL-6 production and inflammatory responses through Brg1-mediatedchromatin remodeling. Cellular & Molecular Immunology. 2019Jun 13. doi: 10.1038/s41423-019-0251-z. [Epub ahead of print]（通讯作者）
(2) Wang Bo^#, Zhou Qingqing^#, Bi Yong^#, ZhouWeihui, Zeng Qiyan, Liu Zhongmin, Liu Xingguang^*, Zhan Zhenzhen^*.Phosphatase PPM1L Prevents Excessive Inflammatory Responses and CardiacDysfunction after Myocardial Infarction by Inhibiting IKKβ Activation. JImmunol. 2019 Jul 22. pii: ji**. doi: 10.4049/jimmunol.**.[Epub ahead of print]（通讯作者）
(3) Jing Yang, Bo Wang, Na Li, Qingqing Zhou, Wenhui Zhou, ZhenzhenZhan^*. Salvia miltiorrhiza and Carthamus tinctorius extractprevents cardiac fibrosis and dysfunction after myocardial infarction byepigenetically inhibiting Smad3 expression. Evidence-Based Complementaryand Alternative Medicine. 2019 May 30; 2019:**. doi:10.1155/2019/**. eCollection 2019.（通讯作者）
(4) Yang, Linshan; Wang, Bo; Zhou, Qingqing; Wang, Yiru; Liu, Xingguang;Liu, Zhongmin^*; Zhan Zhenzhen^*. MicroRNA-21prevents excessive inflammation and cardiac dysfunction after myocardialinfarction through targeting KBTBD7. Cell Death and Disease.2018;9(7):769. （通讯作者）
(5) Liu, Xingguang^#; Cao, Hao^#; Li, Jian^#;Wang, Bo; Zhang, Peng; Zhang, Xu Dong; Liu, Zhongmin; Yuan, Hongbin^*;Zhan, Zhenzhen^*. Autophagy induced by DAMPs facilitates theinflammation response in lungs undergoing ischemia-reperfusion injury throughpromoting TRAF6 ubiquitination. Cell Death and Differentiation,2017, 24(4): 683~693. （通讯作者）
(6) Zhan, Zhenzhen^*; Cao, Hao; Xie, Xuefeng; Yang,Linshan; Zhang, Peng; Chen, Yihan; Fan, Huimin; Liu, Zhongmin; Liu, Xingguang^*.Phosphatase PP4 negatively regulates type I interferon production and antiviralinnate immunity by dephosphorylating and deactivating TBK1. The Journalof Immunology, 2015, 195(8): 3849~3857. （第一作者兼共同通讯）
(7) Zhan, Zhenzhen^#; Xie, Xuefeng^#; Cao,Hao; Zhou, Xiaohui; Zhang, Xu Dong; Fan, Huimin^*; Liu, Zhongmin^*.Autophagy facilitates TLR4-and TLR3-triggered migration and invasion of lungcancer cells through the promotion of TRAF6 ubiquitination. Autophagy,2014,10(2): 257~268. （第一作者）
(8) Zhan, Zhenzhen; Li, Qun; Wu, Ping; Ye, Yan; Tseng, Hsin-Yi;Zhang, Linjie^*; Zhang, Xudong^*. Autophagy-mediated HMGB1release antagonizes apoptosis of gastric cancer cells induced by vincristinevia transcriptional regulation of Mcl-1. Autophagy, 2012, 8(1):109~121.（第一作者）
(9) Liu, Xingguang; Zhan, Zhenzhen; Li, Dong; Xu, Li; Ma, Feng;Zhang, Peng; Yao, Hangping; Cao, Xuetao^*. Intracellular MHC class IImolecules promote TLR-triggered innate immune responses by maintainingactivation of the kinase Btk. Nature Immunology, 2011,12(5):416~424.
(10) Liu, Xingguang^#; Zhan, Zhenzhen^#; Xu,Li; Ma, Feng; Li, Dong; Guo, Zhenhong; Li, Nan; Cao, Xuetao^*. MicroRNA-148/152Impair Innate Response and Antigen Presentation of TLR-Triggered DendriticCells by Targeting CaMKIIalpha. The Journal of Immunology, 2010,185(12): 7244~7251. （共同第一作者）