高耀辉 讲师
硕士招生类型：学术型、专业型
硕士招生专业：肿瘤学
博士招生类型：
博士招生专业：
所在院系：附属第十人民医院
联系方式：gaoyaohui187@163.com
课题组链接：
研究方向
主要任职
科研业绩

肿瘤微环境及个体化治疗
Tumor microenvironment andindividualized therapy




同济大学附属第十人民医院病理科带组组长
（Team leader at the Department ofPathology, the Tenth People's Hospital, Tongji University）
生物样本库负责人（Bio Bank Manager）




主持课题（Projects）：
1. 同济大学青年优秀人才培养计划, 2016KJ050, HNF-4a在肾透明细胞癌中下调的潜在功能及其分子机制研究
Tongji University Youth Excellent TalentsTraining Program，2016KJ050, The potentialfunction of HNF-4a in down-regulation of renal clear cell carcinoma and itsmolecular mechanism
2. 国家自然基金青年项目，**，HNF-4alpha在VHL缺失的肾透明细胞癌中下调的分子机制及功能研究
National Natural Science Foundation of China,**, Molecular mechanism and function of HNF-4alpha in the down-regulationof VHL-deficient renal clear cell carcinoma
3. 上海市自然基金，14ZR**， VHL缺失的肾透明细胞癌对蒽环类化疗药敏感及其分子机制
Shanghai Natural Science Foundation,14ZR**, VHL-deficient renal clear cell carcinoma is sensitive toanthracycline chemotherapeutic drugs and its molecular mechanism
发表论文（Published papers）：
1.Gao, Y.H., Wu, Z. X. ,Xie, L. Q. ,Li, C. X. ,Mao, Y. Q. ,Duan,Y. T. ,Han, B. ,Han, S. F. ,Yu, Y. ,Lu, H. J. ,Yang, P. Y. ,Xu, T. R. ,Xia, J.L. ,Chen, G. Q. ,Wang, L. S.(2017) VHL deficiency augments anthracyclinesensitivity of clear cell renal cell carcinomas by down-regulating ALDH2. Naturecommunications 8, 15337.
2.Xi, H. #, Gao,Y. H.#, Han, D. Y., Li, Q. Y., Feng, L. J., Zhang, W., Ji, G., Xiao, J. C.,Zhang, H. Z. * , Wei, Q*. (2014) Hypoxia inducible factor-1alpha suppressesPeroxiredoxin 3 expression to promote proliferation of CCRCC cells, FEBSletters. 588, 3390-4.
3.Y.H. Gao, C.X.Li, S.M. Shen, H. Li, G.Q. Chen, Q. Wei*, L.S. Wang*,(2013) Hypoxia induciblefactor 1alpha mediates the down-regulation of superoxide dismutase 2 in vonHippel-Lindau deficient renal clear cell carcinoma. Biochem Biophys Res Commun435 46-51.
4. Chang, Z. #,Cai, C. ,Han, D. ,Gao, Y. ,Li, Q.,Feng, L. ,Zhang, W. ,Zheng, J. ,Jin, J. ,Zhang, H. ,Wei, Q.. (2017).Anoctamin5regulates cell migration and invasion in thyroid cancer. Int J Oncol 51,1311-1319
5.Duan, Y. #,Gao, Y., Zhang, J. , Chen, Y. ,Jiang, Y. ,Ji, J. ,Zhang, J. ,Chen, X. ,Yang,Q. ,Su, L. ,Zhang, J. ,Liu, B. ,Zhu, Z. ,Wang, L. *, Yu, Y*. (2016)Mitochondrial aldehyde dehydrogenase 2 protects gastric mucosa cells againstDNA damage caused by oxidative stress. Free Radic Biol Med 93 165-176.
6. Li, Z. ^#,Chen,Y. ^#,Wang, X.Zhang, H.Zhang, Y.Gao, Y.Weng, M.Wang, L.Liang,H.Li, M.Zhang, F.Zhao, S.Liu, S.Cao, Y.Shu, Y.Bao, R.Zhou, J.Liu, X.Yan,Y.Zhen, L.Dong*, Q.Liu, Y*. (2016).LASP-1 induces proliferation, metastasis andcell cycle arrest at the G2/M phase in gallbladder cancer by down-regulatingS100P via the PI3K/AKT pathway. Cancer letters 372, 239-250
7.Zhang, W. ^#,Zhang, L. ^#, Chen, Y. X., Xie, Y. Y., Zou, Y. F., Zhang, M. J., Gao,Y. H., Liu, Y., Zhao, Q., Huang, Q. H. Chen, N*. (2014) Identification ofnestin as a urinary biomarker for acute kidney injury, American journal ofnephrology. 39, 110-21.
8. Wen, D. #, Zou,Y. F. #, Gao, Y. H., Zhao, Q., Xie, Y. Y., Shen, P. Y., Xu, Y. W., Xu,J., Chen, Y. X., Feng, X. B., Shi, H., Zhang, W*. Inhibitor of DNA Binding 1 IsInduced during Kidney Ischemia-Reperfusion and Is Critical for the Induction ofHypoxia-Inducible Factor-1alpha. BioMed research international 2016,** (2016).
发明专利（Inventionpatent）:
乙醛脱氢酶2作为蒽环类化疗药物处理肿瘤细胞时药物靶标的应用。中国专利申请号：5.0
The application of acetaldehydedehydrogenase 2 as a drug target in the treatment of tumor cells byanthracycline chemotherapy drugs. Chinese patent application number:5.0