毕德玺 讲师，主管技师
硕士招生类型：学术型；专业型
硕士招生专业：肿瘤学
博士招生类型：
博士招生专业：
所在院系：附属第十人民医院
联系方式：bidexi@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

分子病理（Molecular pathology）



科研项目/Funding
1、 国家自然科学基金青年科学基金项目（National Natural ScienceFoundation of China），**，2018/01-2020/12
2、 同济大学附属第十人民医院攀登人才计划（Pandeng ResearchFoundation of Shanghai Tenth People’s Hospital），2018SYPDRC015，2018/09-2020/08
发表论文/Publication
1. BiD,Xie R, Zheng J, Yang H, Ou HY, Wei Q. Large-scale identification of AbaR-type genomicislands in Acinetobacter baumannii reveals diverse insertion sites andclonal lineage-specific antimicrobial resistance gene profiles. Antimicrobial Agents andChemotherapy, 2019,63:e02526-18.
2. YangY, Misra BB, Liang L, Bi D, Weng W, Wu W, Cai S, Qin H, Goel A,Li X, Ma Y. Integrated microbiome and metabolome analysis reveals a novelinterplay between commensal bacteria and metabolites in colorectal cancer. Theranostics,2019; 9:4101-4114.
3. ZhaoW, Yang J, Ni B, Bi D, Sun Y, Xu M, Zhu X, Li C, Jin L, Gao P,Wang P, Hua Y, Li M. Towards automatic prediction of EGFR mutationstatus in pulmonary adenocarcinoma with 3D deep learning. Cancer Medicine,2019, 8:3532–3543. (Cover article)
4. Gao Y,Yan Y, Guo J, Zhang Q, Bi D, Wang F, Chang Z, Lu Ling, Yao X, WeiQ. HNF-4α downregulation promotes tumor migration and invasion via regulatingE-cadherin in renal cell carcinoma. Oncology Reports, 2019, 42:1066-1074.
5. Dong X,Song J, Chen J, Bi D, Wang W, Ren Y, Wang H, Tang KFJ, Wang X,Huang J. Conjugative transfer of the pVA1-type plasmid carrying the pirAB^vpgenes results in the formation of new AHPND-causing Vibrio. Frontiersin Cellular and Infection Microbiology, 2019, 9:195.
6. Wu X,Tan G, Gao R, Yao L, Bi D, Guo Y, Yu F, Fan L. Assessment of theXpert MTB/RIF Ultra assay on rapid diagnosis of extrapulmonary tuberculosis. InternationalJournal of Infectious Diseases, 2019, 81:91-96.
7. Liu M,Li X, Xie Y, Bi D, Sun J, Li J, Tai C, Deng Z, Ou HY. ICEberg2.0: an updated database of bacterial integrative and conjugative elements. NucleicAcids Research, 2019, 47: D660-5.
8. BiD,Zheng J, Li JJ, Sheng ZK, Zhu X, Ou HY, Li Q, Wei Q. In silico typingand comparative genomic analysis of IncFII_K plasmids and insightsinto the evolution of replicons, plasmid backbones and resistance determinantprofiles. AntimicrobialAgents and Chemotherapy, 2018, 62:e00764-18.
9. Bai F,Wei C, Zhang P, Bi D, Ge M, Chen Q, Jia Y, Lu Y, Wu K. Use ofperipheral lymphocytes and support vector machine for survival prediction inbreast cancer patients. Translational Cancer Research, 2018, 7:978-87.
10. Dong X^#,Bi D^#, Wang H, Zou P, Xie G, Wan X, Yang Q, Zhu Y,Chen M, Guo C, Liu Z, Wang W, Huang J. pirAB^vp-Bearing Vibrioparahaemolyticus and Vibrio campbellii pathogens isolated from thesame AHPND-affected pond possess highly similar pathogenic plasmids. Frontiersin Microbiology, 2017, 8:1859. (^# joint-first author)
11. Wei Y,Bi D, Wei D, Ou HY. Prediction of type II toxin-antitoxin loci inKlebsiella pneumoniae genome sequences. Interdisciplinary Sciences: ComputationalLife Sciences, 2016, 8:143-9.
12. BiD,Jiang X, Sheng ZK, Tai C, Wang M, Deng Z, Rajakumar K, Ou HY. Mapping theresistance-associated mobilome of a carbapenem-resistant Klebsiellapneumoniae strain reveals insights into factors shaping these regions andfacilitates generation of a ‘resistance-disarmed’ model organism. Journal ofAntimicrobial Chemotherapy, 2015, 70: 2770-4.
13. Li G^#,Zhang Y^#, Bi D^#, Shen P, Ai F, Liu H, TianY, Ma Y, Wang B, Rajakumar K, Ou HY, Jiang X. First report of a clinical,multidrug-resistant Enterobacteriaceae isolate coharboring fosfomycinresistance gene fosA3 and cabarpenemase gene bla_KPC-2 onthe same transposon, Tn1721. Antimicrobial Agents and Chemotherapy,2015, 59:338-343. (^# joint-first author)
14. BiD,Liu L; Tai C, Deng Z, Rajakumar K, Ou HY. SecReT4: a web-based bacterial typeIV secretion system resource. Nucleic Acids Research, 2013, 41:D660-5.
Bi D, Xu Z, Harrison EM, Tai C, Wei Y, He X, Jia S, Deng Z, Rajakumar K, OuHY. ICEberg: a web-based resource for integrative and conjugative elementsfound in Bacteria. Nucleic Acids Research, 2012, 40: D621-6.