张有华 讲师，主管技师
硕士招生类型：学术型；专业型
硕士招生专业：肿瘤学
博士招生类型：
博士招生专业：
所在院系：附属第十人民医院
联系方式：zhangyouhua@tongji.edu.cn
课题组链接：
研究方向
主要任职
科研业绩

肠道菌群微环境对炎症与癌症的功能调控
Theregulation of inflammation and tumor by gut microbiota microenvironment

无

主持课题：
1. 国家自然科学基金青年科学基金项目，**，整合素β7通过下调IL-17A表达抑制结直肠癌发生发展的机制研究，2018/01-2020/12，20万元
2. 同济大学青年优秀人才培养行动计划，2016KJ054，β7整合素在两种肠道肿瘤发生发展过程中的功能和机制研究，2016年立项，5万元

发表论文：
(1) Zhang, YouHua^#，Pan,YouDong^#，Lin, ChangDong^#，Zheng,YaJuan，Sun, Hao，Zhang,HaiLong，Wang, JunLei，Yuan,MengYa，Duan, Tao^*，Du,QiaoLing^*，Chen, JianFeng^*，Bileacids evoke placental inflammation by activating Gpbar1/NF-kappaB pathway inintrahepatic cholestasis of pregnancy.，J Mol Cell Biol，2016.12.01，8（6）：530~541
(2) Lin,ChangDong^#, Zhang, YouHua^#, Zhang, Kun,Zheng, YaJuan, Lu, Ling, Chang, HaiShuang, Yang, Hui, Yang, YanRong, Wan,YaoYing, Wang, ShiHui, Yuan, MengYa, Yan, ZhanJun, Zhang, RongGuang, He,YongNing, Ge, GaoXiang, Wu, Dianqing, Chen, JianFeng^*, Fever promotesT lymphocyte trafficking via a thermal sensory pathway involving heat shock protein90 and α4integrins,Immunity, 2019.1.15, 50(1): 137-151
(3) Guo, Jun^#,Zhang, Youhua^#, Li, Hua^#, Chu, Huiying^#,Wang, Qinshu, Jiang, Shutan, Li, Yan, Shen, Hongbin, Li, Guohui^*,Chen, Jianfeng^*, Xu, Chenqi^*, Intramembrane ionicprotein–lipid interaction regulates integrin structure and function., PLoS Biol,2018.11.14, 16(11): e**
(4) Du, QiaoLing^#，Pan,YouDong^#，Zhang, YouHua^#，Zhang,HaiLong，Zheng, YaJuan，Lu,Ling，Wang, JunLei，Duan,Tao^*，Chen, JianFeng^*，Placentalgene-expression profiles of intrahepatic cholestasis of pregnancy revealinvolvement of multiple molecular pathways in blood vessel formation andinflammation，BMC Medical Genomics，2014.7.7，7：42
(5) Lu, Ling^#，Lin, ChangDong^#，Yan, ZhanJun，Wang, Shu，Zhang, YouHua，Wang, ShiHui，Wang, JunLei，Liu, Cui，Chen, JianFeng^*，Kindlin-3 Is Essential for the Resting alpha4beta1Integrin-mediated Firm Cell Adhesion under Shear Flow Conditions.，J Biol Chem，2016.5.6，291（19）：10363~10371
(6) Zhang, HaiLong^#，Zheng, YaJuan^#，Pan, YouDong，Xie, Can，Sun, Hao，Zhang,YouHua，Yuan, MengYa，Song,BaoLiang，Chen, JianFeng^*，Regulatory T-cell depletion in the gut caused byintegrin beta7 deficiency exacerbates DSS colitis by evoking aberrant innateimmunity.，Mucosal Immunology，2016.3.01，9（2）：391~400
(7) Du, QiaoLing，Zhang,YouHua，Pan, YouDong^*，Duan,Tao^*，Lithocholic acid-inducedplacental tumor necrosis factor-alpha upregulation and syncytiotrophoblast cellapoptosis in intrahepatic cholestasis of pregnancy.，HepatologyResearch，2014.5.01，44（5）：532~541