张雪梅 副主任医师，讲师
硕士招生类型：学术型
硕士招生专业：肿瘤学
博士招生类型：无
博士招生专业：无
所在院系：附属东方医院
联系方式：zxmzxs0417@163.com
课题组链接：
研究方向
主要任职
科研业绩

非小细胞肺癌对免疫检查点抑制剂耐药的基础和临床研究
上海市抗癌协会肺癌分子靶向与免疫治疗专业委员会委员
上海市抗癌协会癌症康复与姑息治疗专业委员会委员
中国抗癌协会肿瘤标志专业委员会乳腺癌标志物协作组委
中国医药教育协会腹部肿瘤专业委员会委员
中国医药教育协会乳腺疾病专业委员会乳腺癌多学科诊疗学组委
在研课题：上海市自然科学基金面上项目（No.19ZR**）： 长链非编码RNA DSCAM-AS1调控非小细胞肺癌对PD-1抗体耐药的分子机制研究（主持；年限2019~2022）。
近三年发表SCI论文（通讯作者）：1. Peng Fei Zhang, Jing Wu,Yin Wu, Wei Huang, Min Liu, Zhao Ru Dong, Bai Ying Xu, Yong Jin, Fei Wang, Xue Mei Zhang. The lncRNA SCARNA2 mediates colorectal cancer chemoresistance through a conserved microRNA-342-3p target sequence. J Cell Physiol.2019,234(7):10157-10165. (IF：4.522)
2. Jun Liang, Jing Wu, Fei Wang, Pengfei Zhang, Xuemei Zhang. Semaphoring 4D is required for the induction of antioxidant stress and anti-inflammatory effects of dihydromyricetin in colon cancer.International Immunopharmacology. 2019.02. (67):220-230. (IF：3.361)
3.Fei Wang, Hongxia Ma, Zhaoguo Liu, Wei Huang, Xiao jing Xu, Xuemei Zhang. α-Mangostin inhibits DMBA/TPA-induced skin cancer through inhibiting inflammation and promoting autophagy and apoptosis by regulating PI3K/Akt/mTOR signaling pathway in mice.Biomed Pharmacother. 2017.08.(92):672-680. (IF：3.743)
4. Bai Quan Qiu,Peng Fei Zhang,Dian Xiong ,Jian Jun Xu, Xiang Long,Shu Qiang Zhu, Xu Dong Ye,Yin Wu, Xu Pei,Xue Mei Zhang,Yong Bing Wu. CircRNA fibroblast growth factor receptor 3 promotes tumor progression in non‐small cell lung cancer by regulating Galectin‐1‐ AKT/ERK1/2 signaling. J Cell Physiol. 2019. 234(7): 11256-11264. (IF：4.522)
5. Peng Fei Zhang, Fei Wang, Jing Wu,Yin Wu,Wei Huang,Dong Liu, Xiao Yong Huang, Xue Mei Zhang, Ai Wu Ke. LncRNA SNHG3 induces EMT and sorafenib resistance by modulating the miR-128/CD152 pathway in hepatocellular carcinoma.J Cell Physiol.2019, 234(3):2789-2794. (IF：4.522)
6.Wei Li, Wei Zhang, Wenjing Deng, Yujie Zhong , Yonghong Zhang, Zhuo Peng, Haijuan Chen, Ruiying Sun, Xuemei Zhang, Shuanying Yang. Quantitative proteomic analysis of mitochondrial proteins differentially expressed between small cell lung cancer cells and normal human bronchial epithelial cells. Thoracic Cancer. 2018. 9(11) :1366-1375. (IF:2.524)