摘要/Abstract

摘要： 目的·研究体检人群中体质量指数（body mass index，BMI）与中心动脉血流动力学指标之间的关系。方法·纳入2017年12月—2018年6月上海交通大学医学院附属瑞金医院北院体检中心体检者共计287例（男性164例，占57.1%）；根据BMI将对象分为BMI正常组（BMI2）、超重组（24 kg/m2≤BMI2）和肥胖组（BMI≥28 kg/m2）。分别测定外周收缩压(peripheral systolic blood pressure，PSP)、外周舒张压（peripheral diastolic blood pressure，PDP）、外周脉压（peripheral pulse pressure，PPP）、外周平均动脉压（peripheral mean arterial pressure，P-MAP）；采用脉搏波分析测定中心动脉压，包括中心动脉收缩压（central systolic blood pressure，CSP）、中心动脉舒张压（central diastolic blood pressure，CDP）、中心动脉脉压（central pulse pressure，CPP）、中心动脉增强压（central augmentation pressure，AP）、中心动脉反射波增强指数（central augmentation index，AIx）；脉压放大指数为PPP/CPP。结果·①3组之间，PDP、CDP、P-MAP、AP、AIx、PPP/CPP差异有统计学意义（均Pr-0.140，r-0.149，均Pr0.151，r0.155，r0.124，均P结论·随着BMI增加，AP、AIx呈下降趋势，PDP、CDP、PPP/CPP呈上升趋势；BMI与CSP间无明显相关性。
关键词: 体质量指数, 中心动脉压, 中心动脉增强压, 中心动脉反射波增强指数
Abstract:
Objective · To investigate the relationship between body mass index (BMI) and central haemodynamic indices in physical examination population. Methods · December 2017 to June 2018, a total of 287 subjects undergoing health examination (164 males, accounting for 57.1%) in the Physical Examination Center, Ruijin Hospital North, Shanghai Jiao Tong University School of Medicine were included. According to BMI, the subjects were divided into normal BMI group (BMI2), overweight group (24 kg/m2 ≤ BMI2), and obesity group (BMI ≥ 28 kg/m2). The peripheral systolic blood pressure (PSP), the peripheral diastolic blood pressure (PDP), the peripheral pulse pressure (PPP), and the mean arterial pressure (P-MAP) were measured, respectively. The central arterial pressures were measuredpulse wave analysis, including central systolic blood pressure (CSP), central diastolic blood pressure (CDP), central pulse pressure (CPP), central augmentation pressure (AP), and central augmentation index (AIx). The amplification index of pulse pressure was PPP/CPP. Results · ① The differences of PDP, CDP, P-MAP, AP, AIx and PPP/CPP among the three groups were statistically significant (Pr-0.140, r-0.149, Pr0.151, r0.155, r0.124, PConclusion · With the increase of BMI, AP and AIx show a downward trend, but PDP, CDP, and PPP/CPP show an upward trend; BMI and CSP have no significant correlation.
Key words: body mass index (BMI), central arterial pressure, central augmentation pressure (AP), central augmentation index (AIx)


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