摘要/Abstract

摘要： 目的·探讨缺氧诱导因子1α（hypoxia inducible factor 1α，HIF-1α）在慢性心力衰竭（简称心衰）急性失代偿诊断及预后判断中的价值。方法·以32例慢性心衰急性失代偿期患者（A组）为研究对象，同时选取33例慢性心衰稳定期患者（B组）及30例正常体检者（C组），检测血液中HIF-1α、B型利钠肽（B-type natriuretic peptide，BNP）水平及其他相关生化指标，记录A组患者的住院时间及3个月内再入院次数。分析HIF-1α与其他指标间的相关性，绘制HIF-1α及BNP的ROC曲线，计算曲线下面积，比较两者的诊断价值。结果· A组HIF-1α及BNP水平均显著高于B组和C组（均P<0.05）；HIF-1α水平与血肌酐、血红蛋白、BNP、住院时间、3个月内再入院次数等呈正相关（均P<0.05）；HIF-1α及BNP的ROC曲线下面积差异无统计学意义（P>0.05）。结论·慢性心衰急性失代偿期患者HIF-1α水平对其诊断及预后判断有一定的临床价值。
关键词: 缺氧诱导因子1&, alpha, 慢性心力衰竭急性失代偿, B型利钠肽, 诊断, 预后
Abstract:
Objective · To investigate the value of hypoxia-inducible factor 1α (HIF-1α) in diagnosis and prognosis of acute decompensated chronic heart failure (CHF). Methods · 32 patients with acute decompensated CHF (Group A), 33 patients with sCHF (Group B) and 30 controls (Group C) were included. HIF-1α, B-type natriuretic peptide (BNP) and other biochemical indicators in blood were detected. Length of stay and readmission frequency within 3 months of Group A were recorded. Correlations between HIF-1α and other indicators were analyzed. ROC curves of HIF-1α and BNP were developed to compare their diagnostic values. Results · The HIF-1α and BNP levels of Group A were both significantly higher than those of Group B and Group C (P<0.05). HIF-1α was positively correlated with serum creatinine, hemoglobin, BNP, length of stay and readmission frequency within 3 months(P<0.05). Areas under curves of HIF-1α and BNP showed no statistically difference (P>0.05). Conclusion · HIF-1α has a certain value in diagnosis and prognosis of acute decompensated CHF.
Key words: hypoxia-inducible factor 1&, alpha, acute decompensated chronic heart failure, type B natriuretic peptide, diagnosis, prognosis


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