导师姓名： 李兵 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 生物化学与分子细胞生物学系上海交通大学医学院地址：上海市重庆南路280号 西7 楼 213室Bing Li Ph.D Professor and ChairDepartment of Biochemistry and Molecular Cell BiologyShanghai Key Laboratory for Tumor Microenvironment and InflammationShanghai Jiao Tong University School of Medicine280 S. Chongqing RoadShanghai 200025 China.Administrative Assistant: 86+ ext 776696Office (on campus): 776596
邮编： 200025 邮箱地址： bingli@shsmu.edu.cn

研究方向 (点击浏览详细信息)
获得性性状遗传相关重要分子的作用机制
组蛋白核运输及DNA复制关联的染色质组装的调控机理
染色质重塑复合物调控癌症发生发展的分子机理
相变诱发融合转录因子的致癌机理及对染色体三维结构的调控
蛋白质修饰与肿瘤代谢性疾病
干细胞谱系分化的表观遗传机制
癌症表观遗传学及新一代表观抗癌小分子药物开发

社会任职
杂志审稿专家：Cell, Molecular Cell, Genes and Development, Nature Chemical Biology, Nature Communication, Nature Reviews Molecular Cell Biology, Cell Research, PLOS Biology, PNAS, Cell Reports, eLife, the EMBO Journal, the EMBO reports, Nucleic Acids Research, Molecular and Cellular Biology, Journal of Biological Chemistry, Scientific Reports, PLOS One, Cancer Letter
American Heart Association member
American Society of Clinical Oncology member
中国细胞生物学学会染色质分会委员
生物化学与细胞分子生物学系 系主任
American Society for Biochemistry and Molecular Biology member

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 共转录表观遗传复合物在移动中聚合酶上功能调节的机制研究 国家自然科学基金重点项目 2021-01~2025-12 284万元 课题负责人
** RNA聚合酶II CTD 相互作用组功能调控的分子机理 国家自然科学基金面上项目 2019-01~2022-12 60万元 课题负责人
2018YFC** 获得性性状遗传相关重要分子的作用 国家重点研发计划“生殖健康及重大出生缺陷防控研究” 重点专项-子课题 2018-12~2021-12 422万元 子课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Dian-Jia Liu, Fan Zhang, Yi Chen, Yi Jin, Yuan-Liang Zhang, Shu-Bei Chen, Yin-Yin Xie, Qiu-Hua Huang, Wei-Li Zhao, Lan Wang, Peng-Fei Xu, Zhu Chen, Sai-Juan Chen, Bing Li, Aijun Zhang, Xiao-Jian Sun setd2 knockout zebrafish is viable and fertile: differential and developmental-stress-related requirements for Setd2 and histone H3K36 trimethylation in different vertebrate animals Cell Discovery 2020 0（0）：0
Xu Zhu*, Bingxue Lan*, Xianfu Yi*, Chaoran He, Lin Dang, Xingquan Zhou, Yumei Lu, Yongzhan Sun, Zhiheng Liu, Xue Bai, Kai Zhang, Bing Li, Mulin Jun Li, Yupeng Chen, Lirong Zhang HRP2-DPF3a-BAF complex coordinates histone modification and chromatin remodeling to regulate myogenic gene transcription Nucleic Acids Research 2020 48(12):6563-6582
Julia V. DiFiore, Travis S. Ptacek, Yi Wang, Bing Li, Jeremy Simon and Brian D. Strahl Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions Cell Reports 2020 31(10):107751
Wei Wang, Jun Xu, Oliver Limbo, Jia Fei, George A. Kassavetis, Jenny Chong, James T. Kadonaga, Paul Russell, Bing Li and Dong Wang （通讯作者） Molecular basis of chromatin remodeling by Rhp26, a yeast CSB ortholog Proc Natl Acad Sci USA. 2019 116(13):6120-6129
Jun Wu, Yimin Lao and Bing Li Nuclear actin switch of the INO80 remodeler J Mol Cell Biol. 2019 11(5):343-344
Yanhua Du, Jun Lin, Rulin Zhang, Wanli Yang, Heng Quan, Lijuan Zang, Yaqin Han, Bing Li*, Hong Sun and Jun Wu Ubiquitin Specific Peptidase 5 Promotes Ovarian Cancer Cell Proliferation Through Deubiquitinating HDAC2 Aging 2019 11(21):9778-9793
Buki Kwon, Palinda Ruvan Munashingha, Yong-Keol Shin, Chul-Hwan Lee, Bing Li and Yeon-Soo Seo Physical and functional interactions between nucleosomes and Rad27, a critical component of DNA processing during DNA metabolism The FEBS Journal 2017 283(23):4247-4262
Andria Schibler, Evangelia Koutelou, Junya Tomida, Marenda Wilson-Pham, Li Wang, Yue Lu, Alexa Parra Cabrera, Renee J. Chosed, Wenqian Li, Bing Li, Xiaobing Shi, Richard D. Wood, and Sharon Y.R. Dent Histone H3K4 methylation regulates deactivation of the Spindle Assembly Checkpoint through direct binding of Mad2 Genes& Development 2016 30(10):1187-97
Chun Ruan, Haochen Cui, Chul-Hwan Lee, Sheng Li, Bing Li （通讯作者） Homodimeric PHD-domain containing Rco1 constitutes a critical interaction hub within the Rpd3S histone deacetylase complex J. Biol. Chem. 2016 291(10):5428-38
Yi Wang, Yanling Niu, Bing Li （通讯作者） Balancing acts of SRI and an auto-inhibitory domain specify Set2 function at transcribed chromatin Nucleic Acids Research 2015 43(10):4881-92
Chun Ruan, Chul-Hwan Lee, Haochen Cui, Sheng Li, Bing Li （通讯作者） Nucleosome contact triggers conformational changes of Rpd3S driving high affinity H3K36me nucleosome engagement Cell Reports 2015 10(2): 204-215
Hong Wen, Yuanyuan Li, Yuanxin Xi, Shiming Jiang, Sabrina Stratton, Danni Peng, Kaori Tanaka, Yongfeng Ren, Zheng Xia, Jun Wu, Bing Li, Michelle Barton, Wei Li, Haitao Li and Xiaobing Shi ZMYND11 links histone H3.3 K36 trimethylation to transcription elongation and tumor suppression Nature 2014 508(7495):263-8
Chul-Hwan Lee, Jun Wu, Bing Li （通讯作者） Chromatin remodelers fine-tune H3K36me-directed deacetylation of neighbor nucleosomes by Rpd3S Molecular Cell 2013 52(2):255-63
Jae-Wan Huh, Jun Wu, Chul-Hwan Lee, Miyong Yun, Daniel Gilada, Chad A. Brautigam, Bing Li （通讯作者） Multivalent di-nucleosome recognition enables the Rpd3S histone deacetylase complex to tolerate decreased H3K36 methylation levels EMBO J. 2012 31(17):3564-74
Miyong Yun, Jun Wu, Jerry Workman, Bing Li （通讯作者） Readers of histone modifications Cell Research 2011 21:564–578
Bing Li, Jessica Jackson, Matthew D. Simon, Brian Fleharty, Madelaine Gogol, Chris Seidel, Jerry L. Workman and Ali Shilatifard Histone H3 lysine 36 di-methylation (H3K36me2) is sufficient to recruit the Rpd3S histone deacetylase complex and to repress spurious transcription. J. Biol. Chem. 2009 284(12):7970-6
Bing Li, Madelaine Gogol, Mike Carey, Samantha Pattenden, Chris Seidel and Jerry Workman Infrequently transcribed long genes depend on the Set2/Rpd3S pathway for accurate transcription Genes& Development 2007 21(11):1422-30
Bing Li, Madelaine Gogol, Mike Carey, Daeyoup Lee, Chris Seidel and Jerry Workman Combined action of PHD and Chromo domains directs the Rpd3S HDAC to transcribed chromatin Science 2007 316, 1050-1054
Bing Li, Michael Carey, Jerry Workman The role of chromatin during transcription Cell 2007 128(4):707-719
Daeyoup Lee, Elena Ezhkova, Bing Li, Samantha Pattenden, William Tansey, Jerry Workman The Proteasome Regulatory Particle Alters the SAGA Coactivator to Enhance Its Interactions with Transcriptional Activators Cell 2005 123(3):423-36.
Michael. Carrozza, Bing Li, Laurence Florens, Tamaki Suganuma, Selene Swanson, Kenneth Lee,Wei-Jong Shia, Scott Anderson, John Yates, Michael Washburn and Jerry Workman Histone H3 methylation by Set2 directs deacetylation of coding regions by Rpd3S to suppress spurious intragenic transcription Cell 2005 123(4):581-92
Bing Li, Samantha Pattenden, Daeyoup Lee, José Gutiérrez, Jie Chen, Chris Seidel, Jennifer Gerton and Jerry Workman Preferential occupancy of histone variant H2AZ at inactive promoters influence local histone modifications and chromatin remodeling Proc. Natl. Acad. Sci. USA 2005 102(51): 18385-18390
Bing Li, LeAnn Howe, Scott Anderson, John Yates III and Jerry Workman The Set2 histone methyltransferase functions through the phosphorylated carboxyl-terminal domain of RNA polymerase II J Biol. Chem. 2003 278(11):8897-8903
Bing Li, Joseph Reese Ssn6-Tup1 Regulates RNR3 by Positioning Nucleosomes and Affecting the Chromatin Structure at the Upstream Repression Sequence. J. Biol. Chem. 2001 276(36): 33788-97.
Bing Li, Joseph Reese Derepression of DNA Damage-Regulated Genes Requires Yeast TBP-Associated Factors EMBO J. 2000 19(15):4091-100
Bing Li, Cheng Gu and Jindong Zhao Molecular cloning and expression of pfu DNA polymerase, and its application in long-distance PCR Chinese Science Bulletin 1998 43(10):863-867