导师姓名： 陈广洁 专业代码： 100100
性别： 女 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式： 上海市重庆南路280号5号楼908室邮箱：chenguangjie@sjtu.edu.cn, guangjie_chen@163.com办公室电话：-776665
邮编： 200025 邮箱地址： chenguangjie@sjtu.edu.cn

研究方向 (点击浏览详细信息)
免疫调节与自身免疫病

社会任职

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** 关节滑膜肥大细胞的区域免疫特性及其介导的Th17活化和相互作用在类风湿关节炎发病中的研究 国家自然科学基金，面上项目 2018-01~2021-10 55万元 课题负责人
** IFN-β调控OPN/Th17炎性通路在多发性硬化中的机理研究 国家自然科学基金 2014-01~2017-12 70万元 课题负责人
** β-干扰素对多发性硬化的免疫调节机制研究 卫生局科技发展基金 2012-01~2012-12 3万元 课题负责人
12ZZ103 IFN-β恢复多发性硬化IFN-β在实验性自身免疫性脑脊髓炎中的免疫调节机制研究 上海市教委科研创新(重点) 2012-01~2014-12 16万元 课题负责人
11JC** IFN-β恢复多发性硬化Treg/Th17平衡作用机制的研究 上海市科委基础研究重点项目 2012-01~2014-12 15万元 课题负责人
** 免疫活性肽段ergotype在类风湿关节炎中的免疫调节作用研究 国家自然基金，面上项目 2010-01~2012-12 32万元 课题负责人
09YZ104 免疫活性肽段ergotope对类风湿关节炎的免疫干预研究 上海市教委基金 2009-01~2011-12 8万元 课题负责人
** 类风湿关节炎中骨桥蛋白调控IL-17表达的机制及发病学意义 上海市卫生局,局级课题 2008-01~2010-12 3万元 课题负责人
07ZR14066 骨桥蛋白调控IL-17表达在类风湿关节炎中发病机制的研究 上海市科委,自然基金 2007-11~2009-11 10万元 课题负责人

学术论文 作者论文标题期刊名出版年卷期页码
Jinglue Song, Hongli Liu, Qi Zhu, Yutong Miao, Feiyan Wang, Fan Yang, Wenjing Cheng, Yebin Xi, Xiaoyin Niu, Dongyi He,Guangjie Chen. （通讯作者） T-614 Promotes Osteoblastic Cell Differentiation by Increasing Dlx5 Expression and Regulating the Activation of p38 and NF-??B BioMed Research International 2018 **:1
Xiao-Xiao Hou, Guangjie Chen （共同第一作者）, Amir M. Hossini, Tingting Hu, Lanqi Wang, Zhanyan Pan, Lingyi Lu, Ke Cao, Ying Ma, Christos C. Zouboulis, Longqing Xia, Qiang Ju. Aryl Hydrocarbon Receptor Modulates the Expression of TNF-α and IL-8 in Human Sebocytes via the MyD88-p65NF-κB/p38MAPK Signaling Pathways. J Innate Immun. 2018 1-13
Cennan Yin1,Chenyun Wu, Xinyue Du, Yan Fang, Juebiao Pu, Jianhua Wu,Lili Tang, Wei Zhao, Yongqiang Weng, Xiaokui Guo, Guangjie Chen （通讯作者）,Zhaojun Wang PRL2 Controls Phagocyte Bactericidal Activity by Sensing and Regulating ROS .Frontiers in immunology 2018 9:2609.
Qing Zhao, Wenjing Cheng, Yebin Xi, Zheyi Cao, Yunzhi Xu, Ting Wu, Chengzhen Li, Xiaoyin Niu, Guangjie Chen. （通讯作者） IFN-β regulates Th17 differentiation partly through the inhibition of osteopontin in experimental autoimmune encephalomyelitis. Molecular Immunology 2018 93:20–30
Niu Xiaoyin,Deng Shaohua,Li Shan,Xi Yebin,Li Chengzhen,Wang Li,He Dongyi,Wang Zhaojun, Chen Guangjie （通讯作者） Effect of Ergotope Peptides on Collagen-Induced Arthritis by Downregulation of Inflammatory and Th1/Th17 Responses and Induction of Regulatory T cells. Mol Immunol 2016 22：608~620
Wu Ting,Chen Guangjie （通讯作者） miRNAs Participate in MS Pathological Processes and Its Therapeutic Response Mediators of Inflammation 2016 2016
Shicheng Guo ,Qi Zhu,Ting Jiang,Rongsheng Wang,Yi Shen,Xiao Zhu,Yan Wang,Fengmin Bai,Qin Ding,Xiaodong Zhou,Guangjie Chen （通讯作者）,Dong Yi He. Genome-wide DNA methylation patterns in CD4+ T cells from Chinese Han patients with rheumatoid arthritis. Modern Rheumatology 2016 1：1~7
Fang Y, Wu C, Chen Q, Wu J, Yang Y, Guo X, Chen G, Wang Z （通讯作者） SjE16.7 activates macrophages and promotes Schistosoma japonicum egg-induced granuloma development. Acta Trop 2015 149:49-58
Li C, Xi Y, Li S, Zhao Q, Cheng W, Wang Z, Zhong J, Niu X, Chen G （通讯作者） Berberine ameliorates TNBS induced colitis by inhibiting inflammatory responses and Th1/Th17 differentiation Molecular Immunology 2015 pii: S0161-5890(15)30021-3. doi: 10.1016/j.molimm
Xu Yunzhi,Zhu Qi,Song Jinglve,Liu Hongli,Miao Yutong,Yang Fan,Wang Feiyan,Cheng Wenjing,Xi Yebin,Niu iaoyin,He Dongyi, Chen Guangjie （通讯作者） Regulatory Effect of Iguratimod on the Balance of Th Subsets and Inhibition of Inflammatory Cytokines in Patients with Rheumatoid Mediators Inflamm 2015 2015:356040-356040
Xu YZ, Chen GJ （通讯作者） Mast Cell and Autoimmune Diseases Mediators of Inflammation 2015 Volume 2015, Article ID 246126
Cheng WJ, Zhao Q, Xi YB, Li CZ, Xu YZ, Wang L, Niu XY,Wang ZJ, Chen GJ （通讯作者） IFN-β inhibits infiltrated T cells accumulation in the central nervous system by reducing the expression of chemokines in experimental autoimmune encephalomyelitis Molecular Immunology. 2015 64:152-162.
Cheng WJ, Chen GJ （通讯作者） Chemokines and Chemokine Receptors in Multiple Sclerosis. Mediators of Inflammation Mediators of Inflammation 2014 2014:659206-14
Zhao Q, Chen GJ （通讯作者） Role of IL-33 and Its Receptor in T Cell-Mediated Autoimmune Diseases BioMed Research International 2014 Volume 2014, Article ID 587376
Niu XY, Chen GJ （通讯作者） Clinical Biomarkers and Pathogenic-Related Cytokines in Rheumatoid Arthritis Journal of Immunology Research 2014 Volume 2014, Article ID 698192
Li S, Niu XY, Xi YB, Deng SH, Li CZ, Zhao Q, Chen GJ. （通讯作者） T Cell Vaccination Inhibits Th1/Th17/Tfh Frequencies and Production of Autoantibodies in Collagen-Induced Arthritis. Clinical and Developmental Immunology 2013 2013:967301-9
Niu XY, Chen GJ （通讯作者） IL-21 and Related Diseases Clinical and J Clin Cell Immunol 2013 2013:1-008
Chen M, Chen G(co-first author) （共同第一作者）, Deng S, Liu X, Hutton GJ, Hong J. IFN-? induces the proliferation of CD4+CD25+Foxp3+ regulatory T cells through upregulation of GITRL on dendritic cells in the treatment of multiple sclerosis. J Neuroimmunol. 2012 242:39-46
Chang SH, Reynolds JM, Pappu BP, Chen G, Martinez GJ, Dong C Interleukin-17C Promotes Th17 Cell Responses and Autoimmune Disease via Interleukin-17 Receptor E. Immunity 2011 35:1–11
Niu XY, He DY, Deng SH, Li WY, Xi YB, Xie CY, Jiang T, Zhang J, Dong C, Chen GJ （通讯作者） Regulatory immune responses induced by IL-1 receptor antagonist inrheumatoid arthritis. Molecular Immunology 2011 49:290-296
Xiaoyin Niu, Dongyi He, Xin Zhang, Ningli Li, Jingwu Z Zhang, Chen Dong, Guangjie Chen. （通讯作者） IL-21 regulates Th17 cells in rheumatoid arthritis. Human Immunology 2010 71(4):334-341
Deng SH, Xi YB, Wang H, Hao J, Niu XY, Li WY, Yue T, Chen GJ （通讯作者） Regulatory effect of vasoactive intestinal peptide on the balance of Treg and Th17 in collagen-induced arthritis. Cell Immunol. 2010 265(2):105-10
Chen GJ, Zhang X, Li RS, Niu XY, zheng YX, He DY, Xu R, Zhang JW. Role of Osteopontin in Synovial Th17 Differentiation in Rheumatoid Arthritis. Arthritis & Rheumatism 2010 62(10):2900–2908
Guangjie Chen （通讯作者） Immunotherapy of Rheumatoid Arthritis：targeting on inflammatory cytokines and autoreactive T cells. Archivum Immunologiae et Therapiae Experimentalis 2010 58:27-36
Yang H, Qiu LH, Di W, Zhao AM, Chen GJ, Hu K, Lin QD. Proportional Change of CD4+CD25+ Regulatory T Cells after lymphocyte therapy in Unexplained Recurrent Spontaneous Abortion Patients. Fertility and Sterility 2009 92(1):301-5
Chen MY, Chen GJ(co-first author) （共同第一作者）, Nie H, Zhang X, Niu XY, Zang Y, Skinner SM, Zhang JW, Killian JM, Hong J. Regulatory effect of Interferon-Beta on Production of IL-17 and Osteopontin in CD4+ T Cells in Multiple Sclerosis. European Journal of Immunology. 2009 39(9):2525-2536
Chen GJ, Hao J, Xi YB, Wang W, Wang ZJ, Li NL & Li WY. The Therapeutic Effect of Vasoactive Intestinal Peptide on Experimental Arthritis is Associated with CD4+CD25+ T Regulatory Cells. Scandinavian Journal of Immunology. 2008 68:572–578
Yan B, Ye S, Chen GJ, Kuang M, Shen N, Chen SL. Dysfunctional CD4+CD25+regulatory T cells in untreated active systemic lupus erythematosus secondary to interferon-α producing antigen-presenting cells. Arthritis & Rheumatism 2008 58(3):801-812
Yang H, Qiu LH, Chen GJ, Ye Z, Lv CJ, Lin QD. Proportional Change of CD4+CD25+ Regulatory T Cells in Decidua and Peripheral Blood in Unexplained Recurrent Spontaneous Abortion Patients. Fertility and Sterility 2008 89(3):656-661
Han YP, Chen GJ （通讯作者） A Method of Analyzing the Structures of Misfolding Proteins like Prion Protein. Proceeding of 2nd International Conference on Bioinformatics and Biomedical Engineering (iCBBE2008) 2008 1:253-255
Chen GJ, Li NL, Zang YQ, Zhang DQ, He DY, Feng GZ, Ni LQ, Xu R, Wang L, Shen BH, Zhang JW. Vaccination with selected synovial T cells in Rheumatoid arthritis. Arthritis & Rheumatism 2007 56(2)453-463