导师姓名： 陈国强 专业代码： 100100
性别： 男 专业名称： 基础医学
培养单位： 基础医学院 三级学科/
专业领域：
导师类型： 博士生导师 专业学位导师：
联系方式：
邮编： 200025 邮箱地址： chengq@shsmu.edu.cn

研究方向 (点击浏览详细信息)
肿瘤的病理生理学与治疗学基础研究

社会任职
《癌症》、《生理学报》、《国际病理和临床科学杂志》副主编
中国生物化学与分子生物学学会理事、常务理事、副理事长
国务院学位委员会第七届学科评议组基础医学组成员
美国血液学会、美国生物化学和分子生物学学会和美国化学学会会员
《中国科学——生命科学》、《科学通报》、《中华医学杂志》、《中华肿瘤防治杂志》、《中国病理生理学杂志》、《Frontiers of Medicine in China》、《IJBMB 》、《Chemico-Biological Interactions》、《AJBR》等编委
中国病理生理学学会副理事长

科研项目 项目编号项目名称课题来源起止年月批准经费承担职责
** FBXO22降解核PTEN及其在mRNA可变剪接与肿瘤发生发展中的作用 国家自然科学基金 2019-01~2023-12 297万元 课题负责人
** 化学干预CBX4对低氧诱导因子1a的SUMO化修饰及其抗肿瘤效应 国家自然科学基金 2019-01~2023-12 320万元 课题负责人
** 应激与肿瘤 国家自然科学基金 2018-01~2022-12 1050万元 课题负责人
** Cbx4经SUMO化修饰增强HIF-1a转录活性的分子机制与肝癌发生发展 国自基金（重点项目） 2015-01~2019-12 320万元 课题负责人
2015CB910403 代谢应激过程中蛋白质修饰相关的生物标志物和潜在靶点的发现 国家科技部 2015-01~2019-12 195万元 课题负责人
** 腺花素清除白血病起始细胞的分子机制 国自基金（重大研究计划培育项目） 2015-01~2015-12 80万元 课题负责人
** 基于小分子探针的细胞命运决定的分子机制研究 国家自然基金（重大集成） 2013-01~2015-12 202.5万元 课题负责人
** 肿瘤细胞中的凋亡诱导因子表达下调导致EMT的机制 国家自然基金（重点） 2013-01~2017-12 290万元 课题负责人
11JC** SUMO-E3连接酶Pc2调控HIF-1活性和促进VEGF表达的机制 上海市科委基础研究重点项目（连续支持） 2012-01~2014-12 30万元 课题负责人
** 白血病细胞分化与凋亡信息基础的化学生物学研究 国家自然基金委,重点项目 2009-01~2012-12 250万元 课题负责人
2009CB918404 蛋白质翻译后修饰的发生与调控机制及其生理病理效应 国家重大研究计划（首席科学家） 2009-01~2013-08 840万元 课题负责人
08JC** 造血相关转录因子抑制HIF-1的转录活性和肿瘤血管形成的实验研究 上海市科委重点项目 2008-10~2010-09 30万元 课题负责人
KSCX2-YW-R-097 白血病细胞分化和凋亡信息基础研究 中国科学院知识创新工程重要方向性研究 2007-10~2010-10 150万元 课题负责人
07HX21001 低氧诱导因子和白血病细胞分化的系统研究 横向课题 2007-01~2009-12 77.9万元 课题负责人
** 低氧诱导因子和白血病细胞分化的系统研究 国家自然基金委,重点项目 2007-01~2010-12 150万元 课题负责人
LJ06020 白血病细胞分化新信号机制的系统研究 上海市卫生局,医学领军人才 2006-01~2010-12 50万元 课题负责人
05JC14032 白血病细胞分化新机制的深入研究 上海市科委,重点科技攻关 2005-10~2007-09 50万元 课题负责人
** 以自主的原创性模型研究白血病细胞分化的信息基础 国家自然基金委,面上项目 2005-01~2007-12 35万元 课题负责人
2002CB512805 利用蛋白质-蛋白质相互作用信息发现针对M2b型白血病的药物靶标 国家973项目 2002-12~2008-09 444万元 课题负责人
2002CB512800 基于生物信息学的药物新靶标的发现和功能研究 国家科技部,973项目 2002-12~2007-08 2500万元
08JC** 造血相关转录因子抑制HIF-1的转录活性和肿瘤血管形成的实验研究 上海市科委，基础重点项目 ~2010-09 30万元

学术论文 作者论文标题期刊名出版年卷期页码
Ge MK, Zhang N, Xia L, Zhang C, Dong SS, Li ZM, Ji Y, Zheng MH, Sun J, Chen GQ （通讯作者）, Shen SM FBXO22 degrades nuclear PTEN to promote tumorigenesis Nat Commun 2020 11(1): 1720
Shen SM, Zhang C, Ge MK, Dong SS, Xia L, He P, Zhang N, Ji Y, Yang S, Yu Y, Zheng JK, Yu JX, Xia Q, Chen GQ （通讯作者） PTENα and PTENβ promote carcinogenesis throughWDR5 and H3K4 trimethylation Nat Cell Biol 2019 21:1436-1448
Shen SM, Ji Y, Zhang C, Dong SS, Yang S, Xiong Z, Ge MK, Yu Y, Xia L, Guo M, Cheng JK, Liu JL, Yu JX, Chen GQ （通讯作者） Nuclear PTEN safeguards pre-mRNA splicing to link Golgi apparatus for its tumor suppressive role Nature Communications 2018 9: 2392
Huang Z, Zhao J, Deng W, Chen Y, Shang J, Song K, Zhang L, Wang C, Lu S, Yang X, He B, Min J, Hu H, Tan M, Xu J, Zhang Q, Zhong J, Sun X, Mao Z, Lin H, Xiao M, Chin YE, Jiang H, Xu Y, Chen G （通讯作者）, Zhang J Identification of a cellularly active SIRT6 allosteric activator Nat Chem Biol 2018 14(12):1118-1126
Zhang F, Liu X, Chen C, Zhu J, Yu Z, Xie J, Xie L, Bai H, Zhang Y, Fang X, Gu H, Wang C, Weng W, Zhang CC, Chen GQ （通讯作者）, Liang A, Zheng J CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling Haematologica 2017 102(4):707-718
Gao YH, Wu ZX, Xie LQ, Li CX, Mao YQ, Duan YT, Han B, Han SF, Yu Y, Lu HJ, Yang PY, Xu TR, Xia JL, Chen GQ （通讯作者）, Wang LS VHL deficiency augments anthracycline sensitivity of clear cell renal cell carcinomas by down-regulating ALDH2 Nat Commun 2017 8:15337
Liu TH, Tang YJ, Huang Y, Wang L, Guo XL, Mi JQ, Liu LG, Zhu H, Zhang Y, Chen L, Liu X, Zhang LH, Ye QJ, Li BS, Tang JY, Ford A, Enver T, Liu F, Chen GQ （通讯作者）, Hong DL Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin Leukemia 2017 31(5):1079-1086
Yang S, Zhou L, Reilly PT, Shen SM, He P, Zhu XN, Li CX, Wang LS, Mak TW, Chen GQ （通讯作者）, Yu Y ANP32B deficiency impairs proliferation and suppresses tumor progression by regulating AKT phosphorylation Cell Death Dis 2016 7:e2082
Xia L, Wang XR, Wang XL, Liu SH, Ding XW, Chen GQ （通讯作者）, Lu Y A novel role for pyruvate Kinase M2 as a corepressor for P53 during the DNA damage response in human tumor cells J Biol Chem 2016 291(50):26138-26150
Gu H, Chen C, Hao X, Wang C, Zhang X, Li Z, Shao H, Zeng H, Yu Z, Xie L, Xia F, Zhang F, Liu X, Zhang Y, Jiang H, Zhu J, Wan J, Wang C, Weng W, Xie J, Tao M, Zhang CC, Liu J, Chen GQ （通讯作者）, Zheng J Sorting protein VPS33B regulates exosomal autocrine signaling to mediate hematopoiesis and leukemogenesis J Clin Invest 2016 126(12):4537-4553
Zhou CX, Wang CL, Yu AL, Wang QY, Zhan MN, Tang J, Gong XF, Yin QQ, He M, He JR, Chen GQ （通讯作者）, Zhao Q MiR-630 suppresses breast cancer progression by targeting metadherin Oncotarget 2016 7(2):1288-99
Xiong Z, Guo M, Yu Y, Zhang FF, Ge MK, Chen GQ （通讯作者）, Shen SM Downregulation of AIF by HIF-1 contributes to hypoxia-induced epithelial-mesenchymal transition of colon cancer Carcinogenesis 2016 37(11):1079-1088
Fan L, Liu MH, Guo M, Hu CX, Yan ZW, Chen J, Chen GQ （通讯作者）, Huang Y FAM122A, a new endogenous inhibitor of protein phosphatase 2A Oncotarget 2016 7(39):63887-63900
Huang X, Zheng Y, Zhang F, Wei Z, Wang Y, Carrell RW, Read RJ, Chen GQ （通讯作者）, Zhou A Molecular Mechanism of Z α1-antitrypsin Deficiency J Biol Chem 2016 291(30):15674-86
Jiao HK, Xu Y, Li J, Wang W, Mei Z, Long XD, Chen GQ （通讯作者） Prognostic significance of Cbx4 expression and its beneficial effect for transarterial chemoembolization in hepatocellular carcinoma Cell Death Dis 2015 2015;6:e1689
Liu XY, Yu XT, Xie JJ, Zhan MN, Yu Z, Xie L, Zeng HX, Zhang FF, Chen GQ （通讯作者）, Yi XH, Zheng JK ANGPTL2/LILRB2 signaling promotes the propagation of lung cancer cells Oncotarget 2015 6(25):21004-15
Shen SM, Guo M, Xiong Z, Yu Y, Zhao XY, Zhang FF, Chen GQ （通讯作者） AIF inhibits tumor metastasis by protecting PTEN from oxidation EMBO reports 2015 16(11):1563-80
Hou JK, Huang Y, He W, Yan ZW, Fan L, Liu MH, Xiao WL, Sun HD, and Chen GQ （通讯作者） Adenanthin targets peroxiredoxin I/II to kill hepatocellular carcinoma cells Cell Death Dis 2015 5:e1400
Jiao HK, Xu Y, Li J, Wang W, Mei Z, Long XD, Chen GQ （通讯作者） Prognostic significance of Cbx4 expression and its beneficial effect for trans-arterial chemoembolization in hepatocellular carcinoma Cell Death Dis 2015 6: e1689
Li J, Xu Y, Long XD, Wang W, Jiao HK, Mei Z, Yin QQ, Ma LN, Zhou AW, Wang LS, Yao M, Xia Q, Chen GQ （通讯作者） Cbx4 Governs HIF-1α to Potentiate Angiogenesis of Hepatocellular Carcinoma by Its SUMO E3 Ligase Activity Cancer Cell 2014 25(1):118-31
Duan CW, Shi J, Chen J, Wang B, Yu YH, Qin X, Zhou XC, Cai YJ, Li ZQ, Zhang F, Yin MZ, Tao Y, Mi JQ, Li LH, Enver T, Chen GQ （通讯作者）, Hong DL. Leukemia propagating cells rebuild an evolving niche in response to therapy Cancer Cell 2014 25(6):778-793
Yin QQ, Liu CX, Wu YL, Wu SF, Wang Y, Zhang X, Hu XJ, Pu JX, Lu Y, Zhou HC, Wang HL, Nie H, Sun HD, Chen GQ （通讯作者） Preventive and Therapeutic Effects of Adenanthin on Experimental Autoimmune Encephalomyelitis by Inhibiting NF-kB Signaling J Immunol 2013 191(5):2115-25
He M, Wang QY, Yin QQ, Tang J, Lu Y, Zhou CX, Duan CW, Hong DL, Tanaka T, Chen GQ （通讯作者）, Zhao Q HIF-1α downregulates miR-17/20a directly targeting p21 and STAT3: a role in myeloid leukemic cell differentiation Cell Death and Differentiation 2013 20(3):408-18
Xia L, Wang TD, Shen SM, Zhao M, Sun H, He Y, Xie L, Wu ZX, Han SF, Wang LS, Chen GQ （通讯作者） Phosphoproteomics Study on the Activated PKCδ-Induced Cell Death J Proteome Res 2013 12(10):4280-301
Wang LS, Xia L, Shen SM, Zheng Y, Yu Y, Chen GQ （通讯作者） Dissecting cell death with proteomic scalpels Proteomics 2012 12(4-5):597-606.
Liu B, Zheng Y, Wang TD, Xu HZ, Xia L, Zhang J, Wu YL, Chen GQ （通讯作者）, Wang LS Proteomic identification of common SCF ubiquitin ligase FBXO6-interacting glycoproteins in three kinds of cells J Proteome Res 2012 11(3):1773-81.
Liu CX, Yin QQ, Zhou HC, Wu YL, Pu JX, Xia L, Liu W, Huang X, Jiang T, Wu MX, He LC, Zhao YX, Wang XL, Xiao WL, Chen HZ, Zhao Q, Zhou AW, Wang LS, Sun HD, Chen GQ （通讯作者） Adenanthin targets peroxiredoxin I and II to induce differentiation of leukemic cells Nat Chem Biol 2012 8(5):486-93.
Xu Y, Li J, Zuo Y, Deng J, Wang LS, Chen GQ （通讯作者） SUMO-specific protease 1 regulates the in vitro and in vivo growth of colon cancer cells with the upregulated expression of CDK inhibitors Cancer Lett 2011 309(1):78-84.
Zhao XY, Zhao KW, Jiang Y, Zhao M, Chen GQ （通讯作者） Synergistic Induction of Galectin-1 by CCAAT/Enhancer Binding Protein Alpha and Hypoxia-inducible Factor 1Alpha and Its Role in Differentiation of Acute Myeloid Leukemic Cells J Biol Chem 2011 286(42):36808-36819.
Zhang B, Liu XX, He JR, Zhou CX, Guo M, He M, Li MF, Chen GQ （通讯作者）, Zhao Q Pathologically decreased miR-26a antagonizes apoptosis and facilitates carcinogenesis by targeting MTDH and EZH2 in breast cancer Carcinogenesis 2011 32(1):2-9.
Huang Y, Hou JK, Chen TT, Zhao XY, Yan ZW, Zhang J, Yang J, Kogan SC, Chen GQ （通讯作者） PML-RARalpha enhances constitutive autophagic activity through inhibiting the Akt/mTOR pathway Autophagy 2011 7(10):1132-44.
Shen SM, Yu Y, Wu ZX, Zheng Y, Chen GQ （通讯作者）, Wang LS Apoptosis-inducing factor is a target gene of C/EBPalpha and participates in adipocyte differentiation FEBS Lett 2011 585(14):2307-12.
Shen SM, Yu Y, Wu YL, Cheng JK, Wang LS, Chen GQ （通讯作者） Downregulation of ANP32B, a novel substrate of caspase-3, enhances caspase-3 activation and apoptosis induction in myeloid leukemic cells. Carcinogenesis 2010 31(3):419-426.
Wu SF, Huang Y, Hou JK, Yuan TT, Zhou CX, Zhang J, Chen GQ （通讯作者） The downregulation of onzin expression by PKCepsilon-ERK2 signaling and its potential role in AML cell differentiation. Leukemia 2010 24(3):544-551.
Wu YL, Zhou HC, Chen GQ （通讯作者） Molecular mechanisms of leukemia-associated protein degradation Front Med China 2010 4(4):363-370
Xu Y, Zuo Y, Zhang HZ, Kang XL, Yue F, Yi ZF, Liu MY, Edward T. H. Yeh, Chen GQ （通讯作者）, Cheng JK Induction of SENP1 in Endothelial Cells Contributes to Hypoxia-driven VEGF Expression and Angiogenesis The Journal of Biological Chemistry 2010 285(47):36682-36688
Duan XF, Wu YL, Xu HZ, Zhao M, Zhuang HY, Wang XD, Yan H, Chen GQ （通讯作者） Synergistic mitosis-arresting effects of arsenic trioxide and paclitaxel on human malignant lymphocytes. Chem Biol Interact 2010 183 : 222-230.
Xu HZ, Huang Y, Wu YL, Zhao Y, Xiao WL, Lin QS, Sun HD, Dai W, Chen GQ （通讯作者） Pharicin A, a novel natural ent-kaurene diterpenoid, induces mitotic arrest and mitotic catastrophe of cancer cells by interfering with BubR1 function Cell Cycle 2010 9(14):1-11.
Gu ZM, Wu YL, Zhou MY, Liu CX, Xu HZ, Yan H, Zhao Y, Huang Y, Sun HD, Chen GQ （通讯作者） Pharicin B stabilizes retinoic acid receptor-a and presents synergisticdifferentiation induction with ATRA in myeloid leukemic cells Blood 2010 116(24):5289-5297.
Zhao XY, Chen TT, Xia L, Guo M, Xu Y, Yue F, Jiang Y, Chen GQ （通讯作者）, Zhao KW Hypoxia inducible factor-1 mediates expression of galectin-1: the potential role in migration/invasion of colorectal cancer cells Carcinogenesis 2010 31(8):1367-1375
Yuan TT, Huang Y, Zhou CX, Yu Y, Wang LS, Zhuang HY, Chen GQ （通讯作者） Nuclear translocation of dihydrofolate reductase is not a pre-requisite for DNA damage induced apoptosis. Apoptosis 2009 14(5):699–710.
Liao SH, Zhao XY, Han YH, Zhang J, Wang LS, Xia L, Zhao KW, Zheng Y, Guo M, Chen GQ （通讯作者） Proteomics-based identification of two novel direct targets of hypoxia- inducible factor-1a and their potential roles in migration/invasion of cancer cells. Proteomics 2009 9(15):3901-3912.
Zheng Y, Wang LS, Xia L, Han YH, Liao SH, Wang XL, Cheng JK, Chen GQ （通讯作者） NDRG1 is down-regulated in the early apoptotic event induced by camptothecin analogs: The potential role in proteolytic activation of PKCd and apoptosis. Proteomics 2009 9(8):2064–2075.
Zhao M, Duan XF, Zhao XY, Zhang B, Lu Y, Liu W, Cheng JK, Chen GQ （通讯作者） Protein kinase Cd stimulates proteasome-dependent degradation of C/EBPα during apoptosis induction of leukemic cells. PlosONE 2009 4(8): e6552
Gao FH, Wu YL, Zhao M, Liu CX, Wang LS, Chen GQ （通讯作者） Protein Kinase C-δ mediates down-regulation of heterogeneous nuclear ribonucleoprotein K protein: involvement in apoptosis induction. Exp Cell Res 2009 315(19):3250-3258.
Zhang J, Song LP, Huang Y, Zhao Q, Zhao KW, Chen GQ （通讯作者） Accumulation of hypoxia-inducible factor-1a protein and its role in the differentiation of myeloid leukemic cells induced by all-trans retinoic acid. Haematologica 2008 93(10):1480-1487.
Yang L, Jiang Y, Wu SF, Zhou MY, Wu YL and Chen GQ CCAAT/enhancer-binding protein a antagonizes transcriptional activity of hypoxia-inducible factor 1 a with direct protein–protein interaction. Carcinogenesis 2008 29(2):291–298.
Song LP, Zhang J, Wu SF, Huang Y, Zhao Q, Cao JP, Wu YL, Wang LS, Chen GQ （通讯作者） Hypoxia-inducible factor-1a-induced differentiation of myeloid leukemic cells is its transcriptional activity independent. Oncogene 2008 27(4):519–527.
Lu Y, Peng ZG, Yuan TT, Yin QQ, Xia L, Chen GQ （通讯作者） Multi-sites cleavage of leukemogenic AML1-ETO fusion protein by caspase-3 and its contribution to increased apoptotic sensitivity. Leukemia 2008 22(2):378–386.
Peng ZG, Zhou MY, Huang Y, Qiu JH, Wang LS, Liao SH, Dong S, Chen GQ （通讯作者） Physical and functional interaction of Runt-related protein 1 with hypoxia-inducible factor-1a. Oncogene 2008 27(6):839–847.
Yu Y, Wang LS, Shen SM, Xia L, Zhang L, Zhu YS, Chen GQ （通讯作者） Subcellular proteome analysis of camptothecin analogue NSC606985-treated acute myeloid leukemic cells. J Proteome Res 2007 6(9): 3808-3818.
Yan H, Wang YC, Li D, Wang Y, Liu W, Wu YL, Chen GQ （通讯作者） Arsenic trioxide and proteasome inhibitor bortezomib synergistically induce apoptosis in leukemic cells: the role of protein kinase Cd. Leukemia 2007 21 (7):1488-1495.
Liu W, Guo M, Xu YB, Li D, Zhou ZN, Wu YL, Chen Z, Kogan SC, Chen GQ （通讯作者） Induction of tumor arrest and differentiation with prolonged survival by intermittent hypoxia in a mouse model of acute myeloid leukemia. Blood 2006 107 (2):698-707.
Huang Y, Zhao Q, Zhou CX, Gu ZM, Li D, Xu HZ, Wiedmer T, Sims PJ, Zhao KW, Chen GQ （通讯作者） Antileukemic roles of human phospholipid scramblase 1 gene, evidence from inducible PLSCR1-expressing leukemic cells. Oncogene 2006 25 (50): 6618-6627.
Song MG, Gao SM, Du KM, Xu M, Yu Y, Zhou YH, Wang Q, Chen Z, Zhu YS, Chen GQ （通讯作者） Nanomolar concentration of NSC606985, a camptothecin analog, induces leukemic-cell apoptosis through protein kinase Cd-dependent mechanisms. Blood 2005 105(9):3714-3721.
Zhao KW, Li X, Zhao Q, Huang Y, Li D, Peng ZG, Shen WZ, Zhao J, Zhou Q, Chen Z, Sims PJ, Wiedmer T, Chen GQ （通讯作者） Protein kinase Cd mediates retinoic acid and phorbol myristate acetate-induced phospholipid scramblase 1 gene expression: its role in leukemic cell differentiation Blood 2004 104(12): 3731-3738.